LOCUS       NM_009759               3005 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus BMX non-receptor tyrosine kinase (Bmx), mRNA.
ACCESSION   NM_009759
VERSION     NM_009759.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3005)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3005)
  AUTHORS   Yang,F., Duan,M., Zheng,F., Yu,L., Wang,Y., Wang,G., Lin,J.,
            Han,S., Gan,D., Meng,Z. and Zhu,S.
  TITLE     Fas signaling in adipocytes promotes low-grade inflammation and
            lung metastasis of colorectal cancer through interaction with Bmx
  JOURNAL   Cancer Lett 522, 93-104 (2021)
   PUBMED   34536556
  REMARK    GeneRIF: Fas signaling in adipocytes promotes low-grade
            inflammation and lung metastasis of colorectal cancer through
            interaction with Bmx.
REFERENCE   3  (bases 1 to 3005)
  AUTHORS   Li,Z., Yin,M., Zhang,H., Ni,W., Pierce,R.W., Zhou,H.J. and Min,W.
  TITLE     BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and
            Vascular Leakage During Early Sepsis
  JOURNAL   Circ Res 126 (4), 471-485 (2020)
   PUBMED   31910739
  REMARK    GeneRIF: Data show that bone marrow kinase on the X chromosome
            (BMX) specifically repressed thrombin-PAR1 (protease-activated
            receptor-1) signaling in endothelial cells by directly
            phosphorylating PAR1 and promoting its internalization and
            deactivation.
REFERENCE   4  (bases 1 to 3005)
  AUTHORS   Vanlandewijck,M., He,L., Mae,M.A., Andrae,J., Ando,K., Del
            Gaudio,F., Nahar,K., Lebouvier,T., Lavina,B., Gouveia,L., Sun,Y.,
            Raschperger,E., Rasanen,M., Zarb,Y., Mochizuki,N., Keller,A.,
            Lendahl,U. and Betsholtz,C.
  TITLE     A molecular atlas of cell types and zonation in the brain
            vasculature
  JOURNAL   Nature 554 (7693), 475-480 (2018)
   PUBMED   29443965
  REMARK    Erratum:[Nature. 2018 Aug;560(7716):E3. doi:
            10.1038/s41586-018-0232-x.. PMID: 29925939]
REFERENCE   5  (bases 1 to 3005)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3005)
  AUTHORS   Bagheri-Yarmand,R., Mandal,M., Taludker,A.H., Wang,R.A.,
            Vadlamudi,R.K., Kung,H.J. and Kumar,R.
  TITLE     Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity
            of breast cancer cells
  JOURNAL   J Biol Chem 276 (31), 29403-29409 (2001)
   PUBMED   11382770
REFERENCE   7  (bases 1 to 3005)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   8  (bases 1 to 3005)
  AUTHORS   Weil,D., Power,M.A., Smith,S.I. and Li,C.L.
  TITLE     Predominant expression of murine Bmx tyrosine kinase in the
            granulo-monocytic lineage
  JOURNAL   Blood 90 (11), 4332-4340 (1997)
   PUBMED   9373244
REFERENCE   9  (bases 1 to 3005)
  AUTHORS   Ekman,N., Lymboussaki,A., Vastrik,I., Sarvas,K., Kaipainen,A. and
            Alitalo,K.
  TITLE     Bmx tyrosine kinase is specifically expressed in the endocardium
            and the endothelium of large arteries
  JOURNAL   Circulation 96 (6), 1729-1732 (1997)
   PUBMED   9323053
REFERENCE   10 (bases 1 to 3005)
  AUTHORS   Rinke de Wit,T.F., Izon,D.J., Revilla,C., Oosterwegel,M.,
            Bakker,A.Q., van Ewijk,W. and Kruisbeek,A.M.
  TITLE     Expression of tyrosine kinase gene in mouse thymic stromal cells
  JOURNAL   Int Immunol 8 (11), 1787-1795 (1996)
   PUBMED   8943574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040936.1 and AK036707.1.
            
            On Apr 14, 2009 this sequence version replaced NM_009759.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040936.1, U88091.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2985              AK040936.1         2-2986
            2986-3005           AK036707.1         2845-2864
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.12 cM"
     gene            1..3005
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /note="BMX non-receptor tyrosine kinase"
                     /db_xref="GeneID:12169"
                     /db_xref="MGI:MGI:1101778"
     exon            1..146
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2111
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /EC_number="2.7.10.2"
                     /note="TYRO8 protein tyrosine kinase 8; bone marrow
                     tyrosine kinase gene in chromosome X protein homolog"
                     /codon_start=1
                     /product="cytoplasmic tyrosine-protein kinase BMX"
                     /protein_id="NP_033889.2"
                     /db_xref="CCDS:CCDS30519.2"
                     /db_xref="GeneID:12169"
                     /db_xref="MGI:MGI:1101778"
                     /translation="MDDNMESKSILEELLLKKSQQKKKMSPNNYKERLFVLTKTSLSY
                     YEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEES
                     RCQWLKALQKEIRGNPHLLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYADLHIAI
                     SDEKHRAPTFPERLLKIPRAVPVLKMDASSSGAILPQYDSYSKKSCGSQPTSNIRYIP
                     REDCPDWWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAYDW
                     FAGNISRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTN
                     AENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGIWEL
                     KREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHP
                     KLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLE
                     SHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY
                     FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQI
                     MYSCWHELPEKRPTFQQLLSAIEPLREQDKP"
     exon            147..293
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            294..398
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            399..480
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            481..600
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            601..665
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            666..841
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            842..913
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            914..967
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1022
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1102
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1230
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1305
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1477
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1694
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1759
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1878
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2036
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..3005
                     /gene="Bmx"
                     /gene_synonym="Etk; Etk/Bmx; Tyro8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccatttct gacccaacag ccaggggaaa aaaaaatgtg atacaattca ctgctgctgg
       61 agagaggaca gcccgaggtt gcgttcttgc aggagcagct tcgcttcacc gtggtggacc
      121 ccagggagac agaaggagcc caaatggacg acaatatgga gagtaaatcc attctggaag
      181 aactgcttct caaaaagtca cagcaaaaga agaaaatgtc accaaataat tacaaggagc
      241 ggctttttgt tctaaccaaa acaagccttt cctactatga atacgacaaa atgaaaagag
      301 gaagcagaaa aggatcaata gaaattaaga aaatcagatg tgtggaaaaa gtcaaccttg
      361 aggagcagac accggtggag agacagtacc catttcagat tgtgtataaa gatgggcttc
      421 tttatgtcta tgcatcgaat gaagagagcc gatgtcagtg gttaaaagcg ctgcaaaaag
      481 agatacgggg caaccctcac ctgttgatca agtatcacag tggcttcttt gtggatggaa
      541 agttcctgtg ttgccagcag agctgcaaag cagccccagg atgcactctc tgggaagcat
      601 atgctgatct gcacatcgca atcagtgatg agaaacacag agctcccact ttcccagaga
      661 ggctactgaa gattccaagg gcagttcccg ttctcaaaat ggatgcatca tcttcaggtg
      721 ccattctacc ccaatatgac agctattcaa agaaaagttg tggttcccag ccaaccagca
      781 acatacgcta tattccaagg gaagactgcc ctgactggtg gcaagtaaga aaactgaaaa
      841 gcgaggaaga cattgcatgc agtaaccaac tggaaagaaa tatcgcctct cacagcacct
      901 caaagatgtc atggggattc cctgagtcaa gttcatcaga agaagaggaa aatctgcatg
      961 cttatgactg gtttgctggg aatatctcca ggtcacaatc tgagcagtta ctgagacaaa
     1021 agggaaaaga aggagcattt atggttcgga attccagcca gatgggaatg tacactgtgt
     1081 ccttatttag taaggctgta aatgataaaa aaggaactgt caagcattac cacgtgcata
     1141 ctaatgctga aaataaatta tacctggctg aaaactactg ctttgattcc attccaaagc
     1201 tcattcacta tcaccaacat aattcagcag gcatgatcac acggctccgc cacccagtgt
     1261 caaccaaggc caacaaggtc ccggtgtctg tggctctggg aagtggaatt tgggaactga
     1321 aaagagaaga gattaccttg ctgaaggagc tgggcaatgg ccagtttgga gtggtccagc
     1381 tgggccagtg gaaggggcaa tatgatgtgg ctgtaaagat gatcaaggag ggtgccatgt
     1441 cagaagatga attctttcag gaggcccaga ccatgatgaa actcagccat cccaagctgg
     1501 tgaagttcta cggagtatgc tcaaagaaat accccatcta tatagtaact gagtatataa
     1561 caaatggttg cttgcttaat tacctgaaga gtcatgggaa aggactagaa agttgccagc
     1621 tcttagaaat gtgttatgat gtctgtgaag gcatggcctt cttggagagc catcagttca
     1681 tacatcgaga tttggctgct cggaactgtt tggtggacag tgatctctct gtgaaagtct
     1741 cagactttgg aatgacgaga tatgtccttg atgatcagta tgtcagctca gtaggaacca
     1801 agtttccagt caagtggtca gctccagagg tgtttcacta cttcaaatac agcagcaagt
     1861 cggatgtatg ggcatttggg atcctgatgt gggaggtgtt tagtctaggg aagcagccct
     1921 atgacttata tgataactcc gaggtggttg tgaaggtctc ccagggccac agactctacc
     1981 ggccccaact ggcatcagac accatctacc agatcatgta cagctgctgg catgagcttc
     2041 cagaaaagcg ccccacattt cagcaactcc tgtctgccat agaaccactt cgggaacaag
     2101 ataaaccatg aagagaaatt tcagagtggt gatgagaaca aatgtcaata ttaactaaca
     2161 ctctcattgt ttgtaaggga agtagaaaga ctcaatgcaa tgtagctcgt tcttaacaat
     2221 ggtctatgtg ctgtttatct gttatattat ctaccaaaaa aagcaaggta ggaaacaaga
     2281 tagttctttg aaatttaggt caaattggta attttgtttg tgctgctttt aaggtatact
     2341 tccaagacta tggtagaagt tcatttttag attgcaattt acaaattgta ctgtgtataa
     2401 aggtagagca gaattgaaaa ggtgatttgt tgggaactcc ctttttttaa aaaaaaattg
     2461 gcactagtgt gataattaaa tatcttttca agaacggaaa tgtatatgtt tgcttctgta
     2521 tgagaaatgt ctcaggcatt tgaatatttg ttctctgtgg cactgtttgg gggaggttta
     2581 ggaggtatgg gcttgatgga ggaatgatgt caatggagcg ggctgtgaga gcctaaggct
     2641 tcaccctact atctctgctt cttgcttaca attcaagatg tgagctctca gaagctgaaa
     2701 aggtggcttg gtgcttaaga acaccggctg ttcttctaga ggacccagac tcaattccta
     2761 gcacccacac agtggtttac aacttgtcta tgaatccagt tctaaggtat ctgatgacgt
     2821 cttttggcct tcatggacac catggacacg tgtggtacac tgacatgtat acaggcaaag
     2881 aagaaaaata aaggatgaga gctctcagca tcctgctcta tctgcctgtt tgcaagttgc
     2941 ctttgccctg ccattttgaa ctctaacttt ctggaactat aagccaaata aagcctttct
     3001 tctat
//
