LOCUS       NM_001358737            4876 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus BRCA1/BRCA2-containing complex, subunit 3 (Brcc3),
            transcript variant 5, mRNA.
ACCESSION   NM_001358737
VERSION     NM_001358737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4876)
  AUTHORS   Li,Y., Chen,X., Xiong,Y., Xu,X., Xie,C., Min,M., Liang,D., Chen,C.
            and Mao,H.
  TITLE     BRCC36 regulates beta-catenin ubiquitination to alleviate vascular
            calcification in chronic kidney disease
  JOURNAL   J Transl Med 22 (1), 820 (2024)
   PUBMED   39227917
  REMARK    GeneRIF: BRCC36 regulates beta-catenin ubiquitination to alleviate
            vascular calcification in chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4876)
  AUTHORS   Shen,H., Gao,Y., Ge,D., Tan,M., Yin,Q., Wei,T.W., He,F., Lee,T.Y.,
            Li,Z., Chen,Y., Yang,Q., Liu,Z., Li,X., Chen,Z., Yang,Y., Zhang,Z.,
            Thistlethwaite,P.A., Wang,J., Malhotra,A., Yuan,J.X., Shyy,J.Y. and
            Gong,K.
  TITLE     BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells:
            Implication in Pulmonary Hypertension
  JOURNAL   Circulation 150 (2), 132-150 (2024)
   PUBMED   38557054
  REMARK    GeneRIF: BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells:
            Implication in Pulmonary Hypertension.
REFERENCE   3  (bases 1 to 4876)
  AUTHORS   Huang,Q., Zheng,S., Gu,H., Yang,Z., Lu,Y., Yu,X. and Guo,G.
  TITLE     The deubiquitinase BRCC3 increases the stability of ZEB1 and
            promotes the proliferation and metastasis of triple-negative breast
            cancer cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (4), 564-575 (2024)
   PUBMED   38449391
  REMARK    GeneRIF: The deubiquitinase BRCC3 increases the stability of ZEB1
            and promotes the proliferation and metastasis of triple-negative
            breast cancer cells.
REFERENCE   4  (bases 1 to 4876)
  AUTHORS   Huang,X., Tan,J., Ji,Y., Luo,J., Zhao,Y. and Zhao,J.
  TITLE     BRCC3 mediates inflammation and pyroptosis in cerebral
            ischemia/reperfusion injury by activating the NLRP6 inflammasome
  JOURNAL   CNS Neurosci Ther 30 (3), e14697 (2024)
   PUBMED   38544474
  REMARK    GeneRIF: BRCC3 mediates inflammation and pyroptosis in cerebral
            ischemia/reperfusion injury by activating the NLRP6 inflammasome.
REFERENCE   5  (bases 1 to 4876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4876)
  AUTHORS   Sato,N., Sugimura,Y., Hayashi,Y., Murase,T., Kanou,Y., Kikkawa,F.
            and Murata,Y.
  TITLE     Identification of genes differentially expressed in mouse fetuses
            from streptozotocin-induced diabetic pregnancy by cDNA subtraction
  JOURNAL   Endocr J 55 (2), 317-323 (2008)
   PUBMED   18323671
REFERENCE   7  (bases 1 to 4876)
  AUTHORS   Wang,B. and Elledge,S.J.
  TITLE     Ubc13/Rnf8 ubiquitin ligases control foci formation of the
            Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
  JOURNAL   Proc Natl Acad Sci U S A 104 (52), 20759-20763 (2007)
   PUBMED   18077395
REFERENCE   8  (bases 1 to 4876)
  AUTHORS   Dong,Y., Hakimi,M.A., Chen,X., Kumaraswamy,E., Cooch,N.S.,
            Godwin,A.K. and Shiekhattar,R.
  TITLE     Regulation of BRCC, a holoenzyme complex containing BRCA1 and
            BRCA2, by a signalosome-like subunit and its role in DNA repair
  JOURNAL   Mol Cell 12 (5), 1087-1099 (2003)
   PUBMED   14636569
REFERENCE   9  (bases 1 to 4876)
  AUTHORS   Mallery,D.L., Vandenberg,C.J. and Hiom,K.
  TITLE     Activation of the E3 ligase function of the BRCA1/BARD1 complex by
            polyubiquitin chains
  JOURNAL   EMBO J 21 (24), 6755-6762 (2002)
   PUBMED   12485996
REFERENCE   10 (bases 1 to 4876)
  AUTHORS   Fisch,P., Forster,A., Sherrington,P.D., Dyer,M.J. and Rabbitts,T.H.
  TITLE     The chromosomal translocation t(X;14)(q28;q11) in T-cell
            pro-lymphocytic leukaemia breaks within one gene and activates
            another
  JOURNAL   Oncogene 8 (12), 3271-3276 (1993)
   PUBMED   8247530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671860.6 and BC048179.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038919.1, DV060546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL671860.6         11224-11437
            215-231             AL671860.6         12173-12189
            232-286             AL671860.6         13007-13061
            287-406             AL671860.6         17375-17494
            407-494             AL671860.6         30061-30148
            495-583             AL671860.6         30702-30790
            584-639             AL671860.6         32532-32587
            640-771             AL671860.6         41752-41883
            772-815             AL671860.6         42399-42442
            816-4834            AL671860.6         44565-48583
            4835-4876           BC048179.1         4211-4252
FEATURES             Location/Qualifiers
     source          1..4876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.22 cM"
     gene            1..4876
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /note="BRCA1/BRCA2-containing complex, subunit 3"
                     /db_xref="GeneID:210766"
                     /db_xref="MGI:MGI:2389572"
     exon            1..214
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..967
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /EC_number="3.1.2.15"
                     /note="6.1A protein; BRISC complex subunit BRCC36; BRCA1-A
                     complex subunit BRCC36; BRCA1/BRCA2-containing complex
                     subunit 36"
                     /codon_start=1
                     /product="lys-63-specific deubiquitinase BRCC36"
                     /protein_id="NP_001345666.1"
                     /db_xref="CCDS:CCDS41031.1"
                     /db_xref="GeneID:210766"
                     /db_xref="MGI:MGI:2389572"
                     /translation="MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELND
                     DIRSDSKFTYTGTEMRTVQEKMDTIRIVHIHSVIILRRSDKRKDRVEISPEQLSAAST
                     EAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIED
                     KNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHITIGKVCLESAVELPKILCQEE
                     QDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQEL
                     QQEKEELMEELSSLE"
     exon            215..231
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            232..286
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            287..406
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            407..494
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            495..583
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            584..639
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            640..771
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            772..815
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     exon            816..4848
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      963..968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /note="hexamer: AATAAA"
     polyA_site      988
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /note="major polyA site"
     regulatory      4829..4834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
                     /note="hexamer: ATTAAA"
     polyA_site      4848
                     /gene="Brcc3"
                     /gene_synonym="C6.1A"
ORIGIN      
        1 gcggagcctc aagctaaggg ctggtcgctg cgtctgagcg ccgggttgga cgagccgctg
       61 tgcgcccttg gcggacgtga gcggaaagaa gatggcggtg caggtggtgc aagctgtgca
      121 ggcggttcat cttgagtctg acgctttcct agtttgtctc aaccatgctc tgagcacaga
      181 aaaggaggaa gtgatgggtc tgtgtatagg ggagttgaat gatgacataa ggagtgactc
      241 caaatttaca tacactggaa cggaaatgcg cacagtccaa gaaaagatgg ataccatcag
      301 aattgttcat atccattctg tcatcatctt gcggcgttct gacaagagaa aggaccgtgt
      361 agaaatttct ccagagcagc tgtctgcagc ttcaacagag gcagaaaggt tggctgaact
      421 aacaggtcgt cccatgagag ttgttggctg gtatcattcc caccctcata taactgtttg
      481 gccttcacat gttgatgttc gtacacaagc catgtaccaa atgatggatc aaggctttgt
      541 aggacttatt ttttcctgtt tcatagaaga caaaaacaca aagactggcc gggtactcta
      601 tacttgcttc caatccatac aagcccaaaa aagctcagag tatgagagaa ttgaaatccc
      661 aatccatatt gtacctcata tcactattgg gaaagtatgc cttgaatctg cagtagagct
      721 gccaaaaatc ctgtgtcagg aagaacagga tgcatataga aggattcaca gccttacaca
      781 tctggactca gtgaccaaga tccataatgg ctcagtattt accaagaatt tgtgcagtca
      841 gatgtcagca gtcagtgggc ctctactgca gtggttggaa gacagattgg agcaaaacca
      901 gcagcatttg caggagttgc aacaagaaaa ggaagagctt atggaagagc tgtcttccct
      961 agaataaagc atgagaacaa caaaaaaatg tggtaatatt ttttttcaat ttgtttgctg
     1021 aatatggtcc aaaactatgc acaactccta tataggcaaa tatgattttt tttagaaata
     1081 ttaggattta ggttgtaata gaaatcatgc tctaaaaaaa atgtgatgag catagcattc
     1141 cttcatatgt aaccactaat tctaaatgtg ctttcagaaa aagagttgag cctgttgcat
     1201 cctgggaact aaagtgggaa ctggaaaaag ggtgaaaaga aagaaaacag atagtaatag
     1261 tcccaaccac agtgatattt ggaattttgg cttgttgcct tattttttcc tagattattg
     1321 tttttcagct tccagaaccg cttgcatcag aattgctcag agttcaaact caatcattga
     1381 ggctagaacc taaaaatcta catgacctac ttagctgatt ctgaggcata cttatatttg
     1441 aaaacaaata ttcgtagggc atatggaatg taaatgtatt ttctttaatt ctctcccaca
     1501 tttattattt ctttattttc ttttttatag ggcagatgaa aatacctggc atataattta
     1561 ttatattaaa tcaattttga aaaagataat gttggaggga ctacattata taacttcaag
     1621 acttattata aagctacaat aatcaagata ctatgttttt tgcagaagaa tcaatgcaat
     1681 aggaaagaaa attcagaaat aagcccacaa taatatgctt aactaatttt gaaaaagtaa
     1741 aaatgtgatt caaggaagaa aaaacagtca tttcaacgca ttgaacctcc acaagccaac
     1801 aaagtatatt ctaaaagtac ctccaaatat atcatgcatt taaatgtact atgaaaaacc
     1861 tagaaaaaat attcaagaaa aattttcagg agttaagtac ttaatattca actcaaaagc
     1921 acaatttcat aagaaaacaa agtagattta ttggacttca tcaaaattaa agctttctat
     1981 tctgcaaaac tattaagaga aaatcatgta atatctgatc agtgaaaaga tatgcttaaa
     2041 actcgaaaat aaacaatacc agtagaaaat gaaaaaaggt tttaacattg tcactacagt
     2101 gggtatatag atggcagata attatgtgca tatatattga atctcataca tcattgatga
     2161 atgcaactta aaactacagt atggtgtggc atatacttat caggactgct atagaaaaag
     2221 atagtgaaaa taccaaatac ggttgaggat gcaaactaga tttctcatac accaatgaca
     2281 ggaatgtaaa aatacagcta ctgagtagaa gagtttggaa tttttttttt ttaagttaaa
     2341 catacactta acatgaccca gcaataatac tgtcttggca caaaaacttt tacaaaattt
     2401 ttcttggcag ctttatctgt gatagctgca aattagaaat aacccaaata ctctgcagtg
     2461 agtaaatggc tcaacaaacc attcttacta tggactacta ctatgtagtg gaaaggaaca
     2521 tactgctaat atgatgagcc ttgggcagtt atagtaaatg aaaaaaaggt tgtcttaaaa
     2581 gagcacttac tgtatggttg catttctaga gctttgttta aatgtcagaa ttaatgacaa
     2641 gaacagatta atgatttcta gagtcaggga atagacattg tatagcatat gtgttcttcc
     2701 tacagtgtga cctaaaagtt aatttaggct gatgaaacag ttttgtacct taaatttagt
     2761 gtttaatata gaagtctgtt cctgtgctaa catattttag attcatatac atataaatta
     2821 atacatgtaa aaatctagaa gtgagtagga attaagattc cactttatga aataattaga
     2881 gtgatatatg agccatatgt agtgtcacat gcctatagtc ccagtgctca ggaggctgaa
     2941 gcaggaacat ttcaagttta gagctattct gagctatata gttcccagct ggttgggcta
     3001 cagtgtgaga ccttgcttca gaaaaaaagg gcggggaggg taggtgataa aaagaaaacc
     3061 tgggggtggg gataaaatga tttgaatatt cttataagcc aactatgaac acaagtctgt
     3121 gcttcacttt catgaataaa ataagattat agtatatgac catcaagtat acttttagat
     3181 cagtgttcat actttaaaaa tattgatcat cagaaagaac agtggtatga atgaaatgtg
     3241 attattttcc tagttgtacc tgtatggttt acctttacac aaaacattgt attccaacat
     3301 ataaccttgt atcctctctg atttttcttt ttcaatcata gtcaaattct gttgggaaca
     3361 gaaagtactt gtttagatag gtatgctctc catctggttt ttttaaaacc tttttgagat
     3421 agggcatcac tcaacagccc agtctggccc caatctagca gttctcttac aaccatgcct
     3481 ggctgatttc ttattttcta tacatggatc ctgcatctga ccttgtctat actatttttg
     3541 aaaccattcc tcccatagtc aatgatgata tccactagtc aagctcattt gtttttgaga
     3601 actgtcattg gtaaaactct agcttttact atttttgtgg ataaatgaat aaataataaa
     3661 taataaatac tgacttgaca ctttcatcat tcttccaaat ctaccacttt tggtctttgt
     3721 tatcatatac tttattattt cttatttcca gactgtccct cccaaaattc attcatacgc
     3781 ctctctatac agttacagac aaatccattt ctctatacct ctgtctgaac tccagactca
     3841 gatttcaagt gacccattat atatttctag taggtagtct tattgataca ttgactttga
     3901 taaatctaaa tatgaacatg gttttggcct aatctatatt ctcttatatg tcttacctca
     3961 gtgaaggagg catccatatg caaaaactgg aatctagaca gacaacccca acatctctat
     4021 taccttttac agtatttgca ttgagttata gcagtttgtt tgttttttgg ttttgggttt
     4081 tttttttgta atctaatcag agttgcaata tgtagaatag gtattcgtga agaggaatgg
     4141 gcaggtagaa tatcaaggtt ctcactggtt aggattactt catgaaaaca taagagttcc
     4201 ttagccttgc agcaccagag caagaacaag atctagtgaa agttgtcctg tgtcagtatc
     4261 ctcagaatca gagtgaagag gagaaaatga tctcttaaac taaaatgatg gagcaaataa
     4321 gcatgctttg aggaaaattg aagttttttt catacttgaa acattatata cagatatgta
     4381 aaaaaaaagt ataaaattat tccctgtgat gttaaataga aaaagttgat atgatcattt
     4441 taaaagggaa ttacatatat gtatatattg agagaatgat cagtacatct atatacctcc
     4501 acttcttatc tctccccatt aagagagaat agaaatggta gttcactagc taatgagcac
     4561 acctggcacc aaggtactgg acttcaaata gtattttcca ctattagtga atagaattga
     4621 gtccagaaat gaatgcatat gtatgtgata aactgatttt taacaaaaat gccaagacta
     4681 tttgaatggg gaaaaatagt cttttcaaca gctgatgatt tcagaactaa atacctacac
     4741 agaataatga agctggaccc ctgccccata tcatgtatga atgttaacta aaaatgtatc
     4801 aaatatttaa atgtaagaac ttgtaactat taaaatatta aaacagcaaa aaaaaaaaaa
     4861 aaaaaaaaaa aaaaaa
//
