LOCUS       NM_001363710            1349 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus 2,3-bisphosphoglycerate mutase (Bpgm), transcript
            variant 5, mRNA.
ACCESSION   NM_001363710 XM_006505412
VERSION     NM_001363710.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Barakat,A., Jasuja,R., Tomlinson,L., Wenzel,Z., Ramaiah,L.,
            Petterson,B.A., Kapinos,B., Sawant,A., Pagan,V., Lintner,N.,
            Field,D., Ahn,Y. and Knee,K.M.
  TITLE     Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD model
            mice
  JOURNAL   Am J Hematol 98 (12), 1838-1846 (2023)
   PUBMED   37688507
  REMARK    GeneRIF: Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD
            model mice.
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Lim,M., Brown,H.M., Rose,R.D., Thompson,J.G. and Dunning,K.R.
  TITLE     Dysregulation of bisphosphoglycerate mutase during in vitro
            maturation of oocytes
  JOURNAL   J Assist Reprod Genet 38 (6), 1363-1372 (2021)
   PUBMED   34052998
  REMARK    GeneRIF: Dysregulation of bisphosphoglycerate mutase during in
            vitro maturation of oocytes.
REFERENCE   5  (bases 1 to 1349)
  AUTHORS   Xu,G., van Bruggen,R., Gualtieri,C.O., Moradin,N., Fois,A.,
            Vallerand,D., De Sa Tavares Russo,M., Bassenden,A., Lu,W., Tam,M.,
            Lesage,S., Girouard,H., Avizonis,D.Z., Deblois,G., Prchal,J.T.,
            Stevenson,M., Berghuis,A., Muir,T., Rabinowitz,J., Vidal,S.M.,
            Fodil,N. and Gros,P.
  TITLE     Bisphosphoglycerate Mutase Deficiency Protects against Cerebral
            Malaria and Severe Malaria-Induced Anemia
  JOURNAL   Cell Rep 32 (12), 108170 (2020)
   PUBMED   32966787
  REMARK    GeneRIF: Bisphosphoglycerate Mutase Deficiency Protects against
            Cerebral Malaria and Severe Malaria-Induced Anemia.
REFERENCE   6  (bases 1 to 1349)
  AUTHORS   Finn,E.H., Smith,C.L., Rodriguez,J., Sidow,A. and Baker,J.C.
  TITLE     Maternal bias and escape from X chromosome imprinting in the
            midgestation mouse placenta
  JOURNAL   Dev Biol 390 (1), 80-92 (2014)
   PUBMED   24594094
REFERENCE   7  (bases 1 to 1349)
  AUTHORS   Gu,M., Pritlove,D.C., Boyd,C.A. and Vatish,M.
  TITLE     Placental expression of 2,3 bisphosphoglycerate mutase in IGF-II
            knock out mouse: correlation of circulating maternal 2,3
            bisphosphoglycerate and fetal growth
  JOURNAL   Placenta 30 (10), 919-922 (2009)
   PUBMED   19733906
  REMARK    GeneRIF: Placental expression of BPGM can influence maternal
            2,3-bisphosphoglycerate (BPG) blood levels and supports a
            hypothesis under which BPG synthesized in the placenta may act on
            maternal haemoglobin to enhance delivery of oxygen to the
            developing fetus.
REFERENCE   8  (bases 1 to 1349)
  AUTHORS   Feng,Y., Valley,M.T., Lazar,J., Yang,A.L., Bronson,R.T.,
            Firestein,S., Coetzee,W.A. and Manley,J.L.
  TITLE     SRp38 regulates alternative splicing and is required for Ca(2+)
            handling in the embryonic heart
  JOURNAL   Dev Cell 16 (4), 528-538 (2009)
   PUBMED   19386262
REFERENCE   9  (bases 1 to 1349)
  AUTHORS   Zeng,F. and Schultz,R.M.
  TITLE     Gene expression in mouse oocytes and preimplantation embryos: use
            of suppression subtractive hybridization to identify oocyte- and
            embryo-specific genes
  JOURNAL   Biol Reprod 68 (1), 31-39 (2003)
   PUBMED   12493692
REFERENCE   10 (bases 1 to 1349)
  AUTHORS   Le Boulch,P., Joulin,V., Garel,M.C., Rosa,J. and Cohen-Solal,M.
  TITLE     Molecular cloning and nucleotide sequence of murine
            2,3-bisphosphoglycerate mutase cDNA
  JOURNAL   Biochem Biophys Res Commun 156 (2), 874-881 (1988)
   PUBMED   2847721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115767.14.
            
            On May 30, 2018 this sequence version replaced XM_006505412.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.72357.1, DV657824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC115767.14        179710-179776
            68-483              AC115767.14        190889-191304
            484-1349            AC115767.14        207625-208490
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.01 cM"
     gene            1..1349
                     /gene="Bpgm"
                     /note="2,3-bisphosphoglycerate mutase"
                     /db_xref="GeneID:12183"
                     /db_xref="MGI:MGI:1098242"
     exon            1..67
                     /gene="Bpgm"
                     /inference="alignment:Splign:2.1.0"
     exon            68..483
                     /gene="Bpgm"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..662
                     /gene="Bpgm"
                     /EC_number="5.4.2.4"
                     /EC_number="5.4.2.11"
                     /note="isoform 3 is encoded by transcript variant 5;
                     bisphosphoglycerate mutase; BPG-dependent PGAM;
                     2,3-bisphosphoglycerate synthase; 2,3-bisphosphoglycerate
                     mutase, erythrocyte"
                     /codon_start=1
                     /product="bisphosphoglycerate mutase isoform 3"
                     /protein_id="NP_001350639.1"
                     /db_xref="GeneID:12183"
                     /db_xref="MGI:MGI:1098242"
                     /translation="MALNHGEEQVRLWRRSYNVTPPPIEESHPYFHEIYSDRRYKVCD
                     VPLDQLPRSESLKDVLERLLPYWKERIAPEILKGKSILISAHGNSSRALLKHLEGISD
                     EDIINITLPTGVPILLELDENLRAVGPHQFLGNQEAIQAAIKKVDDQGKVKQGKQ"
     exon            484..1349
                     /gene="Bpgm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      658..663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpgm"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="Bpgm"
                     /note="major polyA site"
     regulatory      1316..1321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bpgm"
                     /note="hexamer: AATAAA"
     polyA_site      1342
                     /gene="Bpgm"
ORIGIN      
        1 gaatcctcac tggcgtctgc agcacggcgt taccgaggac cggctgctac tggtagtttc
       61 cttgcaggtc cattcacaca gcctggctga tcctggaaga gctggggcag gagtgggtgc
      121 ctgtggagag ctcctggcgt ctgaatgagc gtcactatgg agccttgatt ggcctcaaca
      181 gggagaaaat ggctttgaat catggtgaag agcaggtaag gctctggagg agaagctaca
      241 acgtgacccc acctcctata gaggagtctc atccctactt ccacgagatc tacagtgacc
      301 ggaggtacaa agtgtgcgat gtgcccttgg atcaactgcc acgttcagaa agcttgaagg
      361 atgttctgga gagacttctt ccctactgga aggaaaggat tgctccggaa atcttaaagg
      421 gcaaaagcat tctgatatct gctcacggga atagcagtag agctctcctg aaacatctgg
      481 aaggtatctc agacgaggat attatcaaca tcactctgcc cactggagtt ccgattctgc
      541 tggagttgga tgagaacctg cgtgccgttg ggcctcacca gttcctgggc aaccaggagg
      601 ccatccaggc agccattaag aaagtggatg atcaagggaa agtgaaacaa ggcaaacaat
      661 aaagtgtggc caggaacgag tttggggtgg catgcagtgt gttccgagcg ggcttctccc
      721 cctcctccga cgggccccct ctccctaagt ctaggctgtg tggtagagtt tgtgtaggta
      781 actaggtaat ttatcgtggc ccagacgtga ccttcgaatg ctgaagagct ttgtctgaag
      841 cctgaatgaa cttttctgct cctcccgttt gaattaactt tgcaaagtag tagccagcgg
      901 ggggatttga ccagggtggt tttgtgtttt ggagacagga gagtaacaag tggagatgaa
      961 attgtttatc cttaacaagt cattgcagag tcaccactga caggtgctat tccagtgagc
     1021 aggtcaccgt tttattcaat aatacttctc gagaagacta ctaggtagca cttgggcagt
     1081 ttagatcaga ggcgcatcga atggcagagt cacaggcggg tccgagggaa ggcatctgag
     1141 cgccacagta gcacaaggcc ctttgatgtc tagcccagtg ccatcctgtc tgccgtcagt
     1201 agaaaccaac ttcagccagt tagaaggacc agggtatgca cagtggtagc agtttatatc
     1261 cttctgtttc atttttaact tttgaacttt aatctttggg gacttcacag tttaaaataa
     1321 agctttgtga ctgcatacaa cacgcgcaa
//
