LOCUS       NM_023326                861 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus brain expressed myelocytomatosis oncogene (Bmyc),
            mRNA.
ACCESSION   NM_023326
VERSION     NM_023326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 861)
  AUTHORS   Chen,S., Yao,X., Li,Y., Saifudeen,Z., Bachvarov,D. and El-Dahr,S.S.
  TITLE     Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the
            ureteric bud epithelium
  JOURNAL   Development 142 (6), 1180-1192 (2015)
   PUBMED   25758227
REFERENCE   2  (bases 1 to 861)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 861)
  AUTHORS   Turunen,H.T., Sipila,P., Strauss,L., Bjorkgren,I., Huhtaniemi,I.
            and Poutanen,M.
  TITLE     Loss of Bmyc results in increased apoptosis associated with
            upregulation of Myc expression in juvenile murine testis
  JOURNAL   Reproduction 144 (4), 495-503 (2012)
   PUBMED   22869780
  REMARK    GeneRIF: Data from knockout mice suggest that Bmyc is a regulator
            of Myc (myelocytomatosis oncogene) in vivo and that overexpression
            of Myc in developing testis leads to increased apoptosis of
            spermatogenic cells.
REFERENCE   4  (bases 1 to 861)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 861)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 861)
  AUTHORS   Domashenko,A.D., Latham,K.E. and Hatton,K.S.
  TITLE     Expression of myc-family, myc-interacting, and myc-target genes
            during preimplantation mouse development
  JOURNAL   Mol Reprod Dev 47 (1), 57-65 (1997)
   PUBMED   9110315
REFERENCE   7  (bases 1 to 861)
  AUTHORS   Asker,C.E., Magnusson,K.P., Piccoli,S.P., Andersson,K., Klein,G.,
            Cole,M.D. and Wiman,K.G.
  TITLE     Mouse and rat B-myc share amino acid sequence homology with the
            c-myc transcriptional activator domain and contain a B-myc specific
            carboxy terminal region
  JOURNAL   Oncogene 11 (10), 1963-1969 (1995)
   PUBMED   7478514
REFERENCE   8  (bases 1 to 861)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   9  (bases 1 to 861)
  AUTHORS   Ingvarsson,S., Sundaresan,S., Jin,P., Francke,U., Asker,C.,
            Sumegi,J., Klein,G. and Sejersen,T.
  TITLE     Chromosome localization and expression pattern of Lmyc and Bmyc in
            murine embryonal carcinoma cells
  JOURNAL   Oncogene 3 (6), 679-685 (1988)
   PUBMED   2577870
REFERENCE   10 (bases 1 to 861)
  AUTHORS   Ingvarsson,S., Asker,C., Axelson,H., Klein,G. and Sumegi,J.
  TITLE     Structure and expression of B-myc, a new member of the myc gene
            family
  JOURNAL   Mol Cell Biol 8 (8), 3168-3174 (1988)
   PUBMED   2850482
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060207.1.
            
            On Dec 3, 2005 this sequence version replaced NM_023326.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC056436.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.82 cM"
     gene            1..861
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
                     /note="brain expressed myelocytomatosis oncogene"
                     /db_xref="GeneID:107771"
                     /db_xref="MGI:MGI:88184"
     exon            1..843
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..560
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
                     /codon_start=1
                     /product="protein B-Myc"
                     /protein_id="NP_075815.2"
                     /db_xref="CCDS:CCDS15789.1"
                     /db_xref="GeneID:107771"
                     /db_xref="MGI:MGI:88184"
                     /translation="MPLHVSLANGNRDLDYDSVQPYFMCDDEEEDVHHQQPPQPPAPS
                     EDIWKKFELLPTPRPSPGHAGLYSPPCEAVAVSFAPRDHDGDSFSIADLPELPGGDAV
                     KQSFVCDPDDETFVKNIILQDCMWNGFSASAKLVSKLDPYQAVRKEGTGVSLAADVEP
                     ATPPDCTCNT"
     regulatory      772..777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
                     /note="hexamer: AATAAA"
     polyA_site      793
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
                     /note="major polyA site"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
                     /note="hexamer: TATAAA"
     polyA_site      823
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
     polyA_site      843
                     /gene="Bmyc"
                     /gene_synonym="2900002K07Rik; Mycb"
ORIGIN      
        1 gcagccctgc acccctccgg gtcgcctcca aacgcaacgc cgcgaccatg cccctccacg
       61 tgagcctcgc taacggcaac cgcgacctgg actatgactc ggtgcagcca tacttcatgt
      121 gcgacgatga ggaggaggac gtgcaccacc agcagccgcc gcagccgcca gcgcccagcg
      181 aggacatctg gaagaaattc gagctgctgc ccacgccgcg cccgtccccg ggccacgccg
      241 ggctctactc gcctccctgc gaagcggtcg ccgtgtcttt cgcccccagg gaccacgacg
      301 gtgatagctt ctccatcgca gacctgcccg agctgccagg aggagacgcg gtgaagcaga
      361 gcttcgtctg cgacccggat gacgagacct tcgtgaagaa catcatcctg caggactgta
      421 tgtggaatgg cttctcggcc tccgccaagc tggtctccaa gctggacccc taccaggctg
      481 tgcgcaaaga aggcaccggc gtgagcctgg ccgccgacgt ggagcctgct acgcctccag
      541 actgcacctg caacacctga gcgcacagca cggggggctt tggactgtaa gcttcagcca
      601 tgttaactgc ctcaaatcct gggcgtaaga gaaccctccc ctccctcttt tcttttttaa
      661 gcttgccacc cttcctcact ccccttaaca gatttgtatt tgtttaaaaa aggaatctta
      721 aagtatatca attttccaac atcagctgga cccttaagtg taaataacat caataaaaac
      781 gtcttatcag ttatacaaga ttttaggata tgaaatataa aaaggtatat tttcctttca
      841 aaaaaaaaaa aaaaaaaaaa a
//
