LOCUS       NM_030147               4730 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bromodomain containing 8 (Brd8), transcript variant 1,
            mRNA.
ACCESSION   NM_030147 NM_144864 XM_484717
VERSION     NM_030147.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4730)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4730)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   3  (bases 1 to 4730)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4730)
  AUTHORS   Fisher,C.L., Marks,H., Cho,L.T., Andrews,R., Wormald,S.,
            Carroll,T., Iyer,V., Tate,P., Rosen,B., Stunnenberg,H.G.,
            Fisher,A.G. and Skarnes,W.C.
  TITLE     An efficient method for generation of bi-allelic null mutant mouse
            embryonic stem cells and its application for investigating
            epigenetic modifiers
  JOURNAL   Nucleic Acids Res 45 (21), e174 (2017)
   PUBMED   28981838
REFERENCE   5  (bases 1 to 4730)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   6  (bases 1 to 4730)
  AUTHORS   Couture,J.P., Nolet,G., Beaulieu,E., Blouin,R. and Gevry,N.
  TITLE     The p400/Brd8 chromatin remodeling complex promotes adipogenesis by
            incorporating histone variant H2A.Z at PPARgamma target genes
  JOURNAL   Endocrinology 153 (12), 5796-5808 (2012)
   PUBMED   23064015
  REMARK    GeneRIF: incorporation of the histone variant H2A.Z at the promoter
            regions of PPARgamma target genes by p400/Brd8 is essential to
            allow fat cell differentiation
REFERENCE   7  (bases 1 to 4730)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 4730)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 4730)
  AUTHORS   Mori,A.D., Zhu,Y., Vahora,I., Nieman,B., Koshiba-Takeuchi,K.,
            Davidson,L., Pizard,A., Seidman,J.G., Seidman,C.E., Chen,X.J.,
            Henkelman,R.M. and Bruneau,B.G.
  TITLE     Tbx5-dependent rheostatic control of cardiac gene expression and
            morphogenesis
  JOURNAL   Dev Biol 297 (2), 566-586 (2006)
   PUBMED   16870172
  REMARK    Erratum:[Dev Biol. 2007 Sep 15;309(2):386]
REFERENCE   10 (bases 1 to 4730)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD555707.1, AK032320.1, AK161689.1 and AV322131.1.
            
            On Jan 24, 2014 this sequence version replaced NM_030147.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032320.1, SRR9219382.39974.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               CD555707.1         1-289
            290-2738            AK032320.1         2-2450
            2739-3486           AK161689.1         2233-2980
            3487-4605           AK032320.1         3199-4317
            4606-4682           AV322131.1         109-185
            4683-4730           AK032320.1         4395-4442
FEATURES             Location/Qualifiers
     source          1..4730
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.69 cM"
     gene            1..4730
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /note="bromodomain containing 8"
                     /db_xref="GeneID:78656"
                     /db_xref="MGI:MGI:1925906"
     exon            1..326
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            327..423
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            424..493
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            494..543
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            544..666
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..747
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            748..812
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            813..949
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1168
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1313
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1523
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1804
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2257
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2351
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2398
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2613
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2706
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2775
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2953
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3058
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3103
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..4730
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /note="hexamer: AATAAA"
     polyA_site      3519
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /note="major polyA site"
ORIGIN      
        1 gcagagccta ccggaagacc gtttgctttt aatgtgggtc cgggttacca actgacactt
       61 ccatgttgtt catcctggta ttcttgtcgc ttaattctaa atctagacgt ttcttttctg
      121 aggcttcagc cgcaatccct tgtcctttat tagttaaaaa gcagattttt ttttcctaga
      181 ggaacttcgc ttctattagg gcaaactgac ccacccacat tacccacgag gcaccgcgaa
      241 cggattcgca ctgtgtttcc cagagttccc cgcgtctgtc gccaacgttg aagacgtcga
      301 agccaagatg gcgaccggga caggcaagca caagctgctg agtactggcc caacagagcc
      361 atggtccatc cgagagaagt tgtgtttagc atcttctgtc atgaggagtg gggatcagaa
      421 ctgggtatca gttagcagag caatcaagcc ctttgcagaa cctggccggc ctccagactg
      481 gttctctcaa aaacattgtg cttctcagta ttctgagctc ttagagacta ctgagactcc
      541 aaaacggaaa cggggtgaaa aaggagaagt ggtagaaact gttgaagatg ttattgttcg
      601 caaactgact gctgagagag ttgaagaact gaagaaagtc ataaaggaga cacaggagag
      661 atacaggcgt ctgaaaagag atgcagaact aatccaagcc gggcacatgg acagcagact
      721 ggatgagctc tgcaatgaca ttgcaatgaa aaagaaattg gaagaggaag aggctgaagt
      781 aaaaaggaag gccaccgatg ctgcgtacca ggcgcgacaa gcagtgaaaa cgcctcctcg
      841 aaggttaccg actgtgatgg tccgctctcc tgtagactct gcctccccag gaggtgatta
      901 cccacttgga gacttgactc caaccactat ggaagaggct acctctgggg taacccctgg
      961 gactttgccg agtaccccag tcacctcgtt tcctgggatt cctgacaccc ttcctccagg
     1021 ctctgcaccc ttagaagccc ccatgacccc aataacagat gattcacccc agaaaaagat
     1081 gcttggacag aaagcaactc cacccccctc ccctctgctg tcagagctct tgaagaaggg
     1141 cagcctcctg cctactagcc ccagactggt gaatgagagt gaaatgcctg taccccctgg
     1201 ccatctgaac agcacagggg ttctcttgga ggtaggaggg gttcttccca tgatacatgg
     1261 tggggagata cagccaacaa ccagtgctgt ggcggcctcc ccggctgcct caggtgctcc
     1321 cactctttcc cggcttttag aagctgggcc cacacagttc accactcctc ttccttcctt
     1381 cactactgtt gccagtgagc cgccagttaa gcttgtgcca ccccctgtag agtctgtgtc
     1441 ccaggctacc attgtcatga tgcccgcgct gccagcacca tcctctgctg cggctgtctc
     1501 cacttctgaa agtggagctc cagtgagcca gcctgagccc tgtgtacccc tggaagctgt
     1561 gggggatcca catactgtga ctgtttccat ggatagcaat gaaatctcca tgatcattaa
     1621 ttccatcaaa gaagagtgtt tccgctcagg ggtagcagag gctcctggtg gatcaaaggc
     1681 tccaagcata gatgggaagg aagacttgga tctagcggag aagatggata ttgctgtgtc
     1741 ttacacaggt gaagagttgg actttgaaac agttggagac atcattgcca tcattgagga
     1801 caaggtggat gatcaccctg aagtgctgga tgtggcagcg gtagaagcgg cgttatcgtt
     1861 ctgtgaagag aatgatgacc ctcagtccct gcctggcccc tgggagcacc ctatccagca
     1921 ggagcgcgac aagccagtac ctctgccagc accagagatg acagtcaaac aagagaggct
     1981 agacttcgag gaatcagaaa acaaagggct ccatgacctg gtggacatca gggattccgg
     2041 tgttgagatt aaggtggaac ccacagagcc agagccaggc atgtctgggg ctgagatagt
     2101 agctggagtt ggtccagttc caagtatgga gccaccagaa ctcaggagtc aagactcaga
     2161 tgaagaacct agaagttctg cagctggaga cattggtgag gcagatggtt ccagtgggaa
     2221 aggcgatgag aggccacttt cagctgtgaa gacagaggca tcccctgaga gcatgttgtc
     2281 tccatcacat ggctcaaatc ttattgaaga tcctttagag gcagagactc aacacaagtt
     2341 tgaaatgtca gactcattga aagaagaatc agggactatt tttggaagcc agataaagga
     2401 tgccccaggt gacgatgagg aagaagatgg agtcagtgaa gcagctagcc tagaggagcc
     2461 taaggaagag gatcaaggag aaggctattt gtctgagatg gataatgagc cccctgtgag
     2521 tgagagtgat gatggcttta gtatacataa cgccacactg cagtcacaca ctctggcaga
     2581 ctccatccca agcagccctg cctcctccca gttttccgtg tgcagtgaag atcaagaagc
     2641 aattcaggct cagaaaatat ggaagaaagc catcatgctt gtatggaggg ctgcagcaaa
     2701 tcataggtat gccaatgtgt tcctgcaacc tgttacagat gacatagctc ctggttacca
     2761 tagcattgta cagaggccta tggatttgtc aactataaag aaaaacattg aaaatggact
     2821 gatccgaagc acagctgagt ttcagcgtga catcatgctg atgtttcaga atgctgttat
     2881 gtacaatagc tcagaccatg atgtctatca catggcagta gagatgcaga gagatgtctt
     2941 ggaacagatc cagcaattct tggccacaca gttgattatg caaacatctg agtctggaat
     3001 cagtgctaaa agtctccggg ggagagactc tacccgaaaa caagatgctt cagagaagga
     3061 cagtgtcccc atgggctctc ctgccttcct tctctctctc tttgatgggg gaaccagggg
     3121 acgccgctgt gccattgaag cagatatgaa gatgaagaag tgaatgccct ctttgagctg
     3181 agcctgaaat agaaataagc aagatacttt agcttgggct tgtgggctca gttccacact
     3241 tgatcttagt caaaaggctg agaagcaggg agtccagaag tggaattaca gaagaggagg
     3301 tgcctgggcc aaatgacatg agttgagaaa atctcttttc agagagttgg agtagcacag
     3361 atgcctgttt tagggcagaa atcatgggct ctgttaatgc cctaatgtgt aactagcaga
     3421 ttgtagctaa tttgtactgt cttgtgaagt gtacagattt tttaaataat aataataata
     3481 aacctgtgaa gtgtgtatat ataacaatca gaaggaaaac tctggccttt ggtgtgtcct
     3541 ttgtgtttga gatgtgtttt cttttttttt tttttttttt tttttaaaga ctttatttat
     3601 tattatagta agtacactgt agctatcttc agacacacca gaagagggag tcagatcttg
     3661 ttacggatgg ttgtgagcca ccatgtggtt gctgggatat gaaccctgga ccttcggaag
     3721 aacagtcggg tgctcttacc cactgagcca tctcaccagc cccgagatgt gttttcttta
     3781 ccatgataac tgagtgtgta tgggatacaa tggttagagc tgagtagtcc catagactgc
     3841 ctgctatgac tgagaggagg taagtaacca agaccaaagt agtaattagt gtttttaaag
     3901 gacttgattg tgtaaaaagg acaatttgac tattttactg ggcatttctt gaatgtttgg
     3961 gaaatactaa gggttttaag atctggttat atttcttagg gattagacca cgggcaaatg
     4021 tagcagacag gtcagtcctt gccgatgctg tcaacctctc tataggtaga actagtgtac
     4081 agtgttagtt tggttatttt gaggtggagt ctcccttttt tgataatgct agcctacagc
     4141 tcaaaatctt tcaatttgaa ctttcccagt agcttggttt tacaggtgtg tgtagcacgc
     4201 taggccaaga gtgcttaaaa aaaaaaacaa acaaaattta ctattacatt tgtgtaaagg
     4261 ttactctttg agggttgtga tgtttggggc tgggaatgtt tttggtagaa taatggtaca
     4321 gcttttggct agtttccttg tcaattgcca gtgctgggag aaagaaatcc catggaaaca
     4381 cataccagta attccaacac tgaaaaccga ggcaagagga taactgacag tttgaagcta
     4441 gcctgggcta cagagggaga cattgtctca aaacaatcta ttagtggggc ctgcatggag
     4501 ttctcagtgg gttcagacgc ctgctaacat gcctgaccat ctgagtctga tctctgaaac
     4561 ccacgtggtg ggaggaaaga actgactcct gcaaggtgtg ttctgacctc cacgcattgt
     4621 ggcatgtgca ttctcatata tatgtacatg tatgtgtgca cacaaatgta atgtgttaat
     4681 atgtcctcag ttctaacttc tgttactaaa taaaaatttg attcagcagt
//
