LOCUS       NM_012047               4064 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus bromodomain containing 7 (Brd7), transcript variant 1,
            mRNA.
ACCESSION   NM_012047
VERSION     NM_012047.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4064)
  AUTHORS   Xiao,Y., Liang,Z., Qiao,J., Zhu,Z., Liu,B. and Tian,Y.
  TITLE     BRD7 facilitates ferroptosis via modulating clusterin promoter
            hypermethylation and suppressing AMPK signaling in diabetes-induced
            testicular damage
  JOURNAL   Mol Med 30 (1), 100 (2024)
   PUBMED   38992588
  REMARK    GeneRIF: BRD7 facilitates ferroptosis via modulating clusterin
            promoter hypermethylation and suppressing AMPK signaling in
            diabetes-induced testicular damage.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4064)
  AUTHORS   Kim,Y., Lee,J.M., Han,Y., Tao,R., White,M.F., Liu,R. and Park,S.W.
  TITLE     BRD7 improves glucose homeostasis independent of IRS proteins
  JOURNAL   J Endocrinol 258 (3), e230119 (2023)
   PUBMED   37578842
  REMARK    GeneRIF: BRD7 improves glucose homeostasis independent of IRS
            proteins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4064)
  AUTHORS   Polanetzki,V., Frob,F., Baroti,T., Schimmel,M., Tamm,E.R. and
            Wegner,M.
  TITLE     Role of the Pbrm1 subunit and the PBAF complex in Schwann cell
            development
  JOURNAL   Sci Rep 12 (1), 2651 (2022)
   PUBMED   35173232
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4064)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4064)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   7  (bases 1 to 4064)
  AUTHORS   Cuppen,E., van Ham,M., Pepers,B., Wieringa,B. and Hendriks,W.
  TITLE     Identification and molecular characterization of BP75, a novel
            bromodomain-containing protein
  JOURNAL   FEBS Lett 459 (3), 291-298 (1999)
   PUBMED   10526152
REFERENCE   8  (bases 1 to 4064)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   9  (bases 1 to 4064)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   10 (bases 1 to 4064)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155170.3.
            
            On Dec 6, 2019 this sequence version replaced NM_012047.2.
            
            Transcript Variant: Variants 1 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF084259.1, SRR7652917.852110.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AC155170.3         210377-210643       c
            268-476             AC155170.3         209973-210181       c
            477-606             AC155170.3         206371-206500       c
            607-664             AC155170.3         206008-206065       c
            665-809             AC155170.3         203100-203244       c
            810-920             AC155170.3         200271-200381       c
            921-1105            AC155170.3         195345-195529       c
            1106-1229           AC155170.3         194301-194424       c
            1230-1305           AC155170.3         193620-193695       c
            1306-1413           AC155170.3         192053-192160       c
            1414-1549           AC155170.3         191206-191341       c
            1550-1661           AC155170.3         187880-187991       c
            1662-1718           AC155170.3         185552-185608       c
            1719-1830           AC155170.3         182576-182687       c
            1831-1974           AC155170.3         182209-182352       c
            1975-2118           AC155170.3         181352-181495       c
            2119-4064           AC155170.3         179069-181014       c
FEATURES             Location/Qualifiers
     source          1..4064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 43.07 cM"
     gene            1..4064
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /note="bromodomain containing 7"
                     /db_xref="GeneID:26992"
                     /db_xref="MGI:MGI:1349766"
     exon            1..267
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2174
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase, non-receptor type 13
                     interacting protein; bromodomain-containing protein 7; 75
                     kDa bromodomain protein; bromodomain protein 75 kDa"
                     /codon_start=1
                     /product="bromodomain-containing protein 7 isoform 1"
                     /protein_id="NP_036177.1"
                     /db_xref="CCDS:CCDS22510.1"
                     /db_xref="GeneID:26992"
                     /db_xref="MGI:MGI:1349766"
                     /translation="MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGH
                     DSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRAENEVD
                     RDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPV
                     TDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYY
                     KAAKKLLHSGMKILSQERIQSLKQSIDFMSDLQKTRKQKERTDACQSGEDSGCWQRER
                     EDSGDAETQAFRSPAKDNKRKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLA
                     NSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDK
                     RNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLA
                     TCQDYPYVMADSLLDVLTKGGHSRSLQDLDMSSPEDEGQTRALDTAKEAEITQIEPTG
                     RLESSSQDRLTALQAVTTFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLST
                     RPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIV
                     GNSFVDLTGECEEPKETSTAECGPDAS"
     exon            268..476
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            477..606
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            607..664
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            665..809
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            810..920
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1105
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1229
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1305
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1413
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1549
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1661
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1718
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1830
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1974
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2118
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..4064
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /note="hexamer: AATAAA"
     polyA_site      2351
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /note="major polyA site"
     regulatory      4045..4050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
                     /note="hexamer: AATAAA"
     polyA_site      4064
                     /gene="Brd7"
                     /gene_synonym="BP75; CELTIX1; Ptpn13ip"
ORIGIN      
        1 ctctcgccac tggtgtcgcg cttcggtcgc gtcccgcgcg tggttttttt tttttctcgt
       61 gagggacctc gcgccgccgg gcgcgtgccg tccccctgcc tcgcggcgcg ggctctcgcg
      121 ggccccgctc ccgccctccg ctcgcctggc ccggaccgga agcggcgccg cacggcctgg
      181 gcctggcgcg gggggcgggc tctggggccc ggtcggacat gggcaagaag cacaagaagc
      241 acaagtcgga ccgccacttc tacgaggagt acgtggagaa gcccctgaag ctggtcctca
      301 aagtcggggg gagcgaggtc accgagctct ccacgggcag ctccgggcac gactccagcc
      361 tcttcgaaga cagaagcgac catgacaaac acaaggacag aaaacggaaa aagaggaaga
      421 aaggcgagaa gcaggctccg ggggaagaga aggggagaaa acggagaaga gtcaaggagg
      481 ataaaaagaa gcgggatcga gaccgtgcag agaatgaggt ggacagagat ctccagtgtc
      541 atgtccctat aagattagac ttacctcctg agaagcctct tacaagctcg ttagccaaac
      601 aagaagaagt agaacagaca ccccttcagg aagctttgaa tcagctcatg agacaattgc
      661 aaagaaaaga cccaagtgct ttcttttcat ttcctgtgac ggattttatt gcgcctggct
      721 actccatgat tattaaacac ccaatggatt ttagtaccat gaaagaaaag atcaagaata
      781 acgactacca gtccatagaa gaactaaagg ataacttcaa gctaatgtgt actaatgcaa
      841 tgatttacaa taagccagag accatttatt ataaagctgc aaagaagctg ttgcactcag
      901 ggatgaaaat tctcagtcag gagagaattc agagcctgaa gcagagtata gacttcatgt
      961 cagacttgca gaaaactcgg aagcagaaag aacgaacaga tgcctgtcag agtggggagg
     1021 acagcggctg ctggcagcgc gagagggaag actctggaga tgctgaaaca caggccttca
     1081 gaagccccgc taaggacaat aaaaggaaag acaaagatgt gcttgaagac aaatggagaa
     1141 gcagcaactc agaaagggag catgagcaga ttgagcgcgt tgtccaggag tcaggaggca
     1201 agctaacacg gcggctggca aacagtcagt gtgaatttga aagaagaaaa ccagatggga
     1261 caacaacact ggggcttctc catcctgtgg atcccattgt gggagagcca ggctactgcc
     1321 ctgtgagatt ggggatgaca actggaagac tgcagtctgg agtgaacact ctgcaggggt
     1381 tcaaagagga taaaaggaac agagtaaccc cagtattata cttgaattat ggaccctaca
     1441 gttcttatgc cccacattat gactctacat ttgccaatat tagcaaagat gattctgatt
     1501 taatctactc aacatatggg gaagactctg accttccaaa caatttcagc atctctgagt
     1561 ttttggccac atgccaagat tacccgtatg ttatggcaga tagtttactg gatgttctaa
     1621 caaaaggagg acattccagg agcctgcagg acttggacat gtcatctcct gaagatgaag
     1681 gccagaccag agcattggac acagcaaaag aagcagagat tacacaaata gagccaacag
     1741 ggcgtttgga gtccagcagt caggacaggc tcacagcact gcaagctgta acaacctttg
     1801 gtgctccagc tgaagtcttt gactccgaag aggctgaggt gttccagagg aagcttgatg
     1861 agacgacaag attgctcagg gagctccagg aggcacagaa tgagcgactg agcactaggc
     1921 ctcctcccaa tatgatctgt ctcctgggtc cttcttacag agaaatgtac cttgctgaac
     1981 aagtgaccaa taacctcaaa gaactcacac agcaagtgac tccaggtgat gttgtaagca
     2041 tacacggagt gcgaaaagca atggggattt ctgttccttc ccccatcgtg ggaaacagct
     2101 tcgtagattt gacaggagag tgtgaagaac ctaaggagac cagcactgct gagtgtgggc
     2161 ctgacgcgag ctgaactagc ctggtatttg attctattat gtacatagtt tttcattctg
     2221 aacttggagg tgcttttcag aagatattaa ctatttgtaa attgtgtttt aattaagctt
     2281 tgggacagtt ccttttaatg ttccaaagat tggccttgta ttaggaaata aagctgaacc
     2341 tgggactgtg aggctcgctg gtgtgtcagc tgaattaccc tttgccttgc tcggccttgg
     2401 ttctgaggat ggacacctag gacacacacc agcctttctc atggtcatct ttcaaaggag
     2461 cagtcctcaa attaattccc caagttttca tatttaccac tcttactaga acaattataa
     2521 gcagctagtt ataagctctg ccctaccaga gctcatctga gtgacattca gaaagtagcc
     2581 ttatgagatg gcctttcaga ctgccactaa tgatggtctg actttttatt attattttta
     2641 ttattatatt gttgaatgtg tattatgtac atacatacat acatgcatgt agcccctccc
     2701 ccttttgggg tttttttgtt tggtttagtt ttgttttttt gttgtttttt tgagataggg
     2761 tttctctgtg tagccctgac tgtcctgaaa ttagctctgt agaccaggct gtctaagagg
     2821 tccgcctgcc tctgcatcct gaatcctagg attaaaggtg tgcaccacct agcttagaac
     2881 aacttttagg aaaagacttt ctgcttccat tgtagattcc atggattgaa ctcaggacat
     2941 cagacttctc agaaaatgat tttttattca ctaaactatc tcagtggctg agggcccaac
     3001 tttttaatca tagttctgtc cactgagact ttctagccta acaccgtgaa agtaaacaca
     3061 ctcgagataa tgttaaagtt tcccactatg gcttccttct ctgtacctaa tgggaatggt
     3121 gtcctccttc atggttatta gctgctgggt ctgctaggag gatggtggtg atgaaacgtg
     3181 tctagtgtgt tttcttttcc ttctttctgt ttttcccagt tactttggag caattgcaaa
     3241 tggatgaacc aagtaagatg agccaagtca cccttagaca catcagagtc tagagttagt
     3301 ggagagcttg ctcctgctca gttttccaaa ggccacctgt gtttcatttg tgcccccaaa
     3361 tcatttccct gttctgaaat acacaggtca agtgactgag cacattaggt aggagaccat
     3421 cggatatgta cccttatatc acactcagtc actggactga gataaataat agtttttcca
     3481 aatataacct ctttaagagg caagctgggt atggtaggtt gcatttataa tcccagtatt
     3541 tgagtggctg agagaggagg attgccatga atttgagtcc agctgggcta tgagaccatg
     3601 cctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaggtgagga
     3661 tgagagtgca ggagagatag cccatcagtt aagagaacat actgcgcttg cagaggactg
     3721 gagttgagtt ctccacaccc acattgctca aaaccaccta taagttacaa ttcagggaac
     3781 ctcgtacctc tggccgcctc tgcaagcact ggtactgtgt gcacatagcc acatgaacac
     3841 acatgatttt aaaataagta tgtcagtata gatagaacct agtttagcaa acagatgtct
     3901 caccctttta cagagcctgt ctgcaagacg tctagacagg catacctatt ttcttgattt
     3961 gaaattaata ttaagcaaga acagtaaaga aaacttgttt ctctccataa attacagggt
     4021 ggtccttttg tagacaggta tgctaataaa atacatcaat tcaa
//
