LOCUS       NM_008953                974 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BPI fold containing family A, member 2 (Bpifa2), mRNA.
ACCESSION   NM_008953
VERSION     NM_008953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Hauser,B.R., Aure,M.H., Kelly,M.C., Hoffman,M.P. and Chibly,A.M.
  CONSRTM   Genomics and Computational Biology Core
  TITLE     Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland
            Development
  JOURNAL   iScience 23 (12), 101838 (2020)
   PUBMED   33305192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Nandula,S.R., Huxford,I., Wheeler,T.T., Aparicio,C. and Gorr,S.U.
  TITLE     The parotid secretory protein BPIFA2 is a salivary surfactant that
            affects lipopolysaccharide action
  JOURNAL   Exp Physiol 105 (8), 1280-1292 (2020)
   PUBMED   32390232
  REMARK    GeneRIF: The parotid secretory protein BPIFA2 is a salivary
            surfactant that affects lipopolysaccharide action.
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Kota,S.K., Pernicone,E., Leaf,D.E., Stillman,I.E., Waikar,S.S. and
            Kota,S.B.
  TITLE     BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is
            an Early Biomarker of AKI
  JOURNAL   J Am Soc Nephrol 28 (12), 3473-3478 (2017)
   PUBMED   28775000
  REMARK    GeneRIF: BPIFA2 may have a role in acute kidney injury
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Belknap,J.K., Phillips,T.J. and O'Toole,L.A.
  TITLE     Quantitative trait loci associated with brain weight in the BXD/Ty
            recombinant inbred mouse strains
  JOURNAL   Brain Res Bull 29 (3-4), 337-344 (1992)
   PUBMED   1393606
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Pilz,A., Le Tissier,P., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Mapping of the structural gene for S-adenosyl homocysteine
            hydrolase to mouse chromosome 2, and related sequences to
            chromosomes 8 and X
  JOURNAL   Mamm Genome 3 (11), 633-636 (1992)
   PUBMED   1450513
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Welsh,J., Petersen,C. and McClelland,M.
  TITLE     Polymorphisms generated by arbitrarily primed PCR in the mouse:
            application to strain identification and genetic mapping
  JOURNAL   Nucleic Acids Res 19 (2), 303-306 (1991)
   PUBMED   2014169
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Siracusa,L.D., Silan,C.M., Justice,M.J., Mercer,J.A., Bauskin,A.R.,
            Ben-Neriah,Y., Duboule,D., Hastie,N.D., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     A molecular genetic linkage map of mouse chromosome 2
  JOURNAL   Genomics 6 (3), 491-504 (1990)
   PUBMED   1970329
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Joseph,D.R., Sullivan,P.M., Wang,Y.M., Kozak,C.,
            Fenstermacher,D.A., Behrendsen,M.E. and Zahnow,C.A.
  TITLE     Characterization and expression of the complementary DNA encoding
            rat histidine decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 733-737 (1990)
   PUBMED   2300558
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1990 Sep;87(18):7346]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC010288.1.
            
            On Jun 19, 2003 this sequence version replaced NM_008953.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053336.1, BG870337.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384,
                                           SAMN00849387 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.15 cM"
     gene            1..974
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /note="BPI fold containing family A, member 2"
                     /db_xref="GeneID:19194"
                     /db_xref="MGI:MGI:97787"
     exon            1..36
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            37..165
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..752
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /note="parotid secretory protein; BPI fold containing
                     family A, member 2E"
                     /codon_start=1
                     /product="BPI fold-containing family A member 2 precursor"
                     /protein_id="NP_032979.1"
                     /db_xref="CCDS:CCDS16923.1"
                     /db_xref="GeneID:19194"
                     /db_xref="MGI:MGI:97787"
                     /translation="MFQLGSLVVLCGLLIGNSESLLGELGSAVNNLKILNPPSEAVPQ
                     NLNLDVELLQQATSWPLAKNSILETLNTADLGNLKSFTSLNGLLLKINNLKVLDFQAK
                     LSSNGNGIDLTVPLAGEASLVLPFIGKTVDISVSLDLINSLSIKTNAQTGLPEVTIGK
                     CSSNTDKISISLLGRRLPIINSILDGVSTLLTSTLSTVLQNFLCPLLQYVLSTLNPSV
                     LQGLLSNLLAGQVQLAL"
     exon            166..307
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            308..415
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            416..568
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            569..650
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            651..714
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            715..789
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            790..961
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      944..949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /note="hexamer: ATTAAA"
     polyA_site      961
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /note="major polyA site"
ORIGIN      
        1 caaggatctc tctcgtgtgc atccttcttc aaagcaaacc aaagatgttc caacttggga
       61 gccttgttgt cttgtgtggc ctgctcattg ggaactcaga gtcacttctt ggtgaacttg
      121 gcagcgctgt gaataatttg aaaattctga atcctccctc tgaagctgtc cctcagaacc
      181 tgaatctgga tgtggagttg cttcagcaag ccacaagttg gccattagcc aagaacagca
      241 ttctagaaac gttgaacaca gcggaccttg gcaatttaaa aagctttaca tctttgaatg
      301 gtttattgtt gaaaatcaat aatctcaaag tcctggattt tcaagctaag ctgtcttcca
      361 acggcaatgg cattgatctg acggtgccct tggctgggga agcctccttg gttctgcctt
      421 tcattggcaa gacggtcgac atttctgttt ccttggacct cataaattca ctctccatta
      481 aaaccaatgc ccagactggc cttcctgagg tgaccatagg caaatgctcc agtaatacag
      541 ataaaatctc catttccttg ttgggaagac gattacccat catcaacagt attctggatg
      601 gtgtctctac cctccttaca agtacattgt caaccgtcct gcaaaacttc ctatgtccat
      661 tgcttcagta cgtcctcagc acactgaatc caagtgttct tcagggtctc ctctctaatc
      721 tactggcagg acaggtacaa cttgccctct gaagaggaag aacagaagga tgccacaact
      781 ctcctgctgg ctactctcca gtggtttcat cttacttctg atggcatttc cctctagaaa
      841 gtgctactat catccacaca tttctacctg agaccaccca aaggaccctc ccaaattctc
      901 ttcctctctg agtagtctcc acacctgtta ccaccatccc agaattaaaa tcctaactgc
      961 aaaaaaaaaa aaaa
//
