LOCUS       NP_079962                420 aa            linear   ROD 02-JUN-2024
DEFINITION  transcription factor IIIB 50 kDa subunit [Mus musculus].
ACCESSION   NP_079962
VERSION     NP_079962.1
DBSOURCE    REFSEQ: accession NM_025686.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 420)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (residues 1 to 420)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012680.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012680.1, AK028228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.91 cM"
     Protein         1..420
                     /product="transcription factor IIIB 50 kDa subunit"
                     /note="B-related factor 2; BRF2, subunit of RNA polymerase
                     III transcription initiation factor, BRF1-like"
                     /calculated_mol_wt=46860
     Region          5..233
                     /region_name="SUA7"
                     /note="Transcription initiation factor TFIIIB, Brf1
                     subunit/Transcription initiation factor TFIIB
                     [Transcription]; COG1405"
                     /db_xref="CDD:441015"
     Region          66..162
                     /region_name="CYCLIN_BRF2"
                     /note="cyclin box found in B-related factor 2 (BRF-2) and
                     similar proteins; cd20555"
                     /db_xref="CDD:410258"
     Site            order(66,68,105,107..111,113..114,127,134..135,147,150,
                     153..154,158)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410258"
     Region          72..157
                     /region_name="Repetitive region"
                     /note="1; propagated from UniProtKB/Swiss-Prot (Q3UAW9.1)"
     Region          108..114
                     /region_name="Interaction with target DNA.
                     /evidence=ECO:0000250|UniProtKB:Q9HAW0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UAW9.1)"
     Region          173..249
                     /region_name="Repetitive region"
                     /note="2; propagated from UniProtKB/Swiss-Prot (Q3UAW9.1)"
     Region          316..387
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UAW9.1)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HAW0; propagated from
                     UniProtKB/Swiss-Prot (Q3UAW9.1)"
     Region          358..364
                     /region_name="Required for the formation of a ternary
                     complex with DNA and TBP, not required for interaction
                     with TBP in the absence of DNA.
                     /evidence=ECO:0000250|UniProtKB:Q9HAW0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UAW9.1)"
     Region          366..420
                     /region_name="Required for interaction with TBP and
                     formation of a ternary complex with DNA and TBP.
                     /evidence=ECO:0000250|UniProtKB:Q9HAW0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UAW9.1)"
     CDS             1..420
                     /gene="Brf2"
                     /gene_synonym="2700059M06Rik; 5730512K07Rik; BRFU;
                     TFIIIB50"
                     /coded_by="NM_025686.2:59..1321"
                     /db_xref="CCDS:CCDS22211.1"
                     /db_xref="GeneID:66653"
                     /db_xref="MGI:MGI:1913903"
ORIGIN      
        1 mpngsrcpdc gsselvedsh ysqsqlvcsd cgcvvtegvl tttfsdegnf revtysrstg
       61 eneqvsrcqq rdlrrvrdlc rilklpltfe dtaisyyqka yqlsgiraar lqkkevlvgc
      121 cvlitcrqhn wpltmgtict llyadldlfs gtymqmvkll gldvpslcla dlvksycssf
      181 klfqaspsvp akyvedkdkm lsrtlllvel adetwlvtgr hplpiitaat flawqslrps
      241 drltcslaqf cklanvdlpy paasrlqell avllqmagql awlqvlklnk rsvvkhigdl
      301 lqhrhmlvrt afrdgtaeve tqqqqqqqqg qgqgqqdevg dgpfdlpkrk rpasptpllp
      361 pcmlkppkrt htlppesavt gdedisdsei eqylrtpqev rdferaqaas qaamrvpnpp
//
