LOCUS       NM_016778               1575 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus BCL2-related ovarian killer (Bok), mRNA.
ACCESSION   NM_016778
VERSION     NM_016778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Walter,F., D'Orsi,B., Jagannathan,A., Dussmann,H. and Prehn,J.H.M.
  TITLE     BOK controls ER proteostasis and physiological ER stress responses
            in neurons
  JOURNAL   Front Cell Dev Biol 10, 915065 (2022)
   PUBMED   36060797
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   Ke,F.F.S., Brinkmann,K., Voss,A.K. and Strasser,A.
  TITLE     Some mice lacking intrinsic, as well as death receptor induced
            apoptosis and necroptosis, can survive to adulthood
  JOURNAL   Cell Death Dis 13 (4), 317 (2022)
   PUBMED   35393408
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   Ke,F., Voss,A., Kerr,J.B., O'Reilly,L.A., Tai,L., Echeverry,N.,
            Bouillet,P., Strasser,A. and Kaufmann,T.
  TITLE     BCL-2 family member BOK is widely expressed but its loss has only
            minimal impact in mice
  JOURNAL   Cell Death Differ 19 (6), 915-925 (2012)
   PUBMED   22281706
  REMARK    GeneRIF: Bok protein have a role that largely overlaps with that of
            other members of the Bcl-2 family, or may have a function
            restricted to specific stress stimuli and/or tissues.
            Erratum:[Cell Death Differ. 2013 Jan;20(1):183]
REFERENCE   7  (bases 1 to 1575)
  AUTHORS   Shaposhnikov,D., Descot,A., Schilling,J. and Posern,G.
  TITLE     Myocardin-related transcription factor A regulates expression of
            Bok and Noxa and is involved in apoptotic signalling
  JOURNAL   Cell Cycle 11 (1), 141-150 (2012)
   PUBMED   22185759
  REMARK    GeneRIF: two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip
            are directly transcriptionally induced by activated MAL and upon
            activation of the actin-MAL-SRF pathway
REFERENCE   8  (bases 1 to 1575)
  AUTHORS   Rodriguez,J.M., Glozak,M.A., Ma,Y. and Cress,W.D.
  TITLE     Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and
            Sensitizes to Stress-induced Apoptosis
  JOURNAL   J Biol Chem 281 (32), 22729-22735 (2006)
   PUBMED   16772296
  REMARK    GeneRIF: Bok represents a cell cycle-regulated pro-apoptotic member
            of the Bcl-2 family
REFERENCE   9  (bases 1 to 1575)
  AUTHORS   Pfisterer,P., Ehlermann,J., Hegen,M. and Schorle,H.
  TITLE     A subtractive gene expression screen suggests a role of
            transcription factor AP-2 alpha in control of proliferation and
            differentiation
  JOURNAL   J Biol Chem 277 (8), 6637-6644 (2002)
   PUBMED   11741941
REFERENCE   10 (bases 1 to 1575)
  AUTHORS   Inohara,N., Ekhterae,D., Garcia,I., Carrio,R., Merino,J., Merry,A.,
            Chen,S. and Nunez,G.
  TITLE     Mtd, a novel Bcl-2 family member activates apoptosis in the absence
            of heterodimerization with Bcl-2 and Bcl-XL
  JOURNAL   J Biol Chem 273 (15), 8705-8710 (1998)
   PUBMED   9535847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ072720.1, AK168373.1 and BE991146.1.
            
            On Aug 27, 2015 this sequence version replaced NM_016778.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156243.1, AF027707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               CJ072720.1         98-286
            190-1556            AK168373.1         2-1368
            1557-1575           BE991146.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.28 cM"
     gene            1..1575
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /note="BCL2-related ovarian killer"
                     /db_xref="GeneID:51800"
                     /db_xref="MGI:MGI:1858494"
     exon            1..280
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /inference="alignment:Splign:2.1.0"
     exon            281..532
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /inference="alignment:Splign:2.1.0"
     exon            533..661
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /inference="alignment:Splign:2.1.0"
     exon            662..825
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1559
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1533..1538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /note="hexamer: AATAAA"
     polyA_site      1553
                     /gene="Bok"
                     /gene_synonym="matador; mtd"
                     /note="major polyA site"
ORIGIN      
        1 gggggttgcc gtttccttag aaggcgaagc cctaagcctg gcttctcgcc cgcggggaga
       61 ccgcggtacg cctcccgcac ccctcgggac caggacttct gcgagcgcgc gggaagaccg
      121 gcggagcctg tgcttcagct cgggtgtgga cggggcgggc gctggggcgg ggcgcgcgct
      181 cgcgggtttg aatggaaggg tctagaccgc cggagacggc agcgagcggg tcctgaaacc
      241 agaactccac cgccgccccg cgcgccatga ggcgggagag gtgtggcgcc tctcgcccgc
      301 gcttcggcca tggaggtgct gcggcgctct tctgtctttg cagcggagat catggacgcc
      361 tttgatcgct cgcccacaga caaggagctg gtggcccagg ctaaggcact aggccgggag
      421 tacgtgcacg cgcggctttt gcgcgccggc ctctcctgga gcgctccaga gcgtgcctcg
      481 cctgcccctg gaggacgctt ggcagaggtg tgcacagtgc tgctgcgctt gggagatgag
      541 ctggagcaga tccgtcccag cgtataccgg aacgtggccc ggcagctgca catccccctg
      601 cagtcggagc ctgtggtgac ggatgccttc ctggcagtgg caggccacat cttctcagca
      661 ggtatcacat ggggcaaggt agtgtccctg tattccgtgg ccgcggggct agcggtggac
      721 tgtgtccggc aggctcagcc tgccatggtt catgccctgg ttgactgcct gggggagttt
      781 gtacgcaaga ccttggctac ctggcttcgg aggcgtggtg gatggacgga tgtcctcaag
      841 tgtgtggtca gcacagatcc tggcttccgc tcccactggc tcgtggccac gctctgcagc
      901 tttggccgct tcctgaaggc agcattcttc ctgttgttgc cagagagatg agctggccac
      961 cagggcaggg gccactccta gggtccctgg gcccaatcca aggggcctcc agtacctaca
     1021 aagcacctcc ctcactcaaa ttgggagcat ttagcccctg gggccctgtc ccaaacccat
     1081 tcctttgtgg accctggcct ctgagagagg agtgtggaga aagccagagt ctggagctgg
     1141 cctctgtgac tgctctagct cttctcctgg aactcctgcc agaaagtcag ggtcggtgtc
     1201 cagccctaga gaaagggacc tgtgaatact ttcactcgat ttcccaggcc ccacccaagg
     1261 aaggggcctt ccccagacat gagctggcct cagtctttgt ggaaagcagg tcctgtacat
     1321 ttgacctgaa ggggactctg gctaatgcag gagaagccag ggatgcagag taagagagct
     1381 tcttgcttag gctatttcta gatgaagaag gtatccctaa gccacgatgg gtccttcatg
     1441 gcaggaacca gagaggtagg gctctaggct agttcacctg accaatgaac aagagatcct
     1501 gtggatgagg gggtctgtat aagttatact ccaataaagc tttacctagt gaagtgtgaa
     1561 aaaaaaaaaa aaaaa
//
