LOCUS       NM_007563               1594 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus 2,3-bisphosphoglycerate mutase (Bpgm), transcript
            variant 1, mRNA.
ACCESSION   NM_007563
VERSION     NM_007563.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Barakat,A., Jasuja,R., Tomlinson,L., Wenzel,Z., Ramaiah,L.,
            Petterson,B.A., Kapinos,B., Sawant,A., Pagan,V., Lintner,N.,
            Field,D., Ahn,Y. and Knee,K.M.
  TITLE     Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD model
            mice
  JOURNAL   Am J Hematol 98 (12), 1838-1846 (2023)
   PUBMED   37688507
  REMARK    GeneRIF: Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD
            model mice.
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Lim,M., Brown,H.M., Rose,R.D., Thompson,J.G. and Dunning,K.R.
  TITLE     Dysregulation of bisphosphoglycerate mutase during in vitro
            maturation of oocytes
  JOURNAL   J Assist Reprod Genet 38 (6), 1363-1372 (2021)
   PUBMED   34052998
  REMARK    GeneRIF: Dysregulation of bisphosphoglycerate mutase during in
            vitro maturation of oocytes.
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Xu,G., van Bruggen,R., Gualtieri,C.O., Moradin,N., Fois,A.,
            Vallerand,D., De Sa Tavares Russo,M., Bassenden,A., Lu,W., Tam,M.,
            Lesage,S., Girouard,H., Avizonis,D.Z., Deblois,G., Prchal,J.T.,
            Stevenson,M., Berghuis,A., Muir,T., Rabinowitz,J., Vidal,S.M.,
            Fodil,N. and Gros,P.
  TITLE     Bisphosphoglycerate Mutase Deficiency Protects against Cerebral
            Malaria and Severe Malaria-Induced Anemia
  JOURNAL   Cell Rep 32 (12), 108170 (2020)
   PUBMED   32966787
  REMARK    GeneRIF: Bisphosphoglycerate Mutase Deficiency Protects against
            Cerebral Malaria and Severe Malaria-Induced Anemia.
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Finn,E.H., Smith,C.L., Rodriguez,J., Sidow,A. and Baker,J.C.
  TITLE     Maternal bias and escape from X chromosome imprinting in the
            midgestation mouse placenta
  JOURNAL   Dev Biol 390 (1), 80-92 (2014)
   PUBMED   24594094
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Gu,M., Pritlove,D.C., Boyd,C.A. and Vatish,M.
  TITLE     Placental expression of 2,3 bisphosphoglycerate mutase in IGF-II
            knock out mouse: correlation of circulating maternal 2,3
            bisphosphoglycerate and fetal growth
  JOURNAL   Placenta 30 (10), 919-922 (2009)
   PUBMED   19733906
  REMARK    GeneRIF: Placental expression of BPGM can influence maternal
            2,3-bisphosphoglycerate (BPG) blood levels and supports a
            hypothesis under which BPG synthesized in the placenta may act on
            maternal haemoglobin to enhance delivery of oxygen to the
            developing fetus.
REFERENCE   8  (bases 1 to 1594)
  AUTHORS   Feng,Y., Valley,M.T., Lazar,J., Yang,A.L., Bronson,R.T.,
            Firestein,S., Coetzee,W.A. and Manley,J.L.
  TITLE     SRp38 regulates alternative splicing and is required for Ca(2+)
            handling in the embryonic heart
  JOURNAL   Dev Cell 16 (4), 528-538 (2009)
   PUBMED   19386262
REFERENCE   9  (bases 1 to 1594)
  AUTHORS   Zeng,F. and Schultz,R.M.
  TITLE     Gene expression in mouse oocytes and preimplantation embryos: use
            of suppression subtractive hybridization to identify oocyte- and
            embryo-specific genes
  JOURNAL   Biol Reprod 68 (1), 31-39 (2003)
   PUBMED   12493692
REFERENCE   10 (bases 1 to 1594)
  AUTHORS   Le Boulch,P., Joulin,V., Garel,M.C., Rosa,J. and Cohen-Solal,M.
  TITLE     Molecular cloning and nucleotide sequence of murine
            2,3-bisphosphoglycerate mutase cDNA
  JOURNAL   Biochem Biophys Res Commun 156 (2), 874-881 (1988)
   PUBMED   2847721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115767.14.
            
            On May 30, 2018 this sequence version replaced NM_007563.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078119.1, AK043412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC115767.14        179710-179776
            68-728              AC115767.14        190644-191304
            729-1594            AC115767.14        207625-208490
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.01 cM"
     gene            1..1594
                     /gene="Bpgm"
                     /note="2,3-bisphosphoglycerate mutase"
                     /db_xref="GeneID:12183"
                     /db_xref="MGI:MGI:1098242"
     exon            1..67
                     /gene="Bpgm"
                     /inference="alignment:Splign:2.1.0"
     exon            68..728
                     /gene="Bpgm"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..907
                     /gene="Bpgm"
                     /EC_number="5.4.2.4"
                     /EC_number="5.4.2.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bisphosphoglycerate mutase; BPG-dependent PGAM;
                     2,3-bisphosphoglycerate synthase; 2,3-bisphosphoglycerate
                     mutase, erythrocyte"
                     /codon_start=1
                     /product="bisphosphoglycerate mutase isoform 1"
                     /protein_id="NP_031589.1"
                     /db_xref="CCDS:CCDS19994.1"
                     /db_xref="GeneID:12183"
                     /db_xref="MGI:MGI:1098242"
                     /translation="MSKHKLIILRHGEGQWNKENRFCSWVDQKLNNDGLEEARNCGRQ
                     LKALNFEFDLVFTSILNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREK
                     MALNHGEEQVRLWRRSYNVTPPPIEESHPYFHEIYSDRRYKVCDVPLDQLPRSESLKD
                     VLERLLPYWKERIAPEILKGKSILISAHGNSSRALLKHLEGISDEDIINITLPTGVPI
                     LLELDENLRAVGPHQFLGNQEAIQAAIKKVDDQGKVKQGKQ"
     exon            729..1594
                     /gene="Bpgm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpgm"
                     /note="hexamer: AATAAA"
     polyA_site      924
                     /gene="Bpgm"
                     /note="major polyA site"
     regulatory      1561..1566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpgm"
                     /note="hexamer: AATAAA"
     polyA_site      1587
                     /gene="Bpgm"
ORIGIN      
        1 gaatcctcac tggcgtctgc agcacggcgt taccgaggac cggctgctac tggtagtttc
       61 cttgcagata tactgctgtt cttgaacatc atcccattga gaaccccagg gtagttcagc
      121 caccagcatg tccaagcaca aacttattat actaagacat ggagagggcc aatggaataa
      181 ggagaaccga ttctgtagtt gggtggacca gaaacttaac aacgacggac tggaggaggc
      241 tcggaactgt gggaggcagc tcaaagctct caacttcgag tttgatcttg tcttcacatc
      301 catccttaac aggtccattc acacagcctg gctgatcctg gaagagctgg ggcaggagtg
      361 ggtgcctgtg gagagctcct ggcgtctgaa tgagcgtcac tatggagcct tgattggcct
      421 caacagggag aaaatggctt tgaatcatgg tgaagagcag gtaaggctct ggaggagaag
      481 ctacaacgtg accccacctc ctatagagga gtctcatccc tacttccacg agatctacag
      541 tgaccggagg tacaaagtgt gcgatgtgcc cttggatcaa ctgccacgtt cagaaagctt
      601 gaaggatgtt ctggagagac ttcttcccta ctggaaggaa aggattgctc cggaaatctt
      661 aaagggcaaa agcattctga tatctgctca cgggaatagc agtagagctc tcctgaaaca
      721 tctggaaggt atctcagacg aggatattat caacatcact ctgcccactg gagttccgat
      781 tctgctggag ttggatgaga acctgcgtgc cgttgggcct caccagttcc tgggcaacca
      841 ggaggccatc caggcagcca ttaagaaagt ggatgatcaa gggaaagtga aacaaggcaa
      901 acaataaagt gtggccagga acgagtttgg ggtggcatgc agtgtgttcc gagcgggctt
      961 ctccccctcc tccgacgggc cccctctccc taagtctagg ctgtgtggta gagtttgtgt
     1021 aggtaactag gtaatttatc gtggcccaga cgtgaccttc gaatgctgaa gagctttgtc
     1081 tgaagcctga atgaactttt ctgctcctcc cgtttgaatt aactttgcaa agtagtagcc
     1141 agcgggggga tttgaccagg gtggttttgt gttttggaga caggagagta acaagtggag
     1201 atgaaattgt ttatccttaa caagtcattg cagagtcacc actgacaggt gctattccag
     1261 tgagcaggtc accgttttat tcaataatac ttctcgagaa gactactagg tagcacttgg
     1321 gcagtttaga tcagaggcgc atcgaatggc agagtcacag gcgggtccga gggaaggcat
     1381 ctgagcgcca cagtagcaca aggccctttg atgtctagcc cagtgccatc ctgtctgccg
     1441 tcagtagaaa ccaacttcag ccagttagaa ggaccagggt atgcacagtg gtagcagttt
     1501 atatccttct gtttcatttt taacttttga actttaatct ttggggactt cacagtttaa
     1561 aataaagctt tgtgactgca tacaacacgc gcaa
//
