LOCUS       NM_177730               6494 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus 3'(2'), 5'-bisphosphate nucleotidase 2 (Bpnt2), mRNA.
ACCESSION   NM_177730
VERSION     NM_177730.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6494)
  AUTHORS   Eisele,B.S., Wu,A.J., Luka,Z., Hale,A.T. and York,J.D.
  TITLE     Bisphosphate nucleotidase 2 (BPNT2), a molecular target of lithium,
            regulates chondroitin sulfation patterns in the cerebral cortex and
            hippocampus
  JOURNAL   Adv Biol Regul 83, 100858 (2022)
   PUBMED   34920982
  REMARK    GeneRIF: Bisphosphate nucleotidase 2 (BPNT2), a molecular target of
            lithium, regulates chondroitin sulfation patterns in the cerebral
            cortex and hippocampus.
REFERENCE   3  (bases 1 to 6494)
  AUTHORS   Eisele,B.S., Luka,Z., Wu,A.J., Yang,F., Hale,A.T. and York,J.D.
  TITLE     Sulfation of glycosaminoglycans depends on the catalytic activity
            of lithium-inhibited phosphatase BPNT2 in vitro
  JOURNAL   J Biol Chem 297 (5), 101293 (2021)
   PUBMED   34634304
  REMARK    GeneRIF: Sulfation of glycosaminoglycans depends on the catalytic
            activity of lithium-inhibited phosphatase BPNT2 in vitro.
REFERENCE   4  (bases 1 to 6494)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6494)
  AUTHORS   Capulli,M., Costantini,R., Sonntag,S., Maurizi,A., Paganini,C.,
            Monti,L., Forlino,A., Shmerling,D., Teti,A. and Rossi,A.
  TITLE     Testing the Cre-mediated genetic switch for the generation of
            conditional knock-in mice
  JOURNAL   PLoS One 14 (3), e0213660 (2019)
   PUBMED   30865697
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6494)
  AUTHORS   Hudson,B.H., Frederick,J.P., Drake,L.Y., Megosh,L.C., Irving,R.P.
            and York,J.D.
  TITLE     Role for cytoplasmic nucleotide hydrolysis in hepatic function and
            protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 110 (13), 5040-5045 (2013)
   PUBMED   23479625
REFERENCE   7  (bases 1 to 6494)
  AUTHORS   Frederick,J.P., Tafari,A.T., Wu,S.M., Megosh,L.C., Chiou,S.T.,
            Irving,R.P. and York,J.D.
  TITLE     A role for a lithium-inhibited Golgi nucleotidase in skeletal
            development and sulfation
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 11605-11612 (2008)
   PUBMED   18695242
  REMARK    GeneRIF: Golgi plays an important role in glycosaminoglycan
            sulfation and define a function for gPAPP in the formation of
            skeletal elements derived through endochondral
            ossification[3'-phosphoadenosine 5'-phosphate phosphatase]
REFERENCE   8  (bases 1 to 6494)
  AUTHORS   McGowan,K.A., Li,J.Z., Park,C.Y., Beaudry,V., Tabor,H.K.,
            Sabnis,A.J., Zhang,W., Fuchs,H., de Angelis,M.H., Myers,R.M.,
            Attardi,L.D. and Barsh,G.S.
  TITLE     Ribosomal mutations cause p53-mediated dark skin and pleiotropic
            effects
  JOURNAL   Nat Genet 40 (8), 963-970 (2008)
   PUBMED   18641651
REFERENCE   9  (bases 1 to 6494)
  AUTHORS   Sohaskey,M.L., Yu,J., Diaz,M.A., Plaas,A.H. and Harland,R.M.
  TITLE     JAWS coordinates chondrogenesis and synovial joint positioning
  JOURNAL   Development 135 (13), 2215-2220 (2008)
   PUBMED   18539921
  REMARK    GeneRIF: identify JAWS as a key regulator of chondrogenesis and
            synovial joint positioning required for the restriction of joint
            formation to discrete stereotyped locations in the embryonic
            skeleton
REFERENCE   10 (bases 1 to 6494)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772346.5.
            
            On May 8, 2018 this sequence version replaced NM_177730.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048776.1, AK045511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AL772346.5         135622-136205       c
            585-747             AL772346.5         121092-121254       c
            748-843             AL772346.5         119213-119308       c
            844-1005            AL772346.5         112211-112372       c
            1006-6494           AL772346.5         105383-110871       c
FEATURES             Location/Qualifiers
     source          1..6494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.56 cM"
     gene            1..6494
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /note="3'(2'), 5'-bisphosphate nucleotidase 2"
                     /db_xref="GeneID:242291"
                     /db_xref="MGI:MGI:1915720"
     exon            1..584
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1274
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /EC_number="3.1.3.7"
                     /note="inositol monophosphatase 3; myo-inositol
                     monophosphatase A3; inositol-1(or 4)-monophosphatase 3;
                     inositol monophosphatase domain containing 1; inositol
                     monophosphatase domain-containing protein 1;
                     golgi-resident PAP phosphatase; Golgi 3-prime
                     phosphoadenosine 5-prime phosphate 3-prime phosphatase;
                     phosphoadenosine phosphate 3'-nucleotidase"
                     /codon_start=1
                     /product="Golgi-resident adenosine 3',5'-bisphosphate
                     3'-phosphatase"
                     /protein_id="NP_808398.1"
                     /db_xref="CCDS:CCDS17947.1"
                     /db_xref="GeneID:242291"
                     /db_xref="MGI:MGI:1915720"
                     /translation="MAPMGIRLSPLGVAVFFLLGLGVLYHLYSGFLAGRFSLFGLGSE
                     PAAGEAEVASDGGTVDLREMLAVAVLAAERGGDEVRRVRESNVLHEKSKGKTREGADD
                     KMTSGDVLSNRKMFYLLKTAFPNVQINTEEHVDASDKEVIVWNRKIPEDILKEIAAPK
                     EVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMV
                     DGGSNVKARSSYNEKTPKIIVSRSHAGMVKQVALQTFGNQTSIIPAGGAGYKVLALLD
                     VPDMTQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLNGEEISYTGSDGIEGGLL
                     ASIRMNHQALVRKLPDLEKSGH"
     exon            585..747
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /inference="alignment:Splign:2.1.0"
     exon            748..843
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1005
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..6494
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4924..4929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /note="hexamer: AATAAA"
     polyA_site      4947
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /note="major polyA site"
     regulatory      6468..6473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /note="hexamer: AATAAA"
     polyA_site      6490
                     /gene="Bpnt2"
                     /gene_synonym="1110001C20Rik; B230207P20; gPAPP; IMP 3;
                     Impad1; IMPase 3; Jaws"
                     /note="major polyA site"
ORIGIN      
        1 ggccgaccgt tggcctacgc ggaaggccga tcggccagct gctggctgct gcaaggcagg
       61 gccgtggggt acggggcgtg ggaggcggcg gcggcgcggc tttccctgag cggtgatggc
      121 gcgggagggc gccaggaagc gggcgccttt gtagcggact cagcggcggg cctgaagcgg
      181 ccttagcgcc ggtcgcgcgc gccatggccc ccatgggcat ccgcctgtcc ccgctggggg
      241 tggccgtatt tttcctgctg gggctcgggg tgctctacca cctctactcg ggcttcctgg
      301 ccggccgctt cagcctcttc ggcctgggca gcgagccggc ggcaggggag gccgaggtgg
      361 cgtccgacgg gggcacggtg gacctgcgcg agatgctggc cgtggccgtg ctggcggccg
      421 agcgcggcgg cgacgaggtg aggcgggtcc gcgagagcaa tgtccttcac gagaagtcca
      481 aggggaagac gcgcgagggc gccgatgata agatgaccag cggcgacgta ctgtccaacc
      541 gcaagatgtt ctacctgctc aagacggcct tccccaacgt gcagataaat actgaggaac
      601 atgtggatgc ctctgacaag gaggtcattg tatggaaccg gaagattcct gaggacatcc
      661 tgaaggaaat cgctgctcct aaggaggtac cagcagaaag tgtgacagtt tggattgacc
      721 cacttgatgc tacacaggaa tacacagagg atcttcgaaa gtatgtcact accatggtgt
      781 gtgtagctgt gaatggcaaa cctgtgttag gagttattca taagccattt tctgaatata
      841 cagcttgggc aatggtagat ggtggttcaa atgtgaaagc ccgttcttcc tacaatgaga
      901 agaccccaaa gatcattgtg tctcgctctc atgcaggaat ggtcaaacag gttgctcttc
      961 agacgtttgg aaaccagact tcaattatcc cagctggggg tgctggttat aaagttttag
     1021 cactcttgga tgtgcctgat atgactcaag aaaaagcaga tctatatatt catgtgacat
     1081 acatcaaaaa gtgggatata tgtgctggca atgccatctt aaaagccctt ggtggccata
     1141 tgaccactct gaatggagaa gagatcagtt acactgggtc tgatggcatt gaagggggac
     1201 ttcttgctag catcagaatg aaccaccaag ctctggtcag aaaacttccg gatttagaaa
     1261 agtcaggaca ttagtaagca ttcctgacca caagatgcac ctcttccaga tgtgaattat
     1321 tcggcctgag ctgttggaac tgttgaagtg ctggtggaga tgatgcatgg ttaaggccgc
     1381 cctgaagtac tttggaagta cttatgaagc agcagagact tactttccct gtaataggat
     1441 acaaaatcag ggaaattaga ttgcttcatt tctcaagtat tgtctttatt tttgagacta
     1501 ttttcataca gttgtcatat acaaggtgca tatatatata tgtatgtatg tatatatata
     1561 catatatata tatttgtgaa ttaatatcta gaactgagtc tacactgtta tgagtcacca
     1621 ttttcacaca acaaatgatg agtctgcatt gttgatactt ccatatagaa tgggatttga
     1681 gaaagggaag gttttgtttt atgtagagtt tagtgtaact tctaggttgt atattattaa
     1741 aaataaaatc attggtgatt tttactcctc agatggaaag cacaagaagt ctcatattca
     1801 ttaatatgca acaagtgctc tgttcatctg cctttctatg gatttcatag aaatggctta
     1861 agtcggttat tttctttgaa attgtactaa cagattgacc agctggtaga aggtagacag
     1921 atgactgaat tatactggaa ttgtctgagt gttgcagttg attttcattt ccctatgaaa
     1981 ggggccattg ttcatccttt ctccactgat caggatttag tcttcaccag gaaagttggt
     2041 tcaagtttca gtattagtct catgatatgc atattttctc ttcagagatg aactatgttg
     2101 taagatgctc taagaatata aatgattcta tgattgttga aagttacttg acatatagat
     2161 tgaatagttt tagctatttt tcaagaatta tgttttgttt atgtaataat gtttcttaat
     2221 ttttgaaacc ttgccaggtt tatctctaga cattctctta tcatcaagaa tggctatgac
     2281 ttttttctta gctattaata gacttaaaag aaccaaatta tcagaggaat tacttttgac
     2341 ataattctag ttttctcatt gataaaattt tttttcccac tcagttgaca gaatgtggtt
     2401 aaaaaaagat atggtagcat ttgtcgtgtt gctataactc agaacttgtt tttttgagct
     2461 gtatttgttg gtgtgagtag tttttcttag tatggcctag aaaattggta taaataataa
     2521 atcatggttt ttttcatgtg gctttgatgc ccttgtaaac gttaatgagg aatttctcat
     2581 tttttctttt ttaaaaatgt aagcctaaag aaaatttcta tttattttcc tatttcagag
     2641 ctaaaattga gcaaaggatg gacattctag tctggtatat tgtgcatact ttaggtttgc
     2701 atgtcataga gcccaaagcc tggcactcct cagcagggga ctgaatctta atgcagcaca
     2761 agtgcttttc cccgtactta acagtatgta acagtatgtt acagtatgta acggcactaa
     2821 attggccttt gtgtgatgaa aattcagttt tggtgtttgg aaacttggta ttaatttaat
     2881 aggagttgtt agtttttaaa acagtttcag acaactagtc taatcaccag ataatatgac
     2941 aggagaaagg aaatcctgct ttctctggcg agatgccaga gcagatcgtc tcaccagaat
     3001 cctgtattag gaacctctgt gtcactgtaa catgtcaacg cagaaaatag aacttaattg
     3061 ggtaattttt taatgtgcag aaactttatc atttattaca agtaaaacta gttcatattt
     3121 tgtaagcaca attgcttttg tttttagttt cattaacagt tatcactaag aataggaaca
     3181 ttgtgtgttg ggctcagaag caaagatgct ggctgagagg tggaagtagt ttttataatt
     3241 tgttcgtgtt atctaatgat tttacgtact tttatagaca gttcattttt taatataatt
     3301 ttgtttcaaa gccaatatac attacaagga aaacagtatt tatttatatg aggtattatt
     3361 gtgccagaac atatctgctg tggagtatgt aatatctctc agaattaatg ttaaattgtt
     3421 ttatttctaa aacataccaa aacaagtttc tatttagaaa cttacctgtt tttcctttag
     3481 tagaagcaga gacatccaca gcctcaacag atcacaccag ctgtctcctc ctcactcacg
     3541 atatcccagc tccatttttt tttctttttt tggctctctt tcttagctag tatgctacct
     3601 tgccccacgc ttaaccaaaa ttttcttata aactctttct tctgtatatt ggccactgaa
     3661 caggtagaat tgagactttg gtaaagttca caatgaaagt gttcaatcct ggaagaggtt
     3721 tagttaacca ttatttttta ggcttcatga gatgtaaaga aaattgcctt gggaaccata
     3781 aacaattcat gctcttatat gactcaatac taacattttt acaaagtacc tcttcctgcc
     3841 catctcaaga atataagcct ggaatatgct agggaattgg ataggtaagc ccacttgaag
     3901 aaccttgttt ttctgttggt tttcattctt acatcccagc ctccacttca gttgagttta
     3961 caaggctgta caaacagtca tatttgtctt tgtggttttt ctcctttccc caattttatg
     4021 ttttgttttg ttttgttttg ttttgtttac taaaatactt aatgagatat tagtgataac
     4081 taatgaactg tcaagaacat ctagatttat gtttatatga cagttatggg gcttgtttcc
     4141 tgaggctcct ttggactgtc tacagattat gtcagaagaa ataggtaggg ccaaggttag
     4201 gaagagatgg aagattcaga agcccagggc agagagatca gtgagggtga gaggctagca
     4261 tttgccctgg ctcctgtcct caccctgctc ttagatccga gttcaaaaat aagataaaac
     4321 tctacctatg atggcagtgc tcaggtaact caggcagaag tacagtcaag tgccaaccat
     4381 tttaactttc ttgatcatag ctgatggcct tcctgggaca acctggaagg tcaaagcaag
     4441 aactcttgag attattctag ctgcaactac cagtggtggc tgtgtatatt actgctgtgt
     4501 agaaacatta gtagtgtttt cattttaggt ccaagtaaga tgtttttagt gatatacctg
     4561 cagaatggct ctgtcttaaa actgtgtaga aaaaccctaa tctttaggag ctttccctaa
     4621 ggaaaaaaaa aaaaaagttg tgccttacat agggcgttgt gtgttaatta tattaataag
     4681 tgggggtagc ttgttcccat taaatgtaag ttctgttaat gtgtttttat cagagttggg
     4741 ggaaagtcat taaaattaaa taaaactgat ggattatttt tgcataatgt agcatttata
     4801 gttgaagtac atttttctaa gaattggatc atgatgtata taagtctgaa atgatgtttc
     4861 atcatttggt ttttaattaa atgtaagacc aggatagatt ggattttaaa aatcttactt
     4921 ttcaataaat tatttcagac aacttcatat ttctctaatt ctctggagta actttggtta
     4981 aaaaatagct gttagtggta caaatttggt ggtctcttag ttaaatgata ttgtgtgttg
     5041 ttcctaatga gggaaggatt ctaatcttga ccagcaatgg ttgtgagggc tgcttcttca
     5101 cagtagtgaa gttcagcaac aacatggttc tgtgaggtgc tgatatgcat gtaaattgtt
     5161 cttttctttc attatcaaag cccagcaggt atatgtattc tgacttccca ttgacaggat
     5221 ttttgtttgt ttgtttattt tttattgtta tttttttgtt gggcagtaaa ttaatttaat
     5281 ggaagaaatg agatgtttgc ctttgaaata atacaggaca aactctgaag aatgatgaat
     5341 aatactaaga cagctgatta tatattgtgt ttgtggtcat tccctaaagt tattatataa
     5401 tatatcttat aaagtgcaaa agcaggggtt gtaatgtttt gtcagtatat ttaattaata
     5461 ttttaaggtg taaaacagag gtcattctgg aaagacttgt tcctctgttt aaagaaaaaa
     5521 aaaaaaaaac ctaggaaaga aacacactaa gttaacatga gatacttaac ctgaaagaaa
     5581 tctcatgtcc tcacatatgg tcttcagcct ttatagtgtg gagacattta gagaaggacc
     5641 cttcgtgtcc tgtacttgca gtgaccagca ccggcctttg tagtgtaaca gggtgttgag
     5701 agtgatggac tacatgttca taggacttgt tcacattgac agtgctgcct tgaccagcct
     5761 atgcctgtgt caccagaact gtgtcctttc cctaatattt taaactattt ttttatcctc
     5821 tcttcctgtt aatgcatttc ttaaaatggg tcaacggtga gagaaattta aatatttacc
     5881 tttgaatact tctctctttt catatatata aagccatgga agaaataagc tgttttcctt
     5941 tggcagagat gccacatttt cttaacaggc tctgacctgc caacccactt caccagattg
     6001 aagtggaggt cagtggtgtt acctgaagaa acatctccat ccatggcctt agaagagtgc
     6061 tttatgcctc accacaccac ttttataaat gctattagtg ttcttgctaa ggagatggag
     6121 gatgtctggt tttgtgtgtg cgttttcacc atatccccag tacctagagt cttgcacaaa
     6181 ctcagtccag actgtgtgtt gagttgaact aaagggtcac tactagtgtt agcatgcttc
     6241 atacctcagt agtataagct agttgtttcc tttgctgata tttgtaatta ttacccatac
     6301 acactacatt gtttttgttg ttgttttaaa agttaggcct tttcgctaga tactacacca
     6361 tggtcaatta actgtaaaaa aaataaaaat gtgattgctt ctaatgaaat aatttcccca
     6421 aaccctgccc ctgaatatac tttgacaagt gaaatttgaa ttcatcaaat aaatcagtca
     6481 tgtctgaaaa ggtt
//
