LOCUS       NM_009758               5481 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus bone morphogenetic protein receptor, type 1A (Bmpr1a),
            mRNA.
ACCESSION   NM_009758
VERSION     NM_009758.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5481)
  AUTHORS   Luo,Y., Cao,K., Chiu,J., Chen,H., Wang,H.J., Thornton,M.E.,
            Grubbs,B.H., Kolb,M., Parmacek,M.S., Mishina,Y. and Shi,W.
  TITLE     Defective mesenchymal Bmpr1a-mediated BMP signaling causes
            congenital pulmonary cysts
  JOURNAL   Elife 12, 91876 (2024)
   PUBMED   38856718
  REMARK    GeneRIF: Defective mesenchymal Bmpr1a-mediated BMP signaling causes
            congenital pulmonary cysts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5481)
  AUTHORS   Lademann,F., Rijntjes,E., Kohrle,J., Tsourdi,E., Hofbauer,L.C. and
            Rauner,M.
  TITLE     Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a
            expression in osteoblasts
  JOURNAL   Commun Biol 7 (1), 548 (2024)
   PUBMED   38719881
  REMARK    GeneRIF: Hyperthyroidism-driven bone loss depends on BMP receptor
            Bmpr1a expression in osteoblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5481)
  AUTHORS   Niu,Z., Zhou,Y., Liang,M., Su,F., Guo,Q., Jing,J., Xie,J., Zhang,D.
            and Liu,X.
  TITLE     Crosstalk between ALK3(BMPR1A) deficiency and autophagy signaling
            mitigates pathological bone loss in osteoporosis
  JOURNAL   Bone 182, 117052 (2024)
   PUBMED   38408588
  REMARK    GeneRIF: Crosstalk between ALK3(BMPR1A) deficiency and autophagy
            signaling mitigates pathological bone loss in osteoporosis.
REFERENCE   4  (bases 1 to 5481)
  AUTHORS   Ito,A., Miller,C. and Imamura,F.
  TITLE     Suppression of BMP signaling restores mitral cell development
            impaired by FGF signaling deficits in mouse olfactory bulb
  JOURNAL   Mol Cell Neurosci 128, 103913 (2024)
   PUBMED   38056728
REFERENCE   5  (bases 1 to 5481)
  AUTHORS   Ihle,C.L., Straign,D.M., Canari,J.A., Torkko,K.C., Zolman,K.L.,
            Smith,E.E. and Owens,P.
  TITLE     Unique macrophage phenotypes activated by BMP signaling in breast
            cancer bone metastases
  JOURNAL   JCI Insight 9 (1), e168517 (2024)
   PUBMED   38193534
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5481)
  AUTHORS   Dewulf,N., Verschueren,K., Lonnoy,O., Moren,A., Grimsby,S., Vande
            Spiegle,K., Miyazono,K., Huylebroeck,D. and Ten Dijke,P.
  TITLE     Distinct spatial and temporal expression patterns of two type I
            receptors for bone morphogenetic proteins during mouse
            embryogenesis
  JOURNAL   Endocrinology 136 (6), 2652-2663 (1995)
   PUBMED   7750489
REFERENCE   7  (bases 1 to 5481)
  AUTHORS   Mishina,Y., Suzuki,A., Gilbert,D.J., Copeland,N.G., Jenkins,N.A.,
            Ueno,N. and Behringer,R.R.
  TITLE     Genomic organization and chromosomal location of the mouse type I
            BMP-2/4 receptor
  JOURNAL   Biochem Biophys Res Commun 206 (1), 310-317 (1995)
   PUBMED   7818535
REFERENCE   8  (bases 1 to 5481)
  AUTHORS   Katagiri,T., Yamaguchi,A., Komaki,M., Abe,E., Takahashi,N.,
            Ikeda,T., Rosen,V., Wozney,J.M., Fujisawa-Sehara,A. and Suda,T.
  TITLE     Bone morphogenetic protein-2 converts the differentiation pathway
            of C2C12 myoblasts into the osteoblast lineage
  JOURNAL   J Cell Biol 127 (6 Pt 1), 1755-1766 (1994)
   PUBMED   7798324
  REMARK    Erratum:[J Cell Biol 1995 Feb;128(4):following 713]
REFERENCE   9  (bases 1 to 5481)
  AUTHORS   Gorecki,D., Geng,Y., Thomas,K., Hunt,S.P., Barnard,E.A. and
            Barnard,P.J.
  TITLE     Expression of the dystrophin gene in mouse and rat brain
  JOURNAL   Neuroreport 2 (12), 773-776 (1991)
   PUBMED   1793820
REFERENCE   10 (bases 1 to 5481)
  AUTHORS   Burgoyne,P.S., Buehr,M. and McLaren,A.
  TITLE     XY follicle cells in ovaries of XX----XY female mouse chimaeras
  JOURNAL   Development 104 (4), 683-688 (1988)
   PUBMED   3268409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166105.4 and AC160930.2.
            
            On Mar 21, 2007 this sequence version replaced NM_009758.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.830674.1,
                                           SRR11927937.4698290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC166105.4         54073-54224
            153-266             AC166105.4         96007-96120
            267-473             AC166105.4         108641-108847
            474-636             AC166105.4         112638-112800
            637-739             AC166105.4         115418-115520
            740-836             AC166105.4         121885-121981
            837-936             AC166105.4         122141-122240
            937-1081            AC166105.4         126819-126963
            1082-1274           AC160930.2         3865-4057
            1275-1572           AC160930.2         6146-6443
            1573-1748           AC160930.2         13121-13296
            1749-1879           AC160930.2         14113-14243
            1880-5481           AC160930.2         14334-17935
FEATURES             Location/Qualifiers
     source          1..5481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.81 cM"
     gene            1..5481
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /note="bone morphogenetic protein receptor, type 1A"
                     /db_xref="GeneID:12166"
                     /db_xref="MGI:MGI:1338938"
     exon            1..152
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            153..266
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            267..473
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..2005
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /EC_number="2.7.11.30"
                     /note="BMP type-1A receptor; BMP-2/BMP-4 receptor; activin
                     receptor-like kinase 3; serine/threonine-protein kinase
                     receptor R5"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1A
                     precursor"
                     /protein_id="NP_033888.2"
                     /db_xref="CCDS:CCDS26938.1"
                     /db_xref="GeneID:12166"
                     /db_xref="MGI:MGI:1338938"
                     /translation="MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDLDQKKP
                     ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMK
                     YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVVLISM
                     AVCIVAMIIFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGS
                     GSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE
                     IYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKL
                     AYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTN
                     EVDIPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIV
                     EEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNP
                     ASRLTALRIKKTLAKMVESQDVKI"
     exon            474..636
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            637..739
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            740..836
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            837..936
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1081
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1274
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1572
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1748
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1879
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..5481
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3360..3365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /note="hexamer: AATATA"
     polyA_site      3385
                     /gene="Bmpr1a"
                     /gene_synonym="1110037I22Rik; ALK-3; ALK3; Bmpr; BMPR-1A;
                     BMPR-IA; SKR5"
                     /note="major polyA site"
ORIGIN      
        1 ccgcgcgaga cgacgactgt acggccgcgc gaggggcgac cgggcccggg ccgctgcacg
       61 ccgagggcgg aggccgagcc gggccccgcc gccccgcggc tgtccgtgcc cgcccgcgcc
      121 gagcgccgga ggatgagttt ctcgggatcc cgatttatga aaatatgcat cgctttgata
      181 ctgtcttgga attcatgaga tggaagcata ggtcaaagct gttcggagaa attggaacta
      241 cagttttatc tagccacatc tctgagaatt ctgaagaaag cagcaggtga aagtcattgc
      301 caagtgattt tgttctgtaa ggaagcctcc ctcattcact tacaccagtg agacagcagg
      361 accagtcatt caaagggccg tgtacaggac gcgtgcgaat cagacaatga ctcagctata
      421 cacttacatc agattactgg gagcctgtct gttcatcatt tctcatgttc aagggcagaa
      481 tctagatagt atgctccatg gcactggtat gaaatcagac ttggaccaga agaagccaga
      541 aaatggagtg actttagcac cagaggatac cttgcctttc ttaaagtgct attgctcagg
      601 acactgccca gatgatgcta ttaataacac atgcataact aatggccatt gctttgccat
      661 tatagaagaa gatgatcagg gagaaaccac attaacttct gggtgtatga agtatgaagg
      721 ctctgatttt caatgcaagg attcaccgaa agcccagcta cgcaggacaa tagaatgttg
      781 tcggaccaat ttgtgcaacc agtatttgca gcctacactg ccccctgttg ttataggtcc
      841 gttctttgat ggcagcatcc gatggctggt tgtgctcatt tccatggctg tctgtatagt
      901 tgctatgatc atcttctcca gctgcttttg ctataagcat tattgtaaga gtatctcaag
      961 caggggtcgt tacaaccgtg atttggaaca ggatgaagca tttattccag taggagaatc
     1021 attgaaagac ctgattgacc agtcccaaag ctctgggagt ggatctggat tgcctttatt
     1081 ggttcagcga actattgcca aacagattca gatggttcgg caggttggta aaggccgcta
     1141 tggagaagta tggatgggta aatggcgtgg tgaaaaagtg gctgtcaaag tgttttttac
     1201 cactgaagaa gctagctggt ttagagaaac agaaatctac cagacggtgt taatgcgtca
     1261 tgaaaatata cttggtttta tagctgcaga cattaaaggc actggttcct ggactcagct
     1321 gtatttgatt actgattacc atgaaaatgg atctctctat gacttcctga aatgtgccac
     1381 actagacacc agagccctac tcaagttagc ttattctgct gcttgtggtc tgtgccacct
     1441 ccacacagaa atttatggta cccaagggaa gcctgcaatt gctcatcgag acctgaagag
     1501 caaaaacatc cttattaaga aaaatggaag ttgctgtatt gctgacctgg gcctagctgt
     1561 taaattcaac agtgatacaa atgaagttga catacccttg aataccaggg tgggcaccaa
     1621 gcggtacatg gctccagaag tgctggatga aagcctgaat aaaaaccatt tccagcccta
     1681 catcatggct gacatctata gctttggttt gatcatttgg gaaatggctc gtcgttgtat
     1741 tacaggagga atcgtggagg aatatcaatt accatattac aacatggtgc ccagtgaccc
     1801 atcctatgag gacatgcgtg aggttgtgtg tgtgaaacgc ttgcggccaa tcgtgtctaa
     1861 ccgctggaac agcgatgaat gtcttcgagc agttttgaag ctaatgtcag aatgttgggc
     1921 ccataatcca gcctccagac tcacagcttt gagaatcaag aagacacttg caaaaatggt
     1981 tgaatcccag gatgtaaaga tttgacaatt aaacaatttt gagggagaat ttagactgca
     2041 agaacttctt cacccaagga atgggtggga ttagcatgga ataggatgtt gacttggttt
     2101 ccagactcct tcctctacat cttcacaggc tgctaacagt aaaccttacc gtactctaca
     2161 gaatacaaga ttggaacttg gaacttcaaa catgtcattc tttatatatg gacagctttg
     2221 ttttaaatgt ggggtttttt tgttttgctt tttttgtttt gttttggttt tgatgctttt
     2281 ttggttttta tgaactgcat caagactcca atcctgataa gaagtctctg gtcaacctct
     2341 gggtactcac tatcctgtcc ataaagtggt gctttctgtg aaagccttaa gaaaattaat
     2401 gagctcagca gagatggaaa aaggcatatt tgccttctac cagagaaaac atctgtctgt
     2461 gttctgtctt tgtaaacagc ctatagatta tgatctcttt gggatactgc ctggtttatg
     2521 atggtgcacc atacctttga tatgcatacc agaattctct gctgccctag ggcttagaag
     2581 acaagaatgt aaaggttgca caggaaggta tttgtggcca gtggtttaaa tatgcaatat
     2641 ctagttgaca atcgccaatt tcataaaagc catccacctt gtaactgtag taacttctcc
     2701 actgacttta tttttagcat aatagttgtg aaggccaaac tccatgtaaa gtgtccatag
     2761 acttggactg ttttccccca gtcaccattt tgttctcctt ttggtaatta tttttgttat
     2821 aaaaagccac ctatccagaa ttggagctct ctgtcttgaa ccatactttg aaagaaacgc
     2881 ctcttccgta ctgcatctga tcacaatgtg catacctatg atcaaattct ggagtctttg
     2941 ttctcggtac ctcctaaaaa ggaaagttga ttcttgtgta acatgctttt attttcagaa
     3001 cctgcacagc tgtcattcta gccatgtttt acctacacac tcagttctat acaagacagc
     3061 ccatacactc tgtctcacat ctgatccttg gtgggaagtg ttttaaagta gaactatgta
     3121 tgaatttcag aattcatgca ttttaaaact tcactaagat attgtctcat atctttatga
     3181 gaatgtcagc tgacttttca actaacagta aatgtatttt agatatctaa atcttttgaa
     3241 atttggtttt acaatttctg gtccctaatt gtgaagacaa gaggcagaag tacccagtca
     3301 ctacccatat ttacactgaa cgttattaaa taaaatgatg tgtattttat tataaaataa
     3361 atataggcct tgttatctca aaaaacagat ctggttcaaa cttattatac caatatcata
     3421 ctatttaaat gttctaagta aacaagccat gtgagcatca agtggcattg gctctttgga
     3481 tgaaacataa acttaaggtg attgtatcaa cacatagagt gactgaaatt aaatgggagg
     3541 caggtagagc atatgtccat ctgtccacct acaggcatga ctaaactaca gctcatattc
     3601 cacaaatttg agatttgtct tgcctggttt gtttagtgag tctcatctga tgtacctaaa
     3661 gcctgagagt actgaggtct gattttatat ctttcctgaa taaactaaat cttttttgtc
     3721 acttatcatc ttaatgatat acctaaggaa taattctttg gcatgtttca gttgtgtgtg
     3781 gcagccactg taatgactct tctctaagaa aggctgtcag gagttaatta taaggcaggc
     3841 agtgagcgct ctagtcactg ccttcccacg ctgccatcac tgcattcatg ggaatcagtg
     3901 acgttctcga aatggcaaac gctgctgctt ttccttattt ggaatcctaa aatcaaaagt
     3961 tgcattaaac ttactgtgtt ctcttctccc tctcagccat aaatgtaaaa ttcagtaagt
     4021 aaaaatattt aaagagtgta tcagcccttt ggccagtgag atagctcagt agataaaggc
     4081 atttgctgcc aagtcctcaa cctcaattca gactctgggg gacacatggc gaagggagga
     4141 gccaactacc ccatcattgt cctctgactt ccacacactc catggcttgc gcccctcccc
     4201 acagacacac accatgtact ccacaaaagt agtttaaagg aaaaaaagaa tagaacccac
     4261 tgtgtaatgg aataagtatt atgtagttac ttaacaactt gtaaaaatct ggaaactatg
     4321 atttggttcc cctttgaatc tagagtttaa aaaacagatg gctaaaatca gccatcattt
     4381 aaataattaa aaataaaagc cccaaacccc aaactgccta aataaatacc aagtaatcca
     4441 ggaagccgtc atgtgtggtt tgtatgacca gtagttctct ggtacagagc atgttaagat
     4501 ttgccccagc ctgattctct gaggtctctg cattactgag tactgttctg agtataaaat
     4561 ctgaactgat ttctctagaa atactgtaac aaaaaggtat tttagtcagc atgttatgtt
     4621 aacccttcca ctgtctagaa acttgaataa gcacataaag acaccttttg ctgtcatcat
     4681 ctgttgtcct ggaatgtgcc agttttaatt tattcattct aatgatattc aatttgcttt
     4741 tcttttttag atgtttttct tgtttagagt aaaaggacga atttttcaag aaccttgcat
     4801 ctctgatttg gcctaaggtc aaattggata ttgagtagtc tattccaggg cagatttcct
     4861 aagcaatact tgtcttttca gctatgtatt gttttgaaat gtttccattt caacagaggt
     4921 gtaagtcatg tgaaaagaaa ggtggtgtag cccttgtggt aatgacacaa gttgacttgc
     4981 gtcagatgtt aagcagggac agttctccca cctcctggct gtaaggagtg gaaactaggc
     5041 aagcagtgta tcagtccaca gaggacagga agggtcatcc cataaagaaa gcctgtgagt
     5101 atggctttgg caaaaaatta gacataatac tgtcctttta ggttgtgctc tgttctttcc
     5161 tttcagtgga attatttaag ctctttagtg gcctttgttt ttcccactta aaaactaaaa
     5221 tgtagcatat attgtataaa atggaaatat taatagctta gggaaactgt acataaggca
     5281 ttgacaggtt taaaaaaagc atttttatta tgcagttgta aaacaccaaa aatatagatt
     5341 catcttgata tgtaacacta agtgtatttt gtacagcatc tgatttgaaa ggtgccttat
     5401 gaagtttacc attaattgct ttgttctata tacagattat gtccaatgta tcatttttca
     5461 gtaaataacc ttattttagt a
//
