LOCUS       NM_009760               1756 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus BCL2/adenovirus E1B interacting protein 3 (Bnip3),
            mRNA.
ACCESSION   NM_009760
VERSION     NM_009760.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1756)
  AUTHORS   Chen,Y., Yang,F., Shi,Y., Sheng,J., Wang,Y., Zhang,L., Zhou,J.,
            Jin,Y. and Yan,Y.
  TITLE     RNF31 alleviates liver steatosis by promoting p53/BNIP3-related
            mitophagy in hepatocytes
  JOURNAL   Free Radic Biol Med 219, 163-179 (2024)
   PUBMED   38615890
  REMARK    GeneRIF: RNF31 alleviates liver steatosis by promoting
            p53/BNIP3-related mitophagy in hepatocytes.
REFERENCE   2  (bases 1 to 1756)
  AUTHORS   Zhong,J., Xu,J., Chen,X., Li,N., Li,S., Deng,Z., Feng,H., Ling,X.,
            Wang,C., Zhou,Z. and Li,L.
  TITLE     Rbm46 inhibits reactive oxygen species in mouse embryonic stem
            cells through modulating BNIP3-mediated mitophagy
  JOURNAL   Biochem Biophys Res Commun 708, 149779 (2024)
   PUBMED   38518724
  REMARK    GeneRIF: Rbm46 inhibits reactive oxygen species in mouse embryonic
            stem cells through modulating BNIP3-mediated mitophagy.
REFERENCE   3  (bases 1 to 1756)
  AUTHORS   Liu,J., Livingston,M.J., Dong,G., Wei,Q., Zhang,M., Mei,S., Zhu,J.,
            Zhang,C. and Dong,Z.
  TITLE     HIF-1 contributes to autophagy activation via BNIP3 to facilitate
            renal fibrosis in hypoxia in vitro and UUO in vivo
  JOURNAL   Am J Physiol Cell Physiol 326 (3), C935-C947 (2024)
   PUBMED   38284121
  REMARK    GeneRIF: HIF-1 contributes to autophagy activation via BNIP3 to
            facilitate renal fibrosis in hypoxia in vitro and UUO in vivo.
REFERENCE   4  (bases 1 to 1756)
  AUTHORS   Jeong,D.J., Um,J.H., Kim,Y.Y., Shin,D.J., Im,S., Lee,K.M.,
            Lee,Y.H., Lim,D.S., Kim,D. and Yun,J.
  TITLE     The Mst1/2-BNIP3 axis is required for mitophagy induction and
            neuronal viability under mitochondrial stress
  JOURNAL   Exp Mol Med 56 (3), 674-685 (2024)
   PUBMED   38443598
  REMARK    GeneRIF: The Mst1/2-BNIP3 axis is required for mitophagy induction
            and neuronal viability under mitochondrial stress.
REFERENCE   5  (bases 1 to 1756)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1756)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   7  (bases 1 to 1756)
  AUTHORS   Vande Velde,C., Cizeau,J., Dubik,D., Alimonti,J., Brown,T.,
            Israels,S., Hakem,R. and Greenberg,A.H.
  TITLE     BNIP3 and genetic control of necrosis-like cell death through the
            mitochondrial permeability transition pore
  JOURNAL   Mol Cell Biol 20 (15), 5454-5468 (2000)
   PUBMED   10891486
REFERENCE   8  (bases 1 to 1756)
  AUTHORS   Chen,G., Cizeau,J., Vande Velde,C., Park,J.H., Bozek,G., Bolton,J.,
            Shi,L., Dubik,D. and Greenberg,A.
  TITLE     Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial
            proteins
  JOURNAL   J Biol Chem 274 (1), 7-10 (1999)
   PUBMED   9867803
REFERENCE   9  (bases 1 to 1756)
  AUTHORS   Reed,J.C.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (bases 1 to 1756)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121.. PMID: 8001138]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140248.3.
            
            On Apr 27, 2007 this sequence version replaced NM_009760.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014223.1, AK075943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC140248.3         157507-157650       c
            145-292             AC140248.3         146825-146972       c
            293-374             AC140248.3         146140-146221       c
            375-481             AC140248.3         142754-142860       c
            482-631             AC140248.3         142524-142673       c
            632-1756            AC140248.3         138980-140104       c
FEATURES             Location/Qualifiers
     source          1..1756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 82.95 cM"
     gene            1..1756
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /note="BCL2/adenovirus E1B interacting protein 3"
                     /db_xref="GeneID:12176"
                     /db_xref="MGI:MGI:109326"
     exon            1..144
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..677
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /note="BCL2/adenovirus E1B 19kDa-interacting protein 1,
                     NIP3; BCL2/adenovirus E1B 19 kDa-interacting protein 1,
                     NIP3; BCL2/adenovirus E1B interacting protein 1, NIP3"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3"
                     /protein_id="NP_033890.1"
                     /db_xref="CCDS:CCDS40168.1"
                     /db_xref="GeneID:12176"
                     /db_xref="MGI:MGI:109326"
                     /translation="MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDA
                     QHESGRSSSKSSHCDSPPRSQTPQDTNRAEIDSHSFGEKNSTLSEEDYIERRREVESI
                     LKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSADFLKVFLP
                     SLLLSHLLAIGLGIYIGRRLTTSTSTF"
     exon            145..292
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /inference="alignment:Splign:2.1.0"
     exon            293..374
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..481
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /inference="alignment:Splign:2.1.0"
     exon            482..631
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1756
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /note="hexamer: AATAAA"
     polyA_site      1628
                     /gene="Bnip3"
                     /gene_synonym="Nip3"
                     /note="major polyA site"
ORIGIN      
        1 agtccagtgt cgcctggcct cagaactgag cggcgcaggc tgcccctgct acctctcggt
       61 gaccgcctcc caggcctgtc gcagttgggt tcgggctcct ttgccgagcc accatgtcgc
      121 agagcgggga ggagaacctg cagggctcct gggtagaact gcacttcagc aatggcaatg
      181 ggagcagcgt tccagcctcc gtctctattt ataatggtga catggaaaaa atactgttgg
      241 atgcccagca tgaatctgga cgaagtagct ccaagagttc tcactgtgac agcccacctc
      301 gctcccagac accacaagat accaacagag ctgaaataga cagccacagc tttggcgaga
      361 aaaacagcac tctgtctgag gaagattata ttgagagaag aagagaagtt gaaagtatcc
      421 tgaagaaaaa ctcagattgg atatgggatt ggtcaagtcg accagaaaat attcccccca
      481 aggagttcct ttttaaacac ccgaagcgca cagctactct cagcatgaga aacacaagcg
      541 ttatgaagaa agggggaatt ttctcagcag actttctgaa ggttttcctt ccatctctgt
      601 tactgtctca tctgctggcc attggcttgg ggatctacat tggaaggcgt ctgacaactt
      661 ccactagcac cttctgatga agatttggat ctgacttctg ttcacacagt gaggattcat
      721 gtctgagctg tgacagctaa ttgaagagct agcatggtcc ttgggtgttt gcactatgtg
      781 tgttaatttg ttctgtaaat gcggtgttcc tgatttagtg agacagaata gactcttgtc
      841 atgacctata attataccta tgggatcaat taataagcat gtcagactga tgcctattgt
      901 agcatttact agtaaatttc tttgaatatt agatataaat agtaaatttc tttgaatatt
      961 agatataaat agtataaata attttaatat agtagcaatg gtgtatttaa aactgatctg
     1021 taatcataat ccagttaaga cactttacac ttcaaaagaa caagtaagtg atattaaaat
     1081 cattaaaggg ttttccccaa aggaatattg tggccttata atcctattac atagcagaaa
     1141 attaaagggt gcgtgcgggt tatctgtaaa ggcctctaac tttgtgaact gagtagcaag
     1201 tagaagctaa ggttacccac gaaccccact ttgcagttcc ccctcgtcct gctttgcagg
     1261 atgaggattc tcgccttgct gtccaccatt accttgggtg gtcagttttg ttgcaggcac
     1321 ctttatcact ctgctgaatt ctcttgtttg tatttaaatc ttatgtgctc tgaaaatcag
     1381 ctgtctactt taaaagactg gaaatgaaaa acaaaatctt tgccaaatcc actggagaat
     1441 actatatttg catatccatt aatcaggatc caaagctgct taaatcgggc gtcctcccag
     1501 tcttctcttt tctatagcat ggttttaaag cctgcctcct tgacatgctg tatatatcct
     1561 gttgtatttg tttcactgtc ccacacttaa ctcaggtgtg ctaaaataaa agtgacattt
     1621 taacagtctt ttgtttatat ttacataatt actagacata gcctatatcc ctttcatttg
     1681 gagcaagatc ctacaggatg taatagtcaa taggtgtttt cttgcttcat tcagtaaagt
     1741 atttttgtaa gaaatt
//
