LOCUS       NM_001276287            3451 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BRCA1-associated ATM activator 1 (Brat1), transcript
            variant 3, mRNA.
ACCESSION   NM_001276287
VERSION     NM_001276287.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3451)
  AUTHORS   Low,L.H., Chow,Y.L., Li,Y., Goh,C.P., Putz,U., Silke,J., Ouchi,T.,
            Howitt,J. and Tan,S.S.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   3  (bases 1 to 3451)
  AUTHORS   So,E.Y. and Ouchi,T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   4  (bases 1 to 3451)
  AUTHORS   So,E.Y. and Ouchi,T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   5  (bases 1 to 3451)
  AUTHORS   Ouchi,M. and Ouchi,T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   6  (bases 1 to 3451)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY788789.1, AK085091.1 and
            AF226663.1.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068301.1, SRR1660817.95904.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               BY788789.1         2-354
            354-3386            AK085091.1         245-3277
            3387-3451           AF226663.1         1836-1900
FEATURES             Location/Qualifiers
     source          1..3451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     gene            1..3451
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /note="BRCA1-associated ATM activator 1"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
     exon            1..163
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2649
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     BRCA1-associated protein required for ATM activation
                     protein 1"
                     /codon_start=1
                     /product="BRCA1-associated ATM activator 1 isoform 3"
                     /protein_id="NP_001263216.1"
                     /db_xref="CCDS:CCDS71696.1"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
                     /translation="MVHFALSGLIPVAEGCGGGIRTPRLTRSRRERTSYPDLGGTACL
                     IMDPECSRLLPALCAVLADPRQLVADDTCLEKLLDWFKTVTEAESSLQLLQDHPCLME
                     LLSHVLKPQDVSPRVLSFALRLVGVFAAQEDCFEYLQQGELLLGLFGESGAPGWAAWS
                     IPSVRSGWIQGLCYLAHHPSALHFLADSGAVDTLFSLQGDPSLFVASAASQLLVHILA
                     LSMQGGAPGSPVPEAAAWPMCAQKIVNHVDESLHAKATPQVTQALNVLTTTFGRCHNP
                     WTGVLWERLSPPVARLFERDPIPAVHALMDLLLSVARSPVLNFAACGLWEMLAQTLSR
                     LSPIQAGPLALGTLKLQHCPQELRTQAFGVLLQPLACILKATTQAPGPPGLLDGTVGS
                     LLTVDILLASKSACVGLLCQTLAHLEELQMLPQCPSPWPQVHLLQAALTILHLCDGSA
                     DPSSSAGGRLCGTLGGCVRVQRAALDFLGTLSQGTSPLELVLEVFAVLLKTLESPESS
                     PMVLKKAFQATLRWLQNPHKTPSSSDLSSDALLFLGELFPILQKRLCSPCWEVRDSAL
                     EFLTHLIRHWGGQADFREALRSSEVPTLALQLLQDPESYVRASAVGAAGQLSSQGLQA
                     APASPENSQAQQGLLMDLMHILSTDSEGFPRRAVLRVFTDWLRDGHADVVRDTEWFVA
                     TVLQAVSRDLDWEVRVQGLELARVFLTQALGQPSLHCPYTVGLPRASSPRPHPEFLQT
                     LCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTVPCSSPREAGDSPNSASVEAAL
                     QRWREGEQAQPLGDLDPEAMLAILRALDLEGLQGRLAKSSDHVEKSPQSLLQDMLATV
                     GVLEENEADCY"
     exon            164..307
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..462
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..610
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..983
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1103
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1195
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1314
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1501
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1575
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1678
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1777
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1953
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..3431
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3409..3414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /note="major polyA site"
ORIGIN      
        1 ggagatcctg gtaaggcgga gttcgagctt cggccaggca gtctaatggt gcattttgca
       61 ctctcgggcc taattcccgt agcggaggga tgcgggggcg ggattagaac ccctaggcta
      121 actcgcagtc gccgagagcg cacctcttac ccggatttgg gaggaactgc ctgcctgatc
      181 atggacccag aatgctccag gctcctcccg gctctctgtg ctgttttggc agatcccaga
      241 cagctggtgg cagatgacac ctgcttggag aaactgctgg actggtttaa aacagtgaca
      301 gaggcagagt ctagcctcca actactacag gaccatccct gcttaatgga gctcctgtcc
      361 catgtgctga agccacagga cgtgagccct agggtcctct cctttgctct gcgccttgtt
      421 ggggtcttcg cagcccagga agactgtttt gagtaccttc agcagggaga gttgttgctg
      481 gggctctttg gggagtcagg tgcccccggc tgggcagcct ggagcatccc aagtgtgcgc
      541 agcggctgga tccagggtct gtgctacctg gcacaccacc ctagcgccct gcacttcctg
      601 gctgacagtg gtgctgtgga cacgctcttc tccttgcagg gagaccccag cctgttcgtc
      661 gcctcagcag ccagccagct cctagtacat atcctggctc tgtccatgca aggtggagcc
      721 ccagggtccc ccgtccctga agctgctgct tggcctatgt gtgcccagaa gattgtgaac
      781 catgtggatg agtccctgca tgccaaagcc accccccagg tcacacaggc cttgaatgtc
      841 ctgactacga ccttcgggcg ctgccataac ccctggacag gggtcctctg ggagcggcta
      901 agtccccctg ttgcccgcct gtttgagaga gaccccattc cagccgtgca cgcgctcatg
      961 gaccttcttc ttagtgtggc caggtcgcct gtgttgaatt ttgcagcctg tggcctgtgg
     1021 gagatgctgg cccagactct gagccgcctg agccccatac aagctgggcc tctagccctg
     1081 gggaccctga aacttcagca ctgtccccag gaattgagga cccaggcctt tggagtcctc
     1141 ctacagccac tggcctgtat cctgaaagct accactcagg cccctggacc tccaggcttg
     1201 ctggatggga ctgtgggtag cttgctgact gtggatatac tcttggcttc aaagtcagcc
     1261 tgtgtgggac tcctttgcca gactctggct cacctggagg agctgcagat gctgccccag
     1321 tgcccctcac cctggccaca ggtgcatctg ctgcaagctg ctttgactat attgcatctc
     1381 tgtgatggct cagcggaccc cagctccagt gcaggaggcc gtctctgtgg gactctgggt
     1441 ggctgtgttc gtgtccagcg agcagccctt gacttcttgg ggaccctgtc tcaggggaca
     1501 agccccctgg agttggttct ggaggtattt gctgttctcc tgaagaccct ggagagccca
     1561 gagtccagcc ccatggtcct aaagaaggcc ttccaggcca cactcagatg gctccagaac
     1621 ccacacaaga cccccagcag ctctgatctc agctccgacg ccctgctgtt tctcggagag
     1681 ctgttcccca tactacagaa gcgcctatgc agcccatgtt gggaggtgag ggactctgcc
     1741 ctggagttcc tgacgcatct gatccgacac tggggagggc aggctgactt cagagaggca
     1801 ctgcgttcct cagaagtacc cacacttgcc ctccagcttc tccaagaccc agagagttac
     1861 gtccgagcaa gtgccgtggg tgccgctggg cagctctcca gccagggtct gcaggccgct
     1921 cccgctagcc ccgagaactc gcaggcccaa cagggcctac tcatggacct tatgcatatc
     1981 ctgtccactg actcagaggg cttccctcga agggctgtgt tacgggtctt cacggactgg
     2041 ctgagggatg gccatgctga cgtggttcga gacacggagt ggttcgtggc cactgttctc
     2101 caggcagtga gccgggatct ggactgggag gtccgagtgc agggtttgga gctggcacgg
     2161 gtgttcctca cccaggcact gggccagccc agcctccact gtccctatac agtgggcctg
     2221 cccagggcct cctctccccg cccacacccg gaattcttgc agactctctg ccgtctgccg
     2281 ctctttgagt ttgccttttg tgccttgctt gactgtgacc gaccggtggc ccaaaaggcc
     2341 tgtgacctgc tcctcttctt gagggacaag acagttccct gcagtagccc tcgggaggca
     2401 ggggacagcc ccaactcagc ctcagtggag gctgccctgc agaggtggcg ggaaggagag
     2461 caggcccagc ccctagggga cctggatcct gaggccatgc tagccatcct cagggcctta
     2521 gacctggagg gcctgcaggg caggctggcc aagagcagcg accatgtgga gaagagccca
     2581 cagtccctgc tgcaggacat gctggccacg gtgggtgtgt tggaggagaa cgaagctgac
     2641 tgctactaag gcgtgtccac gtcctgtccc tgtttccatc ctgtgccagc aggaggaccc
     2701 cagcccaggt cagcagctca agagaccctg cagggggtgg atcacatgtt ttaagccggg
     2761 tacgataaca cacctatgat cacagcgttt aaaagaccaa gggaggagaa tgtagagttc
     2821 ccggccagcc tggactagat agcaaccctg tctcaagaaa acccaagaaa tcaaatcaaa
     2881 acaaaatctc caccctttgt gtgctgtgca tgcagaccgg aggccagcct ccagtgttct
     2941 tcctcaggtg ctgtccacct tggtttttga gaaaaggtct ctcactagga cttggtactc
     3001 cctgatgagg cttgccagtg agctccaggg atcccgccac cacctcctca gcaccgggat
     3061 cataatactg tatccctgtg cctgggtcta catacatggg tgctgggatt tgaactcagg
     3121 tcctcatgct tgcacggcaa gcactttacc cactgaacca tctccccagg tcccacagaa
     3181 tcctactttc cacgtgttat taaagaggtg gcttgttttc tgctcagaac aggtagtact
     3241 gatgtctata accttcaatt gtgtatgtgg attaacaaag ccccactgtg atctgcatat
     3301 ggccttcagc tctctgctcc gtcacccaac gtttgaaagt cccataatct ttaaagaatt
     3361 cagatacatt aaaagttcaa agtcacaact gtgggtcctg taaaataaaa taaaaaaaaa
     3421 ttttttttaa aaaaaaaaaa aaaaaaaaaa a
//
