LOCUS       NM_013481               2464 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus block of proliferation 1 (Bop1), mRNA.
ACCESSION   NM_013481
VERSION     NM_013481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2464)
  AUTHORS   Ji,R., Zhang,Z., Yang,Z., Chen,X., Yin,T. and Yang,J.
  TITLE     BOP1 contributes to the activation of autophagy in polycystic ovary
            syndrome via nucleolar stress response
  JOURNAL   Cell Mol Life Sci 81 (1), 101 (2024)
   PUBMED   38409361
  REMARK    GeneRIF: BOP1 contributes to the activation of autophagy in
            polycystic ovary syndrome via nucleolar stress response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2464)
  AUTHORS   Li,J., Hu,W., Zhang,R., Chen,W., Li,X. and Tang,Z.
  TITLE     PDGF-C promotes cell proliferation partially via downregulating
            BOP1
  JOURNAL   Cell Biol Int 47 (12), 1942-1949 (2023)
   PUBMED   37615370
  REMARK    GeneRIF: PDGF-C promotes cell proliferation partially via
            downregulating BOP1.
REFERENCE   3  (bases 1 to 2464)
  AUTHORS   Jia,F., Wu,Q., Wang,Z., Zhang,M., Yuan,S., Che,Y., Li,B., Hu,Z. and
            Hu,X.
  TITLE     BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53
            and Inhibiting Nascent Protein Synthesis
  JOURNAL   Oxid Med Cell Longev 2021, 5986260 (2021)
   PUBMED   33510838
  REMARK    GeneRIF: BOP1 Knockdown Attenuates Neointimal Hyperplasia by
            Activating p53 and Inhibiting Nascent Protein Synthesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2464)
  AUTHORS   Gupta,R., Bugide,S., Wang,B., Green,M.R., Johnson,D.B. and
            Wajapeyee,N.
  TITLE     Loss of BOP1 confers resistance to BRAF kinase inhibitors in
            melanoma by activating MAP kinase pathway
  JOURNAL   Proc Natl Acad Sci U S A 116 (10), 4583-4591 (2019)
   PUBMED   30782837
  REMARK    GeneRIF: BOP1 knockdown promoted down-regulation of the MAPK
            phosphatases DUSP4 and DUSP6 via a transcription-based mechanism,
            leading to increased MAPK signaling.
REFERENCE   5  (bases 1 to 2464)
  AUTHORS   Qi,J., Yu,Y., Akilli Ozturk,O., Holland,J.D., Besser,D.,
            Fritzmann,J., Wulf-Goldenberg,A., Eckert,K., Fichtner,I. and
            Birchmeier,W.
  TITLE     New Wnt/beta-catenin target genes promote experimental metastasis
            and migration of colorectal cancer cells through different signals
  JOURNAL   Gut 65 (10), 1690-1701 (2016)
   PUBMED   26156959
  REMARK    GeneRIF: New direct Wnt/beta-catenin target gene Bop1, which
            induced epithelial-mesenchymal transition, cell migration and
            experimental metastasis of Colorectal cancer cells was identified.
REFERENCE   6  (bases 1 to 2464)
  AUTHORS   Pestov,D.G., Stockelman,M.G., Strezoska,Z. and Lau,L.F.
  TITLE     ERB1, the yeast homolog of mammalian Bop1, is an essential gene
            required for maturation of the 25S and 5.8S ribosomal RNAs
  JOURNAL   Nucleic Acids Res 29 (17), 3621-3630 (2001)
   PUBMED   11522832
REFERENCE   7  (bases 1 to 2464)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2464)
  AUTHORS   Strezoska,Z., Pestov,D.G. and Lau,L.F.
  TITLE     Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and
            5. 8S RRNA processing and 60S ribosome biogenesis
  JOURNAL   Mol Cell Biol 20 (15), 5516-5528 (2000)
   PUBMED   10891491
REFERENCE   9  (bases 1 to 2464)
  AUTHORS   Pestov,D.G., Grzeszkiewicz,T.M. and Lau,L.F.
  TITLE     Isolation of growth suppressors from a cDNA expression library
  JOURNAL   Oncogene 17 (24), 3187-3197 (1998)
   PUBMED   9872334
REFERENCE   10 (bases 1 to 2464)
  AUTHORS   Zhang,Y., Koushik,S., Dai,R. and Mivechi,N.F.
  TITLE     Structural organization and promoter analysis of murine heat shock
            transcription factor-1 gene
  JOURNAL   J Biol Chem 273 (49), 32514-32521 (1998)
   PUBMED   9829985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079627.1 and AV349722.1.
            
            On Feb 5, 2019 this sequence version replaced NM_013481.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.702019.1, AK079627.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2454              AK079627.1         1-2454
            2455-2464           AV349722.1         180-189             c
FEATURES             Location/Qualifiers
     source          1..2464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.91 cM"
     gene            1..2464
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /note="block of proliferation 1"
                     /db_xref="GeneID:12181"
                     /db_xref="MGI:MGI:1334460"
     exon            1..121
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            122..295
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            296..376
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            377..531
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            532..649
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            650..751
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            752..964
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1126
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1207
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1277
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1410
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1591
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1880
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1965
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2073
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2464
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /note="hexamer: AATAGA"
     polyA_site      2317
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /note="hexamer: AATAAA"
     polyA_site      2464
                     /gene="Bop1"
                     /gene_synonym="Erb1p; Kiaa0124; mKIAA0124"
                     /note="major polyA site"
ORIGIN      
        1 agtagatcgg tagccggcgc ggcgcagcat ggcgggggcg tgtggtaagc cccacatgtc
       61 accggcatcg ctgccgggga aacgacgttt ggaacctgat caggagctgc agatacaaga
      121 gcctcctctc ctcagcgatc ctgactccag tctctctgac agcgaggaga gtgtgttttc
      181 aggcctcgaa gatttgggca gtgactcgag tgaggaagac actgaaggag tggccggatc
      241 cagcggtgac gaagacaacc atagggcaga ggagacctct gaggagctgg cacaggctgc
      301 ccctctttgc tcaaggacag aggaagcagg tgctctggcc caagatgaat atgaagagga
      361 cagctctgat gaggaggaca ttcggaacac tgtgggcaat gtgcccctgg catggtacga
      421 tgaattccca catgtgggtt atgacctgga tggcaaacgt atctacaagc ccctgcggac
      481 acgagatgag ctcgaccagt ttctggacaa aatggatgac ccagatttct ggcgcactgt
      541 gcaagacaag atgacagggc gtgatctgcg gctaactgat gagcaggttg ccctggtaca
      601 ccggcttcag agaggccagt tcggagattc aggcttcaat ccctatgagc cagctgtgga
      661 cttcttcagc ggtgacatca tgatccaccc tgtgaccaac cgcccagctg acaagcgtag
      721 tttcatccca tccctagttg aaaaggagaa ggtgtctcga atggtacatg ccatcaagat
      781 ggggtggatc aagcctcgac ggccccacga ccccacccct agcttctatg acctgtgggc
      841 ccaggaggat ccgaatgctg tgttgggacg ccacaagatg catgtgcctg cccccaagct
      901 ggccttgcct ggccatgccg agtcttacaa cccacctccc gagtacctgc ccactgagga
      961 ggagcgctcg gcgtggatgc agcaggagcc tgtggagagg aagcttaact tcttgccaca
     1021 gaaattcccc agcttgagga cagtgcctgc ttacagccgc ttcatccagg agcgtttcga
     1081 gcgctgcctc gatttgtatc tgtgcccacg gcaacgcaag atgagggtga atgtggaccc
     1141 cgaagacctc atccccaaac tccctcggcc aagagacctt cagcctttcc ctgtgtgcca
     1201 ggccctcgtc tacaggggcc acagcgacct tgtccgttgc ctcagtgtct cgccaggggg
     1261 ccagtggcta gcttcaggtt cagacgatgg cacgttgaag ctctgggagg tggccactgc
     1321 ccgctgtatg aagactgtac atgttggagg tgtggtgcgg agcatcgcct ggaaccccaa
     1381 tcctaccata tgcctggtag ctgctgccat ggatgatgcc gtgttgctgc tgaacccagc
     1441 cctgggggac cggctgctgg tgggcagcac agaccagctg ctggaagcct tcactccacc
     1501 tgaggagcca gctctgcagc ctgcccggtg gctagaggtc tcggaggaag agcaccagag
     1561 gggtctgcgc ctacgcatct gccacagcaa accagtgaca caggtgacct ggcatgggcg
     1621 aggggactat ttggcggtgg tgctgtctag tcaagagcac acgcaagtgc tgcttcacca
     1681 ggtgagcagg aggcgcagcc agagcccgtt ccgccgcagc cacgggcagg tgcagtgtgt
     1741 ggccttccat ccctcccggc ccttcctgct cgtggcctcc cagcgcagca tccgcattta
     1801 ccacctgctg cgccaggagc taaccaagaa gctgatgccc aactgcaagt gggtgtccag
     1861 catggctgta catccagcag gtgacaacat catctgtggc agctatgaca gcaaactggt
     1921 gtggtttgac ctggatcttt ccaccaagcc atacaaagtg ctgaggcacc acaagaaggc
     1981 cttgcgggct gtggccttcc acccccgata cccactcttt gcatccggct cagacgacgg
     2041 cagtgttatc gtgtgccatg gcatggtgta caatgacctg ctgcagaacc cattgctggt
     2101 gcctgtcaag gtgctgaaag gacacaccct gacccgagat ctgggtgttc tggatgtggc
     2161 cttccacccc acacagccgt gggtcttctc ctccggggca gatggcacca ttcgactctt
     2221 cagctaagcc aacacactac tctgggtggc ctggaagagg gtgggtgtgc ctccacacag
     2281 aatcctcaat agaatcccat tcttcctgtc ttcctgattc agcctccagc aactgcccag
     2341 ccttgacctt acacagcacc cagaacctgg cttaagccag aagggaaggt ggtattgata
     2401 caatgtcacc cactgaggtg taactggctt tattgggcaa taaattgggg caccacagtc
     2461 ttga
//
