LOCUS       NM_176850              11713 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus bromodomain PHD finger transcription factor (Bptf),
            transcript variant 2, mRNA.
ACCESSION   NM_176850 NM_177961 XM_126724 XM_895267 XM_903112 XM_988508
VERSION     NM_176850.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11713)
  AUTHORS   Noura,M., Tomita,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation
  JOURNAL   Cancer Med 13 (13), e7445 (2024)
   PUBMED   38940430
  REMARK    GeneRIF: NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation.
REFERENCE   2  (bases 1 to 11713)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 11713)
  AUTHORS   Zapata,G., Yan,K. and Picketts,D.J.
  TITLE     Generation of a mouse model of the neurodevelopmental disorder with
            dysmorphic facies and distal limb anomalies syndrome
  JOURNAL   Hum Mol Genet 31 (20), 3405-3421 (2022)
   PUBMED   35604347
REFERENCE   4  (bases 1 to 11713)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11713)
  AUTHORS   Richart,L., Felipe,I., Delgado,P., Andres,M.P., Prieto,J.,
            Pozo,N.D., Garcia,J.F., Piris,M.A., Ramiro,A. and Real,F.X.
  TITLE     Bptf determines oncogenic addiction in aggressive B-cell lymphomas
  JOURNAL   Oncogene 39 (25), 4884-4895 (2020)
   PUBMED   32451433
  REMARK    GeneRIF: Bptf determines oncogenic addiction in aggressive B-cell
            lymphomas.
REFERENCE   6  (bases 1 to 11713)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 11713)
  AUTHORS   Barak,O., Lazzaro,M.A., Lane,W.S., Speicher,D.W., Picketts,D.J. and
            Shiekhattar,R.
  TITLE     Isolation of human NURF: a regulator of Engrailed gene expression
  JOURNAL   EMBO J 22 (22), 6089-6100 (2003)
   PUBMED   14609955
REFERENCE   8  (bases 1 to 11713)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 11713)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   10 (bases 1 to 11713)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596116.14.
            
            On Jun 21, 2019 this sequence version replaced NM_176850.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139,
                              SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               AL596116.14        110424-111297       c
            875-1697            AL596116.14        89963-90785         c
            1698-1921           AL596116.14        78716-78939         c
            1922-2131           AL596116.14        74866-75075         c
            2132-2319           AL596116.14        61663-61850         c
            2320-2675           AL596116.14        60366-60721         c
            2676-2807           AL596116.14        59873-60004         c
            2808-2937           AL596116.14        57670-57799         c
            2938-3076           AL596116.14        56810-56948         c
            3077-3256           AL596116.14        55672-55851         c
            3257-5564           AL596116.14        51833-54140         c
            5565-5689           AL596116.14        47425-47549         c
            5690-5818           AL596116.14        46277-46405         c
            5819-5969           AL596116.14        45096-45246         c
            5970-6012           AL596116.14        44818-44860         c
            6013-6259           AL596116.14        41686-41932         c
            6260-6411           AL596116.14        40834-40985         c
            6412-6520           AL596116.14        39622-39730         c
            6521-6738           AL596116.14        37784-38001         c
            6739-6973           AL596116.14        35022-35256         c
            6974-7836           AL596116.14        33606-34468         c
            7837-7919           AL596116.14        32373-32455         c
            7920-8145           AL596116.14        31939-32164         c
            8146-8489           AL596116.14        26150-26493         c
            8490-8682           AL596116.14        22783-22975         c
            8683-8767           AL596116.14        21825-21909         c
            8768-8954           AL596116.14        19376-19562         c
            8955-11713          AL596116.14        12231-14989         c
FEATURES             Location/Qualifiers
     source          1..11713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.11 cM"
     gene            1..11713
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /note="bromodomain PHD finger transcription factor"
                     /db_xref="GeneID:207165"
                     /db_xref="MGI:MGI:2444008"
     exon            1..874
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..8991
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /note="isoform 2 is encoded by transcript variant 2; fetal
                     Alzheimer antigen"
                     /codon_start=1
                     /product="nucleosome-remodeling factor subunit BPTF
                     isoform 2"
                     /protein_id="NP_789820.2"
                     /db_xref="CCDS:CCDS48964.1"
                     /db_xref="GeneID:207165"
                     /db_xref="MGI:MGI:2444008"
                     /translation="MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPPPPPPPPPPPPPA
                     SGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGGRRKQPPPPPPASGSSASGP
                     GRGGRGGGGGRTGGGGGHLARTTPARRAVNKVVYDDHESDDDDEEEDMVSEEDEEEEE
                     DGDAEETQDSEDEEEDDMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGR
                     RKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVVRNFGNVLRLSP
                     FCFEDFCAALVSQEQCTLMAEMHVALLKAVLREEDTSNTTFGPADLKDSVNSTLYFID
                     GMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENKIKVLQFLVDQFLTTNIAREE
                     LMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHK
                     VPGVTDCVAEVQKNKPYVRHEPIGYDRSRRKYWFLNRRLIIEEDTDNENEKKVWYYST
                     KVQLAELIDCLDKGYWEAELCRVLEDIREEMQQHMDVTEDLTNKARGSNKSFLAAANE
                     EILDSLRIKRGEDIDCDQSPEDPEKDKHEGENNSSKDAEKSREEAEDPSADKDADSKG
                     LEEEPGHGKPEGDFRLEKSNGEVSESPGAGKGTSGSTRIITRLRNPESKLSQLKSQQV
                     AAAAHEANKLFKEGKEVLVVNSQGEVSRLSTKKEVVMKGNINNYFKLGQEGKYRVYHN
                     QYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTIT
                     QLESNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRES
                     LGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYR
                     VTGYGGWSWISKTHVYRFLPKLPGNTNVNYRKPLDGAKNNTDENKDESEKRKSPRSPK
                     KMKTECDSEQGETRDADATAGAAAGAMELSKEPEKKDQDVKELLDSDNDKSFKEEPME
                     IDDTIKTESHVSSLESTEVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIRQFTLEE
                     KQRLEKLKLESGVKGAGKPPMGALKSSSESPGSTKASEGHQGDSLRQEQSPSSSQAST
                     VDLGLGGSQSDPLVLGISPPSLSTHKPDPKDQVLDDVSIQSPGPNCQRQNSVESDLDA
                     RISEPAGKGLELSQTKTEVTDSSSDDSKPTSADDVGILICKSRKLHSQDDSSTVVSSS
                     KSTLPASVPKSPRDRDARAFSKAVDFDGRLGGDSEYSSTLENSSDNMCIRDSAEEDMV
                     VQNSSEATSKRFIAPEQGGESVESTKCQVVSKSTENCEDKLQGKVTEANGKKLGQHPP
                     KPEERAVNRCTDQVSLRHSVDRKNSEPRESEKKGQKANKFQINGKDSKAKGYLKGPGT
                     KDGSDGKVVSSAVEPKVNNINKVIPGNTKSLAGKESAAKPFINGDIIMEELSEQNTSE
                     TNSYSLSSSDAKGNHQDGLHTLPSTKESASTQVITPRAPCPDRNSLSQVEDMETESPE
                     VKRVIPSPVRTGEGSNLSKGFMDDNGLPSSKDENVNGESQRKTVITEVTTMTSTVATE
                     SKTVIKVAKGDKQTVVSSTENCARSTVTTTTTTVTKLSTPSPDTGVDTISVKEQSKTV
                     VTTTVTDSLTTAGSTLVTSMTVSKEYSTRDRVKLMKFSRPKKTRSGTALPSYRKFVTK
                     SSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQ
                     TVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGSTRTETSETEITTTEIIKRRDVGPY
                     GIRSEYCIRKIICPIGVPEAPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIESWVA
                     EEELELWEIRAFAERVEKEKAQAAEQQTKKRLEQQKPAVIAASTTSPANNTSSTVSPA
                     QKVMVAPLSGSVTPGTKMVLATKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGMVQV
                     QQKVLGIIPSTTGPSQQTFTSFQPRTATVTIRPNTSASAGTTTTSQVITGPQIRPGMT
                     VIRTPLQQPALGKAIIRTPVVVQPGTPQQVVTQIIRGQPVSTAISAPSTASSAPVQKG
                     LTPGAAAGPLQPSAPHSPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQ
                     LQLIPQGMTVLPGPGQQLMQAAMPNGTVQRFLFTPLSTSATAASSSSNSSSTTTNATA
                     AGSGEQKQSKILPQTQVQPATTLAPTQSSSVSPAEAQPQPAQPAAQPQPQPQPPAQPE
                     VQTQPAVSSHVPSETQPSQAQTSKPLVATQCQPQSSVQGQSPVRVQSPPLTRIRPSTP
                     SQVTPGQQPQVQTTASQPIPIPPPTSLQAPSQGQPQSQPQVQSSTQTLSSGQTLNQVT
                     VLSPSCPQPQPQVIAVPQLQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQVQQN
                     SAAQTQSVVTVQAASVQEQLQRVQQLRDQQQKKKQQIETEREHTLQASNQSEIIQKQV
                     VMKHNAVIEHLKQKKTMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREES
                     VEQKRSKQNASKLSALLFKHKEQLKAEILRKRALLDKELQIQVQEELKRDLKMKRERE
                     MAQAVQANAASVPTPSVPAPVPAPAPAAPPAPPRSPPPSTHSLPPAGHPTAPLPVTSQ
                     KRKREEEKDSKSKKKKMISTTSKEAKKDTRLYCICKTPYDESKFYIGCDRCQNWYHGR
                     CVGILQSEADLIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFL
                     EPVDPNDAPDYYGVIKEPMDLATMEERIQKRYYEKLTEFVADMTKIFDNCRYYNPRDT
                     PFYQCAEVLESFFVQKLKGFKASRSHNNKLQSTAP"
     exon            875..1697
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1921
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2131
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2319
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2675
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2807
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2937
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3076
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3256
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..5564
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..5689
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            5690..5818
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            5819..5969
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            5970..6012
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6259
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6411
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6520
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            6521..6738
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            6739..6973
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            6974..7836
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            7837..7919
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            7920..8145
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            8146..8489
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            8490..8682
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            8683..8767
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            8768..8954
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     exon            8955..11713
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9830..9835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /note="hexamer: AATAAA"
     polyA_site      9857
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /note="major polyA site"
     regulatory      10961..10966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /note="hexamer: AATAAA"
     polyA_site      10984
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
     regulatory      11687..11692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
                     /note="hexamer: AATAAA"
     polyA_site      11713
                     /gene="Bptf"
                     /gene_synonym="9430093H17Rik; Falz"
ORIGIN      
        1 agtcaccgag cgagagggaa gaaacaagat ggcggctgca ggcgatccgg agcggggccc
       61 cggcaattcg gactgagcct tctccctcca ccccgccgct gccgggccgc gcccctcccg
      121 cccggacccc ggcgccctcc cctccccctc ggccccggcg ccccccgcgc ccctccccca
      181 ccccttccgc tcccccccca cccccccgca agccgcggct ccgacatgag gggccggcgg
      241 ggcaggccgc ccaagcagcc cgcggctcct gctgcggagc gctgcgcccc ggccccgccg
      301 ccgccgccgc cgccgccacc accgccgccg ccaccgccgc cgccgccgcc gcccgcctcc
      361 ggacccatag gggggctgcg ctcgcggcac cgcggcagca gtcggggcag gtgggccgcc
      421 gcccaggctg aggtggcgcc caagacccgg ttgagctcgc ccaggggggg cggccgcagg
      481 aaacagccgc caccgccacc gccggcctcc ggcagcagcg ccagcggccc gggccggggg
      541 ggccgaggag gcgggggcgg caggacgggg ggcgggggcg gccacctggc ccggaccacc
      601 ccggcccgcc gcgccgtcaa caaagtggtg tacgatgacc acgagagtga cgacgacgac
      661 gaggaggagg acatggtctc ggaggaggac gaggaggagg aggaggatgg cgacgccgag
      721 gagacccagg attccgagga cgaggaggaa gatgacatgg aagaagacga cgatgactcc
      781 gattatccgg aggagatgga agacgacgac gacgacgcta gttactgcac ggaaagcagc
      841 ttcaggagcc atagtacata cagcagcact ccaggtaggc gaaaaccaag agtacatcgg
      901 cctcgttctc caatattaga agaaaaagac atcccacccc ttgaatttcc gaagtcctct
      961 gaggatttaa tggtgcctaa tgagcatata atgaatgtca ttgccattta tgaggtggtg
     1021 cggaactttg gcaacgtttt aaggttgtcc cctttttgct ttgaggactt ctgtgcggct
     1081 ctggtgagcc aagagcagtg cacactcatg gcggagatgc acgtggcgct tctgaaagca
     1141 gttcttcgag aagaggacac gtctaacacc acctttggcc ctgcggactt gaaagacagt
     1201 gtaaactcca ccctgtattt catcgacggg atgacgtggc cggaggtcct gagggtctac
     1261 tgtgagagtg acaaggagta ccaccatgtc cttccttacc aggaggcaga ggactatccc
     1321 tacggaccag tggagaacaa aatcaaagtt ctgcagtttc tagtcgatca gttccttacg
     1381 accaatattg ctcgtgagga gctgatgtct gaaggggtaa tccagtatga cgaccattgt
     1441 agggtctgtc acaaacttgg ggatctgctg tgctgtgaga cgtgctcggc tgtgtaccat
     1501 ttagagtgtg tgaagccgcc tcttgaagaa gtgccggagg acgagtggca gtgtgaagtc
     1561 tgtgtggcac acaaggtgcc tggtgtgact gactgtgtcg ctgaagtcca aaagaataaa
     1621 ccctacgttc gacacgaacc tattgggtat gacagaagcc gtaggaaata ctggttttta
     1681 aaccgaagac tcataataga agaagacaca gacaatgaaa acgagaagaa agtttggtac
     1741 tacagcacaa aggtccagtt agcagagcta atagactgcc tagacaaagg atactgggaa
     1801 gcagaactgt gcagagttct agaagacatt cgggaggaga tgcagcagca tatggatgta
     1861 acggaagacc tgaccaacaa ggctcgtggc agcaacaagt ccttcctagc ggcagctaat
     1921 gaggaaattt tggactcctt aagaatcaaa cgaggggaag atattgactg tgatcagagc
     1981 ccagaagacc cagaaaagga caagcatgag ggcgagaaca acagctccaa ggatgctgag
     2041 aagagcaggg aggaggcgga ggacccttcc gcagacaagg acgctgacag caaaggcctg
     2101 gaggaagagc ccgggcatgg aaaacctgag ggtgatttca gactggagaa gtccaatgga
     2161 gaagtttccg agtcccctgg agctgggaaa ggaacatctg ggtccactcg tatcatcacc
     2221 agactgagga acccggagag caaactcagt cagctcaaga gtcagcaggt ggcagctgca
     2281 gcccatgaag caaataaatt gtttaaggag gggaaagagg tgctggtggt taactcccaa
     2341 ggagaggttt cacggctgag caccaaaaag gaggtggtca tgaaagggaa catcaacaac
     2401 tattttaagc tgggacaaga agggaagtat cgagtctacc acaatcaata ctcgaccaat
     2461 tcatttgctc tgaataaaca ccagcacaga gaagaccatg ataagaggag gcatcttgca
     2521 cataaattct gtctcactcc agctggggag ttcaaatgga acgggtctgt tcacgggtcc
     2581 aaagtcctta ccatctcaac cctgagactc accatcacac agctagagag caacattcct
     2641 tcatccttcc ttcaccccaa ttgggcttca cacagggcta attggatcaa ggccgttcag
     2701 atgtgtagta aacccagaga gtttgcgttg gctctcgcaa ttctggagtg tgcagttaag
     2761 ccagttgtga tgctgccaat atggcgggag tctctaggac atacccggtt acataggatg
     2821 acatcaattg aaagggaaga aaaagagaaa gttaaaaaaa aggagaaaaa acaagaggag
     2881 gaggagacaa tgcagcaggc cacatgggta aaatacacat ttccagtgaa gcaccaggtt
     2941 tggaaacaga aaggtgagga gtaccgagtg acagggtacg gcggctggag ctggattagc
     3001 aagacgcacg tttacagatt tcttcccaag ttaccaggaa acacgaatgt aaactacaga
     3061 aagcccttgg atggagccaa aaacaataca gatgaaaata aagatgagtc agagaaaagg
     3121 aaaagtccac gaagtccaaa aaaaatgaag acagaatgtg attctgaaca aggtgagacc
     3181 agagatgcag atgccacagc tggagccgcc gcaggggcaa tggagctgtc taaggaacct
     3241 gagaagaagg atcaagatgt aaaagaactt ttagattctg ataatgacaa atccttcaag
     3301 gaagaaccaa tggagatcga tgataccata aaaacagagt cacacgtgag cagtctggaa
     3361 agcacagagg tagatgtagt caatgttagt gagggcttcc atctaaggac tagttacaaa
     3421 aagaaaacga aatcctctaa gctggacggg cttctggaac ggaggattcg acaatttaca
     3481 ctggaagaaa aacagcgtct tgagaagtta aagctggaga gtggggtgaa gggggcgggg
     3541 aagcccccca tgggtgctct gaaaagctcc tctgagtctc caggctccac aaaagcaagc
     3601 gaagggcatc agggtgactc gctgagacag gaacaaagcc ccagttcaag tcaggctagc
     3661 actgtggact tggggctggg gggctcacaa agtgatccct tggttcttgg catcagtcct
     3721 cctagtctaa gcacgcacaa acctgatcca aaagatcaag tattagatga tgtctccatt
     3781 cagagtccag ggccaaactg tcagaggcaa aactcagttg aaagcgacct agatgccagg
     3841 atctctgaac ctgccggtaa gggactggaa ctaagtcaga ctaaaacaga agtgactgac
     3901 tcttcctctg atgactctaa accaaccagt gcagacgatg ttggcatttt gatctgtaag
     3961 agcagaaagc tgcactcaca ggacgatagc agcaccgttg tgtcttcttc caagagtact
     4021 ttacctgcat cagtacctaa aagtccccgt gacagagatg cccgggcctt ctcaaaagca
     4081 gtggacttcg atgggagact aggtggtgac tctgaatata gtagcacttt ggaaaatagc
     4141 tctgataata tgtgtattcg ggacagtgct gaagaagata tggttgttca gaacagcagt
     4201 gaagccacct cgaaacggtt catagctcca gaacaaggag gagaaagcgt ggagtcgaca
     4261 aaatgtcagg tagtttctaa gtccactgaa aactgtgaag acaaactaca gggtaaggta
     4321 actgaagcaa acggtaagaa actgggccaa catcctccaa agccagagga gagagcagtt
     4381 aacagatgta ctgaccaagt cagcctgcga cacagcgttg acagaaagaa cagtgaacct
     4441 cgagagtctg aaaagaaagg acagaaagca aataaatttc aaataaacgg caaagatagc
     4501 aaagctaagg ggtacctgaa ggggccgggc acgaaggacg gctctgatgg taaagttgtg
     4561 agtagtgctg tagaaccaaa ggtcaataat atcaataaag tcatccctgg gaataccaag
     4621 tcactggctg ggaaggaatc tgctgcgaag ccgttcatca acggtgacat cattatggaa
     4681 gagttgagtg aacaaaacac ttcagaaacc aactcatact cactgagttc ttcagatgcc
     4741 aaaggtaatc accaagatgg cctccatacc ctaccatcca ccaaagagtc tgccagtacc
     4801 caggtaatca caccccgagc cccttgtcca gatcggaact cacttagtca ggtagaagat
     4861 atggaaactg aaagtccaga ggttaagaga gttatcccgt ctcctgttag aactggagag
     4921 ggctctaacc ttagcaaggg cttcatggat gacaatggac tgccttccag caaagacgag
     4981 aacgtcaatg gagaatccca aagaaagacg gtcatcacag aagtcaccac aatgacatct
     5041 actgttgcca cagaatcaaa aactgtcatt aaggtagcaa aaggagacaa gcaaactgtg
     5101 gtttcttcca cagaaaattg tgccagatcc acagtcacaa ctaccactac cactgtgaca
     5161 aagctctcca caccctcccc agacaccggt gtggatacca tctctgtaaa ggagcagagt
     5221 aaaaccgtgg tcaccacgac agtgacggac tccttgacca ctgcaggaag cacactggtg
     5281 acatctatga ccgtgagcaa agagtactcc acgagagaca gggtaaagct gatgaagttc
     5341 tcacgaccca agaagacccg ctcaggcact gccctgccgt cctataggaa gttcgttacc
     5401 aagagcagca aaaagagcat atttgtgtta cctaatgatg acttgaaaaa gctggccagg
     5461 aaaggaggga tccgggaggt cccttacttt aattataacg cgaaacctgc cttggatata
     5521 tggccatacc cttctcctag accgaccttt ggtatcacat ggaggtatag actacagacg
     5581 gtaaagtcct tggctggagt gagcctgatg ttacggttgc tgtgggccag tttgagatgg
     5641 gatgacatgg cagccaaggc tcctccagga ggagggtcta cacggacaga aacatctgaa
     5701 actgaaatca caaccactga gataattaag aggcgtgatg tgggccctta tggcattcgt
     5761 tctgagtatt gtatcaggaa gatcatttgc cccattggag ttccagaagc accaaaagaa
     5821 acacccacac ctcagcggaa gggcctccga tcaagtgcac ttcggccaaa gagaccagag
     5881 acccccaagc agacgggccc tgttatcatt gagagctggg tagcagaaga agagctggag
     5941 ctctgggaga tcagggcttt tgctgagaga gtggagaaag aaaaggctca agcagcagag
     6001 cagcagacca agaaacgttt ggagcagcag aagcctgcag tcatcgcagc gtccaccacg
     6061 tccccagcaa acaacacaag cagcactgtc tctccagccc agaaggtgat ggtggctccc
     6121 ttaagtggct cggtcacccc tggaacaaag atggtgctgg ccacaaaagt cggctcgcct
     6181 gccacagtca cattccagca aaacaagaac ttccatcaaa cttttgccac gtgggtgaag
     6241 caaggccagt ccaattcagg catggtccag gtacagcaga aggtcctggg gatcattcca
     6301 tcgactacag gtccaagcca gcaaaccttt acttcattcc agcccaggac tgcaactgtc
     6361 acaattaggc ccaatacctc agcctctgca ggaaccacta ccacatcaca ggtgatcaca
     6421 gggcctcaga tccgccctgg catgacagtg attagaacgc cactccagca gccagcactg
     6481 ggaaaggcga tcattcgaac accagtggtg gtgcagccag gcacacccca acaagttgtg
     6541 actcaaatca tccgaggaca gcctgtttcc actgccatct ctgctccaag tacagcttcc
     6601 tcagcacctg tacaaaaggg cttaactcca ggagcagcgg ctgggcctct gcagccttca
     6661 gccccacaca gccctcgtcc tcagcaaggg caggtgaagc tcaccatggc tcagctcact
     6721 cagctcacgc agggccatgg cggcaaccaa ggtttaacag tagtgattca aggacaaggg
     6781 cagactactg gacagttgca gttgatacct caggggatga cagtccttcc agggccaggg
     6841 cagcagctca tgcaagctgc aatgccgaat ggcaccgttc agcgtttcct ctttacccca
     6901 ctatcaacat cagccacggc cgccagcagc agcagcaaca gcagcagcac cactactaat
     6961 gctacagcag caggctcagg ggaacaaaaa cagagtaaaa tattacccca gacccaggta
     7021 caaccagcca caaccctggc accaactcag tcatcaagtg tgagtcctgc agaagcccag
     7081 ccacagcctg ctcagcctgc agcacaaccc cagccccagc cccagccccc agctcagcct
     7141 gaagtccaga cccagccagc tgtctcgtcc catgtccctt ctgaaacaca gccctcccaa
     7201 gcacagacat ctaaacccct ggttgcaaca cagtgtcagc ctcagagcag tgtacaagga
     7261 cagtctcctg ttcgagtcca gagtccacca ctgactcgaa tacgtccatc aactccatcc
     7321 caagtgactc ctggacagca accccaggtt cagactacag cttcacagcc gattccaatt
     7381 ccgcccccca catctctgca ggcaccttcc caaggccagc cacagtcaca gccccaggta
     7441 cagtcttcaa ctcaaactct ttcatcagga cagacattaa atcaagttac tgttctatct
     7501 ccatcctgtc ctcagccaca gccccaagtc attgctgtgc ctcagctcca gcaagtccag
     7561 gttctctctc agatccagtc gcaggttgtg gctcagatac aggcccagca aagtggtgtg
     7621 ccccagcaaa tcaaacttca gttgcccatt caagttcagc aaaacagtgc tgcgcagact
     7681 cagagtgtgg tcacagtgca ggcagccagt gtgcaggagc agttgcagag ggttcagcaa
     7741 ctcagggacc agcagcaaaa gaagaagcag cagatagaaa ctgagcgtga acacaccctc
     7801 caagcttcta accaaagtga gatcattcag aaacaggtgg tgatgaagca taatgctgta
     7861 atagaacatt taaaacagaa aaagaccatg actccagctg aaagagaaga aaatcaaagg
     7921 atgattgtct gtaaccaggt gatgaagtat attctggata agatagataa agaagaaaaa
     7981 caggcggcca agaaacgcaa gcgggaggag agtgtggagc agaagcggag caaacagaat
     8041 gccagcaagc tctctgctct gctgttcaaa cacaaggagc agctcaaagc tgagatcctg
     8101 agaaagagag cgctcctgga caaagagttg cagatccaag tgcaggaaga gctgaaaaga
     8161 gacctgaaaa tgaaacgaga gagggagatg gcccaggcgg tacaggccaa tgctgcctca
     8221 gtgcccacac cctccgtgcc agcccctgtg ccagcgcctg caccggcagc ccctccagct
     8281 cctcctcgtt ctccgcctcc ctccacacac agtctgccac ctgcaggcca ccccacagcc
     8341 ccactgcctg tcacttccca gaagaggaag cgggaggaag agaaggactc taagtccaag
     8401 aagaagaaga tgatctctac cacctctaag gaggccaaga aggacaccag gctatattgc
     8461 atctgcaaga caccgtacga tgagtccaaa ttttatattg gctgtgatcg gtgtcagaat
     8521 tggtaccacg ggcgctgtgt tggcatcttg caaagtgagg cagatctcat tgatgagtat
     8581 gtctgtccac agtgccagtc gacagaggac gccatgacag tgctcacacc actgacagag
     8641 aaagattatg agggcttgaa gagggtgctg cgctccttac aggcccacaa gatggcgtgg
     8701 cctttccttg aaccggtaga ccccaatgat gcaccggatt attacggtgt tattaaagag
     8761 ccaatggacc ttgccaccat ggaagaaaga atacaaaaac ggtattatga aaagctgaca
     8821 gagttcgtgg cagatatgac caaaattttt gataactgcc gttattacaa tccccgtgac
     8881 accccttttt accagtgtgc agaagttctt gaatcattct ttgtacagaa actaaaagga
     8941 ttcaaggcca gcaggtctca taacaacaag ctgcaatcta cagctcctta gaactcagcg
     9001 tgtctgtcac ctaagctaga cacagcaagt ctggcgctct gaactattta aactaaagcg
     9061 ccagatattt tcagtcaggc tttcctgaca agaccgtaac ctcgttcata ttggtcacaa
     9121 cagtccagtt gtattcttgg ccaattttgt ccaacggaca aaggaaaagc aaagtcaacg
     9181 gcaccgttgt cttgtcgaga gcaaatggct ttactattgt ggcagaagca ggaaactttg
     9241 tttattggaa aaaaaaaaaa aaaaaagaaa aagcaagaaa aaaaaaaaaa gatactatgg
     9301 ggtcaagtgt aactccgtgg gatgccacat ctgctcttca gtgaagaagc tgtttagagt
     9361 ctcagaaaac tttttgactg tatttattta ttgttgcaaa aaaaagacgc ttttttattg
     9421 ctgccctcat ttgtcagcta attatttttt cttatacaaa tccagccctg gttccgtgta
     9481 tccaccctgt atcctatcat gattcctgta ggtgaagtac aaggcgacct ctaggtgtct
     9541 tttctttcta tgaaaggagc tgctatgtac acatgtgcac acacaactgg gaatcaacaa
     9601 tgagtttatt gttcacggga gacacaagtg aagcttgcgg aaaggttggg ctaagtggtc
     9661 ctggactaac agacttcgtt gccttgaata caccagtaca aattgtcatt tactctgcac
     9721 caggctaaat gagcaaaatc tatttgaagg tatcttgttt gtaaacattg tcagattcta
     9781 atttttttct ttttgtatta aaattcaact atggatgtat acgaatcgaa ataaatggag
     9841 atcatttttc tcccacagat ggaggtctct ttgaatgtgc gctgtgatta cctgtaagcc
     9901 tttgtggggg acggggcggg ggagagacca ggaatgacag gaagacctgg atttctctag
     9961 aatagcagag gcccttcctt tcctaagtcc cttctcacca catcagagaa aatctccagg
    10021 gagccggtcc cttgcatctc ttggtcatcc ctgtaataac gggaatatga cacagtacaa
    10081 gctgccttca tccccgcctt ccaaaactgt agacagattc ctgtgtggga tgaagggtgt
    10141 ttgctggccg ggttccttgg gttttgtttg ttgcagtaga gcagggtaga gggtagagca
    10201 gacaggctcg ccctgcatct tcctcctgcg ggtgctctca ccctccctcc ccttggagct
    10261 gcttgctgtg ttgtgaaaac cagccaggat tgagtcaggc tgcctcgcag atgttttcct
    10321 agatttgcac tagtccatgt tagccctgtc ctgctgggtt ctagaatcta cctagttttt
    10381 gttttttaaa agccgcctct gtgcatttgg tgtcgccctg ctatgcaaag ccttccccag
    10441 cccttagttt cttgaaagga aactgtggca gcagttggca aattcttcct tatgacaggc
    10501 tcaggtgtac aggttcttct gggtcacgtg ctctatggaa gcctactccc tctgtacata
    10561 aaaatgtcac tttagcctgt gcttacagct aaagagactt aactgctcaa tatgatagca
    10621 aagtttttgc ttaaactatt aaggtggaag tagttaaata caggctattt tgttctttta
    10681 gtttacaaaa aagaaaaaag aaaaaaaatg ttccacgttg taggcactgt gctgatgcaa
    10741 gaattctaca tcctaataat acaaagtgat tctgcatctg cccacgtcca gtattcctgt
    10801 actatctatt catatatcta agcatatatg ggcttaatca cttaagcttg ttgcagcaaa
    10861 agctttccta cctgtaggca atagattgct atgtttttaa caaattgtag caaattctaa
    10921 ataatccttt ttgtacgtaa taggacattt catcctaaaa aataaagtaa tgtttttgac
    10981 attggattct gtgcagtttc taatgagaca atgactggtt gggtcaatgt ttgctatatt
    11041 tttctgaagc tgttggcatt gccaagttgt acagaaatgg gggtgggtat gggttgtgga
    11101 tttctgagac caggaagatg ttaatttctt atttgtgtac ttaatgatat aaagactttt
    11161 gcagtttcta tcaccatgta aagacatttt atagttttat cagactgtgg agttttagtc
    11221 tttcaacgta catttatttc aaaagctgct tttctacaga tctcatttga ccttcttcta
    11281 ctcctcaata aaagtgttag gctgtctgct ccgtccggca gaccaagtgg tccgatatgc
    11341 gatatgggta ggactcaggt tctgtgccta gaagttgtat ttctttgctt tgatagattt
    11401 ctttggctaa aagtattttt tagcatttcc tgtgttcatc tccagattca cagtttaaga
    11461 ccatttctta agagatattt tcataacggc ggtaaggctt ttttctcctg tgcaggttct
    11521 tcagggcttg tatttactgt cctgtgctag gtcaaagaaa ttgcgaactt ttggagatgt
    11581 tttctacagt aaaaaaatga cctttttcta tttggagtgg cctggagtgc tgtgtgggac
    11641 cctcccaatg tgctgctgtc tgtaacctgt cctcttaaga gctgcaaata aaacttctct
    11701 ccctgtctcc gtc
//
