LOCUS       NM_001034875            2115 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus BPI fold containing family B, member 4 (Bpifb4), mRNA.
ACCESSION   NM_001034875 XM_355357 XM_905800
VERSION     NM_001034875.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Ciaglia,E., Montella,F., Carrizzo,A., Lopardo,V., Esposito,R.M.,
            Basile,C., Damato,A., De Lucia,M., Maciag,A., Spinetti,G.,
            Milella,M.S., Maselli,D., Vecchione,C. and Puca,A.A.
  TITLE     The longevity-associated BPIFB4 gene guarantees vascular
            homeostasis and immune protection through platelets
  JOURNAL   Geroscience 46 (6), 6347-6359 (2024)
   PUBMED   38884925
  REMARK    GeneRIF: The longevity-associated BPIFB4 gene guarantees vascular
            homeostasis and immune protection through platelets.
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Cattaneo,M., Aleksova,A., Malovini,A., Avolio,E., Thomas,A.,
            Alvino,V.V., Kilcooley,M., Pieronne-Deperrois,M.,
            Ouvrard-Pascaud,A., Maciag,A., Spinetti,G., Kussauer,S., Lemcke,H.,
            Skorska,A., Vasudevan,P., Castiglione,S., Raucci,A., David,R.,
            Richard,V., Beltrami,A.P., Madeddu,P. and Puca,A.A.
  TITLE     BPIFB4 and its longevity-associated haplotype protect from cardiac
            ischemia in humans and mice
  JOURNAL   Cell Death Dis 14 (8), 523 (2023)
   PUBMED   37582912
  REMARK    GeneRIF: BPIFB4 and its longevity-associated haplotype protect from
            cardiac ischemia in humans and mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Cattaneo,M., Beltrami,A.P., Thomas,A.C., Spinetti,G., Alvino,V.V.,
            Avolio,E., Veneziano,C., Rolle,I.G., Sponga,S., Sangalli,E.,
            Maciag,A., Dal Piaz,F., Vecchione,C., Alenezi,A., Paisey,S.,
            Puca,A.A. and Madeddu,P.
  TITLE     The longevity-associated BPIFB4 gene supports cardiac function and
            vascularization in ageing cardiomyopathy
  JOURNAL   Cardiovasc Res 119 (7), 1583-1595 (2023)
   PUBMED   36635236
  REMARK    GeneRIF: The longevity-associated BPIFB4 gene supports cardiac
            function and vascularization in ageing cardiomyopathy.
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Cattaneo,M., Maciag,A., Milella,M.S., Ciaglia,E., Bruno,A. and
            Puca,A.A.
  TITLE     Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in
            the STHdh Cell Model of Huntington Disease
  JOURNAL   Int J Mol Sci 23 (23), 15313 (2022)
   PUBMED   36499641
  REMARK    GeneRIF: Longevity-Associated Variant of BPIFB4 Confers
            Neuroprotection in the STHdh Cell Model of Huntington Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Di Pardo,A., Ciaglia,E., Cattaneo,M., Maciag,A., Montella,F.,
            Lopardo,V., Ferrario,A., Villa,F., Madonna,M., Amico,E.,
            Carrizzo,A., Damato,A., Pepe,G., Marracino,F., Auricchio,A.,
            Vecchione,C., Maglione,V. and Puca,A.A.
  TITLE     The longevity-associated variant of BPIFB4 improves a
            CXCR4-mediated striatum-microglia crosstalk preventing disease
            progression in a mouse model of Huntington's disease
  JOURNAL   Cell Death Dis 11 (7), 546 (2020)
   PUBMED   32683420
  REMARK    GeneRIF: The longevity-associated variant of BPIFB4 improves a
            CXCR4-mediated striatum-microglia crosstalk preventing disease
            progression in a mouse model of Huntington's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Spinelli,C.C., Carrizzo,A., Ferrario,A., Villa,F., Damato,A.,
            Ambrosio,M., Madonna,M., Frati,G., Fucile,S., Sciaccaluga,M.,
            Capunzo,M., Cali,G., Milanesi,L., Maciag,A., Puca,A.A. and
            Vecchione,C.
  TITLE     LAV-BPIFB4 isoform modulates eNOS signalling through
            Ca2+/PKC-alpha-dependent mechanism
  JOURNAL   Cardiovasc Res 113 (7), 795-804 (2017)
   PUBMED   28419216
  REMARK    GeneRIF: LAV-BPIFB4 isoform modulates eNOS signalling through
            Ca2+/PKC-alpha-dependent mechanism.
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Villa,F., Carrizzo,A., Spinelli,C.C., Ferrario,A., Malovini,A.,
            Maciag,A., Damato,A., Auricchio,A., Spinetti,G., Sangalli,E.,
            Dang,Z., Madonna,M., Ambrosio,M., Sitia,L., Bigini,P., Cali,G.,
            Schreiber,S., Perls,T., Fucile,S., Mulas,F., Nebel,A., Bellazzi,R.,
            Madeddu,P., Vecchione,C. and Puca,A.A.
  TITLE     Genetic Analysis Reveals a Longevity-Associated Protein Modulating
            Endothelial Function and Angiogenesis
  JOURNAL   Circ Res 117 (4), 333-345 (2015)
   PUBMED   26034043
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     Comparative analysis of the PLUNC (palate, lung and nasal
            epithelium clone) protein families
  JOURNAL   Biochem Soc Trans 31 (Pt 4), 806-809 (2003)
   PUBMED   12887310
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470156.7.
            
            [WARNING] On Jan 28, 2025 this sequence was replaced by
            NM_001034875.4.
            
            On Feb 12, 2009 this sequence version replaced NM_001034875.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BX470156.7         8280-8400
            122-184             BX470156.7         9262-9324
            185-698             BX470156.7         9961-10474
            699-803             BX470156.7         11403-11507
            804-947             BX470156.7         12136-12279
            948-1011            BX470156.7         14625-14688
            1012-1072           BX470156.7         15042-15102
            1073-1164           BX470156.7         16024-16115
            1165-1368           BX470156.7         17605-17808
            1369-1422           BX470156.7         19533-19586
            1423-1593           BX470156.7         21681-21851
            1594-1661           BX470156.7         24548-24615
            1662-1704           BX470156.7         25137-25179
            1705-1768           BX470156.7         27068-27131
            1769-1845           BX470156.7         28934-29010
            1846-2115           BX470156.7         31001-31270
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.99 cM"
     gene            1..2115
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /note="BPI fold containing family B, member 4"
                     /db_xref="GeneID:381399"
                     /db_xref="MGI:MGI:2685852"
     exon            1..121
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1869
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /note="LBP / BPI / CETP family, N-terminal domain
                     containing protein; long palate, lung and nasal epithelium
                     carcinoma-associated protein 4; ligand-binding protein
                     RY2G5; Novel LBP/BPI/CETP family, N-terminal domain
                     containing protein"
                     /codon_start=1
                     /product="BPI fold-containing family B member 4 precursor"
                     /protein_id="NP_001030047.2"
                     /db_xref="CCDS:CCDS16922.2"
                     /db_xref="GeneID:381399"
                     /db_xref="MGI:MGI:2685852"
                     /translation="MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKS
                     DAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGK
                     YRYGEILDSDGSLRDLRHEDYRPPDSAYHRGSGRYRSAADSSSVGRLYRRELRPGEIP
                     AGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGG
                     ILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNI
                     TAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLC
                     PIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGD
                     LIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDG
                     MFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSE
                     VVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFI
                     LEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST"
     exon            122..184
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            185..698
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            699..803
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            804..947
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1011
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1072
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1164
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1368
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1422
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1593
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1661
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1704
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1768
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1845
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2115
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagcaaca tcagtatgtg gactgcgtgg tgtgtggctg ctctgtcagt ggcagctgtg
       61 tgtggtatcc gccaagacac aaccacagtc ctcagggtta caaaagatgt gctgggcaat
      121 gccatctcag gcacaattca gaagagtgac gccttccgct ccgccctgag ggaggtgccc
      181 gtgggtgtcg gtggtgtccc gtacaacgac ttccatgtcc gagagcctcc ccccaaatac
      241 accaatggca gacagcttgg tggcaattac aaatatggtc acattaaggc gaacgacaat
      301 agagctcagc tggggggcaa gtaccgctat ggggagatcc tggactccga tgggagcctc
      361 agggacctac ggcatgaaga ctaccgtcct ccagacagtg cctaccaccg cggctctggg
      421 cggtacagat ccgccgcaga ctcatcctcg gtgggcaggc tctaccggcg cgaactgagg
      481 cctggagaga tcccagctgg tgtggccact ggggccctgg gccccggagg tctgctgggc
      541 acagggggca tgctggcaaa tgaaggcatt ctggcaggcc aagggggctt gcttggtgga
      601 ggtggtcttc ttggagatgg aggacttctt ggaggaggag gtgtgctcgg tgtgctgggt
      661 gaaggaggca tcctaagcac cgtacaaggc atcactgggt tgcgcatcgt ggaacttacc
      721 cttccccggg tgtccgtgag actcctgccc ggtgtgggtg tctacctgag cttgtacacc
      781 cgtgtggcca tcaacggaag gagcctcatc ggcttcctgg atattgcagt ggaggtaaac
      841 atcacggcca aagttcggct gaccatggac cgcacaggct acccacggtt ggtcattgag
      901 cgctgtgaca ccctcctggg aggtatcaaa gtcaagctgc ttcgagggct tctccccaac
      961 ctggtggaca acttagtgaa ccgagtgctg gccaatgtac tccctgacct gctctgcccc
     1021 attgtggatg tggtattggg tcttgtcaat gaccagctgg gtctcgtgga ctctttggtg
     1081 cctctgggaa tacttgggag tgtgcaatac actttctcca gccttccact ggtgactggg
     1141 gaattccttg agttggacct taatactcta gttggggagg caggaggtga cctcattgac
     1201 taccccctgg ggcggccagc tatattgccc aggccacaga tgccagaact accccccatg
     1261 ggcgacaaca ccaactccca gctggccatc tcagccaatt tcctgagctc ggtgctgacc
     1321 atgctgcaga agcaaggtgc aatggacatt gacatcactg atggcatgtt tgaagatctc
     1381 cctccactta ccacttccac actgggggcc ttgattccca aggtgttcca gcaatacccg
     1441 gaatcccgcc cactcaccat caggatccag gtgcccaacc ctccaactgt gacactgcag
     1501 aaagacaagg cgctggtgaa ggtgttcgcc acctctgaag ttgtggtctc ccagcccaac
     1561 gatgtagaga ccactatctg cctcatcgat gtggacacag acctcttggc ttcattttct
     1621 gtggaaggag ataagctcat gatcgacgcc aagctggata agaccagcct caacctcaga
     1681 acctcaaacg tgggcaactt tgatgtgttc atcttggaaa tgttggttga gaagatcttt
     1741 gacctagcgt ttatgcctgc aatgaatgct atactgggtt ctggagtccc cctgcccaaa
     1801 atcctcaaca ttgacttcag caacgcagac attgatgtgt tggaggacct tctggtgctg
     1861 agcacatgag tgacaaaggt agatgacatg agaagaagtc aaccatcttc agagaggatt
     1921 gtcctagaca ccgccctggt cccaagtctc ttcagccttt atcacaggtc cctgcccaac
     1981 cctcccaccc cttccccttc ctgcccttaa cctgggaaag gatccagcca ctccccattg
     2041 tccaacaatg ccatgctcag gacagcctgg ggactgaggt cttgtgcttt caataaaaca
     2101 tttcactttc cctgc
//
