LOCUS       NM_026512               1220 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus biphenyl hydrolase like (Bphl), transcript variant 1,
            mRNA.
ACCESSION   NM_026512
VERSION     NM_026512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161117.4.
            
            On Mar 23, 2023 this sequence version replaced NM_026512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025162.1, SRR13861889.218968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC161117.4         111129-111270       c
            143-246             AC161117.4         104371-104474       c
            247-413             AC161117.4         101946-102112       c
            414-567             AC161117.4         98464-98617         c
            568-699             AC161117.4         88333-88464         c
            700-823             AC161117.4         84865-84988         c
            824-1220            AC161117.4         74826-75222         c
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.02 cM"
     gene            1..1220
                     /gene="Bphl"
                     /note="biphenyl hydrolase like"
                     /db_xref="GeneID:68021"
                     /db_xref="MGI:MGI:1915271"
     exon            1..142
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..911
                     /gene="Bphl"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; valacyclovir hydrolase; VACVase;
                     valacyclovirase; biphenyl hydrolase-like protein; biphenyl
                     hydrolase-like (serine hydrolase, breast epithelial
                     mucin-associated antigen)"
                     /codon_start=1
                     /product="valacyclovir hydrolase isoform 1 precursor"
                     /protein_id="NP_080788.1"
                     /db_xref="CCDS:CCDS49229.1"
                     /db_xref="GeneID:68021"
                     /db_xref="MGI:MGI:1915271"
                     /translation="MATATVRPAAQRLRLLLSPLKSRICVPQAEPVATFGTAVTSAKV
                     AVNGVHLHYQRVGEGEHAILLLPGMLGSGKTDFAPQLQSLNKKRFTLVAWDPRGYGYS
                     RPPDRDFPRDFFERDAKDAVDLMKALQFKQVSLLGWSDGGITALIAAAKYPSYIRKMV
                     IWGANAYVTEEDSRIYQGIRDVSKWSEKARKPLEALYGYDYLAKTCEDWVDGISQFKQ
                     LPEGNICRHLLPLVQCPTLIVHGEKDPLVPRFHADFLLQHVKGSRLHLMPEGKHNLHL
                     RFADEFNRLVEDFLQ"
     exon            143..246
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     exon            247..413
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     exon            414..567
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     exon            568..699
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     exon            700..823
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1220
                     /gene="Bphl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1201..1206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bphl"
                     /note="hexamer: AATAAA"
     polyA_site      1220
                     /gene="Bphl"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcgttc catggagctt gtgcgacctg gagctatggc gaccgcaaca gttcgcccgg
       61 cggcccagcg gttgcggctg ctcctctcgc ccctgaaatc ccggatctgc gtaccccagg
      121 ccgaacccgt agccaccttc ggcactgcag taacttctgc caaggtggct gtgaatggcg
      181 ttcacctgca ttaccagcgc gtgggagaag gggaacatgc gatcctcctg cttcctggga
      241 tgttgggtag cggaaagacc gattttgcac ctcagcttca gagcctaaat aagaagcgct
      301 tcacattggt ggcctgggac cctcgaggat atggatattc cagaccccca gatcgagatt
      361 ttccacggga tttttttgaa agggatgcaa aggatgctgt tgacttgatg aaggctctac
      421 agttcaagca ggtctccctc ctgggctgga gtgatggcgg cataactgcg ctcatcgctg
      481 ctgcaaagta cccatcttat atccgcaaga tggtgatctg gggagcaaat gcctatgtca
      541 ccgaggaaga cagcaggatt taccagggta tccgagatgt ttctaaatgg agtgagaagg
      601 caaggaaacc cctggaagcc ctgtatggat atgactacct tgccaaaacc tgtgaggact
      661 gggtggatgg cataagccag tttaaacaac tgccagaggg taacatctgc cggcacttgc
      721 tgcccctggt ccagtgccct accctcattg tgcatgggga gaaggaccca ttggtccccc
      781 gctttcatgc tgacttcctt ctccagcatg tgaaagggtc acggttgcat ctgatgccag
      841 aaggcaagca caacttacac ttacgctttg cagacgaatt caacaggttg gtagaagact
      901 ttctacagtg aaagtccagg agacagaccg ctggtgtcca gcagattctg tgttaaaaga
      961 tcatgtcatt gcctgttacc tggatgctcc aaaatgcctt cccttgcttt tggcctcggc
     1021 tcacagacag gcctgccagg ctttctatct tccctgcaat gtgactctat gcaaacagga
     1081 aaaatagcat accgaaatca ggttatagct tcaatagctg aagaaacatg aacatttcca
     1141 tttttaacat taactctcta tcatcgtcta tgagtaagtt cttaccatga tttgttttca
     1201 aataaaattt atgggaaaca
//
