LOCUS       NM_181066               3353 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus BRCA1-associated ATM activator 1 (Brat1), transcript
            variant 2, mRNA.
ACCESSION   NM_181066
VERSION     NM_181066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10, AK085091.1 and
            AF226663.1.
            
            [WARNING] On Oct 1, 2023 this sequence was replaced by NM_181066.4.
            
            On Jan 25, 2013 this sequence version replaced NM_181066.2.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            initiates translation at a downstream start codon, compared to
            variant 3. The encoded isoform (2) has a shorter N-terminus,
            compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085091.1, AK170269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC110253.10        33407-33418         c
            13-3288             AK085091.1         2-3277
            3289-3353           AF226663.1         1836-1900
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     gene            1..3353
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /note="BRCA1-associated ATM activator 1"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
     exon            1..65
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..209
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2551
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     BRCA1-associated protein required for ATM activation
                     protein 1"
                     /codon_start=1
                     /product="BRCA1-associated ATM activator 1 isoform 2"
                     /protein_id="NP_851411.1"
                     /db_xref="CCDS:CCDS19823.1"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
                     /translation="MDPECSRLLPALCAVLADPRQLVADDTCLEKLLDWFKTVTEAES
                     SLQLLQDHPCLMELLSHVLKPQDVSPRVLSFALRLVGVFAAQEDCFEYLQQGELLLGL
                     FGESGAPGWAAWSIPSVRSGWIQGLCYLAHHPSALHFLADSGAVDTLFSLQGDPSLFV
                     ASAASQLLVHILALSMQGGAPGSPVPEAAAWPMCAQKIVNHVDESLHAKATPQVTQAL
                     NVLTTTFGRCHNPWTGVLWERLSPPVARLFERDPIPAVHALMDLLLSVARSPVLNFAA
                     CGLWEMLAQTLSRLSPIQAGPLALGTLKLQHCPQELRTQAFGVLLQPLACILKATTQA
                     PGPPGLLDGTVGSLLTVDILLASKSACVGLLCQTLAHLEELQMLPQCPSPWPQVHLLQ
                     AALTILHLCDGSADPSSSAGGRLCGTLGGCVRVQRAALDFLGTLSQGTSPLELVLEVF
                     AVLLKTLESPESSPMVLKKAFQATLRWLQNPHKTPSSSDLSSDALLFLGELFPILQKR
                     LCSPCWEVRDSALEFLTHLIRHWGGQADFREALRSSEVPTLALQLLQDPESYVRASAV
                     GAAGQLSSQGLQAAPASPENSQAQQGLLMDLMHILSTDSEGFPRRAVLRVFTDWLRDG
                     HADVVRDTEWFVATVLQAVSRDLDWEVRVQGLELARVFLTQALGQPSLHCPYTVGLPR
                     ASSPRPHPEFLQTLCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTVPCSSPREA
                     GDSPNSASVEAALQRWREGEQAQPLGDLDPEAMLAILRALDLEGLQGRLAKSSDHVEK
                     SPQSLLQDMLATVGVLEENEADCY"
     exon            210..364
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..512
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..885
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1005
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1097
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1216
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1403
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1477
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1580
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1679
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1855
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..3333
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcctgcc ttagacaccg gaacctcagc gggcgaggcg cacgcaggcc ggggtggaga
       61 tcctggaact gcctgcctga tcatggaccc agaatgctcc aggctcctcc cggctctctg
      121 tgctgttttg gcagatccca gacagctggt ggcagatgac acctgcttgg agaaactgct
      181 ggactggttt aaaacagtga cagaggcaga gtctagcctc caactactac aggaccatcc
      241 ctgcttaatg gagctcctgt cccatgtgct gaagccacag gacgtgagcc ctagggtcct
      301 ctcctttgct ctgcgccttg ttggggtctt cgcagcccag gaagactgtt ttgagtacct
      361 tcagcaggga gagttgttgc tggggctctt tggggagtca ggtgcccccg gctgggcagc
      421 ctggagcatc ccaagtgtgc gcagcggctg gatccagggt ctgtgctacc tggcacacca
      481 ccctagcgcc ctgcacttcc tggctgacag tggtgctgtg gacacgctct tctccttgca
      541 gggagacccc agcctgttcg tcgcctcagc agccagccag ctcctagtac atatcctggc
      601 tctgtccatg caaggtggag ccccagggtc ccccgtccct gaagctgctg cttggcctat
      661 gtgtgcccag aagattgtga accatgtgga tgagtccctg catgccaaag ccacccccca
      721 ggtcacacag gccttgaatg tcctgactac gaccttcggg cgctgccata acccctggac
      781 aggggtcctc tgggagcggc taagtccccc tgttgcccgc ctgtttgaga gagaccccat
      841 tccagccgtg cacgcgctca tggaccttct tcttagtgtg gccaggtcgc ctgtgttgaa
      901 ttttgcagcc tgtggcctgt gggagatgct ggcccagact ctgagccgcc tgagccccat
      961 acaagctggg cctctagccc tggggaccct gaaacttcag cactgtcccc aggaattgag
     1021 gacccaggcc tttggagtcc tcctacagcc actggcctgt atcctgaaag ctaccactca
     1081 ggcccctgga cctccaggct tgctggatgg gactgtgggt agcttgctga ctgtggatat
     1141 actcttggct tcaaagtcag cctgtgtggg actcctttgc cagactctgg ctcacctgga
     1201 ggagctgcag atgctgcccc agtgcccctc accctggcca caggtgcatc tgctgcaagc
     1261 tgctttgact atattgcatc tctgtgatgg ctcagcggac cccagctcca gtgcaggagg
     1321 ccgtctctgt gggactctgg gtggctgtgt tcgtgtccag cgagcagccc ttgacttctt
     1381 ggggaccctg tctcagggga caagccccct ggagttggtt ctggaggtat ttgctgttct
     1441 cctgaagacc ctggagagcc cagagtccag ccccatggtc ctaaagaagg ccttccaggc
     1501 cacactcaga tggctccaga acccacacaa gacccccagc agctctgatc tcagctccga
     1561 cgccctgctg tttctcggag agctgttccc catactacag aagcgcctat gcagcccatg
     1621 ttgggaggtg agggactctg ccctggagtt cctgacgcat ctgatccgac actggggagg
     1681 gcaggctgac ttcagagagg cactgcgttc ctcagaagta cccacacttg ccctccagct
     1741 tctccaagac ccagagagtt acgtccgagc aagtgccgtg ggtgccgctg ggcagctctc
     1801 cagccagggt ctgcaggccg ctcccgctag ccccgagaac tcgcaggccc aacagggcct
     1861 actcatggac cttatgcata tcctgtccac tgactcagag ggcttccctc gaagggctgt
     1921 gttacgggtc ttcacggact ggctgaggga tggccatgct gacgtggttc gagacacgga
     1981 gtggttcgtg gccactgttc tccaggcagt gagccgggat ctggactggg aggtccgagt
     2041 gcagggtttg gagctggcac gggtgttcct cacccaggca ctgggccagc ccagcctcca
     2101 ctgtccctat acagtgggcc tgcccagggc ctcctctccc cgcccacacc cggaattctt
     2161 gcagactctc tgccgtctgc cgctctttga gtttgccttt tgtgccttgc ttgactgtga
     2221 ccgaccggtg gcccaaaagg cctgtgacct gctcctcttc ttgagggaca agacagttcc
     2281 ctgcagtagc cctcgggagg caggggacag ccccaactca gcctcagtgg aggctgccct
     2341 gcagaggtgg cgggaaggag agcaggccca gcccctaggg gacctggatc ctgaggccat
     2401 gctagccatc ctcagggcct tagacctgga gggcctgcag ggcaggctgg ccaagagcag
     2461 cgaccatgtg gagaagagcc cacagtccct gctgcaggac atgctggcca cggtgggtgt
     2521 gttggaggag aacgaagctg actgctacta aggcgtgtcc acgtcctgtc cctgtttcca
     2581 tcctgtgcca gcaggaggac cccagcccag gtcagcagct caagagaccc tgcagggggt
     2641 ggatcacatg ttttaagccg ggtacgataa cacacctatg atcacagcgt ttaaaagacc
     2701 aagggaggag aatgtagagt tcccggccag cctggactag atagcaaccc tgtctcaaga
     2761 aaacccaaga aatcaaatca aaacaaaatc tccacccttt gtgtgctgtg catgcagacc
     2821 ggaggccagc ctccagtgtt cttcctcagg tgctgtccac cttggttttt gagaaaaggt
     2881 ctctcactag gacttggtac tccctgatga ggcttgccag tgagctccag ggatcccgcc
     2941 accacctcct cagcaccggg atcataatac tgtatccctg tgcctgggtc tacatacatg
     3001 ggtgctggga tttgaactca ggtcctcatg cttgcacggc aagcacttta cccactgaac
     3061 catctcccca ggtcccacag aatcctactt tccacgtgtt attaaagagg tggcttgttt
     3121 tctgctcaga acaggtagta ctgatgtcta taaccttcaa ttgtgtatgt ggattaacaa
     3181 agccccactg tgatctgcat atggccttca gctctctgct ccgtcaccca acgtttgaaa
     3241 gtcccataat ctttaaagaa ttcagataca ttaaaagttc aaagtcacaa ctgtgggtcc
     3301 tgtaaaataa aataaaaaaa aatttttttt aaaaaaaaaa aaaaaaaaaa aaa
//
