LOCUS       NM_139294               9728 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus Braf transforming gene (Braf), mRNA.
ACCESSION   NM_139294
VERSION     NM_139294.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9728)
  AUTHORS   Soleder,S., Gengenbacher,N., Mogler,C., Eckstein,M., Runge,A.,
            Kriegmair,M.C. and Augustin,H.G.
  TITLE     Development of a novel immunocompetent murine tumor model for
            urothelial carcinoma using in vivo electroporation
  JOURNAL   Sci Rep 14 (1), 25619 (2024)
   PUBMED   39463382
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9728)
  AUTHORS   Wee,Y., Wang,J., Wilson,E.C., Rich,C.P., Rogers,A., Tong,Z.,
            DeGroot,E., Gopal,Y.N.V., Davies,M.A., Ekiz,H.A., Tay,J.K.H.,
            Stubben,C., Boucher,K.M., Oviedo,J.M., Fairfax,K.C., Williams,M.A.,
            Holmen,S.L., Wolff,R.K. and Grossmann,A.H.
  TITLE     Tumour-intrinsic endomembrane trafficking by ARF6 shapes an
            immunosuppressive microenvironment that drives melanomagenesis and
            response to checkpoint blockade therapy
  JOURNAL   Nat Commun 15 (1), 6613 (2024)
   PUBMED   39098861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9728)
  AUTHORS   Gao,C., Ge,H., Kuan,S.F., Cai,C., Lu,X., Esni,F., Schoen,R.E.,
            Wang,J.H., Chu,E. and Hu,J.
  TITLE     FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote
            intestinal stemness and cecal tumor formation
  JOURNAL   Elife 13, 94605 (2024)
   PUBMED   38921956
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9728)
  AUTHORS   Ghobashi,A.H., Lanzloth,R., Ladaika,C.A., Masood,A. and
            O'Hagan,H.M.
  TITLE     Single-Cell Profiling Reveals the Impact of Genetic Alterations on
            the Differentiation of Inflammation-Induced Murine Colon Tumors
  JOURNAL   Cancers (Basel) 16 (11), 2040 (2024)
   PUBMED   38893159
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9728)
  AUTHORS   Zhang,P., Guan,L., Sun,W., Zhang,Y., Du,Y., Yuan,S., Cao,X., Yu,Z.,
            Jia,Q., Zheng,X., Meng,Z., Li,X. and Zhao,L.
  TITLE     Targeting miR-31 represses tumourigenesis and dedifferentiation of
            BRAFV600E-associated thyroid carcinoma
  JOURNAL   Clin Transl Med 14 (5), e1694 (2024)
   PUBMED   38797942
  REMARK    GeneRIF: Targeting miR-31 represses tumourigenesis and
            dedifferentiation of BRAF[V600E]-associated thyroid carcinoma.
REFERENCE   6  (bases 1 to 9728)
  AUTHORS   Blackshear,P.J., Tuttle,J.S., Oakey,R.J., Seldin,M.F., Chery,M.,
            Philippe,C. and Stumpo,D.J.
  TITLE     Chromosomal mapping of the human (MACS) and mouse (Macs) genes
            encoding the MARCKS protein
  JOURNAL   Genomics 14 (1), 168-174 (1992)
   PUBMED   1427822
REFERENCE   7  (bases 1 to 9728)
  AUTHORS   Eychene,A., Barnier,J.V., Apiou,F., Dutrillaux,B. and Calothy,G.
  TITLE     Chromosomal assignment of two human B-raf(Rmil) proto-oncogene
            loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed
            pseudogene
  JOURNAL   Oncogene 7 (8), 1657-1660 (1992)
   PUBMED   1630826
REFERENCE   8  (bases 1 to 9728)
  AUTHORS   Sithanandam,G., Druck,T., Cannizzaro,L.A., Leuzzi,G., Huebner,K.
            and Rapp,U.R.
  TITLE     B-raf and a B-raf pseudogene are located on 7q in man
  JOURNAL   Oncogene 7 (4), 795-799 (1992)
   PUBMED   1565476
REFERENCE   9  (bases 1 to 9728)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (bases 1 to 9728)
  AUTHORS   Storm,S.M., Cleveland,J.L. and Rapp,U.R.
  TITLE     Expression of raf family proto-oncogenes in normal mouse tissues
  JOURNAL   Oncogene 5 (3), 345-351 (1990)
   PUBMED   1690378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163109.5, BF466677.1, AK140431.1, CK393545.1 and AC122345.4.
            
            On Jul 25, 2007 this sequence version replaced NM_139294.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AC163109.5         140094-140450       c
            358-529             BF466677.1         221-392
            530-2902            AK140431.1         531-2903
            2903-2942           CK393545.1         1-40                c
            2943-5157           AK140431.1         2944-5158
            5158-9728           AC122345.4         192967-197537       c
FEATURES             Location/Qualifiers
     source          1..9728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.43 cM"
     gene            1..9728
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /note="Braf transforming gene"
                     /db_xref="GeneID:109880"
                     /db_xref="MGI:MGI:88190"
     exon            1..357
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2583
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /EC_number="2.7.11.1"
                     /note="B-Raf proto-oncogene serine/threonine-protein
                     kinase (p94); proto-oncogene B-Raf"
                     /codon_start=1
                     /product="serine/threonine-protein kinase B-raf"
                     /protein_id="NP_647455.3"
                     /db_xref="CCDS:CCDS39463.1"
                     /db_xref="GeneID:109880"
                     /db_xref="MGI:MGI:88190"
                     /translation="MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEP
                     EAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEY
                     TSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVT
                     VRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTT
                     HNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVS
                     KFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADE
                     DHRNQFGQRDRSSSAPNVHINTIEPVNIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQ
                     LMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKA
                     LQKSPGPQRERKSSSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTV
                     YKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVT
                     QWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED
                     LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV
                     LYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDE
                     RPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYG
                     EFAAFK"
     exon            358..459
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            460..529
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            530..624
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            625..728
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            729..831
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            832..980
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1097
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1257
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1293
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1330
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1450
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1593
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1711
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1796
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1973
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2020
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2139
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2271
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2406
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2560
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..9728
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /note="hexamer: AATAAA"
     polyA_site      3925
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /note="major polyA site"
     regulatory      9560..9565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /note="hexamer: AATAAA"
     polyA_site      9586
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
     regulatory      9704..9709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /note="hexamer: AATAAA"
     polyA_site      9728
                     /gene="Braf"
                     /gene_synonym="9930012E13Rik; B-raf; Braf-2; Braf2;
                     C230098H17; D6Ertd631e"
                     /note="major polyA site"
ORIGIN      
        1 ccctcaggct cggctgcgcc ggggccgccg gcgggttcca gaggtggcct ccgccccggc
       61 cgctccgccc acgccccccg cgcctccgcg cccgcctccg cccgccctgc gcctcccttc
      121 cccctccccg ccccgcggcg gccgctcggc ccggctcgcg cttcgaagat ggcggcgctg
      181 agtggcggcg gtggcagcag cagcggtggc ggcggcggcg gtggcggcgg cggtggcggt
      241 ggcgacggcg gcggcggcgc cgagcagggc caggctctgt tcaatggcga catggagccg
      301 gaggccggcg ctggcgccgc ggcctcttcg gctgcggacc cggccattcc tgaagaggta
      361 tggaatatca agcaaatgat taagttgaca caggaacata tagaggccct attggacaaa
      421 tttggtggag agcataaccc accatcaata tacctggagg cctatgaaga gtacaccagc
      481 aagctagatg cccttcagca aagagaacag cagcttttgg aatccctggt ttttcaaact
      541 cccacagatg catcacggaa caaccccaag tcaccacaga aacctatcgt tagagtcttc
      601 ctgcccaaca aacagaggac agtggtaccc gcaagatgtg gtgttacagt tcgagacagt
      661 ctaaagaaag cactgatgat gagaggtctc atcccagaat gctgtgctgt ttacagaatt
      721 caggatggag agaagaaacc aattggctgg gacacggaca tttcctggct tactggagag
      781 gagttacatg ttgaagtact ggagaatgtc ccacttacaa cacacaactt tgtacggaaa
      841 acttttttca ccttagcatt ttgtgacttt tgccgaaagc tgcttttcca gggtttccgt
      901 tgtcaaacat gtggttataa atttcaccag cgttgtagta cagaggttcc actgatgtgt
      961 gtaaattatg accaacttga tttgctgttt gtctccaagt tctttgagca tcacccagta
     1021 ccacaggagg aggcctcctt cccagagact gcccttccat ctggatcctc ttccgcaccc
     1081 ccctcagact ctactgggcc ccaaatcctc accagtccat ctccttcaaa atccattcca
     1141 attccacagc ccttccgacc agcagatgaa gatcatcgca atcagtttgg gcaacgagac
     1201 cggtcctcct cagctcccaa tgttcatata aacacaattg agcctgtgaa tatcgatgaa
     1261 aaattcccag aagtggaatt acaggatcaa agggatttga ttagagacca ggggtttcgt
     1321 ggtgatggag cccccttgaa ccaactgatg cgctgtcttc ggaaatacca atcccggact
     1381 cccagccccc tcctccattc tgtccccagt gaaatagtgt ttgattttga gcctggccca
     1441 gtgttcagag ggtcaaccac aggcttgtcc gccaccccgc ctgcctcatt acctggctca
     1501 ctcactaacg tgaaagcctt acagaaatct ccaggtcctc agcgggaaag gaagtcatct
     1561 tcttcctcat cctcggagga cagaagtcgg atgaaaacac ttggtagaag agattcaagt
     1621 gatgactggg agattcctga tggacagatt acagtgggac agagaattgg atctgggtca
     1681 tttggaactg tctacaaggg aaagtggcat ggtgatgtgg cagtgaaaat gttgaatgtg
     1741 acagcaccca cacctcaaca gctacaggcc ttcaaaaatg aagtaggagt gctcaggaaa
     1801 actcgacatg tgaatatcct ccttttcatg ggctattcta caaagccaca actggcaatt
     1861 gttacacagt ggtgtgaggg ctccagctta tatcaccatc tccacatcat tgagaccaaa
     1921 tttgagatga tcaaacttat agatattgct cggcagactg cacagggcat ggattactta
     1981 cacgccaagt caatcatcca cagagacctc aagagtaata atatatttct tcatgaagac
     2041 ctcacggtaa aaataggtga ctttggtcta gccacagtga aatctcggtg gagtgggtcc
     2101 catcagtttg aacagttgtc tggatctatt ttgtggatgg caccagaagt aatcagaatg
     2161 caagataaaa acccgtatag ctttcagtca gacgtgtatg cgtttgggat tgttctgtac
     2221 gaactgatga ccggccagct accttattca aacatcaaca acagggatca gataattttt
     2281 atggtgggac gaggatacct atctccagat ctcagtaagg tacggagtaa ctgtccaaaa
     2341 gccatgaaga gattaatggc agagtgcctc aaaaagaaaa gagacgagag accactcttt
     2401 ccccaaattc tcgcctccat tgagctgctg gcccgctcat tgccaaaaat tcaccgcagt
     2461 gcatcagaac cttccttgaa tcgggctggt ttccaaacag aagattttag tctgtatgct
     2521 tgtgcttctc cgaaaacacc catccaagca gggggatatg gagaatttgc agccttcaag
     2581 tagccagtcc atcatggcag catctactct ttatttctta agtcttgtgt tcatacagtt
     2641 tgttaacatc aaaacacagt tctgttcctc aaaaaatttt ttaaagatac aaaattttca
     2701 atgcataagt tcatgtggaa cagaatggaa tttcctattc aacaaaagag ggaagaatgt
     2761 tttaggaacc agaattctct gctgcccgtg tttcttcttc aacataacta tcacgtgcat
     2821 acaagtctgc ccattcccaa gaagaaagag gagagaccct gaattctgcc cttttggtgg
     2881 tcaggcatga tggaaagaat ttgctgctgc agcttgggaa aattgctatg gaaagtctgc
     2941 cagtcgactt tgcccttcta accaccagat cagcctgtgg ctggtcatct gatggggcga
     3001 tttccatcac caagcatcgt tcttgcctat tctgggatta tgttgtggag cactttccct
     3061 gtccagcacc gttcatttct gagggatgga gtaaatgcag cattcccttg tgtagcgcct
     3121 gttcagtcct cagcagctgc tgtcacagcg aagcttttta cagttaagtg gtgggggaga
     3181 gttgaggaga gcctgcctcg gggcagagaa aagggggtgc tgcatcttct tcctcacctc
     3241 cagctctctc acctcgggtt gccttgctca ctgggctccg cctaaccact caggctgctc
     3301 agtgctggca cacattgcct tcttttctca ttgggtccag caattgagga gagggttggg
     3361 ggattgtttc ctcctcaatg tagcaaattc tcaggaaaat acagtccata tcttcctctc
     3421 agctcttcca gtcaccaaat acttacgtgg ctcctttgtc caggacataa aacaccgtgg
     3481 acaacaccta attaaaagcc tacaaaactg cttactgaca gttttgaatg tgagacactt
     3541 gtgtaattta aatgtaaggt acaggtttta atttctgagt ttcttctatt tttatttaaa
     3601 agaagaaaat aattttcagt tttaattgga ataaatgagt acttcccaca agactatata
     3661 ccctgaaaat tatatttttg ttaattgtaa acaactttta aagaataatt attatccttt
     3721 tctctaccta aaaattatgg ggaatcttag cataatgaca attatttata ctttttaaat
     3781 aaatggtact tgctggatcc acactaacat ctttgctaac aatcccattg tttcttccaa
     3841 cttaactcct acactacatc ctacatcctc tttctagtct tttatctata atatgcaacc
     3901 taaaataaac gtggtggcgt ctccattcat tctccctctt cctgttttcc ccaagcctgg
     3961 tcttcaaaag gttgggtaat cggtccctga gctccctagc tggcaatgca actattaggg
     4021 acattggagt tgcaggagag caggaagcct gtccccagct gttcttctag aaccctaaat
     4081 cttatctttg cacagatcaa aagtatcacc tcgtcacagt tctccttagc ctttacttac
     4141 aggtaatata aataaaaatc accatagtag taaagaaaac aactggatgg attgatgacc
     4201 agtacctctc agagccagga atcttgaatc tccaggattt atacgtgcaa atttaaggag
     4261 atgtacttag caacttcaag ccaagaactt ccaaaatact agcgaatcta aaataaaatg
     4321 gaattttgag ttatttttaa agttcaaatt ataattgata ccactatgta tttaagccta
     4381 ctcacagcaa gttagatgga ttttgctaaa ctcattgcca gactgtggtg gtggtggtgg
     4441 tagtgtgcac ctttaatcca agcaactcag caatcagaat gaggtaaatc tctgtgaata
     4501 caaggcctgc ctagtctgca gcgctagttc caggatagcc agggctacac acacaaaaac
     4561 cctctctcaa aaaaaacaaa attaattagt tgataataaa aaataactaa agtatcatca
     4621 aaggaaggcc tactggaagt tttatatatt cccagtaaat tgaaaaatat tctgaagtta
     4681 ttaaccagtt agcaacaatg tgtttttaag tcttacataa acagagcaaa gtcttcaaat
     4741 gtttcagagc tgagaagata attgtgcttg atatgaaaaa tagcctctcc atatgatgtg
     4801 ccacattgaa aggcgtcatt acccttttaa atacttctta atgtggcttt gttcccttta
     4861 cccaggatta gctagaaaga gctaggtagg cttcggccac agttgcacat ttcgggcctg
     4921 ctgaagaatg ggagctttga aggctggcct tggtggagga gcccctcagt gctggagggt
     4981 ggggcgtgta cgcagcatgg aagtggtcta gacagagtgc aaagggacag acttctttct
     5041 cattttagta tagggtgatg tctcacttga aatgagaaag tagagttgat attaaacgaa
     5101 gctgtgccca gaaaccaggc tcagggtatt gtgagatttt ctttttaaat agagaatata
     5161 aaagatagaa ataaatattt aaaccttcct tcttattttc tatcaaatag atttttttta
     5221 tcatttgcaa acaacataaa aaaaggtttc ttttgtgggg ttttctttcc ttcttttttt
     5281 tttttttttt tttttaagac tgcagataat cttgttgagc tcctcggaaa atacaaggaa
     5341 gtccgtgttt gtgcagagcg ctttatgagt aactgtatag acagtgtggc tgcttcactc
     5401 atcccagagg gctgcagctg tcggcccatg aagtggctgc agtgcctcgt gagatctgct
     5461 ttgttttgtt tggagtgaag tctttgaaag gtttgagtgc aactatatag gactgttttt
     5521 aaataagtag tattcctcat gaactttctc attgttaagc tacaggaccc aaactctacc
     5581 actaagatat tattaacctc aaaatgtagt ttatagaagg aatttgcaaa tagaatatcc
     5641 agttcgtact tatatgcatc ttcaacaaag attctctgtg acttgttgga tttggttcct
     5701 gaacagccca tttctgtatt tgaggttagg agggcataat gaggcatcct aaaagacaat
     5761 ctgatataaa ctgtatgcta gatgtatgct ggtaggggag aaagcattct gtaaagacat
     5821 gatttaagac ttcagctctg tcaaccagaa accttgtaaa tacttcctgt cttggtgcag
     5881 ccccgcccct ttgatcacac gatgttgtct tgtgcttgtc agacactgtc agagctgctg
     5941 ttcgtccctc tgcagatctc acctgtcccc actgcacacc cacctcctgc ctcttgcaga
     6001 cctcagcatc tagctttagt tggaaacagt tcagggttca ggtgacttct taaaaaaaaa
     6061 aaaaaaccct acctcctcag aatgaggtaa tgaatagtta tttatttaaa gtatgaagag
     6121 tcaggagcgc tcgaacatga aggtgattta agatggttcc tttcgtgtgt attgtagctg
     6181 agcacttgtt tttgtcctaa agggcattat acatttaagc agtgattctg tttaaagatg
     6241 tttttcttta aaggtgtagc tcagagtatc tgttgttgga attggtgcca gagtctgctt
     6301 aatagatttc agaatcctaa gcttaagtca gtcgcatgaa gttaagtagt tatggtaaca
     6361 ctttgctagc catgatataa ttctactttt taggagtagg tttggcaaaa ctgtatgcct
     6421 tcaaagtgag ttggccacag ctttgtcaca tgcacagata ctcatctgaa gagactgccc
     6481 agctaagagg gcggaaggat accctttttt cctacgattc gcttctttgt ccacgttggc
     6541 attgttagta ctagtttatc agcaccttga ccagcagatg tcaaccaata agctattttt
     6601 aaaaccatag ccagagatgg agaggtcact gtgagtagaa acagcaggac gcttacagga
     6661 gtgaaatggt gtagggaggc tctagaaaaa tatcttgaca atttgccaaa tgatcttact
     6721 gtgccttcat gatgcaataa aaaagctaac attttagcag aaatcagtga tttacgaaga
     6781 gagtggccag tctggtttaa ctcagctggg ataatatttt tagagtgcaa tttagactgc
     6841 gaagataaat gcactaaaga gtttatagcc aattcacatt tgaaaaataa gaaaatggta
     6901 aattttcagt gaaatatttt tttaaagcac ataatcccta gtgtagccag aaatatttac
     6961 cacatagagc agctaggctg agatacagtc cagtgacatt tctagagaaa ccttttctac
     7021 tcccacgggc tcctcaaagc atggaaattt tatacaaaat gtttgacatt ttaagatact
     7081 gctgtagttt agttttgaaa tagtatgtgc tgagcagcaa tcatgtacta actcagagag
     7141 agaaaacaac aacaaattgt gcatctgatt tgttttcaga gaaatgctgc caacttagat
     7201 actgagttct cagagcttca agtgtaaact tgcctcccaa gtcctgtttg caaatgaagt
     7261 tggctagtgc tactgactgc tccagcacat gatggaaggc agggggctgt ctctgaagtg
     7321 tcttctataa agggacaata gaatagtgag agacctggtc agtgtgtgtc agctggacac
     7381 tccatgctat gggacttgca tcttctgtcc tcaccatccc caagacattg tgctttcctc
     7441 agttgtcctc tagctgtttc actcagacac caagatgaat tactgatgcc agaaggggcc
     7501 aaaatggcca gtgtgttttg ggggttgtat cagttgactg gacaataact ttaatagttt
     7561 cagatcattt atttttactt ccattttgac agacatttaa atggaaattt agtcctaact
     7621 tttgtcattt gaaaggaaaa attaacagtt cctataagat acttttgagg tggaatctga
     7681 catcctaatt ttttttcttt tcagtgggtt tgcagcgagg gtcttgtatg cactaggcaa
     7741 gggttctacc actaagccac atttcccagg aaataaaatg ttaacagtta aaacatacac
     7801 acaaatacac aaacacctta ttaccacttt agtaaagtga gagatgtgcg tcctttgtct
     7861 cagtctccac gatttcagct gccccttgta tgaataactc agtctcgcta aactgtttac
     7921 ttttatttac ctggtttgac tagttgcagc tatataacca gttgtgcatg aggacaacag
     7981 ccagtgtgtt tgttttgttt ttggtttttt gtggtacatt ttttgtaaag aattctgtag
     8041 attgaagtgc tctttgaaaa cagaactgag atatatttat tcttgttagc atcaaaaaac
     8101 attttgtgca aatgatttgc ttttcctggc aggctgagta ccatatccag cgcccacaat
     8161 tgcgggttcc catctaccat gtccacaggg gagacagacg ggaagcacat gaggggtgtg
     8221 tttacagagt tgtaggagtt atgtagttct cttgttgcct tggaaatcac tgttgtttta
     8281 agactgttga acccgtgtgt ttggctgggc tgtgagttac atgaagaaac tgcaaactag
     8341 catatgcaga caaagctcac agactaggcg taaatggagg aaaatggacc aaaataaggc
     8401 agggtgacac ataaaccttg ggcttcggag aaaactaagg gtggagatga actataatca
     8461 cctgaataca atgtaagagt gcaataagtg tgcttattct aagctgtgaa cttcttttaa
     8521 atcattcctt tctaatacat ttatgtatgt tccattgctg actaaaacca gctatgagaa
     8581 catatgcctt tttattcatg ttaactacca gtttaagtgg ctaaccttaa tgtcttattt
     8641 atcttcattt tgtattagtt tacataccag gtatgtgtgt gtgctgtact cttcttccct
     8701 ttatttgaaa acacttttca ctgggtcatc tccttggcca ttccacaaca caactttggt
     8761 ttggctttca atgtcacctt atttgatggc ctgtgtccca gtagcagaat ttatggtatt
     8821 cccattgctg gctgctcttc cgaccctttg cttctacagc acttgtctct cctaagatag
     8881 tcagaaacta actgatcagg ggatggactt caccattcat cgtgtctctt caattctatt
     8941 aaatagacca ctcttgggct ttagaccagg aaaaaggaga cagctctagc catctaccaa
     9001 gcctcaccct aaaaggtcac ccgtacttct tggtctgagg acaagtctcc actccagtaa
     9061 gggagagggg aggaaatgct tcctgtttga aatgcagtga attcctatgg ctcctgtttc
     9121 accacccgca cctatggcaa cccatataca ttcctcttgt ctgtaactgc caaaggttgg
     9181 gtttatgtca cttcagttcc actcaagcat tgaaaaggtt ctcatggagt ctggggtgtg
     9241 cccagtgaaa agatggggac tttttcatta tccacagacc tctctatacc tgctttgcaa
     9301 aaattataat ggagtaacta tttttaaagc ttatttttca attcataaga aaaagacatt
     9361 tattttcaat caaatggatg atgtctctta tcccttatcc ctcaatgttt gcttgaattt
     9421 tgtttgttcc ctatacctac tccctaattc tttagttcct tcctgctcag gtcccttcat
     9481 ttgtactttg gagtttttct catgtaaatt tgtataatgg aaaatattgt tcagtttgga
     9541 tagaaagcat ggagaaataa ataaaaaaag atagctgaaa atcaaattga agaaatttat
     9601 ttctgtgtaa agttatttaa aaactctgta ttatatttaa agaaaaaagc ccaacccccc
     9661 aaaaagtgct atgtaattga tgtgaatatg cgaatactgc tataataaag attgactgca
     9721 tggagaaa
//
