LOCUS       NM_001113573            5269 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bromodomain containing 3 (Brd3), transcript variant 2,
            mRNA.
ACCESSION   NM_001113573
VERSION     NM_001113573.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5269)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5269)
  AUTHORS   Daneshvar,K., Ardehali,M.B., Klein,I.A., Hsieh,F.K.,
            Kratkiewicz,A.J., Mahpour,A., Cancelliere,S.O.L., Zhou,C.,
            Cook,B.M., Li,W., Pondick,J.V., Gupta,S.K., Moran,S.P., Young,R.A.,
            Kingston,R.E. and Mullen,A.C.
  TITLE     lncRNA DIGIT and BRD3 protein form phase-separated condensates to
            regulate endoderm differentiation
  JOURNAL   Nat Cell Biol 22 (10), 1211-1222 (2020)
   PUBMED   32895492
REFERENCE   4  (bases 1 to 5269)
  AUTHORS   Roberts,T.C., Etxaniz,U., Dall'Agnese,A., Wu,S.Y., Chiang,C.M.,
            Brennan,P.E., Wood,M.J.A. and Puri,P.L.
  TITLE     BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate
            Skeletal Myogenesis
  JOURNAL   Sci Rep 7 (1), 6153 (2017)
   PUBMED   28733670
  REMARK    GeneRIF: Using pharmacological assay and RNA interference, BRD3
            down-regulation resulted in enhanced myogenic differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5269)
  AUTHORS   Ren,W., Sun,D., Wang,C. and Li,N.
  TITLE     [Brd3 promotes IL-6 production via enhancing acetylase CBP
            recruitment and histone 3 acetylation within IL6 promoter]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 32 (10), 1301-1305 (2016)
   PUBMED   27667451
  REMARK    GeneRIF: Brd3 knockout significantly decreased the recruitment of
            acetylase CBP to IL6 gene promoter, and the acetylation level of
            histone3 within IL6 gene promoter was repressed.
REFERENCE   6  (bases 1 to 5269)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 5269)
  AUTHORS   Ishii,H., Mimori,K., Mori,M. and Vecchione,A.
  TITLE     Differentially expressed genes in endothelial differentiation
  JOURNAL   DNA Cell Biol 24 (7), 432-437 (2005)
   PUBMED   16008511
  REMARK    GeneRIF: A conserved but uncharacterized gene encoding Brd3, which
            was down-regulated during endothelial differentiation, was
            identified.
REFERENCE   8  (bases 1 to 5269)
  AUTHORS   Boyer,A., Lussier,J.G., Sinclair,A.H., McClive,P.J. and
            Silversides,D.W.
  TITLE     Pre-sertoli specific gene expression profiling reveals differential
            expression of Ppt1 and Brd3 genes within the mouse genital ridge at
            the time of sex determination
  JOURNAL   Biol Reprod 71 (3), 820-827 (2004)
   PUBMED   15128596
  REMARK    GeneRIF: more strongly expressed in developing testis compared with
            ovary
REFERENCE   9  (bases 1 to 5269)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5269)
  AUTHORS   Eickhoff,H., Schuchhardt,J., Ivanov,I., Meier-Ewert,S., O'Brien,J.,
            Malik,A., Tandon,N., Wolski,E.W., Rohlfs,E., Nyarsik,L.,
            Reinhardt,R., Nietfeld,W. and Lehrach,H.
  TITLE     Tissue gene expression analysis using arrayed normalized cDNA
            libraries
  JOURNAL   Genome Res 10 (8), 1230-1240 (2000)
   PUBMED   10958641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY064662.1, AK160752.1, AK079666.1, AK034797.1 and BM899753.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001113573.2.
            
            Transcript Variant: This variant (2) lacks an internal coding exon,
            as compared to vairant 1. The resulting isoform (2) lacks an
            internal segment, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159827.1, AK136429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY064662.1         2-43
            43-3034             AK160752.1         2-2993
            3035-4180           AK079666.1         136-1281
            4181-5039           AK034797.1         701-1559
            5040-5269           BM899753.1         1-230               c
FEATURES             Location/Qualifiers
     source          1..5269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..5269
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /note="bromodomain containing 3"
                     /db_xref="GeneID:67382"
                     /db_xref="MGI:MGI:1914632"
     exon            1..97
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            98..402
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2373
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bromodomain-containing protein 3; bromodomain-containing
                     FSH-like protein FSRG2"
                     /codon_start=1
                     /product="bromodomain-containing protein 3 isoform 2"
                     /protein_id="NP_001107045.1"
                     /db_xref="CCDS:CCDS15828.1"
                     /db_xref="GeneID:67382"
                     /db_xref="MGI:MGI:1914632"
                     /translation="MSTTAAAPTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQNV
                     VVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQ
                     DFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAA
                     GAQNAGSQQVAAVSSVSPATPFQNIPPTVSQTPVIAATPVPTITANVTSVPVPPPAAP
                     PPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSEPKQAKVVA
                     RRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFY
                     KPVDAEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPP
                     DHEVVAMARKLQDVFEMRFAKMPDEPMEAPALPAPTAPIVSKGAESSRSSEESSSDSG
                     SSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKDKDKE
                     KEKHKAKSEEEKKAKAAPAAKQAQQKKAPTKKANSTTTASRQLKKGGKQASASYDSEE
                     EEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKP
                     TTLRELERYVKSCLQKKQRKPLSTSGKKQAAKSKEELAQEKKKELEKRLQDVSGQLNS
                     KKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSDSE"
     exon            403..540
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..688
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            689..903
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1275
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1404
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1596
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1838
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2131
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2257
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..5257
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2442..2447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /note="hexamer: AATATA"
     polyA_site      2463
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /note="major polyA site"
     regulatory      3630..3635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /note="hexamer: AATATA"
     polyA_site      3650
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
                     /note="hexamer: AATAAA"
     polyA_site      4181
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
     polyA_site      5254
                     /gene="Brd3"
                     /gene_synonym="2410084F24Rik; Fsrg2; ORFX; RINGL3"
ORIGIN      
        1 agctccggcg cgtctattat gctgccgggg ccggcgagcc aaagaggagc cggccgcgcg
       61 ggccgggagc agacggcgct ggagccgcct aggccaagtg cctgattggg cccagaaatg
      121 ggatgccaag cctccacgag gagcgcctct ttgagctgct gctgtgacag caagtgacta
      181 agctgccaga ggatgtccac tacagcggct gcccccacgg ggatcccggc agtcccgggc
      241 cccgtgaacc ctcccccacc tgaggtctcc aaccccagca agcccgggcg aaagactaac
      301 caactgcagt acatgcagaa tgtagtggtg aagacactct ggaaacatca gtttgcctgg
      361 cctttctacc agcctgtgga tgcaatcaag ctgaacctgc ctgattatca taaaataata
      421 aaaaacccaa tggacatggg gactatcaag aagagactag aaaataatta ttattggagt
      481 gccagtgagt gtatgcagga cttcaacacc atgtttacaa actgttatat ttataataag
      541 cccacagatg atatagtgct aatggcccag gccttagaga aaatctttct gcagaaagtg
      601 gcccagatgc ctcaggagga agttgaacta ttgccccctg ctccaaaggg caaaggccgg
      661 aagccagctg caggagccca aaatgcaggt tcccaacaag tggcagctgt gtcttcggtc
      721 tccccagcaa cccccttcca gaacataccc cccaccgtgt cccagacacc cgtcattgcc
      781 gctacccctg taccaaccat cactgcaaac gtcacgtcag ttccagtccc cccacccgct
      841 gcaccgcctc ctcctgcgac acccatcgtc cctgtggtcc ctcccacacc gcctgtagtc
      901 aagaaaaagg gcgtgaagcg gaaagcagac acaaccacac ccacaacatc tgccatcact
      961 gccagccgga gtgagtctcc cccaccactt tcagagccca agcaagccaa ggtagtggcc
     1021 cgaagggaga gcgggggccg ccccatcaaa cctcccaaga aggacctgga agatggtgag
     1081 gtcccacagc acgcgggtaa aaagggaaaa ctgtccgagc acctgcggca ctgtgacagc
     1141 atcctccggg agatgctgtc caagaagcat gctgcctatg cgtggccctt ttacaagcca
     1201 gtggacgcgg aggcgctgga gctgcatgac taccatgaca tcatcaagca ccccatggac
     1261 ctcagcacgg tcaaaaggaa gatggatagc cgagagtacc cagatgcaca gggctttgct
     1321 gctgatatcc ggttaatgtt ctcgaattgt tataagtaca accctccaga ccacgaagtg
     1381 gtggccatgg ccaggaagct ccaggatgtg tttgagatga ggtttgccaa gatgcccgat
     1441 gagcccatgg aggcgcctgc gctgcccgct cccacggccc ccatcgtgag caagggggct
     1501 gagagcagcc gcagtagtga ggagagctct tcagattcag gcagctcaga ctcagaagag
     1561 gagcgagcca ctcggctggc tgagctgcag gagcagctga aggccgtgca cgaacagctg
     1621 gctgccttgt ctcaggcccc agtgaacaaa ccaaagaaga agaaagagaa gaaggaaaag
     1681 gaaaagaaga agaaagacaa ggacaaagac aaagagaagg agaagcacaa ggccaagtct
     1741 gaggaggaga agaaggccaa ggcagcccca gcagccaagc aggcccagca gaaaaaggct
     1801 cccaccaaga aggccaacag cacaaccaca gccagcagac agctcaagaa gggcggcaag
     1861 caggcatctg cgtcctatga ctcagaggaa gaggaggagg gcctgcccat gagctatgat
     1921 gaaaagcgac aacttagcct tgacatcaac cggctgcccg gcgagaagct agggcgtgtg
     1981 gtgcacatca ttcagtctcg ggagccctcg cttcgggact caaacccaga cgagattgag
     2041 attgactttg agaccctgaa gccaaccacg ctgcgggaac tggagagata tgtcaagtct
     2101 tgtttacaaa aaaagcagag gaaaccattg tcaacaagcg ggaagaagca ggcagccaaa
     2161 tcgaaagagg agctagctca ggagaagaaa aaggagctgg agaagcggct gcaggatgtc
     2221 agtggacaac tgaacagcaa aaaacccact aagaaagaga agtccggctc agctccctca
     2281 ggaggcccat caaggctcag cagtagcagc tcctctgagt ctgcgagcag tagctccagt
     2341 ggatcgagct ccgacagcag tgactcagag tgaactcgga ctgggacaga gctggacaga
     2401 tggacgtggt gcacgccaac gcagtgtccc ctcctatggt taatatactt tcgttccatg
     2461 gtgtgcaggt tttcttttac ttcagtgtta tgatctcttc cagctgtgct ccagtagggc
     2521 ggagagcctc gcacgtgcac cagaccccat gagagggccg agctctgcga gggggaaatg
     2581 cctttgcagc tccatttagt tgtttggaga ctgctcctgg gatgctaacc tgatggccat
     2641 agacacggtg ggctggaggc gtggctggat ctgcccaatc cttcctcagg accagcctct
     2701 cccttagtaa cttgaaggaa gctttgcaag ggtgtttctc tggaatgggt tctgtgtttg
     2761 aaagctgtta gaacactaac cagcaggtta cttctctccg caggggctga agacagatgt
     2821 gtcagcccat gggaaccagc ctgggcccta gtggagggtc ctggtagctg cagaccagag
     2881 cctcacacct ctgggttggg tgtggaggaa gaggggtact gagttccctg gtcctttggc
     2941 tgtgtgtgca gcgtgcagat ttcgggacac cgaaactttt acctcaactt aagggaataa
     3001 aaacaaacaa acaaaaaaag attaaaaaaa aaaacaaaac aaaaaaaaca aaacaaaaac
     3061 aaaccttttt tgtaagttca tccattttct acagaagtcc agcccagagt ccccactttg
     3121 ctagtgctgc ctggctgcca ccgcctaacg ctctgaacca ccaccccagg tttatgtata
     3181 tataaatact ttatttatta acatcattgg tcatttttta aaaaatgaaa aagaaaaaaa
     3241 agaagagaaa aacccataaa taagtgcatt gagaagaaca tggagaggat gctgtcctct
     3301 gcaacagaga caggcccgtg gcggggcgcc tctggtcctg gtgctcatca cggctggctt
     3361 ctctgagctc attggctgtt tgtttgtttg gttttttttt ttttttttaa tgaaatgtgg
     3421 ggactttgca agcgtagacg cccttcagct gtagcacatc ttcattttat agtatctatt
     3481 cagtttgttc ttactaactt ctggtctttt aaaagacgtc aacggaggaa cctcggttct
     3541 tcaacacaag ctttgtatgt aagccgagag aaaagtcatg tatatcaggc ctaggtcttg
     3601 acacttaatt ttctattgta aaaagtaata atatacagag tctaacagaa ggtcctgttg
     3661 ggtttgttgt ttttgaggct gccgaatggt tttggaatgc agggtcagcc ttggagtatc
     3721 tctgagcatt gtggcctcag ccaggagcgc actggccagt ctcccaggcc tggaagcact
     3781 gcagtgtgca gaggctctcc ttgacctttc tacttttgac acgggtccct gttcgagaat
     3841 ttccagttag ccccagaaga gactggttct cctgaccccc acccgagagc gagagcgcca
     3901 agtgcagggc cttgtgttgt gtggttttac ttgggctggg ggtggttctt gcggtttctt
     3961 ccattgcttc taggcagagc caaggactca tcctcaccat ccatacatgg gagatattta
     4021 aagtttctaa agtcgatccc accagccctc gatgtgcaca ggcagtgggt gtcaagctcg
     4081 ggaagtggct ggctggctgg ctggcatgtc tagacgcctg gtgagttatc agccagttaa
     4141 acttgtaagc cagttttgtt tataataaag atataagtgg attttaaggt tccatttttt
     4201 taaggttacc cttgtttttc aaaggtattt tttaaacaga tctttaatag aatatttaag
     4261 ctgtgactgt aagaaataaa caagagtaaa ctgacaggcc ttccttcacg tggggtctca
     4321 gtggtggcct accatgacag cttggtcagt gtgcctaggc agggcacatt gcctgggcat
     4381 gtgtagagtg agtgcccctg tgagctgcta ggcaagcaga gtctggctct gaggtgatgt
     4441 ccccgcagca gggtggtggt acagagctgg gcatagggtg gaggtctggc attcctgtgg
     4501 ctgtggtccc tagtaagcag ccttggtcat tggtgctttt aacttttttt ttttttcttt
     4561 ttgtccagac ttaaattgtt ttgtcttcag agttttggag gaccccggtc cccacaatgc
     4621 caggctgcag gataactgcc atccccttct gtgagttatg tacggggact tagactgtcc
     4681 tgtgcagagg tggagggcag ctgtctacag gcttcctaga ggtcacatgc aggactgggg
     4741 tggccacttg gcagagtcct tggggttcag acctccacag gctaggtagc tcagcttgct
     4801 tacagactgg agacattttc ttgtgtggtt ttctgggttt cgtccttctg cagctgtcat
     4861 ggctttacag tcacttggga aatgcaagcc actgttaaag ctttgtcctg ttcatcactg
     4921 tccctgctcc tggcataaca cttccagagg ctttcctttt ttatatatat atctatatat
     4981 atatatattt aaaacgtttc ttttctgtat gatgtgcatg caagtttacc gtaacttttc
     5041 ttaaactttt tagtgccgtt tctagtatat tcctgtaaat gtcagttact gaaaatgagt
     5101 ccattgtaag tagtttagct tgttttttgc aatgccggcc tcaacaccac agagtaaaaa
     5161 aaaaaaaaaa acggtaggaa gtactctggt gtctctggta atcatgaacc tttctcctag
     5221 ggtgtttgtt ttgttttcat aataaaaagg gaaagaaaaa aaaaaaaaa
//
