LOCUS       NM_028472               3806 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus BMP-binding endothelial regulator (Bmper), mRNA.
ACCESSION   NM_028472
VERSION     NM_028472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3806)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   2  (bases 1 to 3806)
  AUTHORS   Garritson,J.D., Zhang,J., Achenbach,A., Ferhat,M., Eich,E.,
            Stubben,C.J., Martinez,P.L., Ibele,A.R., Hilgendorf,K.I. and
            Boudina,S.
  TITLE     BMPER is a marker of adipose progenitors and adipocytes and a
            positive modulator of adipogenesis
  JOURNAL   Commun Biol 6 (1), 638 (2023)
   PUBMED   37311809
  REMARK    GeneRIF: BMPER is a marker of adipose progenitors and adipocytes
            and a positive modulator of adipogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3806)
  AUTHORS   Pankratz,F., Maksudova,A., Goesele,R., Meier,L., Proelss,K.,
            Marenne,K., Thut,A.K., Sengle,G., Correns,A., Begelspacher,J.,
            Alkis,D., Siegel,P.M., Smolka,C., Grundmann,S., Moser,M., Zhou,Q.
            and Esser,J.S.
  TITLE     BMPER Improves Vascular Remodeling and the Contractile Vascular SMC
            Phenotype
  JOURNAL   Int J Mol Sci 24 (5), 4950 (2023)
   PUBMED   36902380
  REMARK    GeneRIF: BMPER Improves Vascular Remodeling and the Contractile
            Vascular SMC Phenotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3806)
  AUTHORS   Li-Villarreal,N., Wong,R.L.Y., Garcia,M.D., Udan,R.S., Poche,R.A.,
            Rasmussen,T.L., Rhyner,A.M., Wythe,J.D. and Dickinson,M.E.
  TITLE     FOXO1 represses sprouty 2 and sprouty 4 expression to promote
            arterial specification and vascular remodeling in the mouse yolk
            sac
  JOURNAL   Development 149 (7) (2022)
   PUBMED   35297995
REFERENCE   5  (bases 1 to 3806)
  AUTHORS   Li,X., Madison,B.B., Zacharias,W., Kolterud,A., States,D. and
            Gumucio,D.L.
  TITLE     Deconvoluting the intestine: molecular evidence for a major role of
            the mesenchyme in the modulation of signaling cross talk
  JOURNAL   Physiol Genomics 29 (3), 290-301 (2007)
   PUBMED   17299133
REFERENCE   6  (bases 1 to 3806)
  AUTHORS   Ikeya,M., Kawada,M., Kiyonari,H., Sasai,N., Nakao,K., Furuta,Y. and
            Sasai,Y.
  TITLE     Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis
  JOURNAL   Development 133 (22), 4463-4473 (2006)
   PUBMED   17035289
  REMARK    GeneRIF: crossveinless 2 has essential pro-Bmp functions for
            locally restricted signal enhancement in multiple aspects of
            mammalian organogenesis.
REFERENCE   7  (bases 1 to 3806)
  AUTHORS   Caruana,G., Cullen-McEwen,L., Nelson,A.L., Kostoulias,X., Woods,K.,
            Gardiner,B., Davis,M.J., Taylor,D.F., Teasdale,R.D., Grimmond,S.M.,
            Little,M.H. and Bertram,J.F.
  TITLE     Spatial gene expression in the T-stage mouse metanephros
  JOURNAL   Gene Expr Patterns 6 (8), 807-825 (2006)
   PUBMED   16545622
REFERENCE   8  (bases 1 to 3806)
  AUTHORS   Kamimura,M., Matsumoto,K., Koshiba-Takeuchi,K. and Ogura,T.
  TITLE     Vertebrate crossveinless 2 is secreted and acts as an extracellular
            modulator of the BMP signaling cascade
  JOURNAL   Dev Dyn 230 (3), 434-445 (2004)
   PUBMED   15188429
  REMARK    GeneRIF: Cv2 is a conserved, positive regulator of bone
            morphogenetic protein signaling.  Its cysteine-rich domains acts as
            both positive and negative modulators of BMP signaling.
REFERENCE   9  (bases 1 to 3806)
  AUTHORS   Moser,M., Binder,O., Wu,Y., Aitsebaomo,J., Ren,R., Bode,C.,
            Bautch,V.L., Conlon,F.L. and Patterson,C.
  TITLE     BMPER, a novel endothelial cell precursor-derived protein,
            antagonizes bone morphogenetic protein signaling and endothelial
            cell differentiation
  JOURNAL   Mol Cell Biol 23 (16), 5664-5679 (2003)
   PUBMED   12897139
REFERENCE   10 (bases 1 to 3806)
  AUTHORS   Coffinier,C., Ketpura,N., Tran,U., Geissert,D. and De Robertis,E.M.
  TITLE     Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila
            extracellular regulator of BMP signaling
  JOURNAL   Mech Dev 119 Suppl 1 (Suppl 1), S179-S184 (2002)
   PUBMED   14516682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF454954.1 and AC154737.3.
            
            On Mar 21, 2013 this sequence version replaced NM_028472.1.
            
            Summary: This gene encodes a secreted protein that contains five
            Von Willebrand factor type C domains and a Von Willebrand factor
            type D domain and a trypsin inhibitory-like domain. The encoded
            protein binds to bone morphogenetic proteins (BMP) and regulates
            their activity. Mutation of the related gene in humans causes
            diaphanospondylodysostosis. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF454954.1, BC066153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3793              AF454954.1         1-3793
            3794-3806           AC154737.3         44538-44550         c
FEATURES             Location/Qualifiers
     source          1..3806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 9.55 cM"
     gene            1..3806
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /note="BMP-binding endothelial regulator"
                     /db_xref="GeneID:73230"
                     /db_xref="MGI:MGI:1920480"
     exon            1..698
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..2623
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /note="BMP-binding endothelial regulator protein; bone
                     morphogenetic protein-binding endothelial cell
                     precursor-derived regulator; crossveinless-2"
                     /codon_start=1
                     /product="BMP-binding endothelial regulator protein
                     precursor"
                     /protein_id="NP_082748.1"
                     /db_xref="CCDS:CCDS22929.1"
                     /db_xref="GeneID:73230"
                     /db_xref="MGI:MGI:1920480"
                     /translation="MLWFFSVRALAERPCRRSPGITCCVLLLLNCSGVPMSLASSFLT
                     GSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACC
                     ERCKGCTHEGRTYNSSFKWQTPAEPCVLRQCQEGVVTESEVRCVVHCKNPAEHQGACC
                     PTCPGCVFEGVQYREGEEFQPEGNKCITCSCVGGRTQCVREVCPILSCPQHLSHTPSG
                     QCCPKCLGQRKVFDLPFGSCLFRSDVYDNGASFVYDNCTVCTCKDSTMVCKKKCSHPG
                     VCNSDEDACCEDCLLRVPPEDIKVCKFGSKIFRDGEMWSSVNCSICACVKGKTECRKK
                     QCVPVSSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTK
                     DCSSPASPFQVLVKNDARRTRSFSWTKSVELMLGESTVSLQQHLTVRWNGSRIALPCH
                     TPHFHIDLDGYLLKVTTRAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDL
                     IGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSW
                     EFQTCHSTVDYTTFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQSC
                     AATQCKHGAVYDTCGPGCVKTCDNWNEIGPCNKPCIAGCHCPANLVLHKGRCIKPVLC
                     PQR"
     exon            699..784
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..884
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..967
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1058
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1141
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1241
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1351
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1492
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1597
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1643
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1973
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2310
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2441
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..3806
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3771..3776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /note="hexamer: AATAAA"
     polyA_site      3806
                     /gene="Bmper"
                     /gene_synonym="3110056H04Rik; Crim3; CV-2; Cv2"
                     /note="major polyA site"
ORIGIN      
        1 gccggggctg ggctagaccg cctggctggg cgttcgcgtg cgccgctgtc gcttctgagc
       61 cggcatagct ccggcgccag gatcgtagtc cctcgtgcga ccctgcggat tccgcgcaga
      121 gcctagtacg cccctcggtc ccgcacggag caagcgcgcg ggccggacac cgcgctcggg
      181 ggccgggccg gagctgcgcg tgcgggagcc ggagctcagc cgggctccag agctgcgagc
      241 gcactcggca gtcgccgccg ccgctcccca gatcccgccg ctcagccacc cctcctcccg
      301 gcccagctct ggcgcggagg ggctgacggc taacccgctg agagcaactc ccttagaaaa
      361 aagccgccgc attggccgag gctggccgca ggacccctcc tcccggggcg cccccactcc
      421 tcccccgccg ctccgggcgc ccgcctccct cagccgactg tctcccggca cgccggccca
      481 cagccctttt gactgcgagc agcggctgcc gagcagaggc ggcgacgcgg gacctgcagt
      541 cgcccgggat tccctccagg tgacgatgct ctggttcttc agcgtcaggg ctctggctga
      601 gcgtccttgc cgacgctcgc ctgggattac ctgctgcgtc ttgctgctgc tcaattgctc
      661 cggggtcccc atgtctctgg cttcctcctt cctgacaggg tctgttgcaa aatgtgaaaa
      721 tgaaggggag gtcctccaaa ttccatttat cacagacaac ccttgcataa tgtgtgtgtg
      781 tttgaacaaa gaggtgactt gtaagaggga gaagtgccct gtgctgtcac gggactgtgc
      841 gctggccatc aagcagagag gcgcctgctg tgaacgatgc aaaggttgta cccatgaagg
      901 aagaacctac aacagttcct tcaagtggca aaccccggct gagccatgtg tccttcggca
      961 gtgccaggag ggtgtggtga cagagtctga ggtgcgctgt gttgttcatt gtaaaaatcc
     1021 cgcagagcat caaggagcct gctgccctac ctgcccaggc tgtgtgtttg aaggtgtgca
     1081 ataccgggaa ggagaagaat ttcagccaga aggaaacaaa tgtattacat gctcctgcgt
     1141 tggaggcagg acacagtgcg tgagagaagt ctgtcccatt ctctcttgtc cccagcacct
     1201 tagtcacaca ccctcaggac agtgctgccc caaatgtttg ggtcagagaa aagtattcga
     1261 ccttcccttt gggagctgcc tgtttcgcag tgatgtttat gacaatggag cctcatttgt
     1321 ctatgataac tgcacagtat gcacttgcaa ggactcaaca atggtttgta agaagaagtg
     1381 ctcccaccct ggtgtctgta acagtgatga ggatgcctgt tgtgaagact gtctcttacg
     1441 ggtgccccct gaagacatca aagtgtgcaa gttcggtagc aagattttca gggatggaga
     1501 gatgtggtcc tcagtcaact gcagcatctg tgcttgtgtg aaggggaaga cagagtgtcg
     1561 aaagaagcag tgtgttcctg tcagcagctg cccacagggt aaaattctca acaggaaagg
     1621 atgctgtcct atctgcactg aaaaacctgg tgtgtgcaca gtattcggag atccccacta
     1681 caacactttt gatgggcgga catttaactt tcaggggacg tgtcagtatg ttttgacaaa
     1741 agactgctcc tccccagcct cacccttcca ggtgctggtg aagaatgatg cacggaggac
     1801 ccgttccttc tcctggacca agtctgtgga gctgatgctg ggcgaaagca cagtcagcct
     1861 gcagcagcac ctcactgtgc gctggaatgg ctctcgcatt gcccttccct gccacacacc
     1921 ccacttccac atcgacctgg acggctacct tttgaaagtg actaccagag caggtttgga
     1981 gatatcgtgg gatggagaca gttttgtgga ggtcatggct gcccctcatc tcaagggcaa
     2041 gctctgtggt ctttgtggca actacaatgg tcataaacgt gatgacttga ttggtggaga
     2101 tgggaacttc aagtttgacg tggatgactt tgctgaatcg tggagggtgg aatccaacga
     2161 attctgcaac cgaccacaga gaaaaccagt acctgagctc tgtcaaggca cagtgaaggt
     2221 gaagcttcga gcccatcgag aatgccagaa actcaagtcc tgggagttcc agacctgcca
     2281 ctctacagtg gactatacca ctttctaccg gtcctgtgta acagacatgt gtgaatgtcc
     2341 agtccataaa aactgttact gtgagtcatt tctggcgtat acccgtgcct gtcagagaga
     2401 gggaatcaaa gtgcactggg aacctcagca gagctgtgca gccacccagt gcaaacatgg
     2461 tgctgtgtat gatacctgtg gcccaggatg tgtgaagaca tgtgataact ggaatgagat
     2521 cggcccatgc aataagccct gcattgcagg ttgccactgc ccagcaaatc tggtccttca
     2581 taagggaagg tgcatcaagc cagtcctctg tcctcagcga tgacctttgt tctagtccat
     2641 agactttgaa atccagtgtc tttgacactg acatgcaaga gccagtgaag gactgttgta
     2701 tttgtgtgcc tgattctgca aatacacaga gtatatatgt gtacatatat atagatatat
     2761 agatatattc gaaacatttc atcatttata taaactatag gtggattatt atatgtatat
     2821 tttttgctat aagacatgta ttatttctag aatcctaata tctaagccat tggatgcatc
     2881 atatacatag gtgcttttaa tttaataaga tggcatgcag actcatcagg tctctttaag
     2941 agtgcgttca tgtgtcattc tggggacatt tcctaagagc cctcatgcct acctgcatta
     3001 attaaagatt tgagtcagga cctttgagtg agattttctt ggagaagggt actttatctg
     3061 ggggtatttt gtatttccaa agactggaat gtatgccaga gaaagatggc atgagattgg
     3121 ggatgagccc tcgtgagtgc aaaccaagga gagtctgtca gatttcaccg ggtcagagct
     3181 ggatattgtc ccccaaactg gatagttgcc acggaatatg tatttttcac tagcatattg
     3241 ccaaataatt tcttttcatt ttttgcatat gtcatgagtc tcctcattac ttatgtgtgc
     3301 aatggatatg accatttgca tgtcctgcac tgaagtcaaa ggatgtctgg ataacatttt
     3361 attaaacacg aaaagctatt tggagagaac attgcacaac atataaagaa tctcagagca
     3421 atttaggatt ggcaaatcca ttgagtggct aggggccatc tacgttttgt cactatctca
     3481 tggtgtataa aatgaaagcc ttcggctatt ctgtctcatt actgtccagt gttgtttgct
     3541 gggtactcat atgttatggg tattgggcag gagggaaggg actgctgacc agttgtttta
     3601 gcttcattcc aaaagagaat tgtttctgta tttgttctaa tttactgatg ttactaacag
     3661 ttattggttc ttgttttctg ttggataaat aaaaatgtca aaaagcaaaa acaaaaaacc
     3721 ccacccccaa ctcactgatg ttgaaaagta aaatgttctg cattgtagta aataaaaggc
     3781 ttaagattta agcaaacagt tttcaa
//
