LOCUS       NM_025563               2176 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus BLOC-1 related complex subunit 7 (Borcs7), mRNA.
ACCESSION   NM_025563
VERSION     NM_025563.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Yordanov,T.E., Hipolito,V.E.B., Liebscher,G., Vogel,G.F.,
            Stasyk,T., Herrmann,C., Geley,S., Teis,D., Botelho,R.J., Hess,M.W.
            and Huber,L.A.
  TITLE     Biogenesis of lysosome-related organelles complex-1 (BORC)
            regulates late endosomal/lysosomal size through PIKfyve-dependent
            phosphatidylinositol-3,5-bisphosphate
  JOURNAL   Traffic 20 (9), 674-696 (2019)
   PUBMED   31314175
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Snouwaert,J.N., Church,R.J., Jania,L., Nguyen,M., Wheeler,M.L.,
            Saintsing,A., Mieczkowski,P., Manuel de Villena,F.P., Armao,D.,
            Moy,S.S., Lorenzo,D.N. and Koller,B.H.
  TITLE     A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC
            Complex Results in Motor Deficits and Dystrophic Axonopathy in Mice
  JOURNAL   Cell Rep 24 (5), 1254-1265 (2018)
   PUBMED   30067980
  REMARK    GeneRIF: Truncated Borcs7 reduces lysosomal transport in neurons
            and causes progressive axonal dystrophy.
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Pu,J., Schindler,C., Jia,R., Jarnik,M., Backlund,P. and
            Bonifacino,J.S.
  TITLE     BORC, a multisubunit complex that regulates lysosome positioning
  JOURNAL   Dev Cell 33 (2), 176-188 (2015)
   PUBMED   25898167
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161865.4.
            
            On Mar 21, 2007 this sequence version replaced NM_025563.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046524.1, SRR9219381.105187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC161865.4         161078-161257       c
            181-243             AC161865.4         151545-151607       c
            244-287             AC161865.4         151382-151425       c
            288-308             AC161865.4         150368-150388       c
            309-2176            AC161865.4         147781-149648       c
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.97 cM"
     gene            1..2176
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /note="BLOC-1 related complex subunit 7"
                     /db_xref="GeneID:66439"
                     /db_xref="MGI:MGI:1913689"
     exon            1..180
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            181..243
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            244..287
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            288..308
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            309..2176
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      667..672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      699
                     /gene="Borcs7"
                     /gene_synonym="2010012O05Rik; 4930569L17Rik"
                     /note="major polyA site"
ORIGIN      
        1 gactcgccgt cgtccggctg cgggtgatcg ctagttgagg tgatggcgac tgggacgccg
       61 gattcgcaag cccgatttgg tcagtccgtg aaggggcttc tcacggagaa ggtgaacacc
      121 tgtggcaccg atgtaatcgc gctcaccaag caggtgctga aaggctcgcg gagctccgag
      181 ctgctggggc aggcagctcg aaacatggta ctacaggaag atgccatctt acactcggaa
      241 gatagtttaa ggaagatggc aataataaca acacaccttc agtaccagca agaagctatt
      301 cagaagaatg tggaacagtc gcctgacctg caggaccagt tgagtcactt actgaagtag
      361 cacatcagat gctaaggagg gcctgtccta cacaaccatc aggccgtggc cttggtctcc
      421 atcttcatct ccagagaatc atctagaaaa gacttgtgaa gccaggcgtg gtggtgcaca
      481 cctttaatcc cagcttttct gagttcaagg ccagcctggt ctacagagtg agttccagga
      541 cagccagagc tacaaaaaaa aaaaaaaaaa aaaaaaaaaa agactcgtga aaagaagaag
      601 ccaagtgact gagcatggaa gcagttctta aattgatgaa ctcatcttca agttggttta
      661 tattgaaata aataggttga atcattagca ctaaaaaaag aaaggtacct cagcttgtta
      721 aaagctgtat tgtctgtgat tctatgtctc tctctctctc tctctctctc tctctctctc
      781 tctctctctc tctctctctc cctctcgcgc tcgctcttgt atgtcttccc cccctccccg
      841 cccccgtgta gcttgtgtgg ctttgaactc ataatccccc tgctgtagcc tctcaactat
      901 tgggattaca aatcaccccc ccctggtcac tgagtaacac atagtctccg atacttggga
      961 ggctgaggca ggaggatcac ttgtgcccag aaagttgaga ccatccaggg caacacagaa
     1021 agaacctatc tccaagaaga agaggaaagg atagagggag gggcccttat tgtaatcttg
     1081 tgagaatgat ttccatttta aaagatgttt attattcatt caagagtctt cacttagtgg
     1141 acacggagca aggataatgg ctgttgtttc ctttctcact acaaattctt atatgaaaat
     1201 caggccagtg gtgtcccccc tggccagctg cagctctgcc ttgacctttg tttctggctt
     1261 ctttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     1321 ctttctctct gtgactcttg attaagtgac cttggttcat tttgtaatca tttatagcca
     1381 ttccattccc ttggaatctg gcagtaaagt cacacaagtg gacccgctga tacttaagta
     1441 atgctacata aaagaactac acagacccaa tctccaacaa aacaaaaagg cgaaaaagat
     1501 ataaaaccac tagggagttt tacatattag tgtgttgaag ggtcacgtca accataaaag
     1561 ggcaaattaa gaaatgcatc actgactatg acgtgtataa agtgagttag acctgaagag
     1621 ttcctcctca gctcgatgcc taaagtgcaa tcaatgtaaa aatgtctgtc tccttataaa
     1681 gacatggcat tacaaagtta gcatttgaaa gaatgtgtcc agatcaattg tgaagaatga
     1741 tccacaaagg gacaaagaag cagcagtgca aatggcattt gcttgtggcc ccattcctgt
     1801 gacttccaca gactgtcaaa gagcagaccc tttccatgta ctcccagcat catataaaat
     1861 atgaccatat gaagataaaa tatgaccata tgaagctggt gcgatggctc agcagttaaa
     1921 aaacacttgc tgcttttgga gaggacccag gttcagttcc catcacccgc ttcagaaagc
     1981 tcactggtgt ctatgactat agctccaagg gatctaatgt cctcttctgg gctccctgga
     2041 cacctgcatt ctcatacata tgcctgaaca cagatacata tctataaaac taaaacattt
     2101 ttttaaaaat tatttaaaat tcatctgcta aagaaaatgt aattttcatt taaaataaaa
     2161 agcacgacgc tataac
//
