LOCUS       NM_001379473            1744 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus BPI fold containing family B, member 3 (Bpifb3),
            transcript variant 2, mRNA.
ACCESSION   NM_001379473 XM_006499812
VERSION     NM_001379473.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Andrault,J.B., Gaillard,I., Giorgi,D. and Rouquier,S.
  TITLE     Expansion of the BPI family by duplication on human chromosome 20:
            characterization of the RY gene cluster in 20q11.21 encoding
            olfactory transporters/antimicrobial-like peptides
  JOURNAL   Genomics 82 (2), 172-184 (2003)
   PUBMED   12837268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833803.8.
            
            On Apr 3, 2020 this sequence version replaced XM_006499812.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.112242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL833803.8         210063-210114
            53-178              AL833803.8         211291-211416
            179-335             AL833803.8         212159-212315
            336-440             AL833803.8         213815-213919
            441-581             AL833803.8         214236-214376
            582-645             AL833803.8         215506-215569
            646-706             AL833803.8         216430-216490
            707-798             AL833803.8         217204-217295
            799-978             AL833803.8         217413-217592
            979-1032            AL833803.8         218955-219008
            1033-1203           AL833803.8         220323-220493
            1204-1271           AL833803.8         220979-221046
            1272-1314           AL833803.8         222176-222218
            1315-1378           AL833803.8         223082-223145
            1379-1455           AL833803.8         223559-223635
            1456-1744           AL833803.8         224377-224665
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.99 cM"
     gene            1..1744
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI fold containing family B, member 3"
                     /db_xref="GeneID:378700"
                     /db_xref="MGI:MGI:2675077"
     exon            1..52
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            53..178
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1485
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="long palate, lung and nasal epithelium
                     carcinoma-associated protein 3; ligand-binding protein
                     RYA3; antimicrobial peptide RYA3"
                     /codon_start=1
                     /product="BPI fold-containing family B member 3 precursor"
                     /protein_id="NP_001366402.1"
                     /db_xref="GeneID:378700"
                     /db_xref="MGI:MGI:2675077"
                     /translation="MMLGVYTLLLLWGLATPCLGLLETVGTLARIDKDELGKAIQNSL
                     VGGPILQNVLGTVTSVNQGLLGAGGLLGGGGLLSYGGIFSLVEELSGLKIEELTLPKV
                     SLKLLPGVGVQLNLHTKVSLHGSGPLVGLLQLAAEVNVSSKVALGMSPRGTPILVLKR
                     CSTLLGHISLMSGLLPTPIFGLVEQTLCKVLPGLLCPVVDSVLSVVNELLGATLSLVP
                     LGPLGSVEFTLATLPLISNQYIELDINPIVKSIAGDVIDFPKPRIPVKVPPKEDHTSQ
                     VTVPLYLFSTVFGLLQTNGALDLDITPEMVPRNVPLTTTDLAALAPEALGKLPPAQHL
                     LLSLRVTKSPMVLLQNKKATVSIPVTIHVLSSVPQGTPVALFQLNGVMTLNAHLAPSS
                     TKLHISLSLERLSVQLASSFPQPFDASRLEEWLSDVVRAAYMQRLNEHLEVGIPLPKI
                     LNVNFANSVVDIIENAVVLTVAP"
     exon            179..335
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            336..440
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..581
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..645
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..706
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..798
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..978
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1032
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1203
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1271
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1314
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1378
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1455
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1744
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="hexamer: AATAAA"
     polyA_site      1744
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="major polyA site"
ORIGIN      
        1 agaggctggc aggaggctgg gaacccactt acagagcagg aggaacaggc tggtgtgcag
       61 ctgatgatgc tgggtgtgta taccctgctt ctgctctggg gcctggccac tccatgcctg
      121 gggctgcttg agacagtggg cacgcttgct cggattgaca aggatgaact gggcaaagcc
      181 atccagaact ccctagttgg gggccctatt ctgcaaaacg tgctggggac tgtgacatca
      241 gtgaaccagg gcctcctggg tgcaggaggg ctgctcggag gtggtggcct gctgagttac
      301 ggtggcatct ttagtcttgt ggaagaactc tctgggctga agatagagga actaactttg
      361 cccaaagtgt cactcaagct gctgccgggg gtcggggtgc agctgaacct gcacaccaag
      421 gttagcctgc atggctccgg tcccctggtg ggcctcctgc agctggccgc agaggtgaac
      481 gtgtcttcga aagtggcact gggcatgagt cctcggggga cacccatcct tgtccttaag
      541 cgctgcagca cgctcctggg tcacatcagt ctgatgtcag ggctgctgcc cacgccaatc
      601 tttgggctcg tagaacagac actgtgcaag gtgctgcctg gactgctgtg ccctgtggta
      661 gacagtgtgc tgagtgtggt gaatgagctc ttgggagcta cgctgagcct ggtgcccctt
      721 gggcctctgg ggtctgtgga gttcactctg gctacacttc ccctaatctc caaccagtac
      781 attgagctgg atataaatcc catcgtgaag agcatagctg gagatgtcat tgatttcccc
      841 aagccacgca tcccagtcaa ggtgcccccc aaagaggacc acacctccca agtgactgtc
      901 ccactctatc tcttcagcac cgtgtttggg ctcctgcaaa ccaacggtgc ccttgacctg
      961 gacatcaccc ctgagatggt tcccaggaat gtccctctga caactactga cctggcagct
     1021 ttggctcctg aggccctggg gaaactgccc cctgctcagc acctcctgct ctcgctgcgg
     1081 gtgacaaaat cgcccatggt cctgctgcag aacaagaagg ccacagtctc catcccagtc
     1141 accatccatg tgctgtcttc tgtccctcaa ggaactcctg tagccctttt ccagttgaat
     1201 ggggttatga ctctaaatgc ccacctggct ccatcctcta ccaagctgca catatctctg
     1261 tccctggaac ggctaagtgt ccagctggcc tcctcctttc cccaaccttt tgatgcatcc
     1321 cgtctggaag aatggctcag tgatgtggtc cgggctgcct acatgcagag gctcaacgag
     1381 cacctggagg ttggaattcc cctgcctaag attctcaatg tcaactttgc caattcagtg
     1441 gtcgatatca ttgagaatgc agttgtgctc acagtggctc cgtgaggcgg tatggctgct
     1501 gctctccctg ttcactacag agtcctatct gtctgcccac tctgcctcag tttccctccc
     1561 agtcttaagc ctgcattggt gacagtataa gtgccccttg cccacccggg cccaccttgc
     1621 cctctgttcc tgtgatcatg cctgttttgg ggtggggatg gctggatagc cactgatctg
     1681 cttcagaaag cacatagcac cttggttcaa tcccagcttt aataaactga tccttggtct
     1741 tgtg
//
