LOCUS       NM_009764               6648 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus breast cancer 1, early onset (Brca1), mRNA.
ACCESSION   NM_009764
VERSION     NM_009764.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6648)
  AUTHORS   Tang,H., Lu,Y.F., Zeng,R., Liu,C., Shu,Y., Wu,Y., Su,J., Di,L.,
            Qian,J., Zhang,J., Tian,Y., Lu,X., Pei,X.H., Zhu,Q. and Zhu,W.G.
  TITLE     DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to
            elicit DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2320804121 (2024)
   PUBMED   39172790
  REMARK    GeneRIF: DOT1L-mediated RAP80 methylation promotes BRCA1
            recruitment to elicit DNA repair.
REFERENCE   2  (bases 1 to 6648)
  AUTHORS   Chehade,H., Gogoi,R., Adzibolosu,N.K., Galoforo,S., Fehmi,R.A.,
            Kheil,M., Fox,A., Kim,S., Rattan,R., Hou,Z., Morris,R.T.,
            Matherly,L.H., Mor,G. and Alvero,A.B.
  TITLE     BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian
            Cancer
  JOURNAL   Cancer Res Commun 4 (8), 2075-2088 (2024)
   PUBMED   39028933
  REMARK    GeneRIF: BRCA Status Dictates Wnt Responsiveness in Epithelial
            Ovarian Cancer.
REFERENCE   3  (bases 1 to 6648)
  AUTHORS   Winship,A.L., Alesi,L.R., Stringer,J.M., Cao,Y., Lewis,Y.M., Tu,L.,
            Swindells,E.O.K., Giridharan,S., Cai,X., Griffiths,M.J., Zerafa,N.,
            Gilham,L., Hickey,M. and Hutt,K.J.
  TITLE     Conditional loss of Brca1 in oocytes causes reduced litter size,
            ovarian reserve depletion and impaired oocyte in vitro maturation
            with advanced reproductive age in mice
  JOURNAL   EBioMedicine 106, 105262 (2024)
   PUBMED   39084071
  REMARK    GeneRIF: Conditional loss of Brca1 in oocytes causes reduced litter
            size, ovarian reserve depletion and impaired oocyte in vitro
            maturation with advanced reproductive age in mice.
REFERENCE   4  (bases 1 to 6648)
  AUTHORS   Wiesheu,R., Edwards,S.C., Hedley,A., Hall,H., Tosolini,M., Fares da
            Silva,M.G.F., Sumaria,N., Castenmiller,S.M., Wardak,L., Optaczy,Y.,
            Lynn,A., Hill,D.G., Hayes,A.J., Hay,J., Kilbey,A., Shaw,R.,
            Whyte,D., Walsh,P.J., Michie,A.M., Graham,G.J., Manoharan,A.,
            Halsey,C., Blyth,K., Wolkers,M.C., Miller,C., Pennington,D.J.,
            Jones,G.W., Fournie,J.J., Bekiaris,V. and Coffelt,S.B.
  TITLE     IL-27 maintains cytotoxic Ly6C+ gammadelta T cells that arise from
            immature precursors
  JOURNAL   EMBO J 43 (14), 2878-2907 (2024)
   PUBMED   38816652
REFERENCE   5  (bases 1 to 6648)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6648)
  AUTHORS   Ramirez-Solis,R., Liu,P. and Bradley,A.
  TITLE     Chromosome engineering in mice
  JOURNAL   Nature 378 (6558), 720-724 (1995)
   PUBMED   7501018
REFERENCE   7  (bases 1 to 6648)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   8  (bases 1 to 6648)
  AUTHORS   Hall,J.M., Friedman,L., Guenther,C., Lee,M.K., Weber,J.L.,
            Black,D.M. and King,M.C.
  TITLE     Closing in on a breast cancer gene on chromosome 17q
  JOURNAL   Am J Hum Genet 50 (6), 1235-1242 (1992)
   PUBMED   1598904
REFERENCE   9  (bases 1 to 6648)
  AUTHORS   Narod,S.A., Feunteun,J., Lynch,H.T., Watson,P., Conway,T., Lynch,J.
            and Lenoir,G.M.
  TITLE     Familial breast-ovarian cancer locus on chromosome 17q12-q23
  JOURNAL   Lancet 338 (8759), 82-83 (1991)
   PUBMED   1676470
REFERENCE   10 (bases 1 to 6648)
  AUTHORS   Hall,J.M., Lee,M.K., Newman,B., Morrow,J.E., Anderson,L.A., Huey,B.
            and King,M.C.
  TITLE     Linkage of early-onset familial breast cancer to chromosome 17q21
  JOURNAL   Science 250 (4988), 1684-1689 (1990)
   PUBMED   2270482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB662609.1, AB221611.1, AB221610.1, BC068303.1 and U36475.1.
            
            On Nov 24, 2007 this sequence version replaced NM_009764.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31625.1, U32446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BB662609.1         2-68
            68-207              BB662609.1         70-209
            208-3077            AB221611.1         2-2871
            3078-5643           AB221610.1         307-2872
            5644-6607           BC068303.1         5477-6440
            6608-6648           U36475.1           6429-6469
FEATURES             Location/Qualifiers
     source          1..6648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.18 cM"
     gene            1..6648
                     /gene="Brca1"
                     /note="breast cancer 1, early onset"
                     /db_xref="GeneID:12189"
                     /db_xref="MGI:MGI:104537"
     exon            1..187
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..286
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..5645
                     /gene="Brca1"
                     /EC_number="2.3.2.27"
                     /note="breast cancer associated 1; RING-type E3 ubiquitin
                     transferase BRCA1; breast and ovarian cancer
                     susceptibility protein"
                     /codon_start=1
                     /product="breast cancer type 1 susceptibility protein
                     homolog"
                     /protein_id="NP_033894.3"
                     /db_xref="CCDS:CCDS25474.1"
                     /db_xref="GeneID:12189"
                     /db_xref="MGI:MGI:104537"
                     /translation="MDLSAVQIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFC
                     KFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSTRFSQLAEELLRIMAAFELDTGMQLT
                     NGFSFSKKRNNSCERLNEEASIIQSVGYRNRVRRLPQVEPGNATLKDSLGVQLSNLGI
                     VRSVKKNRQTQPRKKSVYIELDSDSSEETVTKPGDCSVRDQELLQTAPQEAGDEGKLH
                     SAEEAACEFSEGIRNIEHHQCSDDLNPTENHATERHPEKCQSISISNVCVEPCGTDAH
                     ASSLQPETSSLLLIEDRMNAEKAEFCNKSKQPGIAVSQQSRWAASKGTCNDRQVPSTG
                     EKVGPNADSLSDREKWTHPQSLCPENSGATTDVPWITLNSSVQKVNEWFSRTGEMLTS
                     DSASARRHESNAEAAVVLEVSNEVDGGFSSSRKTDLVTPDPHHTLMCKSGRDFSKPVE
                     DNISDKIFGKSYQRKGSRPHLNHVTEIIGTFITEPQITQEQPFTNKLKRKRSTSLQPE
                     DFIKKADSAGVQRTPDNINQGTDLMEPNEQAVSTTSNCQENKIAGSNLQKEKSAHPTE
                     SLRKEPASTAGAKSISNSVSDLEVELNVHSSKAPKKNRLRRKSSIRCALPLEPISRNP
                     SPPTCAELQIDSCGSSEETKKNHSNQQPAGHLREPQLIEDTEPAADAKKNEPNEHIRK
                     RRASDAFPEEKLMNKAGLLTSCSSPRKSQGPVNPSPQRTGTEQLETRQMSDSAKELGD
                     RVLGGEPSGKTTDRSEESTSVSLVSDTDYDTQNSVSVLDAHTVRYARTGSAQCMTQFV
                     ASENPKELVHGSNNAGSGTEGLKPPLRHALNLSQEKVEMEDSELDTQYLQNTFQVSKR
                     QSFALFSKPRSPQKDCAHSVPSKELSPKVTAKGKQKERQGQEEFEISHVQAVAATVGL
                     PVPCQEGKLAADTMCDRGCRLCPSSHYRSGENGLSATGKSGISQNSHFKQSVSPIRSS
                     IKTDNRKPLTEGRFERHTSSTEMAVGNENILQSTVHTVSLNNRGNACQEAGSGSIHEV
                     CSTGDSFPGQLGRNRGPKVNTVPPLDSMQPGVCQQSVPVSDKYLEIKKQEGEAVCADF
                     SPCLFSDHLEQSMSGKVFQVCSETPDDLLDDVEIQGHTSFGEGDIMERSAVFNGSILR
                     RESSRSPSPVTHASKSQSLHRASRKLESSEESDSTEDEDLPCFQHLLSRISNTPELTR
                     CSSAVTQRMPEKAEGTQAPWKGSSSDCNNEVIMIEASQEHQFSEDPRCSGSMFSSQHS
                     AAQGSTANANSQDSNFIPPSKQRSHQCGNEEAFLSDKELISDNEEMATCLEEDNDQEE
                     DSIIPDSEASGYESETNLSEDCSQSDILTTQQRATMKYNLIKLQQEMAHLEAVLEQRG
                     NQPSGHSPSLLADPCALEDLPDLEPNMSGAAILTSKNINENPVSQNLKSACDDKFQLQ
                     HLEGPTSGDDESGMGRPSPFKSPLAGSRGSAHGCSRHLQKRNSPSQEELLQPAGSEAS
                     SEPHNSTGQSCLPRRELEGTPYLGSGISLFSSRDPESESPKEPAHIGTTPASTSALKI
                     PQGQVAFRSAAAAGADKAVVGIVSKIKPELTSSEERADRDISMVVSGLTPKEVMTVQK
                     FAEKYRLTLTDAITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVVRSIQE
                     RRLLNVHEFEVKGDVVTGRNHQGPRRSRESREKLFKGLQVYCCEPFTNMPKDELERML
                     QLCGASVVKELPSLTHDTGAHLVVIVQPSAWTEDSNCPDIGQLCKARLVMWDWVLDSL
                     SSYRCRDLDAYLVQNITCDSSEPQDSND"
     exon            287..340
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..418
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..507
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..647
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..750
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..796
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..873
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..4188
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4259
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4431
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4561
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4562..4740
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..5021
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5109
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5187
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5188..5228
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5229..5309
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5310..5364
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5365..5438
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5439..5499
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5500..6648
                     /gene="Brca1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6629..6634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brca1"
                     /note="hexamer: AATAAA"
     polyA_site      6648
                     /gene="Brca1"
                     /note="major polyA site"
ORIGIN      
        1 gttccgaaag gctagcgcta ggcgccaagc ggccggtttc cttggcgacg gagagcgcgg
       61 gaattttaga tagattgtaa ttgcggctgc gcggccgctg cccgtgcagc cagaggatcc
      121 agcacctctc ttggggcttc tccgtcctcg gcgcttggaa gtacggatct tttttctcgg
      181 agaaaagttc actggaactg gaagaaatgg atttatctgc cgtccaaatt caagaagtac
      241 aaaatgtcct tcatgctatg cagaaaatct tagagtgtcc gatctgtttg gaactgatca
      301 aagaacctgt ttccacaaag tgtgaccaca tattttgcaa attttgtatg ctgaaacttc
      361 ttaaccagaa gaaagggcct tcacaatgtc ctttgtgtaa gaatgagata accaaaagga
      421 gcctacaggg aagcacaagg tttagtcagc ttgctgaaga gctgctgaga ataatggctg
      481 cttttgagct tgacacggga atgcagctta caaatggttt tagtttttca aaaaagagaa
      541 ataattcttg tgagcgtttg aatgaggagg cgtcgatcat ccagagcgtg ggctaccgga
      601 accgtgtcag aaggcttccc caggtcgaac ctggaaatgc caccttgaag gacagcctag
      661 gtgtccagct gtctaacctt ggaatcgtga gatcagtgaa gaaaaacagg cagacccaac
      721 ctcgaaagaa atctgtctac attgaactag actctgattc ttctgaagag acagtaacta
      781 agccaggtga ttgcagtgtg agagaccagg aattgttaca gaccgcccct caagaagctg
      841 gagatgaagg caagctgcac tctgcagaag aggctgcttg tgagttttct gagggcataa
      901 gaaacattga acatcatcaa tgcagtgatg atttaaaccc tactgagaat catgcaactg
      961 aaaggcatcc agaaaaatgt cagagtattt ctatttcaaa tgtgtgtgtg gagccatgtg
     1021 gcacagatgc tcatgccagc tcattacagc ctgagaccag cagtttattg ctcattgaag
     1081 acagaatgaa tgcagaaaag gctgaattct gtaataaaag caaacagcct ggcatagcag
     1141 tgagccagca gagcagatgg gctgcaagta aaggaacatg taacgacagg caggttccca
     1201 gcactgggga aaaggtaggt ccaaacgctg actcccttag tgatagagag aagtggactc
     1261 acccgcaaag tctgtgccct gagaattctg gagctaccac cgatgttcct tggataacac
     1321 taaatagcag cgttcagaaa gttaatgagt ggttttccag aactggtgaa atgttaactt
     1381 ctgacagcgc atctgccagg aggcacgagt caaatgctga agcagctgtt gtgttggaag
     1441 tttcaaacga agtggatggg ggttttagtt cttcaaggaa aacagactta gtaacccccg
     1501 acccccatca tactttaatg tgtaaaagtg gaagagactt ctccaaacca gtagaggata
     1561 atatcagtga taaaatattt gggaaatcct atcagagaaa gggaagccgc cctcacctga
     1621 accatgtgac tgaaattata ggcacattta ttacagaacc acagataaca caagagcagc
     1681 ccttcacaaa taaattaaaa cgtaagagaa gtacatccct tcaacctgag gacttcatca
     1741 agaaagcaga ttcagcaggt gttcaaagga ctcctgacaa cataaatcag ggaactgacc
     1801 taatggagcc aaatgagcaa gcagtgagta ctaccagtaa ctgtcaggag aacaaaatag
     1861 caggtagtaa tctccagaaa gagaaaagcg ctcatccaac tgaatcattg agaaaggaac
     1921 ctgcttccac agcaggagcc aaatctataa gcaacagtgt aagtgatttg gaggtagaat
     1981 taaacgtcca cagttcaaaa gcacctaaga aaaataggct gaggaggaag tcttctatca
     2041 ggtgtgctct tccacttgaa ccaatcagta gaaatccaag cccacctact tgtgctgagc
     2101 ttcaaatcga tagttgtggt agcagtgaag aaacaaagaa aaaccattcc aaccaacagc
     2161 cagccgggca ccttagagag cctcaactca tcgaagacac tgaacctgca gcggatgcca
     2221 agaagaacga gccaaatgaa cacataagga agagacgtgc cagcgatgct ttcccagaag
     2281 agaaattaat gaacaaagct ggtttattaa ctagctgttc aagtcctaga aaatctcaag
     2341 ggcctgtcaa tcccagccct cagagaacag gaacagagca acttgaaaca cgccaaatgt
     2401 ctgacagtgc caaagaactc ggggatcggg tcctaggagg agagcccagt ggcaaaacca
     2461 ctgaccgatc tgaggagagc accagcgtat ccttggtatc tgacactgac tacgacactc
     2521 agaacagtgt ctcagtcctg gacgctcaca ctgtcagata tgcaagaaca ggatccgctc
     2581 agtgtatgac tcagtttgta gcaagcgaaa accccaagga actcgtccat ggctctaaca
     2641 atgctgggag tggcacagag ggtctcaagc cccccttgag acacgcgctt aacctcagtc
     2701 aggagaaagt agaaatggaa gacagtgaac ttgatactca gtatttgcag aatacatttc
     2761 aagtttcaaa gcgtcagtca tttgctttat tttcaaaacc tagaagtccc caaaaggact
     2821 gtgctcactc tgtgccctca aaggaactga gtccaaaggt gacagctaaa ggtaaacaaa
     2881 aagaacgtca gggacaggaa gaatttgaaa tcagtcacgt acaagcagtt gcggccacag
     2941 tgggcttacc tgtgccctgt caagaaggta agctagctgc tgatacaatg tgtgatagag
     3001 gttgtaggct ttgtccatca tctcattaca gaagcgggga gaatggactc agcgccacag
     3061 gtaaatcagg aatttcacaa aactcacatt ttaaacaatc agtttctccc atcaggtcat
     3121 ctataaaaac tgacaatagg aaacctctga cagagggacg atttgagaga catacatcat
     3181 caactgagat ggcggtggga aatgagaaca ttcttcagag tacagtgcac acagttagcc
     3241 tgaataacag aggaaatgct tgtcaagaag ccggctcggg cagtattcat gaagtatgtt
     3301 ccactggtga ctccttccca ggacaactag gtagaaacag agggcctaag gtgaacactg
     3361 tgcctccatt agatagtatg cagcctggtg tctgtcagca aagtgttcct gtaagtgata
     3421 agtatcttga aataaaaaag caggagggtg aggctgtctg tgcagacttc tctccatgtc
     3481 tattctcaga ccatcttgag caatctatga gtggtaaggt ttttcaggtt tgctctgaga
     3541 cacctgatga cctgctggat gatgttgaaa tacagggaca tactagcttt ggtgaaggtg
     3601 acataatgga gagatctgct gtctttaacg gaagcatcct gagaagggag tccagtagga
     3661 gccctagtcc tgtaacccat gcatcgaagt ctcagagtct ccacagagcg tctaggaaat
     3721 tagaatcgtc agaagagagc gactccactg aggatgaaga tcttccctgc ttccaacact
     3781 tactgagcag aataagcaac acacctgagc ttaccagatg cagcagtgct gtgacacagc
     3841 gtatgccaga gaaagcggag gggacccaag caccatggaa gggtagcagc agtgactgca
     3901 ataatgaggt gatcatgata gaggcatctc aggagcatca gtttagtgag gatccaagat
     3961 gctctggcag catgttctct tcacagcaca gtgctgccca agggtcaact gcaaatgcaa
     4021 actcccagga ttccaatttt attccacctt ccaaacagag gagtcaccag tgtgggaatg
     4081 aggaagcttt cctaagtgac aaggaattga tttcagataa cgaggaaatg gcaacttgcc
     4141 tagaagagga taatgaccaa gaagaggata gtataatccc agattcagag gcatccggat
     4201 acgagagtga aacaaacctt tctgaagact gctcgcagag tgatatttta accactcagc
     4261 agcgggcgac catgaagtat aacctgataa agctgcagca ggaaatggct cacctggaag
     4321 ctgtgctgga gcagcgtggg aaccagcctt ctggccactc cccttccctc ctagcggacc
     4381 cttgtgccct ggaagacctg ccagatctgg aaccaaacat gtcaggagca gcaattttaa
     4441 cttcaaagaa cattaatgag aatcctgtaa gccaaaattt gaagagcgct tgtgatgaca
     4501 aattccaact acaacatctg gagggtccca ccagtggaga tgacgagtca gggatgggaa
     4561 ggccttcccc ttttaaatct ccgttggcag gcagtagggg ctctgcacat ggctgctcta
     4621 ggcatcttca aaagagaaac tccccctctc aggaggagct cctccagcct gctggatcag
     4681 aggcgtcatc tgagccacac aattcaacag ggcagtcttg cctgccaagg cgagagctag
     4741 aaggaacccc atacctggga tctggaatca gccttttctc tagtagagac cccgaatctg
     4801 agtcccctaa agagccagcc cacattggca ccacaccagc ttcaacctct gcactgaaaa
     4861 taccccaagg tcaagttgct ttccggagtg cagctgctgc tggtgctgat aaagcagtgg
     4921 taggaattgt gagcaagata aagccggaat tgacatcttc agaagaaaga gcggatagag
     4981 acatatccat ggtggtgtca ggcttgaccc ccaaagaagt aatgaccgtg caaaagtttg
     5041 ctgaaaaata ccgcctcact ttaactgacg caattactga ggagactaca catgtaatta
     5101 taaaaacaga tgcggagttt gtgtgtgagc ggacactgaa atattttctg ggcattgcag
     5161 gaggaaagtg gatagttagc tattcatggg tggtccggtc tatccaagaa agaagacttc
     5221 tgaatgtgca tgaatttgaa gtcaaaggag atgttgtgac tggaagaaat caccaaggtc
     5281 caaggcgatc cagagaatcc cgggaaaagc tcttcaaggg cctacaggtc tattgttgtg
     5341 agcccttcac caacatgccc aaagatgagc tggagaggat gctgcagctg tgtggggctt
     5401 ccgtggtgaa ggagcttcca tcgctcaccc atgacacagg tgctcatcta gttgtgatcg
     5461 tgcagccaag cgcctggaca gaagacagca actgcccaga tattgggcag ctgtgcaagg
     5521 cacgtcttgt gatgtgggac tgggtgttgg acagtctatc cagctaccgg tgtcgggatc
     5581 tggatgccta cctggtacag aatatcacct gtgacagtag tgagccacaa gactccaatg
     5641 attaatttaa gaaatggtct tccatgcccg gggagcacct ctcagtcttt ggtgcttcca
     5701 caccctactt actaagtatt tttcatgcat ccgcctggaa aaaccagctt ctacctatgt
     5761 gagggtgggt gccttaaagg ttttctaacc aagtccccct ttgaagtctg tcttgaacac
     5821 aaaaagtttt cacctgagaa agctttatcc caccaattga gcaagatgct aatctgttgc
     5881 atatcgttct tggagagaca gtagagtggc ttggctgatc tgagctgggc atggtggtac
     5941 ttgcctataa tcacagcatt tggtggaaag agatgggcat gtcgtgagtt gtatatgact
     6001 gaagaacaaa tagctagtgg tcctgatttg ttccttataa aattgcatgt tcataaaggc
     6061 caagagtcaa gtccttcaag gagatggctt gagatctgtg gtttgactta aaatcagtgc
     6121 tcctcaaggc tccaggttta gtagccagca ccaaacaaca cccagaatag ggtttgtgca
     6181 ggacactgag gaaattcaga gccagattat gtatttgatg tgaatgtgag gtttttcaag
     6241 tgccagtgtc aaggagagcc ttctaattcc ccatagctta tgagcagtgt atctgttgta
     6301 gcagctctaa gtaacccatt cttctttaaa tacacggact ctgatatgaa tatttcatgt
     6361 ctgtacaatg atggattcca ccaggaaagg agttgttgct ttctttgaag taatttcttc
     6421 ccttttgctc cctgttgctg aggcatacta cttcataaat aattttgctt gctgaaggaa
     6481 gagaacatat ttttcatgaa ctcataatct tggactgttt atagatattg gggggagtag
     6541 gtcttctctg gcccccccca gtatgcaagg gcaatggaga cctgattata taaagtatgt
     6601 ttataaatgc tgtgctgtta atactgcaaa taaactaaat agcaaaca
//
