LOCUS       NM_011794               2182 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Mus musculus 3'(2'), 5'-bisphosphate nucleotidase 1 (Bpnt1),
            transcript variant 1, mRNA.
ACCESSION   NM_011794 XM_908133
VERSION     NM_011794.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Hale,A.T., Brown,R.E., Luka,Z., Hudson,B.H., Matta,P.,
            Williams,C.S. and York,J.D.
  TITLE     Modulation of sulfur assimilation metabolic toxicity overcomes
            anemia and hemochromatosis in mice
  JOURNAL   Adv Biol Regul 76, 100694 (2020)
   PUBMED   32019729
  REMARK    GeneRIF: Modulation of sulfur assimilation metabolic toxicity
            overcomes anemia and hemochromatosis in mice.
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Hudson,B.H., Hale,A.T., Irving,R.P., Li,S. and York,J.D.
  TITLE     Modulation of intestinal sulfur assimilation metabolism regulates
            iron homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 115 (12), 3000-3005 (2018)
   PUBMED   29507250
  REMARK    GeneRIF: These studies define a genetic basis for iron-deficiency
            anemia, a molecular approach for rescuing loss of nucleotidase
            function, and an unanticipated link between nucleotide hydrolysis
            in the sulfur assimilation pathway and iron homeostasis.
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Hudson,B.H. and York,J.D.
  TITLE     Tissue-specific regulation of 3'-nucleotide hydrolysis and
            nucleolar architecture
  JOURNAL   Adv Biol Regul 54, 208-213 (2014)
   PUBMED   24309248
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Hudson,B.H., Frederick,J.P., Drake,L.Y., Megosh,L.C., Irving,R.P.
            and York,J.D.
  TITLE     Role for cytoplasmic nucleotide hydrolysis in hepatic function and
            protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 110 (13), 5040-5045 (2013)
   PUBMED   23479625
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Spiegelberg,B.D., Xiong,J.P., Smith,J.J., Gu,R.F. and York,J.D.
  TITLE     Cloning and characterization of a mammalian lithium-sensitive
            bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate
  JOURNAL   J Biol Chem 274 (19), 13619-13628 (1999)
   PUBMED   10224133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129195.3.
            
            On Nov 17, 2006 this sequence version replaced NM_011794.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093938.1, AK150877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC129195.3         46588-46692         c
            106-232             AC129195.3         40619-40745         c
            233-337             AC129195.3         37524-37628         c
            338-445             AC129195.3         33429-33536         c
            446-494             AC129195.3         32128-32176         c
            495-586             AC129195.3         30016-30107         c
            587-784             AC129195.3         26472-26669         c
            785-890             AC129195.3         24789-24894         c
            891-2182            AC129195.3         21082-22373         c
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.49 cM"
     gene            1..2182
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /note="3'(2'), 5'-bisphosphate nucleotidase 1"
                     /db_xref="GeneID:23827"
                     /db_xref="MGI:MGI:1338800"
     exon            1..105
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            106..232
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1039
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /EC_number="3.1.3.57"
                     /EC_number="3.1.3.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     3'(2'),5'-bisphosphate nucleotidase 1; PIP; PAP-inositol
                     1,4-phosphatase; bisphosphate 3'-nucleotidase 1; BPntase
                     1; PAP phosphatase; inositol-polyphosphate 1-phosphatase;
                     3'-phosphoadenosine 5'-phosphate phosphatase"
                     /codon_start=1
                     /product="3'(2'),5'-bisphosphate nucleotidase 1 isoform 1"
                     /protein_id="NP_035924.2"
                     /db_xref="CCDS:CCDS15597.1"
                     /db_xref="GeneID:23827"
                     /db_xref="MGI:MGI:1338800"
                     /translation="MASSHTVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSAT
                     DLQTKADRLVQMSICSSLARKFPKLTIIGEEDLPPGEVDQELIEDGQWEEILKQPCPS
                     QYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAG
                     PDAALGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNQLVTDCISAMNPDTVLRV
                     GGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNALQYNKEV
                     KHMNSAGVLAALRNYEYYASHVPESVKNALIP"
     exon            233..337
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            338..445
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            446..494
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            495..586
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            587..784
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            785..890
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
     exon            891..2182
                     /gene="Bpnt1"
                     /gene_synonym="BPntase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgctgtc cttctcacag cattggacca gtggacttgg aggcagccgg ttcccggaca
       61 gcgagccacc aggccggaca gcgcttaggg gacaccaggc tgagtgttta tcatggcttc
      121 cagccacacc gtgttgatgc ggctggtagc ttcagcatat tctatcgctc aaaaggcagg
      181 aaccatagtc aggtgtgtca ttgctgaagg agacctgggc atcgtgcaga agacctcggc
      241 caccgacctg cagaccaaag ccgaccgctt ggtgcagatg agcatatgct cttccctggc
      301 ccggaagttc ccgaagctga ccatcatagg ggaagaggac ctgcctcctg gggaagtgga
      361 tcaagagctg attgaagacg ggcagtggga ggagatcctg aagcagccgt gcccctcgca
      421 gtacagtgct atcaaggagg aagaccttgt ggtttgggtt gaccccttag atggcaccaa
      481 ggagtacact gaaggtcttc ttgacaatgt aacagttctc attgggattg cttatgaagg
      541 aaaggccatc gcaggcatca tcaaccagcc gtattacaac taccaggcag gacccgacgc
      601 ggcgctgggc aggaccatct ggggagttct gggtttgggt gcttttgggt ttcagctgaa
      661 ggaagcccct gccgggaagc acattatcac aaccaccaga tcccatagca accagctggt
      721 cacagactgc atttccgcca tgaaccccga caccgtgctg cgagtgggag gagcaggaaa
      781 caagattatc cagctgatcg aaggcaaagc ttctgcttat gtgtttgcaa gtcctgggtg
      841 taagaagtgg gacacttgtg ccccggaagt tatcttgcat gctgtgggag ggaagttgac
      901 agacatccat gggaatgccc tgcagtacaa caaggaggtg aaacatatga actctgccgg
      961 tgtcctggct gcactgagga actacgagta ctatgcaagc catgttccag agtcggtcaa
     1021 aaatgcgctc attccatgaa ggggtctcac ttacccagag gccttggttc aaaggaacac
     1081 atcttaatac tgattactaa ttgaacaatt ggagctctgc ctgcatttat cattgatcag
     1141 cgatttatta gtagttaggg atagaagatg gaattaaaga attttcttca catcatctaa
     1201 tacgcttaag acttaagtat atgatacgat tgtcatttct cctgcctaaa aacaaattag
     1261 ccaggtgtgg tggcacttac aatagtcata gctactccag tggttgaatc agaggattgc
     1321 ttgagcctag cctccattac atagcaagat atgcctaaac acagagaagg aaaacaaaaa
     1381 aggaatttaa ttttactaat tagctaacag gaccagttgt ttttttttgt ttttttgttt
     1441 tttttttttt cctttctctt gttgtttggg ctttttgttt gtttgcttgt ttgtgggttt
     1501 tgttttgttt gtttattttt ttgttttttg tttttgtttt caagacaggg tttctctgtg
     1561 tagccctggc tgtcctggaa ctcactttgt agaccaggct ggccttgaac tcagaaatcc
     1621 gcctgcctct gcctcccgag tgctgggatt aaaggcgtgt gccaccaccg gccggcattg
     1681 tttttgtttt tttgagacag ggtttctctg tgcagcccca gctgtcctgg aactcactct
     1741 gtagacaaag ttggccttgc actcagagat tcccctgcct ctgcctcctt agtgcaggga
     1801 ttaagggctt gccccaccac acctggctca aatgttacta tttctaagtg aagaaatgaa
     1861 aaagggttag tttcaaatga ctgtccaagt catttgtgca gtcaacattc ctgctgataa
     1921 accagatttc ttcagggcac agagtcttaa gttactccag aatttcagtt gttttgtttt
     1981 ttcacagtaa tttttaaaat ttctgattcc aaataagaat gcatataatg atattattta
     2041 tgttgattta tgggggaaag tttctctaaa atacatagtc ctatcttttc atattatata
     2101 tcagattttt ttcaaaagta tttgaaaatt ataaataatg tgaggattaa tttattctct
     2161 tgttattaaa atctataatt gg
//
