LOCUS       NM_007557               3670 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus bone morphogenetic protein 7 (Bmp7), mRNA.
ACCESSION   NM_007557
VERSION     NM_007557.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Bongiovanni,C., Bueno-Levy,H., Posadas Pena,D., Del Bono,I.,
            Miano,C., Boriati,S., Da Pra,S., Sacchi,F., Redaelli,S., Bergen,M.,
            Romaniello,D., Pontis,F., Tassinari,R., Kellerer,L., Petraroia,I.,
            Mazzeschi,M., Lauriola,M., Ventura,C., Heermann,S., Weidinger,G.,
            Tzahor,E. and D'Uva,G.
  TITLE     BMP7 promotes cardiomyocyte regeneration in zebrafish and adult
            mice
  JOURNAL   Cell Rep 43 (5), 114162 (2024)
   PUBMED   38678558
  REMARK    GeneRIF: BMP7 promotes cardiomyocyte regeneration in zebrafish and
            adult mice.
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Sun,M., Gao,Y., Li,Z., Yang,L., Liu,G., Xu,Z., Guo,R., You,Y. and
            Yang,Z.
  TITLE     ERK signaling expands mammalian cortical radial glial cells and
            extends the neurogenic period
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2314802121 (2024)
   PUBMED   38498715
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Liu,B., Xie,X., Yang,X., Dou,C., Tang,H. and Liu,J.
  TITLE     The miR-3074/BMP7 axis regulates TGF-beta-caused activation of
            hepatic stellate cells in vitro and CCl4-caused murine liver
            fibrosis in vivo
  JOURNAL   Hum Cell 37 (2), 435-450 (2024)
   PUBMED   38218754
  REMARK    GeneRIF: The miR-3074/BMP7 axis regulates TGF-beta-caused
            activation of hepatic stellate cells in vitro and CCl4-caused
            murine liver fibrosis in vivo.
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Boon,M.R., van der Horst,G., van der Pluijm,G., Tamsma,J.T.,
            Smit,J.W. and Rensen,P.C.
  TITLE     Bone morphogenetic protein 7: a broad-spectrum growth factor with
            multiple target therapeutic potency
  JOURNAL   Cytokine Growth Factor Rev 22 (4), 221-229 (2011)
   PUBMED   21924665
  REMARK    Review article
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Marker,P.C., King,J.A., Copeland,N.G., Jenkins,N.A. and
            Kingsley,D.M.
  TITLE     Chromosomal localization, embryonic expression, and imprinting
            tests for Bmp7 on distal mouse chromosome 2
  JOURNAL   Genomics 28 (3), 576-580 (1995)
   PUBMED   7490098
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Hahn,G.V., Cohen,R.B., Wozney,J.M., Levitz,C.L., Shore,E.M.,
            Zasloff,M.A. and Kaplan,F.S.
  TITLE     A bone morphogenetic protein subfamily: chromosomal localization of
            human genes for BMP5, BMP6, and BMP7
  JOURNAL   Genomics 14 (3), 759-762 (1992)
   PUBMED   1427904
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N. and Oppermann,H.
  TITLE     Murine osteogenic protein (OP-1): high levels of mRNA in kidney
  JOURNAL   Biochem Biophys Res Commun 179 (1), 116-123 (1991)
   PUBMED   1715687
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   Celeste,A.J., Iannazzi,J.A., Taylor,R.C., Hewick,R.M., Rosen,V.,
            Wang,E.A. and Wozney,J.M.
  TITLE     Identification of transforming growth factor beta family members
            present in bone-inductive protein purified from bovine bone
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9843-9847 (1990)
   PUBMED   2263636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF540870.1, CJ094104.1,
            AL929140.16, CJ164635.1, CA316109.1 and CA451657.1.
            
            On Mar 20, 2013 this sequence version replaced NM_007557.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. Mutation of this gene results in
            skeletal, kidney, and other developmental defects. [provided by
            RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010771.1, X56906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               CF540870.1         1-256
            257-724             CJ094104.1         7-474
            725-827             AL929140.16        53912-54014         c
            828-1246            CJ164635.1         1-419
            1247-1570           CA316109.1         381-704
            1571-3081           AL929140.16        6013-7523           c
            3082-3670           CA451657.1         1-589
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.54 cM"
     gene            1..3670
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /note="bone morphogenetic protein 7"
                     /db_xref="GeneID:12162"
                     /db_xref="MGI:MGI:103302"
     exon            1..667
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..860
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1009
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1207
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1284
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1395
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..3670
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /note="hexamer: AATAAA"
     polyA_site      1996
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /note="major polyA site"
     regulatory      3636..3641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /note="hexamer: AATAAA"
     polyA_site      3668
                     /gene="Bmp7"
                     /gene_synonym="OP1"
                     /note="major polyA site"
ORIGIN      
        1 tggagttgct gtgctagcct tgccgtgcgt cctggcgagt gcgggccgag gggccccggg
       61 ccagaactga gtaaaggaca ggggcgtccc gggcaaagcg cagccggccg gggagtggcc
      121 atgtgtggcg aggccgcctt gaagctcgcc tgcagcaagt gacctcgggt cgtggaccgc
      181 tgccctgccc cctccgctgc cacctggggc ggcgcgggcc cggtgccccg gatcgcgcgt
      241 agagccggcg cgatgcacgt gcgctcgctg cgcgctgcgg cgccacacag cttcgtggcg
      301 ctctgggcgc ctctgttctt gctgcgctcc gccctggccg atttcagcct ggacaacgag
      361 gtgcactcca gcttcatcca ccggcgcctc cgcagccagg agcggcggga gatgcagcgg
      421 gagatcctgt ccatcttagg gttgccccat cgcccgcgcc cgcacctcca gggaaagcat
      481 aattcggcgc ccatgttcat gttggacctg tacaacgcca tggcggtgga ggagagcggg
      541 ccggacggac agggcttctc ctacccctac aaggccgtct tcagtaccca gggcccccct
      601 ttagccagcc tgcaggacag ccacttcctc actgacgccg acatggtcat gagcttcgtc
      661 aacctagtgg aacatgacaa agaattcttc caccctcgat accaccatcg ggagttccgg
      721 tttgatcttt ccaagatccc cgagggcgaa gcggtgaccg cagccgaatt caggatctat
      781 aaggactaca tccgggagcg atttgacaac gagaccttcc agatcacagt ctatcaggtg
      841 ctccaggagc actcaggcag ggagtcggac ctcttcttgc tggacagccg caccatctgg
      901 gcttctgagg agggctggtt ggtgtttgat atcacagcca ccagcaacca ctgggtggtc
      961 aaccctcggc acaacctggg cttacagctc tctgtggaga ccctggatgg gcagagcatc
     1021 aaccccaagt tggcaggcct gattggacgg catggacccc agaacaagca acccttcatg
     1081 gtggccttct tcaaggccac ggaagtccat ctccgtagta tccggtccac ggggggcaag
     1141 cagcgcagcc agaatcgctc caagacgcca aagaaccaag aggccctgag gatggccagt
     1201 gtggcagaaa acagcagcag tgaccagagg caggcctgca agaaacatga gctgtacgtc
     1261 agcttccgag accttggctg gcaggactgg atcattgcac ctgaaggcta tgctgcctac
     1321 tactgtgagg gagagtgcgc cttccctctg aactcctaca tgaacgccac caaccacgcc
     1381 atcgtccaga cactggttca cttcatcaac ccagacacag tacccaagcc ctgctgtgcg
     1441 cccacccagc tcaacgccat ctctgtcctc tacttcgacg acagctctaa tgtcatcctg
     1501 aagaagtaca gaaacatggt ggtccgggcc tgtggctgcc actagctctt cctgagaccc
     1561 tgacctttgc ggggccacac ctttccaaat cttcgatgtc tcaccatcta agtctctcac
     1621 tgcccacctt ggcgaggagc caacagacca acctctcctg agccttcccc tcacctcccc
     1681 aaccggaagc atgtaagggt tccagaaacc tgagcgtgca ggcagctgat gagcgccctt
     1741 tccttctggc acgtgacgga caagatccta ccagctacca cagcaaacgc ctaagagcag
     1801 gaaaaatgtc tgccaggaaa gtgtccattg gccacatggc ccctggcgct ctgagtcttt
     1861 gaggagtaat cgcaagcctc gttcagctgc agcagaagga agggcttagc cagggtgggc
     1921 gctggcgtct gtgttgaagg gaaaccaagc agaagccact gtaatgatat gtcacaataa
     1981 aacccatgaa tgaaaatggt taggacgtta cagatatatt ttcctaaaca atttatcccc
     2041 gtttcttggt ttattctgac tttgtaaaca gaagccgggg ctgtggagga tggagaggcc
     2101 cctcctttcc gtctcgtctc cttgtgtgtg tttaccagac ctgcccaaat ccagcctgta
     2161 gggaggagga ggacgatgtc tgctcagaag aggccagtga gggatgtggc ctcaaagggt
     2221 gttgggatga agatggaggg aggtatgcat gcacacacac acacacacac acacacacat
     2281 gcatgcatac acacacacac acacacgcat gcacacacac acacacacac acacacgcac
     2341 atgcatgcat acacacacac acacacacgc atgcacacac acacacacac acacacacgc
     2401 acatgcatgc atacacacac acacacacgc atgcacacac acacacacac acacacgcac
     2461 gcacgcacgc acacgcacgc atgcatgcac acacacacgc gcacacacac acacacacac
     2521 acacatgcat gcatacacac acacacacac acgcatgcac acacacacac acacacacac
     2581 acacgcatgc acgcacgcac gcacgcacgc acgcatgcac atgcacacac acacacacat
     2641 ctgaagcgca tgtagacttt ggaatggctc tgccagtccc tcagccccaa ttcctgcccc
     2701 atggtaggaa atccatgaga aaagcaaagc taacaagcac agcggaccct acctgaggaa
     2761 gcacagagga tgcaggctct tcaggacact gtcctccaaa caaggcccct ctggcacctc
     2821 tgtggccgag ctccagagcc aggtcctggc cttcacagct gcctctcttc actctcaacc
     2881 cctaacagaa ggttctgcga cagattggtt tctggatctg agggagatgg cagaacaggg
     2941 ttgtactggc ttagaaggtt caaccatgct tcctgcttca gaggtgggat gttggttatg
     3001 gctcaaacaa ggcctctctg cctgagtttg cagagcccca gctgccccaa tggttcctag
     3061 cttcaaatgc agagggttaa actggctgcc agtgtttcct gcatccacac aaagaatgag
     3121 gttagccagg caggacctat ggccatgtcg catctggtca ggtggggaac caattcttca
     3181 tgtctgtgtc cctggaaaca ctgggctctc ttctgttctg ttttagtttt tcttcttcag
     3241 tagcttgggc tgcagcttct actctgccca ttcgatgtgg gggaaggcca tttctttttg
     3301 taatttgttc tgtgtgtttg cagatctggg gctttttgtg tgacttccct gtggtgcaca
     3361 ttttacttta gagccctagt ctgcctgcag tcagtgtctc ttatacgttt aaatgtgtaa
     3421 atagttgtga caagacaaag aaattattta tttccatctg aagctctttc caaaggctcc
     3481 tcacagagaa caatgaggcc gacttccttc agtctgtttg ttttcttatt taagactatt
     3541 tattaacagt tggaccgatg tacccatagc tgtcgaataa agtggtcctt agtgaaaatt
     3601 ctgtataaat agagtaagaa ggggtttgac tttgcaataa aaggagacat ttggttctgg
     3661 ttgtccgacc
//
