LOCUS       NM_007559               2965 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.
ACCESSION   NM_007559 XM_003946146
VERSION     NM_007559.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2965)
  AUTHORS   Zhong,S., Du,X., Gao,J., Ji,G. and Liu,Z.
  TITLE     BMP8B Activates Both SMAD2/3 and NF-kappaB Signals to Inhibit the
            Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes
  JOURNAL   Nutrients 16 (1), 64 (2023)
   PUBMED   38201894
  REMARK    GeneRIF: BMP8B Activates Both SMAD2/3 and NF-kappaB Signals to
            Inhibit the Differentiation of 3T3-L1 Preadipocytes into Mature
            Adipocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2965)
  AUTHORS   Rial-Pensado,E., Freire-Agulleiro,O., Rios,M., Guo,D.F.,
            Contreras,C., Seoane-Collazo,P., Tovar,S., Nogueiras,R.,
            Dieguez,C., Rahmouni,K. and Lopez,M.
  TITLE     Obesity induces resistance to central action of BMP8B through a
            mechanism involving the BBSome
  JOURNAL   Mol Metab 59, 101465 (2022)
   PUBMED   35218946
  REMARK    GeneRIF: Obesity induces resistance to central action of BMP8B
            through a mechanism involving the BBSome.
REFERENCE   3  (bases 1 to 2965)
  AUTHORS   Vacca,M., Leslie,J., Virtue,S., Lam,B.Y.H., Govaere,O.,
            Tiniakos,D., Snow,S., Davies,S., Petkevicius,K., Tong,Z.,
            Peirce,V., Nielsen,M.J., Ament,Z., Li,W., Kostrzewski,T.,
            Leeming,D.J., Ratziu,V., Allison,M.E.D., Anstee,Q.M., Griffin,J.L.,
            Oakley,F. and Vidal-Puig,A.
  TITLE     Bone morphogenetic protein 8B promotes the progression of
            non-alcoholic steatohepatitis
  JOURNAL   Nat Metab 2 (6), 514-531 (2020)
   PUBMED   32694734
  REMARK    GeneRIF: Bone morphogenetic protein 8B promotes the progression of
            non-alcoholic steatohepatitis.
REFERENCE   4  (bases 1 to 2965)
  AUTHORS   Vazquez,P., Hernandez-Sanchez,C., Escalona-Garrido,C., Pereira,L.,
            Contreras,C., Lopez,M., Balsinde,J., de Pablo,F. and Valverde,A.M.
  TITLE     Increased FGF21 in brown adipose tissue of tyrosine hydroxylase
            heterozygous mice: implications for cold adaptation
  JOURNAL   J Lipid Res 59 (12), 2308-2320 (2018)
   PUBMED   30352954
REFERENCE   5  (bases 1 to 2965)
  AUTHORS   Pellegrinelli,V., Peirce,V.J., Howard,L., Virtue,S., Turei,D.,
            Senzacqua,M., Frontini,A., Dalley,J.W., Horton,A.R., Bidault,G.,
            Severi,I., Whittle,A., Rahmouni,K., Saez-Rodriguez,J., Cinti,S.,
            Davies,A.M. and Vidal-Puig,A.
  TITLE     Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of
            the neuro-vascular network in adipose tissue
  JOURNAL   Nat Commun 9 (1), 4974 (2018)
   PUBMED   30478315
  REMARK    GeneRIF: BMP8b and NRG4 can be considered as interconnected
            regulators of neuro-vascular remodeling in adipose tissue and are
            potential therapeutic targets in obesity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2965)
  AUTHORS   Zhao,G.Q., Liaw,L. and Hogan,B.L.
  TITLE     Bone morphogenetic protein 8A plays a role in the maintenance of
            spermatogenesis and the integrity of the epididymis
  JOURNAL   Development 125 (6), 1103-1112 (1998)
   PUBMED   9463357
REFERENCE   7  (bases 1 to 2965)
  AUTHORS   DiLeone,R.J., King,J.A., Storm,E.E., Copeland,N.G., Jenkins,N.A.
            and Kingsley,D.M.
  TITLE     The Bmp8 gene is expressed in developing skeletal tissue and maps
            near the Achondroplasia locus on mouse chromosome 4
  JOURNAL   Genomics 40 (1), 196-198 (1997)
   PUBMED   9070944
REFERENCE   8  (bases 1 to 2965)
  AUTHORS   Zhao,G.Q. and Hogan,B.L.
  TITLE     Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in
            the initiation and maintenance of spermatogenesis in the mouse
  JOURNAL   Mech Dev 61 (1-2), 63-73 (1997)
   PUBMED   9076678
REFERENCE   9  (bases 1 to 2965)
  AUTHORS   Zhao,G.Q., Deng,K., Labosky,P.A., Liaw,L. and Hogan,B.L.
  TITLE     The gene encoding bone morphogenetic protein 8B is required for the
            initiation and maintenance of spermatogenesis in the mouse
  JOURNAL   Genes Dev 10 (13), 1657-1669 (1996)
   PUBMED   8682296
REFERENCE   10 (bases 1 to 2965)
  AUTHORS   Zhao,G.Q. and Hogan,B.L.
  TITLE     Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that
            play a role in spermatogenesis and placental development
  JOURNAL   Mech Dev 57 (2), 159-168 (1996)
   PUBMED   8843393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606934.12, AK082895.1,
            BQ551035.1 and BQ031736.1.
            
            On Oct 20, 2015 this sequence version replaced NM_007559.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. The encoded protein may play a role in
            the generation of primordial germ cells, and has been shown to
            stimulate thermogenesis in brown adipose tissue. Male mice lacking
            a functional copy of this gene exhibit variable degrees of
            germ-cell deficiency. Homozygous knockout mice of both sexes
            exhibit impaired thermogenesis and reduced metabolic rate,
            resulting in weight gain. This gene may have arose from a gene
            duplication event and its gene duplicate is also present on
            chromosome 4. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39545.1, AK082895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL606934.12        26476-26479
            5-2059              AK082895.1         2-2056
            2060-2119           BQ551035.1         85-144
            2120-2944           AK082895.1         2118-2942
            2945-2965           BQ031736.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2965
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.38 cM"
     gene            1..2965
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /note="bone morphogenetic protein 8b"
                     /db_xref="GeneID:12164"
                     /db_xref="MGI:MGI:107335"
     exon            1..515
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1390
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /codon_start=1
                     /product="bone morphogenetic protein 8B preproprotein"
                     /protein_id="NP_031585.2"
                     /db_xref="CCDS:CCDS18608.1"
                     /db_xref="GeneID:12164"
                     /db_xref="MGI:MGI:107335"
                     /translation="MAARPGLLWLLGLALCVLGGGHLSHPPHVFPQRRLGVREPRDMQ
                     REIREVLGLPGRPRSRAPVGAAQQPASAPLFMLDLYRAMTDDSGGGTPQPHLDRADLI
                     MSFVNIVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHI
                     SMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVE
                     TEDGHSIDPGLAGLLGRQAPRSRQPFMVGFFRANQSPVRAPRTARPLKKKQLNQINQL
                     PHSNKHLGILDDGHGSHGREVCRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYP
                     LNSCMNSTNHATMQALVHLMKPDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMV
                     VQACGCH"
     exon            516..705
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     exon            706..854
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1049
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1129
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1240
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..2947
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2926..2931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /note="hexamer: AGTAAA"
     polyA_site      2946
                     /gene="Bmp8b"
                     /gene_synonym="Op3"
                     /note="major polyA site"
ORIGIN      
        1 acactcgcta ttccctaccg cgcgggccca cgttgctctg cgggacctac aggctgggct
       61 gctgcctgcg gagcgcgtgg agcgcagtcg tcttagagct gcccgcgaca ggtgcgaact
      121 cgggatccgc ggcgctgtcc catccttgtc gtcgaggcgt cgctggatgc gagtccgcta
      181 aacgtccgag atggctgcgc gtccgggact cctatggcta ctgggcctgg ctctgtgcgt
      241 gttgggcggc ggtcacctct cgcatccccc gcacgtcttt ccccagcgtc gactaggagt
      301 acgcgagccc cgcgacatgc agcgcgagat tcgggaggtg ctggggctgc cggggcggcc
      361 ccgatcccga gcaccggtcg gggctgccca gcagccagcg tctgcgcccc tctttatgtt
      421 ggacctgtac cgtgccatga cggatgacag tggcggtggg accccgcagc ctcacttgga
      481 ccgtgctgac ctgattatga gctttgtcaa catagtggaa cgcgaccgta ccctgggcta
      541 ccaggagcca cactggaagg aattccactt tgacctaacc cagatccctg ctggggaggc
      601 tgtcacagct gctgagttcc ggatctacaa agaacccagt acccacccgc tcaacacaac
      661 cctccacatc agcatgttcg aagtggtcca agagcactcc aacagggagt ctgacttgtt
      721 ctttttggat cttcagacgc tccgatctgg ggacgagggc tggctggtgc tggacatcac
      781 agcagccagt gaccgatggc tgctgaacca tcacaaggac ctaggactcc gcctctatgt
      841 ggaaaccgag gatgggcaca gcatagatcc tggcctagct ggtctgcttg gacgacaagc
      901 accacgctcc agacagcctt tcatggttgg tttcttcagg gccaaccaga gtcctgtgcg
      961 ggcccctcga acagcaagac cactgaagaa gaagcagcta aatcaaatca accagctgcc
     1021 gcactccaac aaacacctag gaatccttga tgatggccac ggttctcacg gcagagaagt
     1081 ttgccgcagg catgagctct atgtcagctt ccgtgacctt ggctggctgg actctgtcat
     1141 tgccccccag ggctactccg cctattactg tgctggggag tgcatctacc cactgaactc
     1201 ctgtatgaac tccaccaacc acgccactat gcaggccctg gtacatctga tgaagccaga
     1261 tatcatcccc aaggtgtgct gtgtgcctac tgagctgagt gccatttctc tgctctacta
     1321 tgatagaaac aataatgtca tcctgcgcag ggagcgcaac atggtagtcc aggcctgtgg
     1381 ctgccactga gtccctgccc aacagcctgc tgccatccca tctatctagt caggcctctc
     1441 ttccaaggca ggaaaccaac aaagagggaa ggcagtgctt tcaactccat gtccacattc
     1501 acagtcttgg ccctctctgt tctttttgcc aaggctgaga agatggtcct agttataacc
     1561 ctggtgacct cagtagccca tctctcatct ccccaaactc cccaatgcag ccaggggcat
     1621 ctatgtcctt tgggattggc acagaagtcc aatttaccaa cttattcatg atcactactg
     1681 gcccagcctg acttgaacct ggaacacagg gtagagctca ggctcttcag tatccatcag
     1741 aagatttagg tgtgtgcaga catgaccaca ctccccctag cactccatag cctgtctctt
     1801 gggggtgcaa aatgggattt ctagagaaga gtttaaaaaa tatggaaaag ctaggtatag
     1861 taatgcacac ttgtaatctt agcacttggg aagctgaggc aagttcaagg ccagcctggg
     1921 atatatatca agatctcatt catatctatc tatctatcta tctatctatc tatctatcta
     1981 tctatctatc tatctatcta tctatctatc tctatatata tatcaagatc ttccttcaaa
     2041 acaaacaaag caaaaccctg gtgtatttat ggatctcagt cactaaacct ctggccacag
     2101 gcagccacaa gaggccagct aatgaaaaaa cctattgcgg atttatcatc tggatttagg
     2161 catcgtcatt aaagaaaatg ccaacagttt ccctgatcca tagtccttgg tgcagctact
     2221 ataggctggc acacagtcac acaccttgac aacagccaga aaaagttgtg ccctgtcttg
     2281 gtgctggagc aaaggtatca caaacaaggt gaccccagaa cagcagccag gcagtcctca
     2341 ggtaagaggc actgcccctc aggtgctcac ggtccgtgca gaggtggcag agctggtatg
     2401 gcagggtgag gagaaacaca gctatgctac taagcattct tgccctggct ccagagctat
     2461 gctggactcc tgcccagcag aggaccagcg tcccatgtct tcccataaga ggactatgac
     2521 atctatcaag aactgcagcc tccctagcta ccttctagag ctgtctttcc tgaagacccc
     2581 caacaaattg agactaaacc cagtaggctt ctcgggactc tcttggcact ggcaataagc
     2641 aggccaagct ccaacctacc tccactgcac catctggatg atctctggca gaggtttggt
     2701 tcatctgtgc agggtttgtg acagctaatc ttggttatca acttgacacc tgggaccctc
     2761 cagtagggaa ttgcctccat cagactgggg catttttgtg atggaggaaa atccaatcca
     2821 atgtgggcag tacaatctct gagcaggttg tataaacagc agcattcatc cacggttgct
     2881 gccctgactt ccctcagtga taaactatga tgtacaagtc aagtaagtaa agcccttcct
     2941 cacgttgaaa aaaaaaaaaa aaaaa
//
