LOCUS       NM_001356542            1770 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus bactericidal permeablility increasing protein (Bpi),
            transcript variant 2, mRNA.
ACCESSION   NM_001356542 XM_006499789
VERSION     NM_001356542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Bulow,S., Ederer,K.U., Holzinger,J.M., Zeller,L., Werner,M.,
            Toelge,M., Pfab,C., Hirsch,S., Gopferich,F., Hiergeist,A.,
            Berberich-Siebelt,F. and Gessner,A.
  TITLE     Bactericidal/permeability-increasing protein instructs dendritic
            cells to elicit Th22 cell response
  JOURNAL   Cell Rep 43 (3), 113929 (2024)
   PUBMED   38457343
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Chuang,H.C., Chen,M.H., Chen,Y.M., Yang,H.Y., Ciou,Y.R.,
            Hsueh,C.H., Tsai,C.Y. and Tan,T.H.
  TITLE     BPI overexpression suppresses Treg differentiation and induces
            exosome-mediated inflammation in systemic lupus erythematosus
  JOURNAL   Theranostics 11 (20), 9953-9966 (2021)
   PUBMED   34815797
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Theprungsirikul,J., Skopelja-Gardner,S., Wierzbicki,R.M.,
            Sessions,K.J. and Rigby,W.F.C.
  TITLE     Differential Enhancement of Neutrophil Phagocytosis by
            Anti-Bactericidal/Permeability-Increasing Protein Antibodies
  JOURNAL   J Immunol 207 (3), 777-783 (2021)
   PUBMED   34272233
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Theprungsirikul,J., Skopelja-Gardner,S., Burns,A.S.,
            Wierzbicki,R.M. and Rigby,W.F.C.
  TITLE     Bactericidal/Permeability-Increasing Protein Preeminently Mediates
            Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent
            Phagocytosis
  JOURNAL   Front Immunol 12, 659523 (2021)
   PUBMED   33981306
  REMARK    GeneRIF: Bactericidal/Permeability-Increasing Protein Preeminently
            Mediates Clearance of Pseudomonas aeruginosa In Vivo via
            CD18-Dependent Phagocytosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Wittmann,I., Schonefeld,M., Aichele,D., Groer,G., Gessner,A. and
            Schnare,M.
  TITLE     Murine bactericidal/permeability-increasing protein inhibits the
            endotoxic activity of lipopolysaccharide and gram-negative bacteria
  JOURNAL   J Immunol 180 (11), 7546-7552 (2008)
   PUBMED   18490755
  REMARK    GeneRIF: data demonstrate that murine BPI is a potent
            LPS-neutralizing protein that may limit innate immune responses
            during Gram-negative infections
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Tanaka,M., Gombart,A.F., Koeffler,H.P. and Shiohara,M.
  TITLE     Expression of bactericidal/permeability-increasing protein requires
            C/EBP epsilon
  JOURNAL   Int J Hematol 85 (4), 304-311 (2007)
   PUBMED   17483073
  REMARK    GeneRIF: the requirement for C/EBP epsilon in mediating BPI gene
            expression in myeloid cells in vitro and in vivo.
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Eckert,M., Wittmann,I., Rollinghoff,M., Gessner,A. and Schnare,M.
  TITLE     Endotoxin-induced expression of murine bactericidal
            permeability/increasing protein is mediated exclusively by
            toll/IL-1 receptor domain-containing adaptor inducing
            IFN-beta-dependent pathways
  JOURNAL   J Immunol 176 (1), 522-528 (2006)
   PUBMED   16365446
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Lennartsson,A., Pieters,K., Vidovic,K. and Gullberg,U.
  TITLE     A murine antibacterial ortholog to human
            bactericidal/permeability-increasing protein (BPI) is expressed in
            testis, epididymis, and bone marrow
  JOURNAL   J Leukoc Biol 77 (3), 369-377 (2005)
   PUBMED   15590754
  REMARK    GeneRIF: The mouse neutrophils store BPI with antibacterial
            activity and that murine BPI is also expressed in testis and
            epididymis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY648037.1.
            
            On Oct 7, 2017 this sequence version replaced XM_006499789.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY648037.1, AY363993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     gene            1..1770
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /note="bactericidal permeablility increasing protein"
                     /db_xref="GeneID:329547"
                     /db_xref="MGI:MGI:3045315"
     exon            1..184
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1506
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; bactericidal permeability-increasing protein"
                     /codon_start=1
                     /product="bactericidal permeability-increasing protein
                     isoform 2 precursor"
                     /protein_id="NP_001343471.1"
                     /db_xref="CCDS:CCDS89574.1"
                     /db_xref="GeneID:329547"
                     /db_xref="MGI:MGI:3045315"
                     /translation="MTWAPDNVRKWSALLLLAIIGTALTAATDPGFVAMISQKGLDFA
                     CQQGVVELQKELQAISVPDFSGVFKIKHLGKGSYEFYSMAVDGFHIPNPKIEMLPSDG
                     LRVFIKDASIKINGKWMSRKNFLKAGGNFELSIQGVSISTDLILGSDSSGHITTICSN
                     CDSHIDSVHIKISGSMLGWLIRLFHRKIETSLKNIIYKKICKIVRDSVSSKLQPYLKT
                     LSVITRVDDVTSVDYSLLAPLTTTNQFLEGQLKGEFFWRGHRDPLPIHPPVMRFVPNG
                     AYMVCMGISDYFFNTEVLAYQQSGTLKMTLGGQLLSNNGRFQLNTDFLRTFLPKVAKM
                     FPSMGVQLLISAPVPVHLSIQPSGLSFNPKLETQAFVVLPNASLVPLFVLGMKTNASL
                     EVDAEENRLVGEMKLGSRWLLELKESKFGPFKVEYLEDVINYLVSTLVLPKINERLRR
                     GFPLPLPAGIRFSHFTFYPYQNFLLLEADLHLI"
     exon            185..299
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..428
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..587
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..651
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..715
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..807
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..984
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1044
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1212
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1280
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1326
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1390
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1467
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1770
                     /gene="Bpi"
                     /gene_synonym="9230105K17Rik; Bpifd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tataggtctc aggttcccat ccgaggcctt gtggtttggg ctgccctaga ggacatgacc
       61 tgggcccctg acaacgtgcg gaaatggtca gccctgttgc tgctggccat cattggcaca
      121 gccctgacag ccgccaccga ccctggcttc gtggccatga tctcccagaa gggtctggac
      181 ttcgcgtgcc agcagggagt ggttgagttg cagaaggagc tacaggctat cagtgttcct
      241 gacttctctg gggtctttaa gatcaagcac ctgggaaagg gttcctacga attctacagc
      301 atggctgtgg atggatttca tattcctaat cccaagatcg agatgctgcc cagtgatggc
      361 ctccgagtgt tcatcaaaga tgccagcatc aagatcaatg gaaagtggat gtcaaggaag
      421 aacttcctca aggccggtgg caattttgaa ctgagcatcc agggcgtctc catctccacc
      481 gacctgattc tgggtagtga ctcctcaggc cacatcacca ccatctgctc caactgcgac
      541 agtcacattg acagtgtcca tatcaaaatc tcaggcagca tgctggggtg gctgatccga
      601 ctgttccaca ggaaaattga gacttccctg aaaaacatca tttacaaaaa gatctgcaag
      661 atcgtgagag actctgtgtc ctccaaactg cagccttatc tgaagaccct ttctgtgata
      721 accagagtgg atgatgtgac ctcggttgac tacagtctgc tggctcccct gacaaccacg
      781 aaccagttcc tggaggggca gctaaagggg gagtttttct ggaggggaca ccgagaccca
      841 cttcccattc acccgccagt aatgaggttt gtgcccaacg gtgcatacat ggtatgcatg
      901 ggcatctctg actacttctt caacactgag gtattggctt accaacagtc tggaaccttg
      961 aagatgaccc tggggggcca actgttatca aataatggca gattccagct gaacactgac
     1021 ttccttagga ccttcctgcc caaggtggcc aagatgttcc ccagcatggg ggtgcagctg
     1081 ctcatctcag cgcccgtgcc tgtgcacctg agcatacagc cctcaggcct ctcattcaat
     1141 cctaagctgg agacccaggc ctttgtggtc ctccccaacg cctccctggt ccctctcttt
     1201 gttcttggca tgaaaacaaa tgcctctttg gaagtggatg ctgaggagaa caggctcgtg
     1261 ggagagatga agcttggcag caggtggttg ctggaattga aggaatccaa atttggcccc
     1321 tttaaggtgg agtacctgga ggatgtcata aactacctcg tatccacact agtgctgccc
     1381 aagatcaatg agaggctgcg tagaggcttc cctctccctt tgcctgctgg gatccggttc
     1441 agccacttca cgttttaccc ctaccagaat ttcctgttgc ttgaagcgga tttacacctt
     1501 atctaagata tcaccttgga ccctgggcca ggaagctctg cagctgctcc catcacactc
     1561 accggctgtc ctgctccagg aatcctattt agtctttggc cctgacctgt agcctcctgc
     1621 ttgcttcccc atgctgaagc tgaggggaaa gcaggagatc tgtgtaccgg ggccctgtgc
     1681 ctctttcaga gcagcccctc cagcatccgc atttccgctg gaggggcgac attactttgg
     1741 gctttacaag aacatccatt tttccccctg
//
