LOCUS       NM_019967               3354 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus bone morphogenic protein/retinoic acid inducible
            neural specific 1 (Brinp1), mRNA.
ACCESSION   NM_019967
VERSION     NM_019967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3354)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3354)
  AUTHORS   Li,J., Sun,L., Peng,X.L., Yu,X.M., Qi,S.J., Lu,Z.J., Han,J.J. and
            Shen,Q.
  TITLE     Integrative genomic analysis of early neurogenesis reveals a
            temporal genetic program for differentiation and specification of
            preplate and Cajal-Retzius neurons
  JOURNAL   PLoS Genet 17 (3), e1009355 (2021)
   PUBMED   33760820
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3354)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   4  (bases 1 to 3354)
  AUTHORS   Kobayashi,M., Hayashi,Y., Fujimoto,Y. and Matsuoka,I.
  TITLE     Decreased parvalbumin and somatostatin neurons in medial prefrontal
            cortex in BRINP1-KO mice
  JOURNAL   Neurosci Lett 683, 82-88 (2018)
   PUBMED   29960053
  REMARK    GeneRIF: The numbers of parvalbumin and somatostatin expressing
            neurons in the medial prefrontal cortex of BRINP1-knockout mice,
            were fewer compared to neurons in medial prefrontal cortex of
            wild-type mice.
REFERENCE   5  (bases 1 to 3354)
  AUTHORS   Berkowicz,S.R., Featherby,T.J., Qu,Z., Giousoh,A., Borg,N.A.,
            Heng,J.I., Whisstock,J.C. and Bird,P.I.
  TITLE     Brinp1(-/-) mice exhibit autism-like behaviour, altered memory,
            hyperactivity and increased parvalbumin-positive cortical
            interneuron density
  JOURNAL   Mol Autism 7, 22 (2016)
   PUBMED   27042284
  REMARK    GeneRIF: Brinp1 plays an important role in normal brain development
            and function by influencing neuronal distribution within the
            cortex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3354)
  AUTHORS   Price,K.L., Woolf,A.S. and Long,D.A.
  TITLE     Unraveling the genetic landscape of bladder development in mice
  JOURNAL   J Urol 181 (5), 2366-2374 (2009)
   PUBMED   19303107
REFERENCE   7  (bases 1 to 3354)
  AUTHORS   Rasmussen,S.B., Jensen,S.B., Nielsen,C., Quartin,E., Kato,H.,
            Chen,Z.J., Silverman,R.H., Akira,S. and Paludan,S.R.
  TITLE     Herpes simplex virus infection is sensed by both Toll-like
            receptors and retinoic acid-inducible gene- like receptors, which
            synergize to induce type I interferon production
  JOURNAL   J Gen Virol 90 (Pt 1), 74-78 (2009)
   PUBMED   19088275
  REMARK    GeneRIF: The authors show that retinoic acid-inducible gene
            (RIG)-I-like receptors (RLRs) in cooperation with Toll-like
            receptor (TLR) 9 is required for expression of type I interferons
            (IFNs) after infection with herpes simplex virus (HSV).
REFERENCE   8  (bases 1 to 3354)
  AUTHORS   Motomiya,M., Kobayashi,M., Iwasaki,N., Minami,A. and Matsuoka,I.
  TITLE     Activity-dependent regulation of BRINP family genes
  JOURNAL   Biochem Biophys Res Commun 352 (3), 623-629 (2007)
   PUBMED   17141197
  REMARK    GeneRIF: From these results, the physiological roles of the
            activity-dependent induction of BRINP1-mRNA are discussed.
REFERENCE   9  (bases 1 to 3354)
  AUTHORS   Kawano,H., Nakatani,T., Mori,T., Ueno,S., Fukaya,M., Abe,A.,
            Kobayashi,M., Toda,F., Watanabe,M. and Matsuoka,I.
  TITLE     Identification and characterization of novel developmentally
            regulated neural-specific proteins, BRINP family
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 60-75 (2004)
   PUBMED   15193423
REFERENCE   10 (bases 1 to 3354)
  AUTHORS   Toshiyuki,N. and Ichiro,M.
  TITLE     Molecular mechanisms regulating cell type specific expression of
            BMP/RA Inducible Neural-specific Protein-1 that suppresses cell
            cycle progression: roles of NRSF/REST and DNA methylation
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 47-59 (2004)
   PUBMED   15193422
  REMARK    GeneRIF: Data show that neuron-restrictive silencing factor (NRSF)
            plays a role in the neural-selective expression of BMP/RA-inducible
            neural-specific protein 1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB060589.1 and AK045420.1.
            
            On Jan 24, 2006 this sequence version replaced NM_019967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045420.1, SRR1660817.43994.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3207              AB060589.1         1-3207
            3208-3354           AK045420.1         3090-3236
FEATURES             Location/Qualifiers
     source          1..3354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 35.03 cM"
     gene            1..3354
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="bone morphogenic protein/retinoic acid inducible
                     neural specific 1"
                     /db_xref="GeneID:56710"
                     /db_xref="MGI:MGI:1928478"
     exon            1..384
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     exon            385..652
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2717
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="deleted in bladder cancer protein 1 homolog;
                     BMP/retinoic acid-inducible neural-specific protein
                     (BRINP); deleted in bladder cancer chromosome region
                     candidate 1; BMP/retinoic acid-inducible neural-specific
                     protein 1"
                     /codon_start=1
                     /product="BMP/retinoic acid-inducible neural-specific
                     protein 1 precursor"
                     /protein_id="NP_064351.2"
                     /db_xref="CCDS:CCDS18272.1"
                     /db_xref="GeneID:56710"
                     /db_xref="MGI:MGI:1928478"
                     /translation="MNWRFVELLYFLFVWGRISVQPSRQEPAGTDQHVSKEFDWLISD
                     RGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQ
                     RSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQS
                     VEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGPLGCNSYDNLDSVSSVLL
                     QSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYVCQNSQCRCQCAEEFPQC
                     NCPITDIQIMEFTLANMAKAWTEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGN
                     DWDLQSRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQ
                     SLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCIIGGNNSCAMCSLANISLCGSC
                     NKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISN
                     EIRLDTFFDPRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNP
                     FSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTR
                     LPTLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQG
                     GQFYSSSSVMLLMLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHA
                     LDLYNTEILKQSDQMTAKLC"
     exon            653..843
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1013
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1119
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1356
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1579
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..3354
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="hexamer: ATTAAA"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="hexamer: AACAAG"
     polyA_site      3125
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="major polyA site"
     polyA_site      3128
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="major polyA site"
     regulatory      3187..3192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="hexamer: GATAAA"
     polyA_site      3212
                     /gene="Brinp1"
                     /gene_synonym="BRINP; Dbc1; Dbccr1; Fam5a"
                     /note="major polyA site"
ORIGIN      
        1 accgcggcgc acttggactt ccctctccat tcgccagccg cctcgctccg agtccccgcg
       61 gctgcgaact gatctggcac agggggtggg caggaggagg agaagagcgc aggcaaagga
      121 gaaggcgaga gagccagaga gccagaggca gagggagtag tggccacctt ttggagtcgg
      181 gattcatgcc tgtcctcggg accagccaag gggactttaa ggctgagtat gagccaggct
      241 gctaggagcc aggtaccccc acgcctgcag tccccgcgcc gtccccggta tgcgagctgg
      301 acgcagggct cttccaagtt cccaccgagc cgaataaaaa gcgtctttcc gctgctctcc
      361 gccaaagacg gacattgact ccaggactcc acagaatgga gcaagaatga gaggaaaaag
      421 gccggcagca aagcatgaac tggaggtttg ttgagctcct ctacttcctg tttgtatggg
      481 gccgtatctc agtgcagccc tcccgccagg agccagctgg gacagaccaa catgtctcca
      541 aggaatttga ttggcttatt tcagacaggg ggcctttcca ccactccagg agctacctat
      601 cctttgtgga aagacaccgg caaggattta caaccagata taaaatatac agggagtttg
      661 cccgttggaa ggtgaggaac acagccatag aaaggagaga cctggtccgt cacccagtgc
      721 ccctcatgcc ggagtttcaa aggagcatcc gtctgcttgg caggagaccc accactcagc
      781 agttcattga taccatcatc aaaaagtacg gcacccacct gctcatctct gctacattgg
      841 gaggagagga ggctttgacc atgtacatgg acaaaagtcg cctggaccgg aagtcaggga
      901 atgctaccca aagtgttgaa gctttgcacc agcttgcatc atcctacttt gtcgaccgtg
      961 atggcaccat gagaaggctc catgagatcc agatttcaac tggagcaatc aaggtcacag
     1021 aaacacgcac tgggcctctg ggctgtaaca gctatgacaa tctggactct gtgagttctg
     1081 tccttctgca aagcacggag agcaaactgc accttcaagg tcttcagata atcttcccgc
     1141 agtatctgca agagaagttt gttcagtcgg ccttgagtta catcatgtgc aatggagagg
     1201 gagagtatgt gtgtcagaac agccagtgtc gctgccagtg tgctgaggag ttcccacagt
     1261 gcaactgccc catcaccgac atccagatca tggagtttac gctggcaaac atggccaagg
     1321 cctggactga agcttataag gacctggaga attcagatga gtttaagtca tttatgaagc
     1381 gtctcccaag caaccacttc ctgacgattg gcagcatcca ccagcactgg ggcaatgact
     1441 gggacctgca gagccgttac aagctcctac agagtgccac tgaggctcag aggcagaaaa
     1501 tccagaggac cgcccgcaag ctctttggcc tcagtgtgcg ctgccgccac aatcccaacc
     1561 accagctgcc tagagagagg acaattcaac agtggcttgc aagggtccag tcacttctct
     1621 attgcaatga gaatgggttc tggggaacct tcctggaaag ccagaggagt tgtgtgtgcc
     1681 atggtagcac cacactgtgc cagcgcccta tcccatgtat cataggtggg aacaacagct
     1741 gtgccatgtg cagcctggcc aacatctcac tctgtggctc ctgcaataag ggctacaagc
     1801 tgtatagagg ccgctgtgaa ccacaaaacg tggactctga gcggagtgag cagttcatca
     1861 gctttgagac cgacctggac ttccaggact tggaactgaa gtacctgttg cagaagatgg
     1921 attcacgcct ctatgtccat actaccttca tcagcaatga gattcgcctg gatacatttt
     1981 ttgaccctcg gtggcgcaag cgcatgtccc tcactctcaa aagcaacaag aaccgcatgg
     2041 actttatcca catggtgatc ggaatgtcca tgcgtatctg ccagatgcgc aacagcagcc
     2101 tggaccctat gttctttgtc tatgtcaatc ccttcagtgg gagccattca gaaggctgga
     2161 acatgccctt tggggaattt ggctaccctc gttgggagaa gatccgtctg caaaacagcc
     2221 aatgctacaa ttggactctc ttgctgggca atcggtggaa aacttttttc gagactgtcc
     2281 atatctacct acgtagtcgg actcggctac ccaccctacg caatgagact ggccagggcc
     2341 cggtggacct gtcggatccc tccaaaaggc agttctacat caagatctct gatgtacagg
     2401 tgtttgggta cagcctgagg ttcaatgctg acctcctacg aagtgccgtg caacaggtga
     2461 atcagtccta tacacagggt ggtcagttct attcctcctc atccgtgatg cttctcatgt
     2521 tggacattcg ggaccgaatc aaccgcctgg cccctcctgt ggccccagga aaaccccagc
     2581 tggacttgtt ttcctgtatg ctgaagcacc gcctgaagct gaccaacagt gagattatca
     2641 gggtgaacca tgccttggac ctctacaaca ctgagatcct caaacagtct gaccagatga
     2701 cagccaaact ctgctaaccc gggacccttt gccatggact ttcccttctg ttgtgcaaat
     2761 acaacagaac aaaacaaagc aaaacaaaag agaacatata catacataca catacagaca
     2821 gacagacaga cacacacacg catacacaaa tttgtaaaat gtaattagta ttcaaaggaa
     2881 aggaggaaaa aacttcattt gttggaagct aacgtgttct agcgactgta taaaaccgtg
     2941 gggcatgtct cttacttcta tattctgtca tgaagaaggg tctcagaatt gtgtgaagct
     3001 ttgagttggt ggcttctttg gcctcaggtg ctgtgtgatg ggggggagaa ggggagagca
     3061 tatgcaatga attgtaaaga cctctgctgt gcaggtgcta agattaaaca ctaaaagaga
     3121 gagaacaagc tatatgtaat gtacctctga cactgccatt tttccttgtg agaggaaatg
     3181 gacgtagata aagaagatat ttcttcggtt aagatttctt tcctctttat gcttaattct
     3241 ttgtgcttct tttgatgctc tgctggggat gggggtggtg ggggtggtgg gtgcaacaac
     3301 actgcaaact tacccatatg gcttctttac gtctcaataa actgacacta aagg
//
