LOCUS       NM_028193               2755 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus BRF1, RNA polymerase III transcription initiation
            factor 90 kDa subunit (Brf1), mRNA.
ACCESSION   NM_028193
VERSION     NM_028193.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2755)
  AUTHORS   Liko,D., Mitchell,L., Campbell,K.J., Ridgway,R.A., Jones,C.,
            Dudek,K., King,A., Bryson,S., Stevenson,D., Blyth,K., Strathdee,D.,
            Morton,J.P., Bird,T.G., Knight,J.R.P., Willis,A.E. and Sansom,O.J.
  TITLE     Brf1 loss and not overexpression disrupts tissues homeostasis in
            the intestine, liver and pancreas
  JOURNAL   Cell Death Differ 26 (12), 2535-2550 (2019)
   PUBMED   30858608
  REMARK    Erratum:[Cell Death Differ. 2024 Sep;31(9):1235-1237. doi:
            10.1038/s41418-024-01344-z.. PMID: 39095545]
REFERENCE   2  (bases 1 to 2755)
  AUTHORS   Tan,F.E. and Elowitz,M.B.
  TITLE     Brf1 posttranscriptionally regulates pluripotency and
            differentiation responses downstream of Erk MAP kinase
  JOURNAL   Proc Natl Acad Sci U S A 111 (17), E1740-E1748 (2014)
   PUBMED   24733888
  REMARK    GeneRIF: Brf1 (zfp36l1), an AU-rich element mRNA-binding protein
            from the Zfp36 protein family, operates downstream of FGF/Erk MAP
            kinase signaling to regulate pluripotency and cell fate decision
            making in mouse embryonic stem cells.
REFERENCE   3  (bases 1 to 2755)
  AUTHORS   Zhong,S., Machida,K., Tsukamoto,H. and Johnson,D.L.
  TITLE     Alcohol induces RNA polymerase III-dependent transcription through
            c-Jun by co-regulating TATA-binding protein (TBP) and Brf1
            expression
  JOURNAL   J Biol Chem 286 (4), 2393-2401 (2011)
   PUBMED   21106530
  REMARK    GeneRIF: Alcohol induces RNA polymerase III-dependent transcription
            through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1
            expression.
REFERENCE   4  (bases 1 to 2755)
  AUTHORS   Benjamin,D., Schmidlin,M., Min,L., Gross,B. and Moroni,C.
  TITLE     BRF1 protein turnover and mRNA decay activity are regulated by
            protein kinase B at the same phosphorylation sites
  JOURNAL   Mol Cell Biol 26 (24), 9497-9507 (2006)
   PUBMED   17030608
  REMARK    GeneRIF: Phosphorylation at serine-92 and serine-203 is involved in
            BRF1 protein stability; high BRF1 protein levels are required to
            reinstate decay upon dissipation of the stabilizing signal.
REFERENCE   5  (bases 1 to 2755)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2755)
  AUTHORS   Raineri,I., Wegmueller,D., Gross,B., Certa,U. and Moroni,C.
  TITLE     Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover
            studied by RNA interference
  JOURNAL   Nucleic Acids Res 32 (4), 1279-1288 (2004)
   PUBMED   14976220
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073562.6 and AC160929.2.
            
            On Nov 17, 2006 this sequence version replaced NM_028193.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164135
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC073562.6         142139-142587
            450-530             AC073562.6         149616-149696
            531-706             AC073562.6         154668-154843
            707-736             AC073562.6         159704-159733
            737-809             AC073562.6         163003-163075
            810-959             AC073562.6         169139-169288
            960-1053            AC073562.6         170405-170498
            1054-1180           AC073562.6         172537-172663
            1181-1220           AC073562.6         173279-173318
            1221-1313           AC073562.6         173403-173495
            1314-1577           AC160929.2         162022-162285       c
            1578-1639           AC160929.2         160477-160538       c
            1640-1721           AC160929.2         159803-159884       c
            1722-1777           AC160929.2         159670-159725       c
            1778-2034           AC160929.2         158669-158925       c
            2035-2086           AC160929.2         158016-158067       c
            2087-2258           AC160929.2         157403-157574       c
            2259-2755           AC160929.2         156155-156651       c
FEATURES             Location/Qualifiers
     source          1..2755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.47 cM"
     gene            1..2755
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /note="BRF1, RNA polymerase III transcription initiation
                     factor 90 kDa subunit"
                     /db_xref="GeneID:72308"
                     /db_xref="MGI:MGI:1919558"
     exon            1..449
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..2296
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /note="BRF-1; hTFIIIB90; B-related factor 1; BRF1 homolog,
                     subunit of RNA polymerase III transcription initiation
                     factor IIIB"
                     /codon_start=1
                     /product="transcription factor IIIB 90 kDa subunit"
                     /protein_id="NP_082469.2"
                     /db_xref="CCDS:CCDS49195.1"
                     /db_xref="GeneID:72308"
                     /db_xref="MGI:MGI:1919558"
                     /translation="MTGRVCRGCGGTDIELDAARGDAVCTGCGSVLEDNIIVSEVQFV
                     ENSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGSQLQL
                     NQHCLDTAFNFFKMAVSKHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNV
                     YVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDW
                     MHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLT
                     IDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELEN
                     SRPKAKGALANLSKDGSGEDATSSPRCEEDTEDEELEAAASHMNKDFYRELLGDDDGS
                     EAAGDPDGGSRPLALESLLGPLPTAASLGISDSIRECISSPSGDPKDSSGDGELDLSG
                     IDDLEIDRYILNESEARVKAELWMRENAEYLREQKEKEARIAKEKELGIYKEHKPKKS
                     CKRREPILASTAGEAIEKMLEQKKISSKINYSVLRDLNSKGGGSPPRDDSQPPERAST
                     KKLSRRKRATTRNSADPGTSTGKRLRPLLSAQPAKKAAVGEALLLSSPALGAEPIKPS
                     AVLVESGPVSYHPEEDADEEDAEDEDGEPCVSALQMMGGNDYGCDGDEDDGY"
     exon            450..530
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            531..706
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            707..736
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            737..809
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            810..959
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1053
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1180
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1220
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1313
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1577
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1639
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1721
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1777
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2034
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2086
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2258
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2755
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2532
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /note="major polyA site"
     regulatory      2553..2558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
                     /note="hexamer: AATGAA"
     polyA_site      2574
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
     polyA_site      2708
                     /gene="Brf1"
                     /gene_synonym="2510002F24Rik; GTF3B; mTFIIIB90; TAF3C;
                     TAFIII90; TFIIIB90"
ORIGIN      
        1 ccgcccggaa ggtcggcggt tcggtcccag cgtcccaacg attcttgagt tcctttatcg
       61 gtcccgcggg cgcggccgtt gcaggcagcg cggcccgcac gcgctgggcg aatctgccgc
      121 gacgaatcgg caggcgtggc gccggcggcc tcgcgagagt gcggcgcaga cggaggcggc
      181 gcgacgggcc ttgcgggctg agggccgcgg gcggagagcg gactgctgag cggctggggg
      241 gccggtgggg ccccgcggct ccaccatgac gggccgcgtc tgccgcggct gcggcggcac
      301 ggacatcgag ttggatgcgg cgcgcggcga tgcggtgtgc acgggctgcg gctcggtgct
      361 cgaggacaac atcatcgtgt ccgaggtgca gttcgtggag aacagcggcg gcggctcgtc
      421 ggcggtcggc cagttcgtgt cgctggacgg tgctgggaaa accccaaccc taggaggtgg
      481 ctttcacgtg aacttgggaa aggaatcaag agcacagacc ctgcagaatg ggcggcgcca
      541 catccaccac ctggggagcc agctgcagct aaaccagcac tgcctggaca cagcattcaa
      601 tttcttcaag atggctgtaa gcaagcatct tacccgagga cggaaaatgg cccatgtgat
      661 tgctgcctgc ctctacttgg tttgccgaac tgaaggcaca cctcatatgc tccttgacct
      721 cagcgacttg ctccaggtta acgtgtatgt gttggggaag acgttcctgc tcttggcgag
      781 ggagctttgc atcaacgcac cagctataga cccatgcttg tacattccac gctttgctca
      841 tctgctggag tttggggaga agaaccatga agtatccatg acagccttga ggcttctgca
      901 gagaatgaaa agggattgga tgcacacggg ccggcgcccc tccggcctct gtggagcagc
      961 acttttggtt gcagccagaa tgcatgactt ccggagaacg gtcaaagaag tcatcagtgt
     1021 ggtcaaagta tgtgagtcca cactacggaa gaggctcaca gaatttgaag acactccaac
     1081 cagtcagctc actattgatg agtttatgaa gattgacttg gaggaagagt gcgaccctcc
     1141 ctcgtacaca gctggccaga ggaagcttcg catgaagcag ctggaacagg tcctatcaaa
     1201 aaagctagaa gaagttgaag gtgaaatatc cagttaccag gatgccattg aaattgagct
     1261 agaaaacagt cgaccaaaag caaaaggggc tctggccaac ttgtcaaagg atggctccgg
     1321 tgaggacgcc acatccagtc cacgctgtga ggaagacact gaggatgagg agctggaggc
     1381 tgctgccagc cacatgaaca aggacttcta ccgagagctc ctcggggacg atgacggctc
     1441 ggaggcagca ggagaccctg atgggggcag cagacccctc gccctggagt ccctacttgg
     1501 tcccctgccc acagcagcca gcctgggcat ctccgactcc atccgagagt gcatctcctc
     1561 cccaagtggg gaccccaaag actcttcagg ggacggggag ctggacctca gtggcatcga
     1621 tgaccttgag attgacagat acatcttgaa tgagtcagaa gcccgagtaa aagctgagtt
     1681 gtggatgcgg gagaatgctg agtacctgcg ggagcagaag gagaaagaag caagaatagc
     1741 gaaggagaag gagcttggca tctataagga gcacaagccc aagaagtctt gcaaacgccg
     1801 ggagccaatc ctggccagca cagctgggga ggctattgag aagatgctgg aacagaagaa
     1861 aatctccagc aagatcaact acagtgtgct gcgggacctt aacagcaagg gtggaggcag
     1921 cccacccagg gacgactcac agcccccaga gcgtgccagc accaagaagc tgtcacggag
     1981 gaaaagagca actaccagaa atagtgctga tcctgggaca agcacaggga agaggttgag
     2041 gcctctgctg tctgcccagc cggcgaagaa ggcagccgtg ggagaggcct tactcttaag
     2101 ttctcctgcc ttgggagcag agccaatcaa gccatcagca gtcttggtag agagtggccc
     2161 tgtgtcgtac catcctgagg aggatgcaga tgaggaggac gccgaggacg aggatggaga
     2221 gccctgcgtc agtgctctgc agatgatggg tggcaatgat tacggctgtg atggtgatga
     2281 agatgatggc tactgagtgg aactcaaggc caggcagcgt cctggtgctg gactccaagt
     2341 gtatctgttt tatgggtgtc agatgggccc tggggccacg gctcatagga atgatttctg
     2401 agactctacc agtcaagcac tgccccactt atttgaagct ctcttcctgt ggctacattg
     2461 tggaccattg tacttactat tgggaatcat gttttgagca atggaaggga tatttttgcc
     2521 cagcaaggga aactagctgt gtgtttatgt gtaatgaaac atggtcagag agtagctggg
     2581 tctggatccc acttcgtggc ctggcctgct agtgactgtt taccagcaat ccccaggcag
     2641 gcactgtgtc ctcctgtcgt taggaaattg aagcacaagg gcttcagtca agaagtccag
     2701 ccagcttagc ctgctgccag tgttctctgc cctgtccttc ccatcctgga gagag
//
