LOCUS       NM_029267               1650 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus boule homolog, RNA binding protein (Boll), transcript
            variant 1, mRNA.
ACCESSION   NM_029267 XM_985535
VERSION     NM_029267.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Su,Y., Guo,X., Zang,M., Xie,Z., Zhao,T. and Xu,E.Y.
  TITLE     RNA binding protein BOULE forms aggregates in mammalian testis
  JOURNAL   J Biomed Res 36 (4), 255-268 (2022)
   PUBMED   35965435
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Gao,L., Chang,S., Xia,W., Wang,X., Zhang,C., Cheng,L., Liu,X.,
            Chen,L., Shi,Q., Huang,J., Xu,E.Y. and Shan,G.
  TITLE     Circular RNAs from BOULE play conserved roles in protection against
            stress-induced fertility decline
  JOURNAL   Sci Adv 6 (46) (2020)
   PUBMED   33177084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Li,H., Liang,Z., Yang,J., Wang,D., Wang,H., Zhu,M., Geng,B. and
            Xu,E.Y.
  TITLE     DAZL is a master translational regulator of murine spermatogenesis
  JOURNAL   Natl Sci Rev 6 (3), 455-468 (2019)
   PUBMED   31355046
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Ungewitter,E.K., Rotgers,E., Kang,H.S., Lichti-Kaiser,K., Li,L.,
            Grimm,S.A., Jetten,A.M. and Yao,H.H.
  TITLE     Loss of Glis3 causes dysregulation of retrotransposon silencing and
            germ cell demise in fetal mouse testis
  JOURNAL   Sci Rep 8 (1), 9662 (2018)
   PUBMED   29941866
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Kim,B. and Rhee,K.
  TITLE     BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress
            Granules in the Mouse Male Germ Cells
  JOURNAL   PLoS One 11 (9), e0163015 (2016)
   PUBMED   27632217
  REMARK    GeneRIF: asked whether BOULE, the founding member of DAZ family
            proteins, is a component of the SGs. We show that BOULE is
            recruited to the SGs upon heat stress, and that these SGs are
            developmental stage-specific
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   He,J., Stewart,K., Kinnell,H.L., Anderson,R.A. and Childs,A.J.
  TITLE     A developmental stage-specific switch from DAZL to BOLL occurs
            during fetal oogenesis in humans, but not mice
  JOURNAL   PLoS One 8 (9), e73996 (2013)
   PUBMED   24086306
  REMARK    GeneRIF: demonstrate that Boll is also transiently expressed during
            oogenesis in the fetal mouse ovary, but is simultaneously
            co-expressed within the same germ cells as Dazl
            Erratum:[PLoS One. 2015 Aug 13;10(8):e0136009. doi:
            10.1371/journal.pone.0136009.. PMID: 26270527]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Shah,C., Vangompel,M.J., Naeem,V., Chen,Y., Lee,T., Angeloni,N.,
            Wang,Y. and Xu,E.Y.
  TITLE     Widespread presence of human BOULE homologs among animals and
            conservation of their ancient reproductive function
  JOURNAL   PLoS Genet 6 (7), e1001022 (2010)
   PUBMED   20657660
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   VanGompel,M.J. and Xu,E.Y.
  TITLE     A novel requirement in mammalian spermatid differentiation for the
            DAZ-family protein Boule
  JOURNAL   Hum Mol Genet 19 (12), 2360-2369 (2010)
   PUBMED   20335278
  REMARK    GeneRIF: Expression of key regulators of spermiogenesis was
            unaffected in Boule(-/-) mice, suggesting that Boule regulates
            germ-cell differentiation through a novel pathway.
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Xu,E.Y., Moore,F.L. and Pera,R.A.
  TITLE     A gene family required for human germ cell development evolved from
            an ancient meiotic gene conserved in metazoans
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7414-7419 (2001)
   PUBMED   11390979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122223.4.
            
            On Feb 25, 2019 this sequence version replaced NM_029267.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272859.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               AC122223.4         40941-41395
            456-599             AC122223.4         43935-44078
            600-691             AC122223.4         48955-49046
            692-746             AC122223.4         55759-55813
            747-822             AC122223.4         58242-58317
            823-950             AC122223.4         64094-64221
            951-1022            AC122223.4         80973-81044
            1023-1070           AC122223.4         98971-99018
            1071-1199           AC122223.4         100068-100196
            1200-1650           AC122223.4         104509-104959
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.08 cM"
     gene            1..1650
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="boule homolog, RNA binding protein"
                     /db_xref="GeneID:75388"
                     /db_xref="MGI:MGI:1922638"
     exon            1..455
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..1316
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="isoform 1 is encoded by transcript variant 1; bol,
                     boule-like"
                     /codon_start=1
                     /product="protein boule-like isoform 1"
                     /protein_id="NP_083543.2"
                     /db_xref="CCDS:CCDS48262.1"
                     /db_xref="GeneID:75388"
                     /db_xref="MGI:MGI:1922638"
                     /translation="METESRAQSTNQTQTDSLSPSPNPVSPVPLNNPTSGPRYGTVIP
                     NRIFVGGIDFKTNENDLRKFFSQYGSVKEVKIVNDRAGVSKGYGFITFETQEDAQKIL
                     QEAEKLNYKDKKLNIGPAIRKQQVGIPRSSLMPAAGTMYLTTSTGYPYTYHNGVAYFH
                     TPEVTSVPPSWPSRSISSSPVMVAQPVYQQPAYHYQAPAQCLPGQWQWGVPQSPASSA
                     PFLYLQPSEVIYQPVEIAQDGGCVPPPLSLMETSVPEPYSDHGVQAAYHQVYASSAIA
                     MPAPMMQPEPIKVRSLF"
     exon            456..599
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..691
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..746
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..822
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            823..950
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1022
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1070
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1199
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1650
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1316
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="major polyA site"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1433
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
     regulatory      1504..1509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1528
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="Boll"
                     /gene_synonym="4930554P13Rik; 4930597B14Rik"
ORIGIN      
        1 acttgtcttc ctgtcttcga gccagctttc ggaagtcccc agaggccact ctctgtagta
       61 gaccctagag gtcggccctc cagggcaggg aaggctcgcc gctcttgcct tccgcggcgc
      121 gttcccctcc gctcgcagtg ctcgcgtccg tccgtccagc cgtccgtcct gccgccgctg
      181 gcagtcgcgg tgcgcgccgt ccgtgccgcc gccccggcgg ccccgggact tgcgcacagc
      241 gccaccgcca ccgccgccgc gcagcccgcc tcccccgccc ccacagggca gctcgcccgg
      301 ctcggagact gcgccactgc agccgccgcc gtcgccgcca gggggagcga gtccccgacg
      361 ggagacgcgc cggctcgctt cctgcgaacg cgccttccaa cttgagcttc ccgcgaactc
      421 cggagattag aaagatggag accgagtccc gggcgcagtc aacaaatcag acacaaacag
      481 attcattatc tccatcccct aatcctgtgt cacctgtgcc tttgaataac ccaacaagtg
      541 gcccaagata cggaactgtg atccctaacc gcatctttgt aggaggaatt gactttaaga
      601 caaacgaaaa tgatttaaga aaatttttct cccaatatgg gtctgtaaaa gaagtgaaga
      661 ttgttaatga cagagctgga gtgtccaaag ggtatggttt catcactttt gaaactcaag
      721 aagatgcaca aaaaatctta caagaggctg aaaaactcaa ttataaggat aagaaactca
      781 acattggtcc agcaataaga aaacaacaag tagggattcc tcgttctagt ctcatgccag
      841 cggctggaac aatgtatctg accacttcaa ctgggtaccc ttatacttac cataatggcg
      901 ttgcttattt tcatactcca gaagtaactt ctgtcccacc atcttggcct tcacgttcca
      961 tatctagttc tcctgtgatg gtggctcagc cagtttatca acagcctgca tatcactatc
     1021 aggccccagc acagtgttta ccagggcagt ggcagtgggg tgttccccag tcccctgctt
     1081 cttctgctcc attcctatat ctgcaacctt ctgaggttat ttatcagcca gtagaaattg
     1141 cgcaagacgg tggctgtgtt cctcctccac tgtctctgat ggaaacttct gttccagagc
     1201 cttattctga ccatggagtt caagcagcat atcaccaggt ttatgcttca agtgccattg
     1261 ctatgcctgc acctatgatg cagcctgagc caattaaagt aaggagttta ttttgacttt
     1321 tttctggttt tcttccatta tgatctggac acattttatc ccatctatga tcaaaagtaa
     1381 aaaaattagt taataatttt atatggagga aataaattct aaattaacaa taatttctgt
     1441 taactaattt tgaaatatta taaatccccc atggttaaaa tgttttattg tgatatagag
     1501 atacataaac ttaagtttac cattttaact attttaagca tctttaattt tattcaaaac
     1561 actataaaaa ttattgccag cattcccaac cttccatcac ctcaaatata aattctattc
     1621 tcatgacaca ataaatcctt cttccctttt
//
