LOCUS       NM_007560               5314 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus bone morphogenetic protein receptor, type 1B (Bmpr1b),
            transcript variant 1, mRNA.
ACCESSION   NM_007560
VERSION     NM_007560.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5314)
  AUTHORS   Qi,L., Iskols,M., Shi,D., Reddy,P., Walker,C., Lezgiyeva,K.,
            Voisin,T., Pawlak,M., Kuchroo,V.K., Chiu,I.M., Ginty,D.D. and
            Sharma,N.
  TITLE     A mouse DRG genetic toolkit reveals morphological and physiological
            diversity of somatosensory neuron subtypes
  JOURNAL   Cell 187 (6), 1508-1526 (2024)
   PUBMED   38442711
REFERENCE   2  (bases 1 to 5314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5314)
  AUTHORS   Bilekova,S., Garcia-Colomer,B., Cebrian-Serrano,A., Schirge,S.,
            Krey,K., Sterr,M., Kurth,T., Hauck,S.M. and Lickert,H.
  TITLE     Inceptor facilitates acrosomal vesicle formation in spermatids and
            is required for male fertility
  JOURNAL   Front Cell Dev Biol 11, 1240039 (2023)
   PUBMED   37691832
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5314)
  AUTHORS   Wolfson,R.L., Abdelaziz,A., Rankin,G., Kushner,S., Qi,L., Mazor,O.,
            Choi,S., Sharma,N. and Ginty,D.D.
  TITLE     DRG afferents that mediate physiologic and pathologic
            mechanosensation from the distal colon
  JOURNAL   Cell 186 (16), 3368-3385 (2023)
   PUBMED   37541195
REFERENCE   5  (bases 1 to 5314)
  AUTHORS   Miyazono,K., Kamiya,Y. and Morikawa,M.
  TITLE     Bone morphogenetic protein receptors and signal transduction
  JOURNAL   J Biochem 147 (1), 35-51 (2010)
   PUBMED   19762341
  REMARK    Review article
REFERENCE   6  (bases 1 to 5314)
  AUTHORS   Ishidou,Y., Kitajima,I., Obama,H., Maruyama,I., Murata,F.,
            Imamura,T., Yamada,N., ten Dijke,P., Miyazono,K. and Sakou,T.
  TITLE     Enhanced expression of type I receptors for bone morphogenetic
            proteins during bone formation
  JOURNAL   J Bone Miner Res 10 (11), 1651-1659 (1995)
   PUBMED   8592941
REFERENCE   7  (bases 1 to 5314)
  AUTHORS   Dewulf,N., Verschueren,K., Lonnoy,O., Moren,A., Grimsby,S., Vande
            Spiegle,K., Miyazono,K., Huylebroeck,D. and Ten Dijke,P.
  TITLE     Distinct spatial and temporal expression patterns of two type I
            receptors for bone morphogenetic proteins during mouse
            embryogenesis
  JOURNAL   Endocrinology 136 (6), 2652-2663 (1995)
   PUBMED   7750489
REFERENCE   8  (bases 1 to 5314)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   9  (bases 1 to 5314)
  AUTHORS   ten Dijke,P., Yamashita,H., Sampath,T.K., Reddi,A.H., Estevez,M.,
            Riddle,D.L., Ichijo,H., Heldin,C.H. and Miyazono,K.
  TITLE     Identification of type I receptors for osteogenic protein-1 and
            bone morphogenetic protein-4
  JOURNAL   J Biol Chem 269 (25), 16985-16988 (1994)
   PUBMED   8006002
REFERENCE   10 (bases 1 to 5314)
  AUTHORS   ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
            Miyazono,K. and Heldin,C.H.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157492.17.
            
            On Feb 25, 2022 this sequence version replaced NM_007560.4.
            
            Summary: This gene encodes a serine/threonine kinase that functions
            as a receptor for bone morphogenetic proteins (BMPs). The encoded
            protein is a type I receptor, and forms a complex of two type II
            and two type I receptors at the cell membrane. This complex signals
            downstream to activate SMAD transcriptional regulators. This
            signaling is important in skeletal and bone development.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065143.1, SRR7345562.4329531.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AC157492.17        152930-153241       c
            313-472             AC157492.17        51366-51525         c
            473-575             AC157492.17        42312-42414         c
            576-678             AC157492.17        41731-41833         c
            679-775             AC157492.17        35490-35586         c
            776-914             AC157492.17        33992-34130         c
            915-1107            AC157492.17        28413-28605         c
            1108-1405           AC157492.17        27358-27655         c
            1406-1581           AC157492.17        16086-16261         c
            1582-1712           AC157492.17        13894-14024         c
            1713-5314           AC157492.17        8148-11749          c
FEATURES             Location/Qualifiers
     source          1..5314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.11 cM"
     gene            1..5314
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /note="bone morphogenetic protein receptor, type 1B"
                     /db_xref="GeneID:12167"
                     /db_xref="MGI:MGI:107191"
     exon            1..312
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            313..472
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            473..575
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            576..678
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            679..775
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            776..914
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1107
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1405
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1581
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1712
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..5314
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5283..5288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /note="hexamer: AATAAA"
     polyA_site      5314
                     /gene="Bmpr1b"
                     /gene_synonym="Acvrlk6; ALK-6; Alk6; BMPR-1B; BMPR-IB;
                     CFK-43a; SKR6"
                     /note="major polyA site"
ORIGIN      
        1 ggagtattac cacggtgttc agtgacacag acctgtgcca tgggcagaga gagctctgag
       61 caagtgtgag ggtcaatatt tatagaccac tacgtagctg ccttgccgag acacacggag
      121 aaacacgcgg acacggagag agccaggcaa ggaagaaaac agtggcgaga acttgaattt
      181 tgagcatttt tgttctaaaa ggaaatttct ttctgtcagg ttaacttcgg ctgaatcaca
      241 accatttggc gctgagctat gacaagagag caaacaaaaa gttaaaggag caacccggcc
      301 ataagtgaag agagaagttt attgataaca tgctcttacg aagctctgga aaattaaatg
      361 tgggcaccaa gaaggaggat ggagagagta cagcccccac ccctcggccc aagatcctac
      421 gttgtaaatg ccaccaccac tgtccggaag actcagtcaa caatatctgc agcacagatg
      481 ggtactgctt cacgatgata gaagaagatg actctggaat gcctgttgtc acctctggat
      541 gtctaggact agaagggtca gattttcaat gtcgtgacac tcccattcct catcaaagaa
      601 gatcaattga atgctgcaca gaaaggaatg agtgtaataa agacctccac cccactctgc
      661 ctcctctcaa ggacagagat tttgttgatg ggcccataca ccacaaggcc ttgcttatct
      721 ctgtgactgt ctgtagttta ctcttggtcc tcattatttt attctgttac ttcaggtata
      781 aaagacaaga agcccgacct cggtacagca ttgggctgga gcaggacgag acatacattc
      841 ctcctggaga gtccctgaga gacttgatcg agcagtctca gagctcggga agtggatcag
      901 gcctccctct gctggtccaa aggacaatag ctaagcaaat tcagatggtg aagcagattg
      961 gaaaaggccg ctatggcgag gtgtggatgg gaaagtggcg tggagaaaag gtggctgtga
     1021 aagtgttctt caccacggag gaagccagct ggttccgaga gactgagata tatcagacgg
     1081 tcctgatgcg gcatgagaat attctggggt tcattgctgc agatatcaaa gggactgggt
     1141 cctggactca gttgtacctc atcacagact atcatgaaaa cggctccctt tatgactatc
     1201 tgaaatccac caccttagac gcaaagtcca tgctgaagct agcctactcc tctgtcagcg
     1261 gcctatgcca tttacacacg gaaatcttta gcactcaagg caagccagca atcgcccatc
     1321 gagacttgaa aagtaaaaac atcctggtga agaaaaatgg aacttgctgc atagcagacc
     1381 tgggcttggc tgtcaagttc attagtgaca caaatgaggt tgacatccca cccaacaccc
     1441 gggttggcac caagcgctat atgcctccag aagtgctgga cgagagcttg aatagaaacc
     1501 atttccagtc ctacattatg gctgacatgt acagctttgg actcatcctc tgggagattg
     1561 caaggagatg tgtttctgga ggtatagtgg aagaatacca gcttccctat cacgacctgg
     1621 tgcccagtga cccttcttat gaggacatga gagaaattgt gtgcatgaag aagttacggc
     1681 cttcattccc caatcgatgg agcagtgatg agtgtctcag gcagatgggg aagcttatga
     1741 cagagtgctg ggcgcagaat cctgcctcca ggctgacggc cctgagagtt aagaaaaccc
     1801 ttgccaaaat gtcagagtcc caggacatta aactctgacg tcagatactt gtggacagag
     1861 caagaatttc acagaagcat cgttagccca agccttgaac gttagcctac tgcccagtga
     1921 gttcagactt tcctggaaga gagcacggtg ggcagacaca gaggaaccca gaaacacgga
     1981 ttcatcatgg ctttctgagg aggagaaact gtttgggtaa cttgttcaag atatgatgca
     2041 tgttgctttc taagaaagcc ctgtattttg aattaccatt ttttttaaaa aagaaagata
     2101 ctttaatttt taccaaaata aaacaaatat tgtagatgtt tgaaggttta tacagctata
     2161 gtttaaataa taacaaaagg tcttcctaga aatgttcctg gaagtcaaaa tgttttctcc
     2221 attggcaaaa tactcttgca ctctagaaaa cagaacagcc tgtgaacata aattagaatt
     2281 caacttactg cccgacacac ctcagactgt ttgggccagc cctgctctgg gctgccagtg
     2341 cagagtcaat gcgcacgcat acaagtcccc cctgcctggg accacagctt ggactcctcc
     2401 tgcagcttca gccagagtga aacaaatgaa gggttggtgt cactggtagg attatgtgtt
     2461 ggtgggttct tcggagccac tcctgctcct gggtgtggta ggcagctctt tcaggcaatg
     2521 cctcctcccc ccttgcatta aacaccagca aagctttctc atgagctgct aagaatcgac
     2581 atgtgcctac ttttgtgctc atagatcaga agatcaatat taaataaaac tgtcaggaat
     2641 gtagtagaga gagacagggg gatttaaaaa tggaagtgat ttgggcgtgt attataagga
     2701 agacgtgcca gtgaggcaga gcggaggctg aaggagcagc agatacatgg cttgttcctt
     2761 ctatgtgcat aagaacccat cacagcagcc caggaaagaa gtgtgcacgg cacagtttgt
     2821 atagatatgt atagttttat gttgtcgtgt tgtctaaatc tctgacttca gagacagaga
     2881 ggaagcatct gatctgtcag gttaatgtcc ctacacttta atttaaaaat aagcagagga
     2941 aagttgatga ggtcatcaaa catcatggct gttgtgattt ctcctagaat agatatatgg
     3001 gtctggtatg gacctcttac atggacattt cacaccttag gtacaactca tttactctca
     3061 tgtgcatttc acttctaatt tattctgttt ctctagtata gcacgtacgc aaaacatctt
     3121 gtgattcagt cctgggaggt cttaactttt gactctctgt gcgaaatcac ttatatgacc
     3181 agtattcctt agaaacagga cggagataaa gtgtaaaatg gcacacggcc ctctcaactt
     3241 tcttcacata gttccttact ctgtttcttc cataaaggtt agaaattgcg ttcttgttat
     3301 taagaaaggt ggaagtactt cctatgcctt agaaagtgac attcctccca gattcctcca
     3361 gggggcagtg ttttcctatg catctcacca ctgggtgcgt gaaagatgga gaccttagga
     3421 aaaattgaca gctgcatgag aaatgaggga atgttttacc ccttttctgg agtagacgtt
     3481 catctggaaa aaagtcctgg agctcagtgt ctttgcgctg tacctggagt ttaggaaaac
     3541 tgtaaagaaa agcatccctc tgtgtttcac tctacggtac tgcagggcca caatttagtt
     3601 tccactacaa tagatttact cagttcttaa atttgaaaag ataaaaactg gttgttaatt
     3661 taacggtcat cacattttgc tcttactgag gtcagtgcaa gctaagccat cgaagcgcct
     3721 tttctctgtt aaattatatt tgctgaagtt ttcccattta ttcctgtcta agtatggcag
     3781 tcacctgagc ctggaagaaa aaccttattg cctctagaca gatccatctg taaacacgta
     3841 cggaagcatt ttgccagttt agtgggtaca ttttgatttt tattttctgg gtttttctta
     3901 ggtttaagtg aggttgtggg gacctcttgg gtcaaactgt attttcttat tggtagattt
     3961 taaaatgtgt gcaaatttaa atcagaatgt tttgtgagga agctgttgat gatttaaagt
     4021 gttctagatt tctagggttc ctgcgaaaaa cggggagaaa tttgagtgtc aaaatttcat
     4081 ctatgtggct cattttattg ctttggggaa aatcaactgc ttatttgcta attattgacc
     4141 ttatttattc agtataaact tcttgaaatt attgagatcc tttaaaaaat ccactcagtt
     4201 attatgaatt ttcaataaga atttataatt tatttatgaa tataatttct gtcttatgaa
     4261 atcctaattg atacaactaa gctgttaagg actacctgtt gactttccag taatccatga
     4321 taacctttaa acttctagca tctcagaaaa atacatttat tttattttat ttttttctct
     4381 aacttcctgc aaattaataa tataattgac tgctgcttac cctcaggact ctttcaaaga
     4441 gcaagatttt cttctaactt ctctcccctg aaggaatcct aaattattaa ttgttagata
     4501 agctttatgt gtccaagttt gtggttgatg tgtgtgtgta tatagtatat aaatatagat
     4561 gtatatgtaa atatgttcat tctggagtct ggcacaactc tagtatgtgg attagaaagt
     4621 aaaatattat ggatgataaa gtcctaaatg aagattaata tttatttatg gaagcatgta
     4681 cattgtgaac tcccaaatga aaagcagtta aacagtgtgt atgactcagg cagcgcaccc
     4741 cgatgttgct cctgcccgtt ctttatactc ccccaacaga aagcttctta ggggacatgc
     4801 tggacttggc ttccaggaaa tttgctggca catttcgttt ggtgtgtggt ccaggctcac
     4861 aagtccctaa taatcaccag ttttcatgtt cctcaggcca accagattca tcacacttct
     4921 tggtttatgg atggaaaggc aatgagaata catttttttt aaacttgaac atgttttggt
     4981 ggttacacca tctcagaaac tcccagtccc ataaagagtg gaaaggaaag gggctgtgtc
     5041 aaaaatgata caatttaaca gaactgactg ttagagaaac taatgccata gattttaaga
     5101 gaaaaattgg taatatttag ggagagcagt tcttttctgt ttgtttcaaa acaagactca
     5161 tttgtgttct atcggggaac cagtgcctta tggaatttgt atatactgta attattcagg
     5221 gttagggaac aaacagttgt atttgttaca aattgtgtat gacttgtttt cttatttccc
     5281 tcaataaaat ggtgtcattc tccccattca aaaa
//
