LOCUS       NM_001012392            1690 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus BPI fold containing family B, member 1 (Bpifb1),
            transcript variant 1, mRNA.
ACCESSION   NM_001012392
VERSION     NM_001012392.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Donoghue,L.J., Markovetz,M.R., Morrison,C.B., Chen,G.,
            McFadden,K.M., Sadritabrizi,T., Gutay,M.I., Kato,T., Rogers,T.D.,
            Snead,J.Y., Livraghi-Butrico,A., Button,B., Ehre,C., Grubb,B.R.,
            Hill,D.B. and Kelada,S.N.P.
  TITLE     BPIFB1 loss alters airway mucus properties and diminishes
            mucociliary clearance
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L765-L775 (2023)
   PUBMED   37847709
  REMARK    GeneRIF: BPIFB1 loss alters airway mucus properties and diminishes
            mucociliary clearance.
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Rogers,T.D., Button,B., Kelada,S.N.P., Ostrowski,L.E.,
            Livraghi-Butrico,A., Gutay,M.I., Esther,C.R. Jr. and Grubb,B.R.
  TITLE     Regional Differences in Mucociliary Clearance in the Upper and
            Lower Airways
  JOURNAL   Front Physiol 13, 842592 (2022)
   PUBMED   35356083
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Donoghue,L.J., Livraghi-Butrico,A., McFadden,K.M., Thomas,J.M.,
            Chen,G., Grubb,B.R., O'Neal,W.K., Boucher,R.C. and Kelada,S.N.P.
  TITLE     Identification of trans Protein QTL for Secreted Airway Mucins in
            Mice and a Causal Role for Bpifb1
  JOURNAL   Genetics 207 (2), 801-812 (2017)
   PUBMED   28851744
  REMARK    GeneRIF: BPIFB1 is a novel regulator of MUC5B expression in airway
            mucosa.
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Furtado,M.B., Solloway,M.J., Jones,V.J., Costa,M.W., Biben,C.,
            Wolstein,O., Preis,J.I., Sparrow,D.B., Saga,Y., Dunwoodie,S.L.,
            Robertson,E.J., Tam,P.P. and Harvey,R.P.
  TITLE     BMP/SMAD1 signaling sets a threshold for the left/right pathway in
            lateral plate mesoderm and limits availability of SMAD4
  JOURNAL   Genes Dev 22 (21), 3037-3049 (2008)
   PUBMED   18981480
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   LeClair,E.E., Nomellini,V., Bahena,M., Singleton,V., Bingle,L.,
            Craven,C.J. and Bingle,C.D.
  TITLE     Cloning and expression of a mouse member of the PLUNC protein
            family exclusively expressed in tongue epithelium
  JOURNAL   Genomics 83 (4), 658-666 (2004)
   PUBMED   15028288
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Hou,J., Yashiro,K., Okazaki,Y., Saijoh,Y., Hayashizaki,Y. and
            Hamada,H.
  TITLE     Identification of a novel left-right asymmetrically expressed gene
            in the mouse belonging to the BPI/PLUNC superfamily
  JOURNAL   Dev Dyn 229 (2), 373-379 (2004)
   PUBMED   14745963
  REMARK    GeneRIF: a novel gene LPlunc1, a member of BPI/PLUNC gene
            superfamily, which is asymmetrically expressed in the developing
            mouse node [LPlunc1 protein]
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060982.1 and U46068.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060982.1, BC100436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               BC060982.1         1-527
            528-1690            U46068.3           492-1654
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="Swiss Webster"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.23 cM"
     gene            1..1690
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /note="BPI fold containing family B, member 1"
                     /db_xref="GeneID:228801"
                     /db_xref="MGI:MGI:2137431"
     exon            1..76
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..233
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1543
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /note="von Ebner minor salivary gland protein; long
                     palate, lung and nasal epithelium carcinoma-associated
                     protein 1; long palate, lung and nasal epithelium
                     carcinoma associated 1; von Ebner minor salivary protein"
                     /codon_start=1
                     /product="BPI fold-containing family B member 1 precursor"
                     /protein_id="NP_001012392.1"
                     /db_xref="CCDS:CCDS16927.1"
                     /db_xref="GeneID:228801"
                     /db_xref="MGI:MGI:2137431"
                     /translation="MAGPWIITLLCGLLGATLVQANVYPPAVLNLGPEVIQKHLTQAL
                     KDHDATAILQELPLLRAMQDKSGSIPILDSFVHTVLRYIIWMKVTSANILQLDVQPST
                     YDQELVVRIPLDMVAGLNTPLIKTIVEFQMSTEVQALIRVERSKSGPAHLNLSDCSSN
                     ESTLRLSLLHKLSFVVNSLAKNVMNLLVPALPQIVKNHLCPVIQQAFDDMYEDFLRLT
                     TAPIALSPGALEFGLLSPAIQDSNILLNLKAKLLDSQARVTNWFNNSATSLMETTPDR
                     APFSLTVRQDLVNAIVTTLVPKEELVILLRFVIPDVARQLQMDIKEINAEAANKLGPT
                     QMLKIFTHSTPHIVLNEGSARAAQSVVLEVFPTNTDVRPFFSLGIEASYEAQFFTEDN
                     RLMLNFNNVSIERIKLMISDIKLFDPEVLKDTLTKILEYTLLPNENGKLRTGVPMSMS
                     KALGYEKAMWSVSKGALKLTPASS"
     exon            234..372
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..480
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..630
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..712
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..776
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..862
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1042
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1096
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1255
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1323
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1369
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1433
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1510
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1673
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
     polyA_site      1673
                     /gene="Bpifb1"
                     /gene_synonym="Lplunc1"
ORIGIN      
        1 agaacaggtg cagaggtgag agaagtcgct tcgcttgggt ctcagaggtt ccacggttgg
       61 acacagccac cccgaggtcc tactacctgc cacctacttc tcagcgacac ccaggaagat
      121 ggccggcccg tggattatca ccctcctctg tggtttgctg ggagccacac tggtccaagc
      181 taacgtctat ccccctgcag tgctcaacct tggcccagaa gtcatccaga aacacctgac
      241 ccaggcactg aaggaccatg atgccactgc catcctccag gagttgccac tgctcagagc
      301 catgcaagat aagtctggca gtatccccat actggacagc ttcgtgcaca ccgttctgag
      361 atacatcata tggatgaagg tcacctctgc taacatcctc cagctggatg tgcagccttc
      421 aacttatgac caggagctgg tggtcagaat ccccctggac atggtggctg gactaaacac
      481 accactgatc aagaccatag tggagttcca aatgagcacc gaggtccaag ccctcatccg
      541 ggtggagagg agcaagagcg gccccgccca cctgaatctc agcgactgct ccagcaatga
      601 gagcaccctg cgcctcagcc tgcttcacaa gctctccttc gtggtcaact ccttggcaaa
      661 gaatgttatg aatctcctgg tgccagccct gccccaaata gtgaaaaacc acctgtgccc
      721 tgtgatccag caggcctttg atgacatgta cgaagacttc ctgagactga caacagcacc
      781 cattgccctc agtcctggag ccctggagtt tggccttctg tctcctgcta tccaggacag
      841 taatatcctg ttgaacctga aggccaagct gctggactca caggcgaggg taaccaactg
      901 gttcaacaac tctgcgactt ctctgatgga gaccacccca gacagggccc ccttcagcct
      961 gaccgtgagg caggacctgg tgaatgccat tgtgaccacc ctggtcccca aggaggagct
     1021 tgtaatcctg ctcagattcg tgattcctga tgtggcccgc cagttacaga tggacatcaa
     1081 ggaaatcaat gcagaggcag ccaacaagct ggggcccacc cagatgttga agatcttcac
     1141 ccacagcacc ccccacattg tgctgaacga gggcagtgcc agggcagccc aaagtgtcgt
     1201 gctggaagtg ttccctacca acactgatgt ccggcccttc ttctctctcg gcattgaggc
     1261 cagttatgaa gctcagttct tcacagaaga caaccggctt atgctcaact tcaataacgt
     1321 cagtattgag cgcatcaagc tgatgatctc agatatcaaa ctattcgatc ctgaagtcct
     1381 gaaggacacc ctgaccaaga tccttgaata cacactgctg cccaatgaga atggcaaact
     1441 gagaactgga gtccccatgt caatgtccaa ggccttggga tacgagaaag ccatgtggtc
     1501 tgtgagcaag ggtgccctca agctcactcc agcctcctcc tagaaccctg gctccccgcc
     1561 cctcctgatg aagacctgga cagtagcagc cagccccggc caggtcccag ccaggagtgt
     1621 ggaagcctac tgtgtagact acccccctgc agttaataaa cacttgcccg tggaaaaaaa
     1681 aaaaaaaaaa
//
