LOCUS       NM_175312               4147 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus S-adenosylmethionine sensor upstream of mTORC1
            (Samtor), mRNA.
ACCESSION   NM_175312
VERSION     NM_175312.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4147)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046745.1, BC145710.1 and CJ318712.1.
            
            On Oct 27, 2007 this sequence version replaced NM_175312.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046745.1, SRR1660817.154080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1032              AK046745.1         2-1033
            1033-2234           BC145710.1         989-2190
            2235-3879           AK046745.1         2236-3880
            3880-4147           CJ318712.1         183-450
FEATURES             Location/Qualifiers
     source          1..4147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.69 cM"
     gene            1..4147
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /note="S-adenosylmethionine sensor upstream of mTORC1"
                     /db_xref="GeneID:101148"
                     /db_xref="MGI:MGI:2141466"
     exon            1..287
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1345
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /note="UPF0532 protein C7orf60 homolog; probable
                     methyltransferase BTM2 homolog; probable methyltransferase
                     BMT2 homolog; base methyltransferase of 25S rRNA 2"
                     /codon_start=1
                     /product="S-adenosylmethionine sensor upstream of mTORC1"
                     /protein_id="NP_780521.2"
                     /db_xref="CCDS:CCDS51723.1"
                     /db_xref="GeneID:101148"
                     /db_xref="MGI:MGI:2141466"
                     /translation="MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRR
                     LRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCR
                     EYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPDFITELLQA
                     SGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAID
                     AFLKQLRNPIDALPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITP
                     DSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPG
                     MLYIPQDFNSVEEEEYSNTSCYVRSDLEDEQLAYGFTELPEAPYDSDSGESQASSIPF
                     YELEDPILLLS"
     exon            288..429
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..600
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..715
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..4141
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /note="hexamer: AATAAA"
     polyA_site      2991
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /note="major polyA site"
     regulatory      4119..4124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /note="hexamer: ATTAAA"
     polyA_site      4141
                     /gene="Samtor"
                     /gene_synonym="B630005N14Rik; Bmt2"
                     /note="major polyA site"
ORIGIN      
        1 agctgtggct cctcggcctc ctccggttgc tgcctctgct gctgcctcct cttccccacc
       61 tcctccgtcc ggggagagac cgcggggccc gaggggcggc ggcggcagcg gcagcggcgg
      121 cggcggcagc gctatggagc cggggccggg tggccgaggc gcagcgcgcg gacagcggcc
      181 cccgaacgcc gcgcagcccc gggagcagga gcggaagctg gagcaggaga agctgtccgg
      241 ggtggtgaag agcgttcatc ggcggctccg caagaagtac cgcgaagtgg gagactttga
      301 taagatctgg cgagaacact gtgaagatgc ggaaacactt tgcgaatatg ctgttgcaat
      361 gaaaaatctg gcagataatc actgggcaaa aacttgtgag ggtgaaggtc gcattgaatg
      421 gtgttgtagt gtatgcagag agtacttcca aaatggtggg aaaagaaaag cacttgagaa
      481 agatgaaaaa cgagctgtcc tcgccactaa gaccactcca gccttaaacg tgcacgagtc
      541 ttctaaactt gaaggtcctt taacaaacct cagctttaca agccctgact ttataactga
      601 gttgcttcaa gcctcaggaa agatcagatt acttgatgtt ggcagctgct ttaatccatt
      661 tttgaagttt gaagaatttt taactgttgg catagatatt gtacctgctg tagagagtgt
      721 gtataagtgt gacttcctga acctgcagct gcagcagcca ctccagcttg cacaagatgc
      781 tatagatgct tttctgaagc agctgagaaa tcctattgat gctcttccgg gggaactttt
      841 tcatgtggtt gtcttctctc tccttctttc ctattttcca tcaccctacc agcgatggat
      901 ttgctgcaag aaagcccatg agctgttagt cctgaacggc ttattgctca tcatcactcc
      961 cgattcctcc catcagaacc ggcacgctat gatgatgaag agctggaaga ttgctataga
     1021 atccctgggt tttaagcgct tcaagtattc aaaattttct catatgcatc tcatggcttt
     1081 tagaaaaacc tcccttaaaa ccacaagtga cttggttagc aggaactatc cagggatgtt
     1141 gtatattcct caagatttca acagtgtaga agaggaggag tattctaaca cttcctgcta
     1201 tgtccgatca gatctagaag atgaacaact cgcatacggt ttcacggagc tccccgaagc
     1261 tccttatgat tccgattctg gagaaagcca agccagctct attccatttt atgagttaga
     1321 ggatcccatc ttacttttaa gctaatgtaa aagcaaaaag cccttccatt ccagattcct
     1381 aaactaaatg cttacactaa tcagaatact aacatgaact cagtatttaa agcctggttt
     1441 gcatagaaga aatgcaaacg tttacagagt ttgctatttt ttctacttct ggatttcaaa
     1501 atttattctt atataggaag cttaaagttt catgcagagt gactctgtct tagcagaaac
     1561 cactgttact ttagcatttt gcattaagat tcaaaaggta ccttttctct ctttagtgct
     1621 gttgtaaagc ctaatgtact atgtatttcc ctcttcagtt tagtgttgac tttacaccct
     1681 tgtcatgagg aacctcaaga tgtgtagaaa gctgtagatt gcactttgat gactcacaag
     1741 ttgaatattt cacataggtt ggtgtagttg tttgtggtac atatttgtct ttttctttaa
     1801 attgttacct tctgcagaaa acagtttcta ctcagtttca tctaacaatc cagtattcct
     1861 gaactttttg aaattggtga caaattttta tattaagctc attcggaaac attagacatt
     1921 ggaagagata tttcccaaag aatgtattct aatgaacaca gtacagcaaa caccattgcc
     1981 aaagtagtat ttctatgaca ttcttactga tacaggtctt ggtgttcagt atatttacct
     2041 gtgaaagcaa atttttattt ttttaaagct tagactgcat ttacagaatg ttctgtttaa
     2101 gcaagaagca atgtatcata cccaacactg gcctggaaca cctttgtgaa agggttgcac
     2161 gtgtaaacgg ttatattctg ctgtgaccag ctctgagagg gtcctcacct gtcctttagg
     2221 gcggtgctgc actataagtt cagaattaca ttaacatttt tttaaattaa ccctctactg
     2281 ataatctcat aaaatggtct tgtccttttg ttatcctaat tctttctaag ccctagcaga
     2341 aaattttctt tgactatata aacaattagt tggctgtggg aaatttccct ttccacattg
     2401 ataaatgcct ttctgtgttt ctgaatcaga agcaaatgat taactagaaa tatatgtcca
     2461 aacaagacaa gattaaacag ttaagaacat ttagtccaca ttgtcttgtc agccagcaat
     2521 tgtcatatgt catgtaaact atcattttaa agagtgccac tgtgtggatt tttttcaagt
     2581 ggttattaca ttaaaattac ctcatactga ggtttttgca ctgaaatatc acagtttcag
     2641 atttcatggt taatgttgta tgagcgtgta tgtatgtgtg tgttgtatgt gtgcatatgt
     2701 atttttaaaa gaaactttca ttttcagtag ttgatcctaa atttcataaa ctgcacttct
     2761 ttactctggt aaaatggatg tttttgtgct tattgtgaat tgcaatagtt aactttgaat
     2821 gtcaaatttt atttagaaat acataagctt acactttaag atatgtgttc attgtatgta
     2881 tccaatattt catgttcagt ttcacatgct aaattaatga aagtaacttg attataacta
     2941 actttagaaa agtcagttgt ctaaatgcaa taaacattaa ttgttaaaag atgtcataag
     3001 taacttgaaa ttttcattta ctttcaatag cacatagtcc catcattact agagtttctt
     3061 tccatttagg cactacagga taatggttta aaactccctc aaaagaaaag aagacaaaag
     3121 attgaagagg cgctgtgttc aggataaaac aaaaatatgt tctggtagca tctctcttac
     3181 cattctgttt tcttgtctgt tttgttaact cattacaatc ctcagagcaa aggaaacaat
     3241 acaccaaatg aaattgcttt gaaagaaaat gaaacagtac tttggaaggt tggtctaggt
     3301 atcacctttg agacaacttt tatgtcacag caaaaatgtt ggtgctataa attcttctgg
     3361 ttgttaactg agattgagtt tgcttttggt ccaaagtttg catgatatat gttaagtact
     3421 taaaaatatc tctttataag atctactact atttagtata aattgatttg atttgatgtc
     3481 attttttttc actgtaaact cagcttactc agattaaaac ttacaccaat acatattcca
     3541 caggccagtt ccatgtgaaa gtgttgaaac ataagcagtc attatgggtt gaggtatata
     3601 agtaataacc agtgaagtta ataggtcctt caaatattgt ataggtacgc taaaattatt
     3661 tcacctggat attgatagtt taaggaattt cctgtcacat tcacacaatt tctccaaaat
     3721 aacttagtat ttcaaaacat gataattggg ccaagtgatg ggggcttaag ccgttagtcc
     3781 cagcacttgg gaggcagagc tatgacttca aggccagcca gcctggtctt caaagcaagt
     3841 tctgggacag ccaaggctac tcaaagaaaa ccatgtctca gaaaaaaaaa aaaaaaaaaa
     3901 aaaaaaaaaa aaaaaaaaaa aggaaggaag gaaggaagga aggaaggaag gaaggaagga
     3961 aaaagccaga tgagaatcat gtggttggtt gggctcatca ggatggtgaa cagatcatgt
     4021 gattttacta tagttacaaa gtggctggag gtagagtacc tgaaaatgta catttgtgtt
     4081 tgatgtattt tttcacattt tgtgaacaaa gcacatttat taaaaaattt aaattttcta
     4141 aaaaaaa
//
