LOCUS       NM_007558               2366 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript
            variant 2, mRNA.
ACCESSION   NM_007558 XM_989162
VERSION     NM_007558.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   de Lope,C., Garcia-Lucena,R., Magarinos,M., Leon,Y.,
            Casa-Rodriguez,N., Contreras,N., Escudero-Iriarte,C.,
            Varela-Nieto,I., Maire,P. and Palmero,I.
  TITLE     Dysfunction of programmed embryo senescence is linked to genetic
            developmental defects
  JOURNAL   Development 150 (9) (2023)
   PUBMED   37017267
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Lu,N., Zhou,X., Rivera,J.,
            Kriti,D., Sebra,R., Williams,A.A., Donovan,M.J., Potter,S.S.,
            Pinto,D., Zhang,B., van Bakel,H. and Jabs,E.W.
  TITLE     Integrated Transcriptome and Network Analysis Reveals
            Spatiotemporal Dynamics of Calvarial Suturogenesis
  JOURNAL   Cell Rep 32 (1), 107871 (2020)
   PUBMED   32640236
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Tanahashi,H. and Suzuki,T.
  TITLE     Deletion of Lrp4 increases the incidence of microphthalmia
  JOURNAL   Biochem Biophys Res Commun 506 (3), 478-484 (2018)
   PUBMED   30352686
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Kelleher,A.M., Peng,W., Pru,J.K., Pru,C.A., DeMayo,F.J. and
            Spencer,T.E.
  TITLE     Forkhead box a2 (FOXA2) is essential for uterine function and
            fertility
  JOURNAL   Proc Natl Acad Sci U S A 114 (6), E1018-E1026 (2017)
   PUBMED   28049832
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   DiLeone,R.J., King,J.A., Storm,E.E., Copeland,N.G., Jenkins,N.A.
            and Kingsley,D.M.
  TITLE     The Bmp8 gene is expressed in developing skeletal tissue and maps
            near the Achondroplasia locus on mouse chromosome 4
  JOURNAL   Genomics 40 (1), 196-198 (1997)
   PUBMED   9070944
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Zhao,G.Q., Deng,K., Labosky,P.A., Liaw,L. and Hogan,B.L.
  TITLE     The gene encoding bone morphogenetic protein 8B is required for the
            initiation and maintenance of spermatogenesis in the mouse
  JOURNAL   Genes Dev 10 (13), 1657-1669 (1996)
   PUBMED   8682296
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Zhao,G.Q. and Hogan,B.L.
  TITLE     Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that
            play a role in spermatogenesis and placental development
  JOURNAL   Mech Dev 57 (2), 159-168 (1996)
   PUBMED   8843393
REFERENCE   9  (bases 1 to 2366)
  AUTHORS   Lyons,K.M., Hogan,B.L. and Robertson,E.J.
  TITLE     Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors
            cooperatively mediate tissue interactions during murine development
  JOURNAL   Mech Dev 50 (1), 71-83 (1995)
   PUBMED   7605753
REFERENCE   10 (bases 1 to 2366)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC052168.1 and AK157978.1.
            
            On Dec 22, 2011 this sequence version replaced NM_007558.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein may play a role in
            development of the reproductive system. Mice lacking a functional
            copy of this gene exhibit degeneration of germ cells and the
            epididymal epithelium. This gene may have arose from a gene
            duplication event and its gene duplicate is also present on
            chromosome 4. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the 3' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal segment in the C-terminal region,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97017.1, AK157978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               BC052168.1         1-339
            340-568             AK157978.1         2-230
            569-621             BC052168.1         567-619
            622-2358            AK157978.1         284-2020
            2359-2366           BC052168.1         2396-2403
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.42 cM"
     gene            1..2366
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /note="bone morphogenetic protein 8a"
                     /db_xref="GeneID:12163"
                     /db_xref="MGI:MGI:104515"
     exon            1..869
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..1744
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; osteogenic protein 2"
                     /codon_start=1
                     /product="bone morphogenetic protein 8A isoform 2
                     preproprotein"
                     /protein_id="NP_031584.1"
                     /db_xref="CCDS:CCDS18616.1"
                     /db_xref="GeneID:12163"
                     /db_xref="MGI:MGI:104515"
                     /translation="MAMRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQ
                     REILAVLGLPGRPRPRAQPAAARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLV
                     MSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHI
                     SMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVE
                     TADGHSMDPGLAGLLGRQAPRSRQPFMVTFFRASQSPVRAPRAARPLKRRQPKKTNEL
                     PHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFP
                     LDSCMNATNHAILQSLVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMV
                     VKACGCH"
     exon            870..1059
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1208
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1403
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1483
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1594
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2366
                     /gene="Bmp8a"
                     /gene_synonym="Bmp7r1; OP-2; OP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagcagaa ggtgagacac tacgggtcct accgctgctc cgggactcag gatcccaccc
       61 tggtgcctgc ttcagaggcc ccaatgtctc ctcgtgtagc caggtatgag ccccggaagc
      121 tggatgggga cccaagacac ccttaaaggc ctctcttcag cccgttcgtt cccacctacg
      181 ggtgcaccag gcggctccca ccacttcgcg cacaagtagt agtgcgacca tccccaggcg
      241 tctttccgca ctcggacccg cccccgtgat cccattggct ggtcggggaa ggggcggggc
      301 cgaggaagag cgctcggcgg tctgagctgc caccaaagtc ctcctgcgga cactcgcaag
      361 tcagcgccgt gagagcccac gttgctctga gggacctacc gacgcggcga tcgcctgccg
      421 agtgcgtggt gagcagctgc tgtaaagctg ccagcgacag gtgcgccgtc tggtcctccc
      481 cgtctgggcg tagcgcccga gcccgaccag ctaccagtgg atgcgcgccg gctgaaagtc
      541 cgagatggct atgcgtcccg ggccactctg gctattgggc cttgctctgt gcgcgctggg
      601 aggcggccac ggtccgcgtc ccccgcacac ctgtccccag cgtcgcctgg gagcgcgcga
      661 gcgccgcgac atgcagcgtg aaatcctggc ggtgctcggg ctaccgggac ggccccgacc
      721 ccgtgcacaa cccgccgctg cccggcagcc agcgtccgcg cccctcttca tgttggacct
      781 ataccacgcc atgaccgatg acgacgacgg cgggccacca caggctcact taggccgtgc
      841 cgacctggtc atgagcttcg tcaacatggt ggaacgcgac cgtaccctgg gctaccagga
      901 gccacactgg aaggaattcc actttgacct aacccagatc cctgctgggg aggctgtcac
      961 agctgctgag ttccggatct acaaagaacc cagcacccac ccgctcaaca caaccctcca
     1021 catcagcatg ttcgaagtgg tccaagagca ctccaacagg gagtctgact tgttcttttt
     1081 ggatcttcag acgctccgat ctggggacga gggctggctg gtgctggaca tcacagcagc
     1141 cagtgaccga tggctgctga accatcacaa ggacctggga ctccgcctct atgtggaaac
     1201 cgcggatggg cacagcatgg atcctggcct ggctggtctg cttggacgac aagcaccacg
     1261 ctccagacag cctttcatgg taaccttctt cagggccagc cagagtcctg tgcgggcccc
     1321 tcgggcagcg agaccactga agaggaggca gccaaagaaa acgaacgagc ttccgcaccc
     1381 caacaaactc ccagggatct ttgatgatgg ccacggttcc cgcggcagag aggtttgccg
     1441 caggcatgag ctctacgtca gcttccgtga ccttggctgg ctggactggg tcatcgcccc
     1501 ccagggctac tctgcctatt actgtgaggg ggagtgtgct ttcccactgg actcctgtat
     1561 gaacgccacc aaccatgcca tcttgcagtc tctggtgcac ctgatgaagc cagatgttgt
     1621 ccccaaggca tgctgtgcac ccaccaaact gagtgccacc tctgtgctgt actatgacag
     1681 cagcaacaat gtcatcctgc gtaaacaccg taacatggtg gtcaaggcct gtggctgcca
     1741 ctgaggcccc gcccagcatc ctgcttctac taccttacca tctggccggg cccctctcca
     1801 gaggcaggaa acccttctat gttatcatag cacagacagg ggcaatggga ggcccttcac
     1861 ttcccctggc cacttcctgc taaaattctg gtcctttccc agttcctctg tccttcatgg
     1921 ggtttgcggg ctatcacccc gccctctcca tcctcctacc ccaagcatag actgaatgca
     1981 cacagcatcc cagagctatg ctaactgaga ggtctggggt cagcactgaa ggcccacatg
     2041 aggaagactg atccttggcc atcctcagcc cacaatggca aattctggat ggtctaagaa
     2101 ggccctggaa ttctaaacta gatgatctgg gctctctgca ccattcattg tggcagttgg
     2161 gacattttta ggtataacag acacatacac ttagatcaat gcatcgctgt actccttgaa
     2221 atcagagcta gcttgttaga aaaagaatca gagccaggta tagcggtgca tgtcattaat
     2281 cccagcgcta aagagacaga gacaggagaa tctctgtgag ttcaaggcca catagaaaga
     2341 gcctgtctcg ggagcaggaa aaaaaa
//
