LOCUS       NP_001030047             617 aa            linear   ROD 06-FEB-2025
DEFINITION  BPI fold-containing family B member 4 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_001030047 XP_006499887 XP_355357 XP_910893
VERSION     NP_001030047.2
DBSOURCE    REFSEQ: accession NM_001034875.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 617)
  AUTHORS   Ciaglia,E., Montella,F., Carrizzo,A., Lopardo,V., Esposito,R.M.,
            Basile,C., Damato,A., De Lucia,M., Maciag,A., Spinetti,G.,
            Milella,M.S., Maselli,D., Vecchione,C. and Puca,A.A.
  TITLE     The longevity-associated BPIFB4 gene guarantees vascular
            homeostasis and immune protection through platelets
  JOURNAL   Geroscience 46 (6), 6347-6359 (2024)
   PUBMED   38884925
  REMARK    GeneRIF: The longevity-associated BPIFB4 gene guarantees vascular
            homeostasis and immune protection through platelets.
REFERENCE   2  (residues 1 to 617)
  AUTHORS   Cattaneo,M., Aleksova,A., Malovini,A., Avolio,E., Thomas,A.,
            Alvino,V.V., Kilcooley,M., Pieronne-Deperrois,M.,
            Ouvrard-Pascaud,A., Maciag,A., Spinetti,G., Kussauer,S., Lemcke,H.,
            Skorska,A., Vasudevan,P., Castiglione,S., Raucci,A., David,R.,
            Richard,V., Beltrami,A.P., Madeddu,P. and Puca,A.A.
  TITLE     BPIFB4 and its longevity-associated haplotype protect from cardiac
            ischemia in humans and mice
  JOURNAL   Cell Death Dis 14 (8), 523 (2023)
   PUBMED   37582912
  REMARK    GeneRIF: BPIFB4 and its longevity-associated haplotype protect from
            cardiac ischemia in humans and mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 617)
  AUTHORS   Cattaneo,M., Beltrami,A.P., Thomas,A.C., Spinetti,G., Alvino,V.V.,
            Avolio,E., Veneziano,C., Rolle,I.G., Sponga,S., Sangalli,E.,
            Maciag,A., Dal Piaz,F., Vecchione,C., Alenezi,A., Paisey,S.,
            Puca,A.A. and Madeddu,P.
  TITLE     The longevity-associated BPIFB4 gene supports cardiac function and
            vascularization in ageing cardiomyopathy
  JOURNAL   Cardiovasc Res 119 (7), 1583-1595 (2023)
   PUBMED   36635236
  REMARK    GeneRIF: The longevity-associated BPIFB4 gene supports cardiac
            function and vascularization in ageing cardiomyopathy.
REFERENCE   4  (residues 1 to 617)
  AUTHORS   Cattaneo,M., Maciag,A., Milella,M.S., Ciaglia,E., Bruno,A. and
            Puca,A.A.
  TITLE     Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in
            the STHdh Cell Model of Huntington Disease
  JOURNAL   Int J Mol Sci 23 (23), 15313 (2022)
   PUBMED   36499641
  REMARK    GeneRIF: Longevity-Associated Variant of BPIFB4 Confers
            Neuroprotection in the STHdh Cell Model of Huntington Disease.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 617)
  AUTHORS   Di Pardo,A., Ciaglia,E., Cattaneo,M., Maciag,A., Montella,F.,
            Lopardo,V., Ferrario,A., Villa,F., Madonna,M., Amico,E.,
            Carrizzo,A., Damato,A., Pepe,G., Marracino,F., Auricchio,A.,
            Vecchione,C., Maglione,V. and Puca,A.A.
  TITLE     The longevity-associated variant of BPIFB4 improves a
            CXCR4-mediated striatum-microglia crosstalk preventing disease
            progression in a mouse model of Huntington's disease
  JOURNAL   Cell Death Dis 11 (7), 546 (2020)
   PUBMED   32683420
  REMARK    GeneRIF: The longevity-associated variant of BPIFB4 improves a
            CXCR4-mediated striatum-microglia crosstalk preventing disease
            progression in a mouse model of Huntington's disease.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 617)
  AUTHORS   Spinelli,C.C., Carrizzo,A., Ferrario,A., Villa,F., Damato,A.,
            Ambrosio,M., Madonna,M., Frati,G., Fucile,S., Sciaccaluga,M.,
            Capunzo,M., Cali,G., Milanesi,L., Maciag,A., Puca,A.A. and
            Vecchione,C.
  TITLE     LAV-BPIFB4 isoform modulates eNOS signalling through
            Ca2+/PKC-alpha-dependent mechanism
  JOURNAL   Cardiovasc Res 113 (7), 795-804 (2017)
   PUBMED   28419216
  REMARK    GeneRIF: LAV-BPIFB4 isoform modulates eNOS signalling through
            Ca2+/PKC-alpha-dependent mechanism.
REFERENCE   7  (residues 1 to 617)
  AUTHORS   Villa,F., Carrizzo,A., Spinelli,C.C., Ferrario,A., Malovini,A.,
            Maciag,A., Damato,A., Auricchio,A., Spinetti,G., Sangalli,E.,
            Dang,Z., Madonna,M., Ambrosio,M., Sitia,L., Bigini,P., Cali,G.,
            Schreiber,S., Perls,T., Fucile,S., Mulas,F., Nebel,A., Bellazzi,R.,
            Madeddu,P., Vecchione,C. and Puca,A.A.
  TITLE     Genetic Analysis Reveals a Longevity-Associated Protein Modulating
            Endothelial Function and Angiogenesis
  JOURNAL   Circ Res 117 (4), 333-345 (2015)
   PUBMED   26034043
REFERENCE   8  (residues 1 to 617)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   9  (residues 1 to 617)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   10 (residues 1 to 617)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     Comparative analysis of the PLUNC (palate, lung and nasal
            epithelium clone) protein families
  JOURNAL   Biochem Soc Trans 31 (Pt 4), 806-809 (2003)
   PUBMED   12887310
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470156.7.
            
            On or before Jan 28, 2025 this sequence version replaced
            XP_006499887.1, NP_001030047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.99 cM"
     Protein         1..617
                     /product="BPI fold-containing family B member 4 isoform 1
                     precursor"
                     /note="LBP / BPI / CETP family, N-terminal domain
                     containing protein; long palate, lung and nasal epithelium
                     carcinoma-associated protein 4; ligand-binding protein
                     RY2G5; Novel LBP/BPI/CETP family, N-terminal domain
                     containing protein"
                     /calculated_mol_wt=64002
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1739
     mat_peptide     18..617
                     /product="BPI fold-containing family B member 4.
                     /id=PRO_0000355589"
                     /note="propagated from UniProtKB/Swiss-Prot (A2BGH0.1)"
                     /calculated_mol_wt=64002
     Region          117..142
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2BGH0.1)"
     Region          221..391
                     /region_name="BPI1"
                     /note="BPI/LBP/CETP N-terminal domain; smart00328"
                     /db_xref="CDD:214622"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A2BGH0.1)"
     Region          417..617
                     /region_name="BPI2"
                     /note="BPI/LBP/CETP C-terminal domain; smart00329"
                     /db_xref="CDD:128624"
     Site            order(425,430,433,437,440,499,532,534,543,579,583,587,613)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     CDS             1..617
                     /gene="Bpifb4"
                     /gene_synonym="Gm1006; Lplunc4"
                     /coded_by="NM_001034875.4:72..1925"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS16922.2"
                     /db_xref="GeneID:381399"
                     /db_xref="MGI:MGI:2685852"
ORIGIN      
        1 mwtawcvaal svaavcgirq dtttvlrvtk dvlgnaisgt iqksdafrsa lrevpvgvgg
       61 vpyndfhvre pppkytngrq lggnykyghi kandnraqlg gkyrygeild sdgslrdlrh
      121 edyrppdsay hrgsgryrsa adsssvgrly rrelrpgeip agvatgalgp ggllgtggml
      181 anegilagqg gllggggllg dggllggggv lgvlgeggil stvqgitglr iveltlprvs
      241 vrllpgvgvy lslytrvain grsligfldi avevnitakv rltmdrtgyp rlviercdtl
      301 lggikvkllr gllpnlvdnl vnrvlanvlp dllcpivdvv lglvndqlgl vdslvplgil
      361 gsvqytfssl plvtgeflel dlntlvgeag gdlidyplgr pailprpqmp elppmgdntn
      421 sqlaisanfl ssvltmlqkq gamdiditdg mfedlppltt stlgalipkv fqqypesrpl
      481 tiriqvpnpp tvtlqkdkal vkvfatsevv vsqpndvett iclidvdtdl lasfsvegdk
      541 lmidakldkt slnlrtsnvg nfdvfileml vekifdlafm pamnailgsg vplpkilnid
      601 fsnadidvle dllvlst
//
