LOCUS       NM_009761               3237 bp    mRNA    linear   ROD 04-MAR-2023
DEFINITION  Mus musculus BCL2/adenovirus E1B interacting protein 3-like
            (Bnip3l), mRNA.
ACCESSION   NM_009761
VERSION     NM_009761.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3237)
  AUTHORS   Wilhelm LP, Zapata-Munoz J, Villarejo-Zori B, Pellegrin S, Freire
            CM, Toye AM, Boya P and Ganley IG.
  TITLE     BNIP3L/NIX regulates both mitophagy and pexophagy
  JOURNAL   EMBO J 41 (24), e111115 (2022)
   PUBMED   36215693
  REMARK    GeneRIF: BNIP3L/NIX regulates both mitophagy and pexophagy.
REFERENCE   2  (bases 1 to 3237)
  AUTHORS   Czernik M, Winiarczyk D, Sampino S, Greda P, Parillo S, Modlinski
            JA and Loi P.
  TITLE     Mitochondrial function and intracellular distribution is severely
            affected in in vitro cultured mouse embryos
  JOURNAL   Sci Rep 12 (1), 16152 (2022)
   PUBMED   36167966
  REMARK    Erratum:[Sci Rep. 2022 Dec 8;12(1):21276. PMID: 36481919]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3237)
  AUTHORS   Kodali S, Li M, Budai MM, Chen M and Wang J.
  TITLE     Protection of Quiescence and Longevity of IgG Memory B Cells by
            Mitochondrial Autophagy
  JOURNAL   J Immunol 208 (5), 1085-1098 (2022)
   PUBMED   35101890
REFERENCE   4  (bases 1 to 3237)
  AUTHORS   Menendez-Montes I, Escobar B, Gomez MJ, Albendea-Gomez T, Palacios
            B, Bonzon-Kulichenko E, Izquierdo-Garcia JL, Alonso AV, Ferrarini
            A, Jimenez-Borreguero LJ, Ruiz-Cabello J, Vazquez J and Martin-Puig
            S.
  TITLE     Activation of amino acid metabolic program in cardiac
            HIF1-alpha-deficient mice
  JOURNAL   iScience 24 (2), 102124 (2021)
   PUBMED   33665549
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3237)
  AUTHORS   Simpson CL, Tokito MK, Uppala R, Sarkar MK, Gudjonsson JE and
            Holzbaur ELF.
  TITLE     NIX initiates mitochondrial fragmentation via DRP1 to drive
            epidermal differentiation
  JOURNAL   Cell Rep 34 (5), 108689 (2021)
   PUBMED   33535046
  REMARK    GeneRIF: NIX initiates mitochondrial fragmentation via DRP1 to
            drive epidermal differentiation.
REFERENCE   6  (bases 1 to 3237)
  AUTHORS   Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L,
            Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H,
            Xu F, Salvesen G and Godzik A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   7  (bases 1 to 3237)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3237)
  AUTHORS   Yussman MG, Toyokawa T, Odley A, Lynch RA, Wu G, Colbert MC, Aronow
            BJ, Lorenz JN and Dorn GW 2nd.
  TITLE     Mitochondrial death protein Nix is induced in cardiac hypertrophy
            and triggers apoptotic cardiomyopathy
  JOURNAL   Nat Med 8 (7), 725-730 (2002)
   PUBMED   12053174
  REMARK    GeneRIF: induced in cardiac hypertrophy and triggers apoptotic
            cardiomyopathy
REFERENCE   9  (bases 1 to 3237)
  AUTHORS   Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H
            and Herrmann BG.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   10 (bases 1 to 3237)
  AUTHORS   Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L,
            Dubik D and Greenberg A.
  TITLE     Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial
            proteins
  JOURNAL   J Biol Chem 274 (1), 7-10 (1999)
   PUBMED   9867803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU560379.1, AK018668.1 and AK004667.1.
            
            [WARNING] On Jun 1, 2023 this sequence was replaced by NM_009761.4.
            
            On Nov 2, 2007 this sequence version replaced NM_009761.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004667.1, AK168482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BU560379.1         4-52
            50-2087             AK018668.1         2-2039
            2088-3237           AK004667.1         2034-3183
FEATURES             Location/Qualifiers
     source          1..3237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     gene            1..3237
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /note="BCL2/adenovirus E1B interacting protein 3-like"
                     /db_xref="GeneID:12177"
                     /db_xref="MGI:MGI:1332659"
     exon            1..190
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..750
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /note="BCL2/adenovirus E1B 19kDa-interacting protein
                     3-like; NIP3-like protein X; BCL2/adenovirus E1B 19
                     kDa-interacting protein 3-like"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3-like"
                     /protein_id="NP_033891.1"
                     /db_xref="CCDS:CCDS27227.1"
                     /db_xref="GeneID:12177"
                     /db_xref="MGI:MGI:1332659"
                     /translation="MSHLVEPPPPLHNNNNNCEEGEQPLPPPAGLNSSWVELPMNSSN
                     GNENGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQ
                     IMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHP
                     KRAASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY
                     "
     exon            191..374
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /inference="alignment:Splign:2.1.0"
     exon            375..447
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /inference="alignment:Splign:2.1.0"
     exon            448..551
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /inference="alignment:Splign:2.1.0"
     exon            552..701
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /inference="alignment:Splign:2.1.0"
     exon            702..3237
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /note="putative"
     polyA_site      3237
                     /gene="Bnip3l"
                     /gene_synonym="D14Ertd719e; Nip3L; Nix"
                     /note="putative"
ORIGIN      
        1 agaaaagggg gcgggggaac tcgacttgtt gtgttgctgc tcgagagccg gatactgtcg
       61 tcctgcggcc gtgccgcttc cagtctccag accatgtctc acttagtcga gccgccgccg
      121 cccttgcaca acaacaacaa caactgcgag gaaggggagc agcccctgcc gccgcccgct
      181 ggcctcaaca gttcctgggt ggagctaccc atgaacagca gcaatggcaa tgagaatgga
      241 aatgggaaga atggggggct ggagcacgtt ccttcctcgt cttccatcca caatggagac
      301 atggagaaga tcctcctgga tgcacagcat gagtcgggac agagcagctc aagaggcagt
      361 tcgcactgtg acagcccttc accacaagaa gatgggcaga tcatgtttga tgttgagatg
      421 cataccagca gggaccacag ctctcagtca gaagaagaag ttgtagaagg agaaaaggaa
      481 gttgaggctt tgaagaaaag tgcagactgg gtatcagact ggtccagtag acccgaaaac
      541 atcccaccca aagagttcca tttcagacac cctaaacgtg ctgcgtctct aagcatgagg
      601 aagagtggag ccatgaagaa agggggcatt ttctctgcag agttcctaaa agttttcatc
      661 ccatctctct tcctttctca tgtgctggcc ttggggctcg gcatctatat tggaaaacga
      721 ctgagcacac cttctgccag cacctactga gggagacgaa aagcccctgg aaattcgtgt
      781 ggcctgtgaa gtggtgtatt gtagtttgaa tttgagacct attgtaagca tgatccctac
      841 ctacaaccct atttttacat acccaattcc agtaactctc aaatccagta ttttactcaa
      901 actctgttgg ggcattttac taaccttgtt ccctttttgg cctgtaagac actttagaga
      961 ttcctaacag agtttactgt tgtttagaaa tttgcaaggg ctttttttca gcaatgccac
     1021 cagcagatta taatcttgtc aacagttcat tgtctcctct tagtaccacc agtcacctgc
     1081 atcattcatg ctagaagctg tgttctagcc atgcagttac atctctttct aaatgaggtc
     1141 aggtttgcaa ataataacaa caaaaaagct ttgtttagtc tttgttttgt tttccaggac
     1201 aaaaacaagc ttccctaagc ttgaatttat agttataaaa tgaaaacaaa accaaaaaaa
     1261 gaaaaaaaaa aaagcaagac acaagaaaaa aaaatatcct gggcaataaa aattacttta
     1321 aaccagctcc agagccgctc ttttcctaag cctcctgtgc cgccttcagt ttgtaggagg
     1381 cagcctgtgt gagtgacaga caggaaacag aagagtagaa catactggca gagttttaca
     1441 ttaggatatt gctgtctttt ctacgataga gaatctttat ttgtaaggaa tgtttcaggc
     1501 ctagacatac atgaaactta tttttgaggt ttttgtgctt ttggtatttt catgtgttac
     1561 ctgcatgtga atttctcatg actttgtttt tctagtttct tttttttttc taagaagaga
     1621 cttggaacga gtctgattca tggtgttaat agaggcttct tgttttagga agctttgctt
     1681 acactctgga gcctttacac tctgaaggag aacttcaggg ttattccaag tacttgtgtg
     1741 acttggaaaa gtagacttgg gttgtgggaa cagttgataa agttctggaa agatgccatt
     1801 cattctacag tcttcccaag gtgtcctagt ctctcccagg cccctgtgat tttctcacat
     1861 aggtgtcttc tcagttctgt caaattcctg atgttctgca atactcagaa aattctttga
     1921 atggcagact ttcttttgtc tgtttctaaa atgtgaagct ttaggaccaa attgttagac
     1981 agcatcagga ttgcggatta tctcaagtag attttgttag agttcagagc acagcatcac
     2041 tctgaaggag tctgtcttat aaatacataa ttactgttta agatgtacac tttgctatag
     2101 ttacagaacc attgtgaatt tcaaagctag caacctacac ggtgcaccag gttgacttga
     2161 ataaatttgg caaccaggtt tgcaagcgtg cagaaactaa ctcctctctc acaaaggctt
     2221 ataaaattgg tgtgtcctat ggaaatggaa agaaagatag ataagacatt tctgtcaatt
     2281 ttcaagaact tggctgttta tctttaagaa agataaaata tatatccaaa ataattttgt
     2341 gagttatttt ccttctggca tttaatacct acatgatttg tgagctactt ctgccttctc
     2401 cttctctgct cttaaacctg gagacgcttg ctctgccttc tcccctatca cttcaagtgt
     2461 ttatacctga gtttcttagg aagaaagtaa gtctgatggc ttgttgtttt gctgtagttg
     2521 ttttgaaaag ccgaaatcaa atggtcaagg ctgctgaggc taaactccag cagagtttgc
     2581 agcgctgatg tgtgagctgg cagagcagaa tcactcttca agcgcttgct cttacaggca
     2641 gacatcgttt tctctctaaa ttcagtagca gtttcatcga cagtgccatt gaactatggg
     2701 aacatttatg attttctttc aacattaaaa ctgaagttag ttttgccatt tttgaaagta
     2761 ttagtaaaat catggaatac atcacagaac agctgtccat cagtgagctt gtacagtgct
     2821 gatttgcagc tccaacatgc gggatgttca tcctcctaca cagattcttg ttgggtgaaa
     2881 cagattgtcc tatcacaaag cagaattcaa caaagttaaa atttaagata aggtttaaaa
     2941 agctttattc ctgtttacaa tttgggatga gaagcaggct tcgttttaag tttattgaaa
     3001 actggctcag atgtttataa gtcaagagga aagcggcaca gagaacagca cagtgaagag
     3061 tgaaatggag aaaactctca cggtgaagca gctgttggaa ctcctggtat taatggagcc
     3121 agagtgacat gcatccttcg tctgtctcat cagcactggc gtcattcctt acagtttaca
     3181 gaactcatgt aacttgtagc tataaacatt ttgtgccatt aaagctctca caaaacc
//
