LOCUS       NM_007561              11094 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus bone morphogenetic protein receptor type 2 (Bmpr2),
            mRNA.
ACCESSION   NM_007561
VERSION     NM_007561.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11094)
  AUTHORS   Song,C., Qin,Y., Li,Y., Yang,B., Guo,T., Ma,W., Xu,D., Xu,K.,
            Fu,F., Jin,L., Wu,Y., Tang,S., Chen,X. and Zhang,F.
  TITLE     Deleterious variants in RNF111 impair female fertility and induce
            premature ovarian insufficiency in humans and mice
  JOURNAL   Sci China Life Sci 67 (7), 1325-1337 (2024)
   PUBMED   38874713
REFERENCE   2  (bases 1 to 11094)
  AUTHORS   Isobe,S., Nair,R.V., Kang,H.Y., Wang,L., Moonen,J.R., Shinohara,T.,
            Cao,A., Taylor,S., Otsuki,S., Marciano,D.P., Harper,R.L.,
            Adil,M.S., Zhang,C., Lago-Docampo,M., Korbelin,J., Engreitz,J.M.,
            Snyder,M.P. and Rabinovitch,M.
  TITLE     Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial
            hypertension
  JOURNAL   Nat Commun 14 (1), 7578 (2023)
   PUBMED   37989727
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11094)
  AUTHORS   Marinho,Y., Villarreal,E.S., Aboagye,S.Y., Williams,D.L., Sun,J.,
            Silva,C.L.M., Lutz,S.E. and Oliveira,S.D.
  TITLE     Schistosomiasis-associated pulmonary hypertension unveils disrupted
            murine gut-lung microbiome and reduced endoprotective
            Caveolin-1/BMPR2 expression
  JOURNAL   Front Immunol 14, 1254762 (2023)
   PUBMED   37908354
  REMARK    GeneRIF: Schistosomiasis-associated pulmonary hypertension unveils
            disrupted murine gut-lung microbiome and reduced endoprotective
            Caveolin-1/BMPR2 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11094)
  AUTHORS   Zhang,S.J., Qin,X.Z., Zhou,J., He,B.F., Shrestha,S., Zhang,J. and
            Hu,W.P.
  TITLE     Adipocyte dysfunction promotes lung inflammation and aberrant
            repair: a potential target of COPD
  JOURNAL   Front Endocrinol (Lausanne) 14, 1204744 (2023)
   PUBMED   37886639
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11094)
  AUTHORS   Miyazono,K., Kamiya,Y. and Morikawa,M.
  TITLE     Bone morphogenetic protein receptors and signal transduction
  JOURNAL   J Biochem 147 (1), 35-51 (2010)
   PUBMED   19762341
  REMARK    Review article
REFERENCE   6  (bases 1 to 11094)
  AUTHORS   Beppu,H., Kawabata,M., Hamamoto,T., Chytil,A., Minowa,O., Noda,T.
            and Miyazono,K.
  TITLE     BMP type II receptor is required for gastrulation and early
            development of mouse embryos
  JOURNAL   Dev Biol 221 (1), 249-258 (2000)
   PUBMED   10772805
REFERENCE   7  (bases 1 to 11094)
  AUTHORS   Zhang,D., Mehler,M.F., Song,Q. and Kessler,J.A.
  TITLE     Development of bone morphogenetic protein receptors in the nervous
            system and possible roles in regulating trkC expression
  JOURNAL   J Neurosci 18 (9), 3314-3326 (1998)
   PUBMED   9547239
REFERENCE   8  (bases 1 to 11094)
  AUTHORS   Roelen,B.A., Goumans,M.J., van Rooijen,M.A. and Mummery,C.L.
  TITLE     Differential expression of BMP receptors in early mouse development
  JOURNAL   Int J Dev Biol 41 (4), 541-549 (1997)
   PUBMED   9303341
REFERENCE   9  (bases 1 to 11094)
  AUTHORS   Beppu,H., Minowa,O., Miyazono,K. and Kawabata,M.
  TITLE     cDNA cloning and genomic organization of the mouse BMP type II
            receptor
  JOURNAL   Biochem Biophys Res Commun 235 (3), 499-504 (1997)
   PUBMED   9207184
REFERENCE   10 (bases 1 to 11094)
  AUTHORS   Katagiri,T., Yamaguchi,A., Komaki,M., Abe,E., Takahashi,N.,
            Ikeda,T., Rosen,V., Wozney,J.M., Fujisawa-Sehara,A. and Suda,T.
  TITLE     Bone morphogenetic protein-2 converts the differentiation pathway
            of C2C12 myoblasts into the osteoblast lineage
  JOURNAL   J Cell Biol 127 (6 Pt 1), 1755-1766 (1994)
   PUBMED   7798324
  REMARK    Erratum:[J Cell Biol 1995 Feb;128(4):following 713]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK149385.1, AK138715.1,
            AK148180.1, AC125377.5 and BM940059.1.
            
            On Mar 20, 2013 this sequence version replaced NM_007561.3.
            
            Summary: This gene encodes a serine/threonine kinase that functions
            as a receptor for bone morphogenetic proteins (BMPs). The encoded
            protein is a type II receptor that binds extracellular BMPs and
            forms a complex of two type II and two type I receptors at the cell
            membrane. This complex signals downstream to activate SMAD
            transcriptional regulators. This signaling is important during
            embryonic development. Mutations in this gene can cause pulmonary
            hypertension. [provided by RefSeq, Mar 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF003942.1, U78048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2113              AK149385.1         882-2994
            2114-3555           AK138715.1         242-1683
            3556-3877           AK148180.1         2374-2695
            3878-10499          AC125377.5         45474-52095
            10500-11094         BM940059.1         1-595               c
FEATURES             Location/Qualifiers
     source          1..11094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.44 cM"
     gene            1..11094
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /note="bone morphogenetic protein receptor type 2"
                     /db_xref="GeneID:12168"
                     /db_xref="MGI:MGI:1095407"
     exon            1..450
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..3491
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /EC_number="2.7.11.30"
                     /note="bone morphogenic protein receptor, type II
                     (serine/threonine kinase); BMP type-2 receptor; BMP type
                     II receptor; bone morphogenetic protein receptor, type II
                     (serine/threonine kinase)"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-2
                     precursor"
                     /protein_id="NP_031587.1"
                     /db_xref="CCDS:CCDS35588.1"
                     /db_xref="GeneID:12168"
                     /db_xref="MGI:MGI:1095407"
                     /translation="MTSSLHRPFRVPWLLWAVLLVSTTAASQNQERLCAFKDPYQQDL
                     GIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVT
                     TTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSV
                     LAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAAAEPSLDLDNLKLLELIGRGRYGAVY
                     KGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYL
                     LVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDL
                     NSRNVLVKNDGACVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAV
                     NLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQ
                     VLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIW
                     ERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNI
                     SSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPST
                     GMTTISEMPYPDETHLHATNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSD
                     ENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPA
                     QIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAE
                     PHVVTVTMNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDT
                     RLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQD
                     ILTQGVTSTAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEKIK
                     RRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTTVS
                     KDIGMNCL"
     exon            451..621
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            622..792
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            793..903
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            904..995
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1226
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1341
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1502
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1650
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1787
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1960
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..3240
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..11087
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10598..10603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /note="hexamer: ATTAAA"
     polyA_site      10620
                     /gene="Bmpr2"
                     /gene_synonym="2610024H22Rik; BMP-2; BMPR-2; BMPR-II;
                     BMPRII; BRK-3; Gm20272"
                     /note="major polyA site"
ORIGIN      
        1 actctggata tgttttctcc cagatctggg tatttttttg atatcgtgaa actacgaggg
       61 aaataattgc aggggtttct tctgggctcc ctgcgtcttc cccatggaca tgccttcaat
      121 ttggggagcc gagacacccc gtcctaggcg aatgaagccc cccagccacg agggagcgaa
      181 atgaagggaa attctgcagt ggaatgagag ctctactagc taggtcctcg catctgccat
      241 ttgtcctttc aaactgcatt gtaatccggg caggataaat cagacgaaga gcagcctcct
      301 agccggattt ctccgcccga atttactttc cagatttctt ttctttgccc tcctgcttct
      361 ttgctggccc agggatgact tcctcgctgc atcggccctt tcgggtgccc tggctgctat
      421 gggccgtcct gctggtcagc actacggctg cttctcagaa tcaagaacgg ctgtgtgcat
      481 ttaaagatcc atatcaacaa gatcttggga taggtgagag tcgaatctct catgaaaatg
      541 ggacaatatt atgttccaaa gggagcacgt gttatggtct gtgggagaaa tcaaaagggg
      601 acatcaatct tgtgaaacaa ggatgttggt ctcacatcgg tgatccccaa gagtgccact
      661 atgaagagtg tgtagtaact accaccccac cctcaattca gaatggaacg taccgctttt
      721 gctgctgtag tacagattta tgtaatgtca actttactga gaactttcca ccccctgaca
      781 caacaccact cagtccacct cattcattta atcgagatga aacgataatc attgctttgg
      841 catcagtttc tgtgttagct gttttgatag tcgccttatg ttttggatac agaatgttga
      901 caggagaccg gaaacagggt cttcacagca tgaacatgat ggaggcggca gcagcagagc
      961 cctcccttga cctggataac ctgaagctgc tggagctgat tggacggggt cgatacggag
     1021 cagtatataa aggttccttg gatgagcgtc cagttgctgt aaaagtattt tcttttgcaa
     1081 accgtcagaa ttttataaat gaaaaaaaca tttacagagt gcctttgatg gaacatgaca
     1141 acattgctcg cttcatagtt ggagacgaga ggctcactgc agacggccgc atggagtatt
     1201 tgcttgtgat ggagtattat cccaatggat ctctgtgcaa atatctgagt ctccacacaa
     1261 gtgattgggt aagctcttgc cgtctggctc attctgtgac tagaggactg gcttatcttc
     1321 acacagaatt accacgagga gatcattata aacccgcaat ctcccaccga gatttaaaca
     1381 gcaggaatgt cctggtaaag aatgacggcg cgtgtgttat cagtgacttt ggtttatcca
     1441 tgaggctaac tggaaatcgg ctggtgcgcc caggggaaga agataatgcg gctataagtg
     1501 aggttggcac aattcgctat atggcaccag aagtgctaga aggagctgtg aacctgaggg
     1561 actgtgagtc agctctgaag caagtggaca tgtatgcgct tggactcatc tactgggagg
     1621 tgtttatgag gtgtacagac ctcttcccag gtgaatctgt accagattac cagatggctt
     1681 ttcagacaga agttggaaac catcccacat ttgaggatat gcaggttctt gtgtccagag
     1741 agaagcagag acccaagttc ccagaagcct ggaaagaaaa tagcctggca gtgaggtcac
     1801 tcaaggaaac aattgaagac tgctgggacc aggatgcaga ggctcggctc actgcacagt
     1861 gtgctgagga gaggatggct gaactcatga tgatatggga gagaaacaag tctgtgagcc
     1921 caacggtcaa cccaatgtca actgctatgc agaatgaacg caacctgtca cataataggc
     1981 gtgtgccaaa aatcgggcct tacccagatt attcctcttc ctcatatatt gaagactcta
     2041 tccatcatac tgacagcatt gtgaagaata tttcctctga gcattcgatg tccagcacac
     2101 cattgacaat aggagaaaag aatcgaaatt caattaatta tgaacgacag caagcacaag
     2161 ctcgaatccc tagcccagaa acaagcgtca caagcctgtc cacaaacaca accaccacaa
     2221 acaccaccgg cctcactcca agtactggca tgaccactat atctgagatg ccatacccag
     2281 atgagacaca tttgcacgcc acaaatgttg cacagtcaat cgggccaacc cctgtctgct
     2341 tacagctgac agaagaagac ttggagacta ataagctaga tccaaaagaa gttgataaga
     2401 acctcaagga aagctctgat gagaatctca tggagcattc tctgaagcag ttcagtgggc
     2461 cagacccatt gagcagtacc agttctagct tgctttatcc actcataaag ctcgcagtgg
     2521 aagtgactgg acaacaggac ttcacacagg ctgcaaatgg gcaagcatgt ttaattcctg
     2581 atgttccacc tgctcagatc tatcctctcc ctaagcaaca gaaccttcct aagagaccta
     2641 ctagtttgcc tttgaacacc aaaaattcaa caaaagaacc ccggctaaaa tttggcaaca
     2701 agcacaaatc aaacttgaaa caagtagaaa ctggagttgc caagatgaat acaatcaatg
     2761 cagcagagcc tcatgtggtg acagtaacta tgaatggtgt ggcaggtaga agccacaatg
     2821 ttaattccca tgctgccaca acccagtatg ccaatggcgc agtgccagct ggccaggcag
     2881 ccaacatagt ggcacatagg tcccaagaaa tgctgcagaa tcaatttatt ggtgaggata
     2941 ccaggctgaa tatcaattcc agtcctgatg agcatgaacc tttactgaga cgagagcaac
     3001 aggctggcca tgatgaaggg gttctggatc gtttggtaga taggagggaa cggccattag
     3061 aaggtggccg aacaaattcc aataacaaca acagcaatcc atgttcagaa caagatatcc
     3121 ttacacaagg tgttacaagc acagctgcag atcctgggcc atcaaagccc agaagagcac
     3181 agaggcccaa ttctctggat ctttcagcca caaatatcct ggatggcagc agtatacaga
     3241 taggtgagtc aacacaagat ggcaaatcag gatcaggtga aaagatcaag agacgtgtga
     3301 aaactccata ctctcttaag cggtggcgcc cgtccacctg ggtcatctcc accgagccgc
     3361 tggactgtga ggtcaacaac aatggcagtg acagggcagt ccattctaaa tctagcactg
     3421 ctgtgtacct tgcagaggga ggcactgcca cgaccacagt gtctaaagat ataggaatga
     3481 attgtctgtg agatgttttc aagcttatgg agtgaaatta tttttttgca tcatttaaac
     3541 atgcagaaga catttaaaaa aaaaactgct ttaacctcct gtcagcaccc cttcccaccc
     3601 ctgcagcaag gacttgcttt aaatagattt cagctatgca gaaaatttta gcttatgctt
     3661 ccataatttt taattttgtt ttttaagttt tgcacttttg tttagtcttg ctaaagttat
     3721 atttgtctgt tatgaccaca ttatatgtgt gcttatcaaa agtggtctca aaatattttt
     3781 ttaagaaaaa agcaaaaaca atggattgct gataatcagt ttggaccatt ttctaaaggt
     3841 cattaaaaca gaagcaaatt cagacaggtt tgactgcaat ggtgtctggt atccatgttt
     3901 tatttctggg cacaagctag ttatgtgtta acgtgttttg accataatct gttggacatt
     3961 cttttctcgt gtattttatt tgaatgtgca atagtctata gaccacaaag aagcttgctt
     4021 acctgctctc tcctaacagg gcacacattc ttccattgtt gaaacatttt tcctcattct
     4081 ttgataatat gaacattgtc tagctttctc ctcatggaga tacatagacg ctgtccaaag
     4141 ggctccacaa aggacttatc aaaacctttt ttgaaatgcc tttgtcttct aaccttccaa
     4201 atgctactat tgtttccttc caggcatttt aataagcata tctggttctg attttggaag
     4261 ttcataagag agcatagaac aaaacagaag aaagcaaata ttagcctttt ccattttatt
     4321 tttctatgta tatgtcacgt ctgtattcat tatttaagaa atatttttta ttagaaaatg
     4381 tatagagctg aacctacatg gaatttttaa gtaagtagct gggcaaggtg actagtatag
     4441 taactttcat tctctgacca tcacaaatta aattacattt tctatttata ataacttcag
     4501 aagtaagtga tagttgattt gaatctttaa tacgtatggt tcgttatttc ccagcacagc
     4561 ctgacagttc tgtgtgaaaa gaacgatccc tccccccgtg acctaaaata ctatggaaag
     4621 ctcatcctcc cagcatgccg attcctgtgg aataaaggct tgctgcaaac ttgccaccag
     4681 tgcgcagacc aggattgacc ctctgtcttt cctaagttta tttcttcact aatcctggct
     4741 ttgtagtgtc cccttctgcc agtttcatgt gttctttgac tgcgagcagc attcactgtg
     4801 tgtgttgtag tagagcatac ttctggtgat gatgcaccgt gacgttgctg tcacgtagct
     4861 tctggtgctg ctgtaccttg atgttgctgt catgcggctt ttgcttcttt tgaaactaat
     4921 gatctctgaa acaacagtct ctgtgtcttt taataaagac tttctatcaa aaattgagga
     4981 gttttccctc aacattgctt cttatcagtt tgcagacaaa ttgttaccat gtgttttcag
     5041 attctcagaa tccttaatat ccgttatctg attacgtttt caaatttagc aggaagataa
     5101 aaagttaagt gcaaatctcc aaattcctga ttttggttct tctgtcttga acaccgtttc
     5161 cttgtctata atcctctctc cttctgttta actcatacac gagcttcctt cacttaccgt
     5221 ctgctgtgct ctgacgtcac agcatttacc gtttggtcag ctgggatgct gactggagct
     5281 cagttcttag gattaagttt atctcacttg tgcccaggat ccctttctca cctttgggtt
     5341 tcattggccc tcttatggtt cagagtctta atatatattt ttgtcttcta acattcagtt
     5401 ttttttcttt ctaattagtt actgtccttt gtatatttaa caaataattt gtatctttca
     5461 cttatttctt ttgtccaaat ggctttcaaa tgcattttag aattttaatt ttcagttgta
     5521 ggacaacttt aaaataagtt atattcctcc catctcccaa tttgaaatat taagagtaaa
     5581 tgaatctttg aggtccaaaa gatcttttcc tgtcagaaaa attgtcctac attctgatac
     5641 agtttgtatt aggaccagtc aattgtgaat tttccaagtc ttttaatgtt tattaacaga
     5701 atgctttaaa aatgaatatg ccagataaaa gaaatctgta gtttcccatc tcattaaaat
     5761 atatataaaa caaataattc ctcgaactgc ttgaagagta ggaaaggtag taagtatagg
     5821 tcattttaac aaattttgaa gtctataata cacagcatgc agaaatccct ttaataactt
     5881 aaattactag ttagatttat ttaatctgat tcttgaagct aaaatggaat ttaccacaaa
     5941 atttcacacg cacaaattaa ttttaggctt tttgaataaa agccattcaa tttaaaaaga
     6001 tttctctgga caataatata atcttaaaaa tatcataata ggacatcaga gtatgatgtt
     6061 tattgtgggg ctggagagat ggcataacaa taacagtgct tcctgtcctc acgagaaccc
     6121 aagttcagtt cccagcagct acatggcagc tcacaacttc cataggatcc agtgacatgc
     6181 atgtaacacc ccacccccaa cacacacaca cacataacta taaatgacag aggagatctt
     6241 aaagtactag ttatatacca gagctcagta atggaaagaa tgtggtttga attatgtatg
     6301 gaataaaatt atttaaataa aaatcctaaa taatttaaat gtataattta aaaaacatgg
     6361 ctactataca agtttgtgaa gacctctgct gaaaactggc attacataca cttatttttt
     6421 catcctcaga gcaaccatat tgtaatattc atattttgca aatgagggaa taaaaattaa
     6481 taggaaattt gtcttaagtt tcatacccag ccacacctgg gagttcactc taggtctgta
     6541 tctccaaatg tcttttatgc acaacacacg gtccactttc tttatgaact gatgtgcagt
     6601 gtactgacat gtactctagc agacctgggt ttgagtgtaa gccaaaccag gtacctaatg
     6661 atcttaagtt aggtaaataa aggtccataa tcacaaacaa ttcctaactc aatacagaat
     6721 tcagcctaca tcgttttacc tgcctccttc tattcttaca ttgcagaacg aaggctaagt
     6781 aagtgttaaa agacacgtga agggagctga gggagcaggg ctccttagtg tgatcccatc
     6841 catccctctc ttgggaaaaa gagttgcatg caagcttaca gtcttcttaa tcctttgact
     6901 ccatctttaa aatttcagct ttaccaatgt caaaaaaatt gttaatccag agaactaaat
     6961 aatctgtaga aagaatacaa ggctaatact ctttttataa agcaggctgg tattgcttcc
     7021 atatgtgtgt atgcttgttc cagaacctgt ttgttggttc tgaatgagaa cgtacggagc
     7081 actcaaatca gtgggaatta caatttttct tttttgaaaa aagacacttt ttaaaaaatt
     7141 ttatttattt aatgtatgag tgctctgctg catatacatc tgcctgcctg aagaaggcat
     7201 catatccccc tatagatggt tgtgagccac catgtggttg atgggaagag cagcctgtgt
     7261 tcttaatctc tgagccatct caccagcccg gaattacaaa ttttatttaa aatatttcca
     7321 agtttggttt ctgaatctca gaggaacacc tgttatggta tcacactgca cttttactct
     7381 gttagtcatt taaaatagga aaaagaaaat aaacatcagc ttcctcttaa tcataatcat
     7441 gttcatggac ataaatattt cattgcaagt cactcacttc tagaatttga tgttacgtca
     7501 tatcacattt tataaaccta tgttaagctt atgtatatgt tattacatga ctatccagat
     7561 ttttgaaaat atataattac attatttcct taactcctta aaatattctg cacacattct
     7621 aattctactg ttctagatca gtcagtcatt ctaggaagtg tgtaacaccc ctcataggcc
     7681 ctagtagtct ctcttagtct ataatgttaa tagtcacacc cttacctagc agtgggttgt
     7741 gtgcattgtg ggtttttttt ttttttcaga ttatgagcta tgcaaacttc atccaaaaac
     7801 taccttacat gatcccttcc taactgtgct cattgattat atcagtctag ccggttactt
     7861 tctgagctac tgaacaaagg ctattatcaa aaaaggcttt tctgtaagtg tccacattaa
     7921 cccagaggaa atctccaagt gcccaaagag gtggtaacac ctacctgttc ctctctttaa
     7981 gtttctcatg gtttatagag cctgtccctt tactatctgg cctgcagtca tatgccagga
     8041 aagttttctc catgcctatt ctgtctctct tgtttgatct aaggtctgtt tctcatacct
     8101 agtagggaga agagatggtc atcctatcta gcactcttca gtcagcttca ggcttctcaa
     8161 caccagatca ccagatcaaa gtgttccact tccttcaggt ttttttcttc ctaaatctat
     8221 tttaattact ttatttatat ttaaagcact aaaattctat gttatattca aattaattac
     8281 tccagttaat ttatagcata gtagtttgat agaattgaga ataaagatgt taccattgaa
     8341 tttaatcacc agaccacctg aaaatcagca cctaattttt gtattatcta acattcttct
     8401 attaaagtat gttttatgat ttttatatct atacagatat aactaaaaag ccatgcatac
     8461 ataattgtct attttttttc cactaaactc tgacctatgt tacagtgtag tattagtatt
     8521 atatgtttgg gtattatgat tgagccacaa caaatattat acatttttct ttatcaaata
     8581 ctatattaaa cactaaatgc aaaactaatt ttcaaaagca gaccctacaa aaatcaggta
     8641 ttcatggatg tttttgtatt tttgtagacc acttttgaaa tgcttatcat tgtttttgca
     8701 gaatagactg gactaaaaca gttttcattt taccttttca gtgattaaag ctaggtattt
     8761 gcatagaacg gaaatcctta aaattttatc ccatggcata tgaattttga gaagctatac
     8821 tttatgttaa gattatgccc cgaataaatc tattaagtct ttttaaattt ttcgatgttg
     8881 tttttactga tgtctgtggt gtttctagtg agcattgcaa acacacacat ttacttgtaa
     8941 aatggagttt gcagcccaca ttaaaatctg gagcagaatc ttagaactat attacttcat
     9001 tcagaatgtc tagtttgtaa ctgaatttaa aaagaaaatt gactgtactt gaatttacca
     9061 cttgactatt ctttgttttt aaaatgcttt tcccccattt aatttgtatt ttaaattcta
     9121 gaaacatctt catggtttgg aatcactttt agacatagta ttacttaaaa actcagggcc
     9181 cctttcatct gtttgtacac tgaaagagtt cagttgctaa caaacaagca attagatcta
     9241 gttgaatact taaagtattt gttgcatagt aatgtttcat catattattt gacttaattc
     9301 acatcaacat gatgtttgat ttcattaatc ataaaacttg cccagttctg taattactga
     9361 atagaaggaa tgactcaact aattggccac ttgttacagc agatttaagc cttggagttg
     9421 aagcactggc ttacacactt tctgttcttg gttctgtgga tatacatgat ggggcaaata
     9481 tttcattctg tttgttttta ataacaagat taggaaaggt aattctgaga tagaattttc
     9541 ttatggggta attagcatta taagacttta taaaagtgag ctgatggctc tagctttggt
     9601 gacagctttg atggctttga gaaggtgagc tatggtgacc agcttttcac attgtcagag
     9661 ccaaacagtt gttctttgag tcaacaaact caagttctaa ttggtctgct gtatatttaa
     9721 atcttagcag tgagtttttt gtaaccagtc tcttgtctca ggctctctgc cttgttatca
     9781 gtcttaagca tataaaagaa acatttgtaa agatgtataa gagtaagaaa actaatgact
     9841 aaaaaatgca attcaaagca attaagtttc aatttaatat tgagttgctt cacttctgtg
     9901 gctttttttt ccctggtaac atatatttat ttaagcaatg ttgtatgcct tgtcttcatt
     9961 tctatagaga ttgtattgta tgtgtttgtg taagctggaa tcatccttaa ttttctgttg
    10021 ctaatttttc aaatgaattt acatgaataa ctgtaaaata cactaactct tagggtgtta
    10081 tagctgaaac acggagatgt gtagctgcca tgctttttct gaatggacag gagaaacata
    10141 agctaccaag tattcatttc tgagggtgct ttgtagggaa agaaaggctg gcacttcctc
    10201 agaaccctct gtcttgttaa cgggtatctt ttgttggtgt gttttgctct tacattacag
    10261 atagaatatc gtgtgtgagc tgatgaataa ttactttcag ttattttgct tttgtataag
    10321 ccatctgaga ccttgctatg ctgtataagt tgtgtgacgg agcagtgtga gtatgaaata
    10381 aagcagatca ctttcctttt gtattatcta tggatgccac tatgaacgct gacattaagc
    10441 cactcaagag ttttctatga ataagtgtaa gtaaatgctt tgatatatat aaacctaaat
    10501 aaaagattgt attgagacag agacattggc aaaggaagtt ttaaggcagt tctttaggtg
    10561 taaaaggctt gctgtaaaat ggtgcgttat tccacttatt aaagatcata ttaatgacaa
    10621 cagtaagtgt atttttgatt tcatgaaatc ttcagaaatt gttactgcta atatgatatt
    10681 gtacagactt tgcaatagag tcagcacaca ctatctctaa catgactctt ataacagtgt
    10741 gatactaaaa aaaaggtcaa ctgagattag aataatagct gctgcttcct agctactaca
    10801 atacaccaaa caccatgtta ctcattttat actcagttga cagtttttac cactgcctta
    10861 gaaacgtgtt ctctgtcttt tataagggaa ggaatagaag gtcaggaaat ttaaatactt
    10921 tctccaagcc acagacctgg taagtgtata agatcctggt aatgtatttt atactttgct
    10981 ttgaactaca gcttttaaat tttgcttgtg gcaaggaaaa ttcataaaca gataaaatgt
    11041 gctcagtggt tatagtggcc aagaccaaat taaagtgact gaaggtaaaa aaaa
//
