LOCUS       NM_011126               1109 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus BPI fold containing family A, member 1 (Bpifa1), mRNA.
ACCESSION   NM_011126
VERSION     NM_011126.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1109)
  AUTHORS   Iannuzo,N., Welfley,H., Li,N.C., Johnson,M.D.L., Rojas-Quintero,J.,
            Polverino,F., Guerra,S., Li,X., Cusanovich,D.A., Langlais,P.R. and
            Ledford,J.G.
  TITLE     CC16 drives VLA-2-dependent SPLUNC1 expression
  JOURNAL   Front Immunol 14, 1277582 (2023)
   PUBMED   38053993
  REMARK    GeneRIF: CC16 drives VLA-2-dependent SPLUNC1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1109)
  AUTHORS   Gao,H., Cao,M., Deng,K., Yang,Y., Song,J., Ni,M., Xie,C., Fan,W.,
            Ou,C., Huang,D., Lin,L., Liu,L., Li,Y., Sun,H., Cheng,X., Wu,J.,
            Xia,C., Deng,X., Mou,L. and Chen,P.
  TITLE     The Lineage Differentiation and Dynamic Heterogeneity of Thymic
            Epithelial Cells During Thymus Organogenesis
  JOURNAL   Front Immunol 13, 805451 (2022)
   PUBMED   35273595
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1109)
  AUTHORS   Jaiswal,A.K., Yadav,J., Makhija,S., Sandey,M., Suryawanshi,A.,
            Mitra,A.K. and Mishra,A.
  TITLE     Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level
            determines steroid-resistant airway inflammation in aging
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (1), L102-L115 (2022)
   PUBMED   34851736
  REMARK    GeneRIF: Short palate, lung, and nasal epithelial clone 1 (SPLUNC1)
            level determines steroid-resistant airway inflammation in aging.
REFERENCE   4  (bases 1 to 1109)
  AUTHORS   Ahmad,S., Kim,C.S.K. and Tarran,R.
  TITLE     The SPLUNC1-betaENaC complex prevents Burkholderia cenocepacia
            invasion in normal airway epithelia
  JOURNAL   Respir Res 21 (1), 190 (2020)
   PUBMED   32680508
  REMARK    GeneRIF: The SPLUNC1-betaENaC complex prevents Burkholderia
            cenocepacia invasion in normal airway epithelia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1109)
  AUTHORS   Del-Pozo,J., MacIntyre,N., Azar,A., Glover,J., Milne,E. and
            Cheeseman,M.
  TITLE     Chronic otitis media is initiated by a bulla cavitation defect in
            the FBXO11 mouse model
  JOURNAL   Dis Model Mech 12 (3) (2019)
   PUBMED   30898767
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1109)
  AUTHORS   LeClair,E.E., Nomellini,V., Bahena,M., Singleton,V., Bingle,L.,
            Craven,C.J. and Bingle,C.D.
  TITLE     Cloning and expression of a mouse member of the PLUNC protein
            family exclusively expressed in tongue epithelium
  JOURNAL   Genomics 83 (4), 658-666 (2004)
   PUBMED   15028288
  REMARK    GeneRIF: splunc5, splunc1, and lplunc1 are expressed in unique
            domains along a continuous corridor of oral, lingual, pharyngeal,
            and respiratory epithelia
REFERENCE   7  (bases 1 to 1109)
  AUTHORS   Sung,Y.K., Moon,C., Yoo,J.Y., Moon,C., Pearse,D., Pevsner,J. and
            Ronnett,G.V.
  TITLE     Plunc, a member of the secretory gland protein family, is
            up-regulated in nasal respiratory epithelium after olfactory
            bulbectomy
  JOURNAL   J Biol Chem 277 (15), 12762-12769 (2002)
   PUBMED   11821380
REFERENCE   8  (bases 1 to 1109)
  AUTHORS   LeClair,E.E., Nguyen,L., Bingle,L., MacGowan,A., Singleton,V.,
            Ward,S.J. and Bingle,C.D.
  TITLE     Genomic organization of the mouse plunc gene and expression in the
            developing airways and thymus
  JOURNAL   Biochem Biophys Res Commun 284 (3), 792-797 (2001)
   PUBMED   11396972
REFERENCE   9  (bases 1 to 1109)
  AUTHORS   Bingle,C.D. and Bingle,L.
  TITLE     Characterisation of the human plunc gene, a gene product with an
            upper airways and nasopharyngeal restricted expression pattern
  JOURNAL   Biochim Biophys Acta 1493 (3), 363-367 (2000)
   PUBMED   11018263
REFERENCE   10 (bases 1 to 1109)
  AUTHORS   Weston,W.M., LeClair,E.E., Trzyna,W., McHugh,K.M., Nugent,P.,
            Lafferty,C.M., Ma,L., Tuan,R.S. and Greene,R.M.
  TITLE     Differential display identification of plunc, a novel gene
            expressed in embryonic palate, nasal epithelium, and adult lung
  JOURNAL   J Biol Chem 274 (19), 13698-13703 (1999)
   PUBMED   10224143
  REMARK    Erratum:[J Biol Chem 2000 Mar 17;275(11):8262]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY121014.1 and BC054375.1.
            
            On Apr 28, 2009 this sequence version replaced NM_011126.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69172.1, BC054375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY121014.1         2-20
            20-1109             BC054375.1         1-1090
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.15 cM"
     gene            1..1109
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /note="BPI fold containing family A, member 1"
                     /db_xref="GeneID:18843"
                     /db_xref="MGI:MGI:1338036"
     exon            1..47
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            48..294
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..896
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /note="palate, lung, and nasal epithelium clone; protein
                     Plunc; palate lung and nasal epithelium clone protein;
                     palate, lung, and nasal epithelium associated; palate,
                     lung, and nasal epithelium expressed transcript"
                     /codon_start=1
                     /product="BPI fold-containing family A member 1 precursor"
                     /protein_id="NP_035256.2"
                     /db_xref="CCDS:CCDS16925.1"
                     /db_xref="GeneID:18843"
                     /db_xref="MGI:MGI:1338036"
                     /translation="MFLVGSLVVLCGLLAHSTAQLAGLPLPLGQGPPLPLNQGPPLPL
                     NQGQLLPLAQGLPLAVSPALPSNPTDLLAGKFTDALSGGLLSGGLLGILENIPLLDVI
                     KSGGGNSNGLVGGLLGKLTSSVPLLNNILDIKITDPQLLELGLVQSPDGHRLYVTIPL
                     GLTLNVNMPVVGSLLQLAVKLNITAEVLAVKDNQGRIHLVLGDCTHSPGSLKISLLNG
                     VTPVQSFLDNLTGILTKVLPELIQGKVCPLVNGILSGLDVTLVHNIAELLIHGLQFVI
                     KV"
     exon            295..454
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            455..562
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            563..712
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            713..791
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            792..855
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            856..931
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1104
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1082..1087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /note="hexamer: AATAAA"
     polyA_site      1102
                     /gene="Bpifa1"
                     /gene_synonym="LUNX; NASG; Plunc; SPLUNC1; SPURT"
                     /note="major polyA site"
ORIGIN      
        1 gtgataggag aggagcccag gacgaccact gagaccttga gactcagaca ccaagagaga
       61 tgtttctagt tgggagcctc gttgtcctct gtgggctgct ggcccacagc acagcacagc
      121 tggcaggctt gccattgccc ctgggccagg gtccaccctt gccactgaac cagggcccac
      181 cgttgccact gaaccagggc cagctgttgc ccctggctca gggtctgcct ttggctgtaa
      241 gcccagcact gccttcaaat cccacagatc ttcttgctgg aaaattcaca gatgctctca
      301 gcggtggcct gctgtctggg gggctgctgg gcattttgga aaatattcca ctcctggatg
      361 ttataaagtc tggaggaggc aattctaatg gccttgttgg gggcctgctg ggaaaactga
      421 cgtcatcagt tcctctcctg aacaacatcc tcgacataaa aatcactgat ccgcagctgc
      481 tagaacttgg tcttgtgcag agtcctgatg gccatcgtct ctatgtcacc atccctctgg
      541 gcttgacact caacgtaaat atgcccgtag ttggaagtct tttgcaattg gctgtgaagc
      601 tgaacattac tgcagaagtc ttagccgtga aagacaatca ggggaggatt catctggttc
      661 ttggtgactg cacccactcc cctggcagcc tgaaaatcag cttgctcaat ggagtcactc
      721 ctgttcaaag ctttttagac aacctcacag ggatattgac taaagtcctt cctgagctga
      781 tccagggcaa ggtatgtcct ctggtcaatg ggattctcag cggtttggat gtcaccctgg
      841 tgcacaacat tgctgaatta ctgatccatg gactacagtt tgtcatcaaa gtttaggcat
      901 cccaggaagg aaggctatct tggctgagct gaatcatttc ttgctgctca gtctcctgcc
      961 tcttgcccag tctcccatgg ctcacagaaa ggggcccaca tcctggaaaa ttatgtcttc
     1021 cttctcctca cggagcctga tctcttccca tcaggcacga ttaatcctgt gatcctcact
     1081 aaataaaata gctcttcatc tgcaaaaaa
//
