LOCUS       NM_009765              10940 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus breast cancer 2, early onset (Brca2), transcript
            variant 2, mRNA.
ACCESSION   NM_009765
VERSION     NM_009765.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10940)
  AUTHORS   Chehade,H., Gogoi,R., Adzibolosu,N.K., Galoforo,S., Fehmi,R.A.,
            Kheil,M., Fox,A., Kim,S., Rattan,R., Hou,Z., Morris,R.T.,
            Matherly,L.H., Mor,G. and Alvero,A.B.
  TITLE     BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian
            Cancer
  JOURNAL   Cancer Res Commun 4 (8), 2075-2088 (2024)
   PUBMED   39028933
  REMARK    GeneRIF: BRCA Status Dictates Wnt Responsiveness in Epithelial
            Ovarian Cancer.
REFERENCE   2  (bases 1 to 10940)
  AUTHORS   Bai,L., Li,P., Xiang,Y., Jiao,X., Chen,J., Song,L., Liang,Z.,
            Liu,Y., Zhu,Y. and Lu,L.Y.
  TITLE     BRCA1 safeguards genome integrity by activating chromosome
            asynapsis checkpoint to eliminate recombination-defective oocytes
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2401386121 (2024)
   PUBMED   38696471
REFERENCE   3  (bases 1 to 10940)
  AUTHORS   Georgieva,D., Wang,N., Taglialatela,A., Jerabek,S., Reczek,C.R.,
            Lim,P.X., Sung,J., Du,Q., Horiguchi,M., Jasin,M., Ciccia,A.,
            Baer,R. and Egli,D.
  TITLE     BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA
            repair pathway choice at replication-associated double-strand
            breaks
  JOURNAL   Cell Rep 43 (4), 114006 (2024)
   PUBMED   38554279
REFERENCE   4  (bases 1 to 10940)
  AUTHORS   Lim,P.X., Zaman,M., Feng,W. and Jasin,M.
  TITLE     BRCA2 promotes genomic integrity and therapy resistance primarily
            through its role in homology-directed repair
  JOURNAL   Mol Cell 84 (3), 447-462 (2024)
   PUBMED   38244544
REFERENCE   5  (bases 1 to 10940)
  AUTHORS   Sengodan,S.K., Hu,X., Peddibhotla,V., Balamurugan,K.,
            Mitrophanov,A.Y., McKennett,L., Kharat,S.S., Sanawar,R.,
            Singh,V.K., Albaugh,M.E., Burkett,S.S., Zhao,Y., Tran,B., Malys,T.,
            Sterneck,E., De,S. and Sharan,S.K.
  TITLE     Mismatch repair protein MLH1 suppresses replicative stress in
            BRCA2-deficient breast tumors
  JOURNAL   J Clin Invest 134 (7), e173718 (2024)
   PUBMED   38271119
  REMARK    GeneRIF: Mismatch repair protein MLH1 suppresses replicative stress
            in BRCA2-deficient breast tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10940)
  AUTHORS   Connor,F., Smith,A., Wooster,R., Stratton,M., Dixon,A.,
            Campbell,E., Tait,T.M., Freeman,T. and Ashworth,A.
  TITLE     Cloning, chromosomal mapping and expression pattern of the mouse
            Brca2 gene
  JOURNAL   Hum Mol Genet 6 (2), 291-300 (1997)
   PUBMED   9063750
REFERENCE   7  (bases 1 to 10940)
  AUTHORS   Sharan,S.K. and Bradley,A.
  TITLE     Identification and characterization of a microsatellite marker
            within murine Brca2 gene
  JOURNAL   Mamm Genome 8 (1), 79 (1997)
   PUBMED   9021166
REFERENCE   8  (bases 1 to 10940)
  AUTHORS   Bignell,G., Micklem,G., Stratton,M.R., Ashworth,A. and Wooster,R.
  TITLE     The BRC repeats are conserved in mammalian BRCA2 proteins
  JOURNAL   Hum Mol Genet 6 (1), 53-58 (1997)
   PUBMED   9002670
REFERENCE   9  (bases 1 to 10940)
  AUTHORS   Rajan,J.V., Wang,M., Marquis,S.T. and Chodosh,L.A.
  TITLE     Brca2 is coordinately regulated with Brca1 during proliferation and
            differentiation in mammary epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 13078-13083 (1996)
   PUBMED   8917547
REFERENCE   10 (bases 1 to 10940)
  AUTHORS   Miyakawa,T., Yagi,T., Kagiyama,A. and Niki,H.
  TITLE     Radial maze performance, open-field and elevated plus-maze
            behaviors in Fyn-kinase deficient mice: further evidence for
            increased fearfulness
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 145-150 (1996)
   PUBMED   8738145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154885.9.
            
            On Dec 19, 2013 this sequence version replaced NM_009765.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U65594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC154885.9         110224-110499
            277-381             AC154885.9         110778-110882
            382-609             AC154885.9         117073-117300
            610-718             AC154885.9         118672-118780
            719-768             AC154885.9         119287-119336
            769-809             AC154885.9         119658-119698
            810-921             AC154885.9         119894-120005
            922-971             AC154885.9         122196-122245
            972-1083            AC154885.9         123042-123153
            1084-2190           AC154885.9         123634-124740
            2191-6999           AC154885.9         126252-131060
            7000-7095           AC154885.9         132498-132593
            7096-7165           AC154885.9         135544-135613
            7166-7512           AC154885.9         136092-136438
            7513-7694           AC154885.9         138435-138616
            7695-7882           AC154885.9         139810-139997
            7883-8053           AC154885.9         140540-140710
            8054-8408           AC154885.9         141758-142112
            8409-8564           AC154885.9         144464-144619
            8565-8709           AC154885.9         144704-144848
            8710-8831           AC154885.9         145993-146114
            8832-9024           AC154885.9         147607-147799
            9025-9188           AC154885.9         148031-148194
            9189-9327           AC154885.9         148288-148426
            9328-9569           AC154885.9         154491-154732
            9570-9731           AC154885.9         155210-155371
            9732-10940          AC154885.9         156542-157750
FEATURES             Location/Qualifiers
     source          1..10940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.52 cM"
     gene            1..10940
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /note="breast cancer 2, early onset"
                     /db_xref="GeneID:12190"
                     /db_xref="MGI:MGI:109337"
     exon            1..276
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            277..381
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..10304
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /note="fanconi anemia group D1 protein homolog"
                     /codon_start=1
                     /product="breast cancer type 2 susceptibility protein
                     homolog"
                     /protein_id="NP_033895.2"
                     /db_xref="CCDS:CCDS39411.1"
                     /db_xref="GeneID:12190"
                     /db_xref="MGI:MGI:109337"
                     /translation="MPVEYKRRPTFWEIFKARCSTADLGPISLNWFEELSSEAPPYNS
                     EPPEESEYKPHGYEPQLFKTPQRNPPYHQFASTPIMFKERSQTLPLDQSPFRELGKVV
                     ASSKHKTHSKKKTKVDPVVDVASPPLKSCLSESPLTLRCTQAVLQREKPVVSGSLFYT
                     PKLKEGQTPKPISESLGVEVDPDMSWTSSLATPPTLSSTVLIARDEEARSSVTPADSP
                     ATLKSCFSNHNESPQKNDRSVPSVIDSENKNQQEAFSQGLGKMLGDSSGKRNSFKDCL
                     RKPIPNILEDGETAVDTSEEDSFSLCFPKRRTRNLQKMRMGKTRKKIFSETRTDELSE
                     EARRQTDDKNSFVFEMELRESDPLDPGVTSQKPFYSQNEEICNEAVQCSDSRWSQSNL
                     SGLNETQTGKITLPHISSHSQNISEDFIDMKKEGTGSITSEKSLPHISSLPEPEKMFS
                     EETVVDKEHEGQHFESLEDSIAGKQMVSRTSQAACLSPSIRKSIFKMREPLDETLGTV
                     FSDSMTNSTFTEEHEASACGLGILTACSQREDSICPSSVDTGSWPTTLTDTSATVKNA
                     GLISTLKNKKRKFIYSVSDDASLQGKKLQTHRQLELTNLSAQLEASAFEVPLTFTNVN
                     SGIPDSSDKKRCLPNDPEEPSLTNSFGTATSKEISYIHALISQDLNDKEAIVIEEKPQ
                     PYTAREADFLLCLPERTCENDQKSPKVSNGKEKVLVSACLPSAVQLSSISFESQENPL
                     GDHNGTSTLKLTPSSKLPLSKADMVSREKMCKMPEKLQCESCKVNIELSKNILEVNEI
                     CILSENSKTPGLLPPGENIIEVASSMKSQFNQNAKIVIQKDQKGSPFISEVAVNMNSE
                     ELFPDSGNNFAFQVTNKCNKPDLGSSVELQEEDLSHTQGPSLKNSPMAVDEDVDDAHA
                     AQVLITKDSDSLAVVHDYTEKSRNNIEQHQKGTEDKDFKSNSSLNMKSDGNSDCSDKW
                     SEFLDPVLNHNFGGSFRTASNKEIKLSEHNVKKSKMFFKDIEEQYPTRLACIDIVNTL
                     PLANQKKLSEPHIFDLKSVTTVSTQSHNQSSVSHEDTDTAPQMLSSKQDFHSNNLTTS
                     QKAEITELSTILEESGSQFEFTQFRKPSHIAQNTSEVPGNQMVVLSTASKEWKDTDLH
                     LPVDPSVGQTDHSKQFEGSAGVKQSFPHLLEDTCNKNTSCFLPNINEMEFGGFCSALG
                     TKLSVSNEALRKAMKLFSDIENSEEPSAKVGPRGFSSSAHHDSVASVFKIKKQNTEKS
                     FDEKSSKCQVTLQNNIEMTTCIFVGRNPEKYIKNTKHEDSYTSSQRNNLENSDGSMSS
                     TSGPVYIHKGDSDLPADQGSKCPESCTQYAREENTQIKENISDLTCLEIMKAEETCMK
                     SSDKKQLPSDKMEQNIKEFNISFQTASGKNTRVSKESLNKSVNIFNRETDELTVISDS
                     LNSKILHGINKDKMHTSCHKKAISIKKVFEDHFPIVTVSQLPAQQHPEYEIESTKEPT
                     LLSFHTASGKKVKIMQESLDKVKNLFDETQYVRKTASFSQGSKPLKDSKKELTLAYEK
                     IEVTASKCEEMQNFVSKETEMLPQQNYHMYRQTENLKTSNGTSSKVQENIENNVEKNP
                     RICCICQSSYPVTEDSALAYYTEDSRKTCVRESSLSKGRKWLREQGDKLGTRNTIKIE
                     CVKEHTEDFAGNASYEHSLVIIRTEIDTNHVSENQVSTLLSDPNVCHSYLSQSSFCHC
                     DDMHNDSGYFLKNKIDSDVPPDMKNAEGNTISPRVSATKERNLHPQTINEYCVQKLET
                     NTSPHANKDVAIDPSLLDSRNCKVGSLVFITAHSQETERTKEIVTDNCYKIVEQNRQS
                     KPDTCQTSCHKVLDDSKDFICPSSSGDVCINSRKDSFCPHNEQILQHNQSMSGLKKAA
                     TPPVGLETWDTSKSIREPPQAAHPSRTYGIFSTASGKAIQVSDASLEKARQVFSEMDG
                     DAKQLSSMVSLEGNEKPHHSVKRENSVVHSTQGVLSLPKPLPGNVNSSVFSGFSTAGG
                     KLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPIPEDVSKILPQPCAEIRTPEYPVNS
                     KLQKTYNDKSSLPSNYKESGSSGNTQSIEVSLQLSQMERNQDTQLVLGTKVSHSKANL
                     LGKEQTLPQNIKVKTDEMKTFSDVPVKTNVGEYYSKESENYFETEAVESAKAFMEDDE
                     LTDSEQTHAKCSLFTCPQNETLFNSRTRKRGGVTVDAVGQPPIKRSLLNEFDRIIESK
                     GKSLTPSKSTPDGTVKDRSLFTHHMSLEPVTCGPFCSSKERQGAQRPHLTSPAQELLS
                     KGHPWRHSALEKSPSSPIVSILPAHDVSATRTERTRHSGKSTKVFVPPFKMKSQFHGD
                     EHFNSKNVNLEGKNQKSTDGDREDGNDSHVRQFNKDLMSSLQSARDLQDMRIKNKERR
                     HLRLQPGSLYLTKSSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNAEY
                     FQFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISS
                     IWVANHYRWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSRRSALKKI
                     LERDDTAAKTLVLCISDIISPSTKVSETSGGKTSGEDANKVDTIELTDGWYAVRAQLD
                     PPLMALVKSGKLTVGQKIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSR
                     LGFFRDPRPFPLPLSSLFSDGGNVGCVDIIVQRVYPLQWVEKTVSGLYIFRSEREEEK
                     EALRFAEAQQKKLEALFTKVHTEFKDHEEDTTQRCVLSRTLTRQQVHALQDGAELYAA
                     VQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQSEFRKALESAEKEEGLSRDV
                     TTVWKLRVTSYKKKEKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERPSI
                     QLTATKRTQYQQLPVSSETLLQVYQPRESLHFSRLSDPAFQPPCSEVDVVGVVVSVVK
                     PIGLAPLVYLSDECLNLLVVKFGIDLNEDIKPRVLIAASNLQCQPESTSGVPTLFAGH
                     FSIFSASPKEAYFQEKVNNLKHAIENIDTFYKEAEKKLIHVLEGDSPKWSTPNKDPTR
                     EPHAASTCCASDLLGSGGQFLRISPTGQQSYQSPLSHCTLKGKSMPLAHSAQMAAKSW
                     SGENEIDDPKTCRKRRALDFLSRLPLPSPVSPICTFVSPAAQKAFQPPRSCGTKYATP
                     IKKEPSSPRRRTPFQKTSGVSLPDCDSVADEELALLSTQALTPDSVGGNEQAFPGDST
                     RNPQPAQRPDQQVGPRSRKESLRDCRGDSSEKLAVES"
     exon            382..609
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            610..718
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            719..768
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            769..809
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            810..921
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            922..971
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1083
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..2190
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..6999
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            7000..7095
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            7096..7165
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            7166..7512
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            7513..7694
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            7695..7882
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            7883..8053
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            8054..8408
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            8409..8564
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            8565..8709
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            8710..8831
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            8832..9024
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            9025..9188
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            9189..9327
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            9328..9569
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            9570..9731
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     exon            9732..10940
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10514..10519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /note="hexamer: AATAAA"
     polyA_site      10540
                     /gene="Brca2"
                     /gene_synonym="Fancd1; RAB163"
                     /note="major polyA site"
ORIGIN      
        1 gggcttttcg cgggagcggg agccgtgagg cgttgccgtc agtcagctac cgctgcggga
       61 gcggagcggg tcggtgcggc cgggtgtggc gggcgtgcgc tccggggtcg tgaggccgtg
      121 agggacgcgc ctgacacccc ggaggagcca gtcgacctcc ttcacggcca cccggagcag
      181 ctgccccggt gcagcccgcg gcgtcctccc agagggatcc ggcgcgtcca gagtccgcgg
      241 tagctgcccc gttctgcagt cgccggatta cctaacactt ccttaccgag catcggagaa
      301 atactgtaga gaaaatgccc gttgaataca aaaggagacc aactttttgg gaaattttta
      361 aggcgagatg cagcacagca gatttaggac cgataagcct caattggttt gaggagcttt
      421 cctcagaagc ccccccatac aattctgaac ctccggagga atctgagtat aagccccacg
      481 gttatgaacc acagctgttt aaaacaccac agaggaatcc cccctaccat cagtttgctt
      541 caactccaat aatgttcaaa gaacgaagtc aaactctacc actggaccag tcgcctttca
      601 gagaattagg gaaggttgtt gcaagtagta aacataaaac tcacagcaaa aagaagacca
      661 aagtggaccc tgtggtagat gttgctagtc cgcctctgaa atcttgtctc agtgaaagcc
      721 ctcttactct gcggtgcaca caggcagtac tacaacgaga aaagccagtg gtatctggaa
      781 gtttatttta tacaccaaaa ctcaaggagg gtcagacacc aaaacctatt tctgagagtc
      841 tgggagttga agtggatcct gatatgtctt ggacaagctc attagctaca ccaccaaccc
      901 ttagttccac tgtgctcata gcccgagatg aagaagcacg cagctctgta acgcctgctg
      961 actctcccgc tactttgaaa agctgttttt ctaaccacaa tgaaagtcca caaaaaaatg
     1021 atagatctgt tccctcagtg attgacagtg aaaacaaaaa ccagcaagaa gcttttagtc
     1081 agggtttggg gaaaatgtta ggagattcat ctggcaaaag aaatagcttc aaagactgcc
     1141 ttagaaagcc aataccaaat attctagaag atggggagac agctgttgat acttccgaag
     1201 aagatagttt ctcattatgt tttcctaagc gtagaaccag aaatctacag aaaatgagaa
     1261 tgggcaagac aaggaaaaaa attttcagtg aaacaagaac tgatgaatta agcgaagaag
     1321 ctagaagaca aactgatgat aaaaactcat ttgtatttga aatggaacta agagagagtg
     1381 atcctttaga tccaggtgta acaagccaga agccctttta cagccagaat gaggaaatct
     1441 gcaatgaagc tgtacagtgt tcagatagta gatggtctca gtcaaacctt tctggtctaa
     1501 atgaaaccca gacaggaaaa ataaccttac ctcatatttc ttctcatagc caaaatattt
     1561 cagaagactt catagatatg aagaaagaag gtactggctc tattacttca gaaaaatctt
     1621 tacctcatat ttctagtctt ccagaaccgg aaaagatgtt cagtgaggag actgtggtag
     1681 ataaggaaca tgaaggacag cattttgaat cacttgaaga ctccattgca gggaagcaaa
     1741 tggtgtctag aacaagtcaa gcagcctgtc tttctccgag tatcaggaag tctatattca
     1801 agatgagaga gccacttgac gagactttgg gtactgtttt ctcagatagt atgaccaact
     1861 caacctttac agaagaacat gaagcctctg catgtggatt gggaatactt actgcatgct
     1921 cacagagaga ggattctata tgtcctagtt cagttgacac tggaagctgg ccaaccactc
     1981 tcactgacac ttctgccact gtgaaaaatg caggtttgat atccactcta aaaaataaaa
     2041 aaagaaagtt tatttactct gtaagtgatg atgcatctct tcaaggaaaa aaactacaga
     2101 cacacagaca gttagagctt actaatcttt cagcccagct tgaagcaagt gcttttgaag
     2161 taccattgac ctttacaaat gtaaattcag gtataccaga ttcttctgac aaaaaacgct
     2221 gtttaccgaa tgatcctgaa gagccatcct tgaccaactc ttttgggact gctaccagta
     2281 aagaaattag ttatattcat gcattgatat ctcaggatct taatgacaaa gaagcaatag
     2341 tcattgaaga aaaaccacag ccatatacag cccgagaagc tgactttctg ttatgcttgc
     2401 cagaaagaac atgtgaaaat gaccaaaaaa gtccaaaagt ttccaatgga aaagaaaaag
     2461 tcttagtttc agcatgtctt ccttcagcag tgcaactcag cagcattagc tttgaatcac
     2521 aggaaaaccc tcttggtgac cacaacggaa caagtactct taaattaact cccagctcaa
     2581 agctacctct gtcaaaggca gacatggttt ctagagagaa aatgtgtaaa atgccagaga
     2641 aactgcaatg tgagagttgt aaagttaata ttgaactaag taaaaacatc ttggaggtaa
     2701 atgaaatatg tatcttaagt gaaaattcta aaactcctgg gcttctgcca cctggtgaaa
     2761 atataataga agtggcctct tcaatgaagt cacagttcaa tcaaaatgca aaaatagtca
     2821 tacagaagga ccaaaaaggc tcacctttta tttcagaagt agcagtcaat atgaactctg
     2881 aagaactttt cccagacagt gggaataatt ttgcttttca agtaactaat aaatgcaata
     2941 agcctgattt aggaagttca gtggaactcc aggaagaaga cctcagccac acacaagggc
     3001 ctagtctcaa gaactctccc atggcagtag atgaagatgt agatgatgcg catgcagccc
     3061 aagtgttgat tacaaaggac tcagattcat tagctgtggt ccatgattat acagagaaga
     3121 gcagaaataa tatagagcag caccagaaag gaaccgaaga caaagatttc aagtcaaatt
     3181 cctccttgaa tatgaaatca gatgggaaca gtgattgttc agacaaatgg tcagagttct
     3241 tggatccagt cttgaaccat aattttggag gtagcttcag aacagcttcc aataaagaaa
     3301 taaaactttc agagcataat gtcaagaaaa gtaaaatgtt cttcaaagat attgaagaac
     3361 agtatcctac taggttagct tgtattgaca ttgttaatac ccttccatta gcaaaccaga
     3421 agaaactaag tgaacctcat atatttgatt tgaaatcagt tactactgta tctacacagt
     3481 ctcacaatca atcatctgtt tctcatgaag atactgacac agcacctcag atgttatctt
     3541 caaagcaaga ttttcattca aataatttaa cgaccagcca aaaagcagaa attacagaac
     3601 tgtctactat tttggaagaa tcaggaagtc agtttgaatt cacacagttc agaaagccaa
     3661 gccacatagc acagaataca tctgaagtgc ctggaaacca gatggttgtt ttaagtaccg
     3721 cttctaagga gtggaaagat actgatcttc acctcccagt ggatccctct gtaggtcaga
     3781 cagatcacag caagcaattt gaaggttcgg ctggagttaa acaaagcttt cctcacctgt
     3841 tagaagacac ttgtaacaaa aatacatctt gttttttacc aaatataaat gaaatggagt
     3901 ttggaggatt ttgttctgct cttggcacaa aacttagtgt gtctaatgag gctctgagaa
     3961 aagctatgaa actgttcagt gacattgaaa atagtgagga gccttctgca aaagtaggac
     4021 caagaggatt ctcttcaagt gcacaccatg attctgttgc ttcagtgttt aagataaaga
     4081 aacaaaacac tgaaaaaagt tttgatgaaa aatctagtaa gtgccaagta acattacaaa
     4141 ataatattga aatgactacc tgtatttttg ttggcagaaa tcctgaaaaa tacataaaga
     4201 atacaaaaca tgaagatagc tatactagct ctcaaagaaa taatttagaa aactctgatg
     4261 gtagtatgtc aagtacaagt ggcccagttt atattcataa aggtgacagt gatttacctg
     4321 ccgatcaagg cagtaagtgt cctgagtcat gtacccaata tgcgagagag gaaaacacac
     4381 aaattaagga aaatatatca gatttaacat gtttggaaat tatgaaagct gaggaaacat
     4441 gtatgaaatc ttcagataaa aaacaattac cttcagataa gatggaacaa aatataaaag
     4501 agtttaatat atcctttcag actgcaagtg ggaaaaatac cagagtctcc aaagagtcat
     4561 taaataaaag tgtgaatatt tttaatcggg aaacagatga attgactgtc atttcagatt
     4621 ctttgaattc taaaattctc catggcataa ataaggacaa aatgcatact tcatgtcaca
     4681 agaaagcaat cagtattaaa aaggtatttg aagaccattt cccaattgta actgtcagtc
     4741 aattaccagc tcagcagcat cctgaatatg aaatagaaag taccaaagaa cctactctgt
     4801 tgagttttca tacagctagt gggaaaaaag tcaaaattat gcaggaatct ttggacaaag
     4861 tgaaaaacct ttttgatgag acacaatatg ttaggaaaac tgccagtttt agtcaaggat
     4921 caaaacccct gaaggacagt aaaaaagaac ttacattagc atatgagaaa attgaagtaa
     4981 ctgcctcaaa atgtgaagaa atgcagaact ttgtctctaa ggagactgaa atgctacctc
     5041 agcaaaatta tcatatgtat aggcaaactg aaaatctcaa aacatcaaat ggtacctctt
     5101 ccaaagtaca agaaaacata gaaaataatg tagaaaagaa tcctagaatt tgctgtattt
     5161 gtcagtcctc ttacccagtc actgaagatt ctgctttggc atattatacg gaggacagta
     5221 ggaaaacttg tgtcagagag tcttctctat ccaaaggcag aaaatggctt agagaacagg
     5281 gtgataagct tggaacaaga aatactatca aaattgagtg tgtaaaggaa cacacagaag
     5341 attttgcagg aaatgcctca tatgaacata gtttggtcat tatcagaact gaaattgata
     5401 caaatcatgt ctctgaaaac caagtgtcaa ccctccttag tgaccctaat gtgtgtcata
     5461 gctatctatc ccagtctagt ttttgtcatt gtgatgacat gcataatgat tcaggatatt
     5521 tcttaaaaaa taaaattgat tctgacgttc cgccagacat gaagaatgct gaaggcaata
     5581 ccatttcccc cagagtatct gctacaaaag aaagaaatct acacccacaa actataaatg
     5641 aatattgtgt tcagaaactg gagactaata cttcaccaca tgcaaataaa gatgtagcca
     5701 ttgacccatc tctgctggat tcaaggaatt gtaaggtagg ctcactcgtg tttattacag
     5761 ctcattcaca agaaactgaa agaacaaaag agatagtcac agataactgt tataaaatag
     5821 ttgagcaaaa cagacagagt aaaccagaca cttgccagac aagctgtcat aaagtattgg
     5881 atgattcaaa ggattttata tgtcctagct cttcaggtga tgtctgcata aactcacgta
     5941 aggatagttt ttgtcctcat aatgaacaaa ttttacaaca taaccaaagt atgtctggac
     6001 tgaagaaagc tgcaacacca cctgttggtt tggaaacttg ggatacaagt aaatctataa
     6061 gagaacctcc ccaggcagcc catccttcac gcacttatgg gatttttagc acagcaagtg
     6121 gaaaagctat acaagtatca gatgcttcat tagaaaaggc aaggcaagtg ttttctgaga
     6181 tggatggtga tgctaaacag ttatcttcca tggtgtcact ggaaggtaat gaaaaaccac
     6241 atcactctgt gaaaagagaa aactctgtgg tgcatagcac ccagggtgta ttgtcactcc
     6301 caaaacccct cccaggcaat gtcaattcat ctgtattctc tggatttagc actgcaggtg
     6361 gaaaactggt cacagtttca gaaagtgcct tacacaaagt taaaggaatg ttagaggagt
     6421 ttgatttgat cagaactgaa catactctcc agcattcacc tatacctgaa gacgtatcaa
     6481 aaatacttcc tcaaccttgt gctgaaatca gaaccccaga ataccctgta aactcaaaat
     6541 tgcagaaaac ctacaatgat aaatccagct taccaagtaa ttataaagaa agtggttctt
     6601 cgggcaatac tcaatctatt gaagtttctc tccaactctc tcagatggag agaaaccaag
     6661 acacacagtt ggtattagga acaaaagtat cccatagtaa ggctaatctt ttgggaaaag
     6721 aacaaacttt accccaaaac ataaaagtaa aaactgatga aatgaaaaca ttttctgatg
     6781 ttcctgtgaa aacaaatgta ggagagtatt actccaaaga gtcagagaac tattttgaaa
     6841 cagaagcagt ggagagtgcc aaagctttta tggaagatga tgagctgaca gattctgaac
     6901 agactcatgc caaatgctca ctgtttacat gcccccaaaa tgagactttg tttaattcga
     6961 gaactaggaa aagaggagga gtgactgttg acgcagttgg acaaccccca atcaaaagaa
     7021 gcttattaaa tgaatttgac aggataatag aaagtaaagg aaaatcctta acaccttcaa
     7081 aaagcactcc agatggcaca gtaaaagaca gaagcttgtt cacacaccac atgtctttag
     7141 agccggttac ctgtggaccc ttctgctcaa gtaaagaaag gcaaggagcc cagcgcccac
     7201 atcttacctc acctgctcaa gagcttctgt ctaaagggca tccctggaga cactcagctt
     7261 tggaaaagtc tccaagcagt cctatagttt caatcttacc ggctcacgac gtttctgcca
     7321 caagaaccga aaggaccaga cattcaggca aatccaccaa agtcttcgtc ccgcctttca
     7381 agatgaaatc acagtttcac ggagatgaac atttcaatag caagaacgtt aatttggagg
     7441 gaaagaacca aaagagcaca gatggagaca gggaagacgg gaacgacagc catgttcgtc
     7501 agtttaacaa agatttaatg tcaagccttc agagtgccag agacctacag gatatgcgaa
     7561 ttaaaaacaa agaaaggcga catctccgtc tgcagccagg cagtctgtat cttacaaagt
     7621 catccaccct gccccggatc tccctgcagg ctgcagtagg agacagggct ccttctgcat
     7681 gttctcctaa gcagctctat atatacggcg tttctaaaga gtgcataaac gttaatagca
     7741 aaaatgctga gtattttcag tttgatattc aggatcattt tggtaaagaa gatctgtgtg
     7801 ctggcaaagg ctttcagttg gcagatggtg gatggctgat cccctccaat gatggcaagg
     7861 ctggaaaaga agaattttat agggctctgt gtgacactcc aggtgtggat ccaaagctta
     7921 tttctagcat ctgggttgct aaccattaca ggtggattgt atggaaactg gcagctatgg
     7981 aatttgcttt tcctaaggaa tttgctaata gatgcctaaa cccagaaaga gtgctgcttc
     8041 aactgaaata cagatacgat gtggaaattg acaacagcag gagatcggct ctaaagaaga
     8101 tactggagag ggatgacaca gctgcaaaaa cccttgttct ctgtatttct gacatcattt
     8161 caccaagcac aaaggtgtct gaaacttcag gcggtaaaac tagtggtgag gatgccaaca
     8221 aagtggacac gatcgaactc acagatgggt ggtacgctgt cagggcccag ctagaccctc
     8281 cactcatggc tcttgtaaag agtggcaaac tgactgtggg tcagaagatc attactcagg
     8341 gagcagagct ggtgggctct cctgatgcct gtgcacctct ggaagcccca gactccctaa
     8401 ggctaaagat ttctgcaaac agcacaaggc ctgctcgctg gcacagcagg ctggggttct
     8461 ttcgtgaccc caggcccttc cctctgccct tgtcctcact gttcagtgac ggaggaaatg
     8521 ttggctgtgt ggatatcatt gttcagagag tgtacccttt acagtgggtg gagaagacag
     8581 tgtctggatt gtacatattt cgtagtgaga gagaagagga gaaggaagca ctgagatttg
     8641 cagaggccca gcagaagaaa ctagaggcct tgttcaccaa agtccacaca gagtttaaag
     8701 accacgaaga agacacaaca cagcggtgtg tgctgtcccg cacactcaca cggcagcaag
     8761 tccatgctct gcaggatgga gcagagctct atgcagcagt gcagtatgca tcagacccag
     8821 atcaccttga ggcttgtttc agcgaagagc agctaagagc cttgaacaac tacagacaaa
     8881 tgctgaatga taagaaacaa gcgcggatcc agtcagaatt ccggaaggcc ctggaatccg
     8941 ctgagaaaga ggagggttta tcaagggatg ttacaactgt gtggaagctg cgggttacaa
     9001 gctacaagaa aaaggaaaaa tcagctctgt tgagtatctg gcgtccatca tcagacttat
     9061 cctccctgtt aacagaagga aagagataca gaatctatca tcttgcagtg tcaaaatcga
     9121 agagtaaatt tgaacggccc agcatccagt taacagccac aaaaagaact cagtatcaac
     9181 agctgccggt ttccagtgag actttactcc aggtttacca gcccagggag tcccttcact
     9241 tcagcagact gtcagaccca gcctttcagc ctccttgttc tgaagtggat gtcgtaggag
     9301 ttgtagtttc tgttgtaaaa ccgataggtc ttgctccttt ggtctacctg tcagacgagt
     9361 gccttaattt attagtggtg aaattcggga tagaccttaa tgaagacata aagccacgtg
     9421 tgctaattgc cgcaagcaac ctccagtgcc agccagaatc cacatcagga gtgccgacct
     9481 tatttgctgg ccatttttcc atattttctg ccagtccaaa ggaggcctac tttcaggaga
     9541 aagtcaacaa cttgaagcat gctattgaga atatcgatac attttacaag gaggcagaaa
     9601 agaagcttat acacgtgctt gagggagaca gtcccaagtg gtccacaccg aacaaagacc
     9661 ccacccgaga gccccatgca gcctccactt gctgtgcttc agatctcctt ggttcaggag
     9721 gtcagttcct gaggatttca cctactggtc agcaaagtta tcaaagtcct ttatcacact
     9781 gcacactgaa agggaagtct atgcccctgg ctcactcagc ccagatggca gcaaagtctt
     9841 ggagtggaga gaacgagatt gatgacccaa aaacctgtcg aaaaagaaga gccttggatt
     9901 tcctaagtcg gctgccctta ccgtccccgg tcagtcccat ctgtaccttt gtctctccag
     9961 ctgcacagaa ggcttttcag ccgccacgga gctgtggcac gaaatacgca acacctatta
    10021 aaaaagaacc cagttccccg cggaggagaa cgccatttca gaagaccagt ggcgtttctc
    10081 tgccggactg tgattcagta gctgatgaag aacttgcctt gctcagcacc caggccctta
    10141 cgcctgactc cgtgggagga aatgaacaag cgtttcccgg tgattccaca aggaaccccc
    10201 agccagcaca gaggccagac cagcaagtag ggcccaggtc caggaaggag tctctcaggg
    10261 actgtagagg cgacagcagt gagaaattag ctgttgagtc ttagcctccc ggtttgtaag
    10321 atgtgtacag ttccaggcta ctcataggtg ttcgtgtgag aaggcgggag tagctgcact
    10381 ctactgaagc gtgtgtttac tgctcagatg ctctacctgg tctgtgttgg tgtaactaaa
    10441 gctggttgtc atcgactgat ttaaaaagct ttaggagtag actggatcac tacaactatc
    10501 attttatata caaaataaac atagctttgc ttttagttta gattactggc taagtatggt
    10561 tactttatat agtctggttc ctgtttttga agttttttct ttttttacct aggaagtcct
    10621 atgaaatagt gttctttcct gcatgattgg ttctgctaga gctccatcct gtcagggtaa
    10681 acagacacaa ccgtgatgtt tacctctgtg tagccttgtc actcctttcc actgtcccag
    10741 tgtaatctct caagttattc tagctagaaa tccagtcagg cataatgaca cacacctgtc
    10801 atcccagcat gtaggagata gagaggggag tttgggccac ccttcattac acagaaggtt
    10861 ctaggcggtg ggttacaaag tccttccctg accacagccc catcggcagg tggatgctct
    10921 cactgaactt cagctgtaaa
//
