LOCUS       NP_084423                951 aa            linear   ROD 30-APR-2024
DEFINITION  bromodomain-containing protein 8 isoform 1 [Mus musculus].
ACCESSION   NP_084423 NP_659113 XP_484717
VERSION     NP_084423.2
DBSOURCE    REFSEQ: accession NM_030147.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 951)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 951)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   3  (residues 1 to 951)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 951)
  AUTHORS   Fisher,C.L., Marks,H., Cho,L.T., Andrews,R., Wormald,S.,
            Carroll,T., Iyer,V., Tate,P., Rosen,B., Stunnenberg,H.G.,
            Fisher,A.G. and Skarnes,W.C.
  TITLE     An efficient method for generation of bi-allelic null mutant mouse
            embryonic stem cells and its application for investigating
            epigenetic modifiers
  JOURNAL   Nucleic Acids Res 45 (21), e174 (2017)
   PUBMED   28981838
REFERENCE   5  (residues 1 to 951)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   6  (residues 1 to 951)
  AUTHORS   Couture,J.P., Nolet,G., Beaulieu,E., Blouin,R. and Gevry,N.
  TITLE     The p400/Brd8 chromatin remodeling complex promotes adipogenesis by
            incorporating histone variant H2A.Z at PPARgamma target genes
  JOURNAL   Endocrinology 153 (12), 5796-5808 (2012)
   PUBMED   23064015
  REMARK    GeneRIF: incorporation of the histone variant H2A.Z at the promoter
            regions of PPARgamma target genes by p400/Brd8 is essential to
            allow fat cell differentiation
REFERENCE   7  (residues 1 to 951)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (residues 1 to 951)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (residues 1 to 951)
  AUTHORS   Mori,A.D., Zhu,Y., Vahora,I., Nieman,B., Koshiba-Takeuchi,K.,
            Davidson,L., Pizard,A., Seidman,J.G., Seidman,C.E., Chen,X.J.,
            Henkelman,R.M. and Bruneau,B.G.
  TITLE     Tbx5-dependent rheostatic control of cardiac gene expression and
            morphogenesis
  JOURNAL   Dev Biol 297 (2), 566-586 (2006)
   PUBMED   16870172
  REMARK    Erratum:[Dev Biol. 2007 Sep 15;309(2):386]
REFERENCE   10 (residues 1 to 951)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD555707.1, AK032320.1, AK161689.1 and AV322131.1.
            
            On Apr 23, 2008 this sequence version replaced NP_084423.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032320.1, SRR9219382.39974.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.69 cM"
     Protein         1..951
                     /product="bromodomain-containing protein 8 isoform 1"
                     /note="bromodomain-containing protein 8"
                     /calculated_mol_wt=102479
     Site            85
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Region          161..273
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Region          <176..356
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            456
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Site            460
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Region          520..547
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Site            554
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Region          584..745
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Site            652
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0E9; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Site            694
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0E9; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Site            710
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0E9; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Site            714
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0E9; propagated from
                     UniProtKB/Swiss-Prot (Q8R3B7.2)"
     Region          782..885
                     /region_name="Bromo_brd8_like"
                     /note="Bromodomain, brd8_like subgroup. In mammals, brd8
                     (bromodomain containing 8) interacts with the thyroid
                     hormone receptor in a ligand-dependent fashion and
                     enhances thyroid hormone-dependent activation from thyroid
                     response elements. Brd8 is thought to be...; cd05507"
                     /db_xref="CDD:99939"
     Site            order(809,814,817,856,860,866)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99939"
     Region          900..922
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R3B7.2)"
     CDS             1..951
                     /gene="Brd8"
                     /gene_synonym="2610007E11Rik; 4432404P07Rik; SMAP"
                     /coded_by="NM_030147.3:308..3163"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50248.1"
                     /db_xref="GeneID:78656"
                     /db_xref="MGI:MGI:1925906"
ORIGIN      
        1 matgtgkhkl lstgptepws ireklclass vmrsgdqnwv svsraikpfa epgrppdwfs
       61 qkhcasqyse llettetpkr krgekgevve tvedvivrkl taerveelkk viketqeryr
      121 rlkrdaeliq aghmdsrlde lcndiamkkk leeeeaevkr katdaayqar qavktpprrl
      181 ptvmvrspvd saspggdypl gdltpttmee atsgvtpgtl pstpvtsfpg ipdtlppgsa
      241 pleapmtpit ddspqkkmlg qkatpppspl lsellkkgsl lptsprlvne sempvppghl
      301 nstgvllevg gvlpmihgge iqpttsavaa spaasgaptl srlleagptq fttplpsftt
      361 vaseppvklv pppvesvsqa tivmmpalpa pssaaavsts esgapvsqpe pcvpleavgd
      421 phtvtvsmds neismiinsi keecfrsgva eapggskaps idgkedldla ekmdiavsyt
      481 geeldfetvg diiaiiedkv ddhpevldva aveaalsfce enddpqslpg pwehpiqqer
      541 dkpvplpape mtvkqerldf eesenkglhd lvdirdsgve ikveptepep gmsgaeivag
      601 vgpvpsmepp elrsqdsdee prssaagdig eadgssgkgd erplsavkte aspesmlsps
      661 hgsnliedpl eaetqhkfem sdslkeesgt ifgsqikdap gddeeedgvs eaasleepke
      721 edqgegylse mdneppvses ddgfsihnat lqshtladsi psspassqfs vcsedqeaiq
      781 aqkiwkkaim lvwraaanhr yanvflqpvt ddiapgyhsi vqrpmdlsti kknienglir
      841 staefqrdim lmfqnavmyn ssdhdvyhma vemqrdvleq iqqflatqli mqtsesgisa
      901 kslrgrdstr kqdasekdsv pmgspaflls lfdggtrgrr caieadmkmk k
//
