LOCUS       NM_001204973            4685 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus bromodomain containing 2 (Brd2), transcript variant 2,
            mRNA.
ACCESSION   NM_001204973
VERSION     NM_001204973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4685)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4685)
  AUTHORS   Gothwal,S.K., Refaat,A.M., Nakata,M., Stanlie,A., Honjo,T. and
            Begum,N.A.
  TITLE     BRD2 promotes antibody class switch recombination by facilitating
            DNA repair in collaboration with NIPBL
  JOURNAL   Nucleic Acids Res 52 (8), 4422-4439 (2024)
   PUBMED   38567724
  REMARK    GeneRIF: BRD2 promotes antibody class switch recombination by
            facilitating DNA repair in collaboration with NIPBL.
REFERENCE   3  (bases 1 to 4685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4685)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   5  (bases 1 to 4685)
  AUTHORS   Tsume-Kajioka,M., Kimura-Yoshida,C., Mochida,K., Ueda,Y. and
            Matsuo,I.
  TITLE     BET proteins are essential for the specification and maintenance of
            the epiblast lineage in mouse preimplantation embryos
  JOURNAL   BMC Biol 20 (1), 64 (2022)
   PUBMED   35264162
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4685)
  AUTHORS   Rhee,K., Brunori,M., Besset,V., Trousdale,R. and Wolgemuth,D.J.
  TITLE     Expression and potential role of Fsrg1, a murine
            bromodomain-containing homologue of the Drosophila gene female
            sterile homeotic
  JOURNAL   J Cell Sci 111 (Pt 23), 3541-3550 (1998)
   PUBMED   9811568
REFERENCE   7  (bases 1 to 4685)
  AUTHORS   Taniguchi,Y., Matsuzaka,Y., Fujimoto,H., Miyado,K., Kohda,A.,
            Okumura,K., Kimura,M. and Inoko,H.
  TITLE     Nucleotide sequence of the ring3 gene in the class II region of the
            mouse MHC and its abundant expression in testicular germ cells
  JOURNAL   Genomics 51 (1), 114-123 (1998)
   PUBMED   9693039
REFERENCE   8  (bases 1 to 4685)
  AUTHORS   Thorpe,K.L. and Beck,S.
  TITLE     DNA sequence and structure of the mouse RING3 gene: identification
            of variant RING3 transcripts
  JOURNAL   Immunogenetics 48 (1), 82-86 (1998)
   PUBMED   9601950
REFERENCE   9  (bases 1 to 4685)
  AUTHORS   Ostrowski,J., Florio,S.K., Denis,G.V., Suzuki,H. and Bomsztyk,K.
  TITLE     Stimulation of p85/RING3 kinase in multiple organs after systemic
            administration of mitogens into mice
  JOURNAL   Oncogene 16 (9), 1223-1227 (1998)
   PUBMED   9528865
  REMARK    GeneRIF: Brd2 autophosphorylation activity is induced in mouse
            tissues (lung, kidney, brain, liver and heart) upon systemic
            treatment with the mitogens Epidermal Growth Factor or Phorbol
            12-Myristate 13-Acetate.
REFERENCE   10 (bases 1 to 4685)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY244178.1, CB527269.1, AK168525.1 and CO040867.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168525.1, SRR7974084.26970.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY244178.1         2-5
            5-218               CB527269.1         2-215
            219-311             BY244178.1         220-312
            312-804             AK168525.1         1-493
            805-1087            AK168525.1         495-777
            1088-4661           AK168525.1         779-4352
            4662-4685           CO040867.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..4685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..4685
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /note="bromodomain containing 2"
                     /db_xref="GeneID:14312"
                     /db_xref="MGI:MGI:99495"
     exon            1..446
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..1741
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1716..4112
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /note="female sterile homeotic-related gene 1"
                     /codon_start=1
                     /product="bromodomain-containing protein 2"
                     /protein_id="NP_001191902.1"
                     /db_xref="CCDS:CCDS28641.1"
                     /db_xref="GeneID:14312"
                     /db_xref="MGI:MGI:99495"
                     /translation="MLQNVTPHKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFES
                     PTMASVPALQLAPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPV
                     DAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDD
                     IVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVS
                     SVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKK
                     GVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQ
                     QQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHP
                     MDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYA
                     KMPDEPLEPGPLPVSTALPPGLTKSSSESSSEESSSESSSEEEEEEEEDEDEEESESS
                     DSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIG
                     IDEDDKGPRAPRPPQPKKSKKAGGGGSNATTLSHPGFGTSGGSSNKLPKKSQKTAPPV
                     LPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEI
                     EIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQD
                     VSGQLNSTKKPPKKASEKTESSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
                     "
     exon            1742..2045
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2183
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2322
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2537
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2912
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3041
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3287
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3550
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3855
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..3978
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4668
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4637..4642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /note="hexamer: AATAAA"
     regulatory      4641..4646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /note="hexamer: AAGAAA"
     polyA_site      4654
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
     polyA_site      4657
                     /gene="Brd2"
                     /gene_synonym="D17H6S113E; Frg-1; Fsrg-1; Fsrg1;
                     mKIAA4005; Nat; Ring3; Rnf3"
                     /note="major polyA site"
ORIGIN      
        1 ttcgtggggc tgcggcagcc atgctgaact cgtaccgaga ggcgagtggg ggggacgggg
       61 gcgaccacag gcgcaaggga ggccggggac ctggcgaggc aacagcctta gcgaggtctg
      121 gggtctcggg acacaggtct gggccttgca gtccctgtga ccccgttcac gaccctccgc
      181 agtgttcgga aacctcgccc tcgtggccgt agggggggcg gacacgtgac ccgccccagc
      241 cagtcggagc gctgctgacg tggccgcgcg gccccgatgc ttttcccccc acccccagcg
      301 gctagggaag ggaggggctg ggggctacgc cccctccccc aacgccttct cggcttccgg
      361 gggggttgac accccggatt ccttgctccc cccccagccg ggctgagggc gactttcgag
      421 ggcccccccg tggctcctgg atccagattc tccactgcgg cggcctcgca gccaagaacc
      481 tttcgcccgc cccgcccgcg cgacccgtcc cactctgcgc cccgcccgcg ccgccaatgg
      541 aaaagctgca aatggcgcga ccagcctgcc gcgggcgacc ggcagaaatt cggtgtgtgc
      601 aagcccggga aggctccgtc agacctggag gtggggacag cgtgttgcag gccccgggga
      661 gatggcgcct acacgccgtt cggcctccat ctctcccagg gttcgccaag ccacggcgca
      721 gccaattggc tcggagacat ggcggggtgc cttttcgcct tggctctctg cggcactctg
      781 ctgccgataa tcgacgcctt ggaactggag tttgtgacgt catccttcga gcggaccaat
      841 aggaaaggct cccgcgaaga ggcgggcctg ccccctcgcc tttgcttctc caggcgcgtg
      901 agcgggcgag cacgcgcgga gggggcgggg gagctcgcga gcagggtggc gcgcatgagc
      961 agcgaagctc cgcccctccg gctatatata aagcgctggc gcggggctcg gcggcgccat
     1021 ttcgcgctgg agtggagcag cctctaggac gagctggagg attgcgccta ctgacccagc
     1081 gtctcggagc ctctgcgggc cgccagtaca atccacgtcc atccgcttgg aaatggactt
     1141 cgtcccggcc cgcgaccgct cccggcggac agtgcagacc ccatagaagc ccccgaggct
     1201 cccctttctc gggccccgcc cagtcctcgg tgtctgtcca cccctctact ccgccctcaa
     1261 gaggatttca aagatggagg cggcggctct ctgaaacccc tttttggtgc tcatccgcct
     1321 ccatcggagg tctgacgcgg ctctcgtgac cccccggcga ccgcggcggg aagaggggac
     1381 ccctgtccac cggcggcagg ccgaattgac gacggtgtcc agtttcgggg actgccgggt
     1441 ttgcagactg cgttctcctg tggctcgccg gccggcagag gccgccgcca ttttcctgct
     1501 gtcgccgcct gcggagcgtg caaagctgcc ggagttgcgg ggaggacggc gcaggagaca
     1561 gcgttcccgc cggtcccgca acgaggctga cgcctggagg gccaagggca gcggccttcc
     1621 ccccacttcc cgggttatgc tgggcccggc ggtgagggga gccgaggcta cccggacttc
     1681 acgcagctga gcggcggcgg ttccctgagg tcaagatgct gcaaaacgtg actccccaca
     1741 agctccctgg ggaagggaat gcagggttac tggggctggg cccagaggca gcagcaccag
     1801 ggaaaaggat tcgaaagcct tctctgctgt atgagggatt tgagagcccc acaatggctt
     1861 ctgtaccagc tttacaactg gcccctgcca atccaccacc ccctgaggtg tccaatccca
     1921 aaaagccagg acgggtaaca aaccaactgc agtacctgca caaggtagtg atgaaggctc
     1981 tgtggaagca tcagtttgca tggccattcc ggcagcctgt ggacgctgtg aagctgggtt
     2041 tgccggatta tcacaaaatt ataaaacagc ctatggacat gggtactatc aagaggagac
     2101 ttgaaaacaa ttactactgg gctgcctcag aatgtatgca ggattttaat actatgttta
     2161 ccaactgtta catttataac aagcccaccg atgatattgt cctaatggca cagacactgg
     2221 aaaagatctt cctacagaaa gtagcatcca tgccacaaga ggagcaagag cttgtggtga
     2281 ccatccctaa aaacagccat aagaaggggg ccaagttagc agcactccag ggcagtatta
     2341 ccagtgccca tcaggtgcct gctgtctctt ctgtgtcgca tacagccctg tatacaccac
     2401 cacctgaaat acctaccact gtcctcaaca ttccccaccc atcagtcatc tcttctcctc
     2461 ttcttaagtc cctgcattct gctggacccc cactccttgc tgtatcagca gcgcctccag
     2521 ctcagcccct tgccaagaaa aaaggcgtta aacggaaagc ggatactacc acccctacac
     2581 ccacagccat cctggctcct ggttccccag ctagtcctcc tgggagtctt gagccaaagg
     2641 cagcaaggct ccctcctatg cgcagagaga gtggccgccc aatcaaaccc ccacgaaaag
     2701 acttgcctga ctcgcaacag caacaccaga gctctaagaa agggaagctg tcagagcagt
     2761 taaagcactg caacggcatc ctgaaggaac tgctctcaaa gaagcacgct gcctacgcct
     2821 ggcccttcta taagccagtg gacgcttctg ctcttggcct tcatgattac catgacatca
     2881 ttaaacaccc catggacctc agcactgtca agcggaagat ggagaaccgt gactaccggg
     2941 atgcacagga gtttgctgct gatgtacggc ttatgttctc caactgctat aagtacaatc
     3001 ctccagacca cgatgttgtg gctatggcac gaaagttgca ggatgtgttt gagtttcgct
     3061 atgccaagat gccagatgag ccactggaac caggacctct accagtctct actgccttgc
     3121 ctcctgggtt gaccaaatcc tcttcagagt cctccagtga ggaaagtagc agtgagagtt
     3181 cctctgagga agaggaggag gaggaagaag atgaggacga ggaggagagt gaaagctcag
     3241 actctgagga ggaaagggct catcgcctag cagagctgca ggagcagctt cgggcagttc
     3301 atgaacaact ggctgccctg tcccagggcc caatatctaa gcccaagcgg aagagagaga
     3361 aaaaggaaaa aaagaagaaa cggaaggcag agaaacatcg tggccgaatt gggatcgatg
     3421 aagatgataa ggggcctagg gcacctcgcc cacctcagcc caagaaatct aagaaagcag
     3481 gtggtggggg tagcaatgct actacactca gccatcctgg ctttgggact tccggaggaa
     3541 gtagcaacaa gctacctaaa aagtctcaaa agacagctcc acctgtcctt cccactggct
     3601 atgattctga ggaggaggaa gaaagcaggc ccatgagtta tgatgagaag agacagttaa
     3661 gcctggatat caataagtta cctggggaaa agctgggtcg agtagtacat atcatccaag
     3721 ccagggaacc ctctctacgt gattcaaatc cagaagaaat tgagattgat tttgaaacac
     3781 tcaagccgtc cacacttaga gagcttgagc gatatgtttt atcctgcctt cgaaagaaac
     3841 cccggaagcc ctacactatt aggaaacctg tgggaaaaac aaaggaggaa ctggctttgg
     3901 agaagaagcg ggagctagag aagcggttgc aggatgtcag tggacagctc aactccacca
     3961 aaaagcctcc caagaaagcg agtgagaaga cagagtcatc tgcacagcaa gtggcagtgt
     4021 cccgtctcag tgcttctagt tccagctcag attccagctc ctcgtcgtca tcttcctctt
     4081 cttcagacac cagcgattca gactcgggct aaggggccag gccagatggg gcaggaaggc
     4141 tccgcaggac cggacccctg aaccaccctt ccccactttc ccttgctgtg acgcttcttc
     4201 atctcacccc tccataggag agctggctct gcagtgggga ggaaggcagg gacatggaca
     4261 aaatacgatt gaattcctag ccctcttggg tgtggtgtcc ctgttgagga tgatgggggt
     4321 ggggcaaggg tatgggtggg agtggggata ggcctggcat aaagccccct gagctgtagc
     4381 tgtcctgttc acttctaagg gccctgtttt gaggttttaa tttatttaag ctatgtggta
     4441 aggctggggg tgtgtagccg tggtcctccc tccagcttcc atggggaggg aagaagaggg
     4501 agctcttttt gttttttaca ttgacttttt ttttctactt ttccctttta cttccactcc
     4561 atttggggcc tggggatttt agtcacctct ccagttggcc ccaagactgt cttttctttc
     4621 ttgagtctaa catgtaaata aagaaaatat tattgaagtt ttgagttaaa aaaaaaaaaa
     4681 aaaaa
//
