LOCUS       NM_007556               3583 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus bone morphogenetic protein 6 (Bmp6), mRNA.
ACCESSION   NM_007556
VERSION     NM_007556.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Lu,G., Ge,Z., Chen,X., Ma,Y., Yuan,A., Xie,Y. and Pu,J.
  TITLE     BMP6 knockdown enhances cardiac fibrosis in a mouse myocardial
            infarction model by upregulating AP-1/CEMIP expression
  JOURNAL   Clin Transl Med 13 (6), e1296 (2023)
   PUBMED   37313693
  REMARK    GeneRIF: BMP6 knockdown enhances cardiac fibrosis in a mouse
            myocardial infarction model by upregulating AP-1/CEMIP expression.
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Kim,H.Y., Lee,J.M., Lee,Y.S., Li,S., Lee,S.J., Bae,S.C. and
            Jung,H.S.
  TITLE     Runx3 regulates iron metabolism via modulation of BMP signalling
  JOURNAL   Cell Prolif 54 (12), e13138 (2021)
   PUBMED   34611951
  REMARK    GeneRIF: Runx3 regulates iron metabolism via modulation of BMP
            signalling.
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3583)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
REFERENCE   7  (bases 1 to 3583)
  AUTHORS   Hahn,G.V., Cohen,R.B., Wozney,J.M., Levitz,C.L., Shore,E.M.,
            Zasloff,M.A. and Kaplan,F.S.
  TITLE     A bone morphogenetic protein subfamily: chromosomal localization of
            human genes for BMP5, BMP6, and BMP7
  JOURNAL   Genomics 14 (3), 759-762 (1992)
   PUBMED   1427904
REFERENCE   8  (bases 1 to 3583)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N. and Oppermann,H.
  TITLE     Murine osteogenic protein (OP-1): high levels of mRNA in kidney
  JOURNAL   Biochem Biophys Res Commun 179 (1), 116-123 (1991)
   PUBMED   1715687
REFERENCE   9  (bases 1 to 3583)
  AUTHORS   Jones,C.M., Lyons,K.M. and Hogan,B.L.
  TITLE     Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in
            morphogenesis and neurogenesis in the mouse
  JOURNAL   Development 111 (2), 531-542 (1991)
   PUBMED   1893873
REFERENCE   10 (bases 1 to 3583)
  AUTHORS   Dickinson,M.E., Kobrin,M.S., Silan,C.M., Kingsley,D.M.,
            Justice,M.J., Miller,D.A., Ceci,J.D., Lock,L.F., Lee,A.,
            Buchberg,A.M. et al.
  TITLE     Chromosomal localization of seven members of the murine TGF-beta
            superfamily suggests close linkage to several morphogenetic mutant
            loci
  JOURNAL   Genomics 6 (3), 505-520 (1990)
   PUBMED   1970330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124549.5 and AC154747.2.
            
            On Sep 27, 2022 this sequence version replaced NM_007556.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein regulates a wide range of
            biological processes including iron homeostasis, fat and bone
            development, and ovulation. Mice lacking this gene exhibit delayed
            ossification of the sternum, iron overload, and reduced fertility
            in females. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135770.1, X80992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1466              AC124549.5         191902-193367
            1467-1659           AC154747.2         82214-82406         c
            1660-1808           AC154747.2         66981-67129         c
            1809-2006           AC154747.2         66084-66281         c
            2007-2083           AC154747.2         54649-54725         c
            2084-2194           AC154747.2         53193-53303         c
            2195-3583           AC154747.2         51713-53101         c
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 18.15 cM"
     gene            1..3583
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="bone morphogenetic protein 6"
                     /db_xref="GeneID:12161"
                     /db_xref="MGI:MGI:88182"
     exon            1..1466
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             812..2344
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="VG-1-related protein"
                     /codon_start=1
                     /product="bone morphogenetic protein 6 preproprotein"
                     /protein_id="NP_031582.1"
                     /db_xref="CCDS:CCDS26462.1"
                     /db_xref="GeneID:12161"
                     /db_xref="MGI:MGI:88182"
                     /translation="MPGLGRRAQWLCWWWGLLCSCGPPPLRPPLPVAAAAAGGQLLGA
                     GGSPVRAEQPPPQSSSSGFLYRRLKTHEKREMQKEILSVLGLPHRPRPLHGLQQPQPP
                     VLPPQQQQQQQQQQTAREEPPPGRLKSAPLFMLDLYNALSNDDEEDGASEGVGQEPGS
                     HGGASSSQLRQPSPGAAHSLNRKSLLAPGPGGGASPLTSAQDSAFLNDADMVMSFVNL
                     VEYDKEFSPHQRHHKEFKFNLSQIPEGEAVTAAEFRVYKDCVVGSFKNQTFLISIYQV
                     LQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGL
                     HVNPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVS
                     RGSGSSDYNGSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHM
                     NATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACG
                     CH"
     exon            1467..1659
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1808
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2006
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2083
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2194
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..3583
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3425..3430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="hexamer: ATTAAA"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="hexamer: AATACA"
     polyA_site      3448
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="major polyA site"
     polyA_site      3451
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="major polyA site"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
                     /note="hexamer: TATAAA"
     polyA_site      3583
                     /gene="Bmp6"
                     /gene_synonym="D13Wsu115e; Vgr1"
ORIGIN      
        1 agcagaaagc ccacgttggc ggcggccggg agcgcagtgc gcagaggcgg gagactgcga
       61 atccccgagc cgacgccgca gcctgcgttc cgagttccgc tcctcgtctc tctcatcgcc
      121 tcggagagcg ggatcctccg ggcacccgag agactgccga gaggaaagct agatcgtggc
      181 cgcctccact tggggaggcg cgcggagatt ccgaggggga gagacggtgc ccgaaggcgg
      241 aggggcgctg agtttcggac cagagggaag ttaaaaccgc gcggagaaaa ttggcttttt
      301 aggacgcagg gacgccacag cctgggaccc acaggggagt aaacttcacg actgtcctac
      361 aagccaggag aggcgtgcga ggggatggtg cccggcatcg cctccacctc ttgatctgtc
      421 gtctccggcc cccctcggcc agccgcctct gagggttcag ggcagcgcac gtgtgcagac
      481 tgcgagtgac cgtgccgtga cccgcccggg gacgccggct gcagcgcagt cctgcctagg
      541 acacacctgg ctcactcagc ccgtgcgcct ccagagacct gcgggagagt ggaggatcct
      601 ggccgtcgcc ccgtcgtctc ttctccaccc gggcttctgg gggcgccgcg gatgaccatg
      661 agagataagg actgagtgcc aggaccggga agagagcccg ccgagaggtg gcgggggctg
      721 cccactccga gggccacagc ctccgcgctc cggcctcgct ccgccgctcg acgcctcgcg
      781 ggccccgcgg gggcagccgg gctgggcggc gatgcccggg ctggggcgga gggcgcagtg
      841 gctgtgctgg tggtgggggt tgctgtgcag ctgcggcccc ccgccactgc ggccccctct
      901 gccggtagcc gcggccgccg ccggggggca gctgctggga gccggcggga gcccggtgcg
      961 cgctgagcag ccaccgccac agtcctcttc ttcgggcttc ctctatcggc ggctcaagac
     1021 ccacgagaag cgggagatgc aaaaggagat cctgtcggtg ctggggctcc cgcacaggcc
     1081 gcggcccctg cacggtctcc agcagcctca gcccccggtg ctcccgccac agcagcagca
     1141 gcagcagcag cagcagcaga cggcccgcga ggagccccct ccagggcggc tgaagtccgc
     1201 tccactcttc atgctggatc tctacaacgc cctgtccaat gacgacgaag aggatggggc
     1261 atcggagggt gtggggcaag agcctgggtc ccacggaggg gccagctcgt cccagctcag
     1321 gcagccgtct cccggcgctg cacactcctt gaaccgcaag agtctcctgg ccccgggacc
     1381 cggtggcggt gcgtccccac tgactagcgc gcaggacagc gctttcctca acgacgcgga
     1441 catggtcatg agctttgtga acctggtgga gtacgacaag gagttctccc cacatcaacg
     1501 acaccacaaa gagttcaagt tcaacctatc ccagattcct gagggtgagg cggtgacggc
     1561 tgctgagttc cgcgtctaca aggactgtgt ggtggggagt tttaaaaacc aaacctttct
     1621 tatcagcatt taccaagtct tgcaggagca tcagcacaga gactctgacc tatttttgtt
     1681 ggacacccgg gtggtgtggg cctcagaaga aggttggctg gaatttgaca tcacagcaac
     1741 tagcaatctg tgggtggtga caccgcagca caacatgggg ctccagctga gtgtggtgac
     1801 tcgggatgga ctccacgtca acccccgtgc ggcgggcctg gtgggcagag acggccctta
     1861 cgacaagcag cccttcatgg tggccttctt caaggtgagc gaggtccacg tgcgcaccac
     1921 caggtcagcc tccagtcggc ggcggcagca gagtcgcaac cggtccaccc agtcgcagga
     1981 cgtgtcccgg ggctccggtt cttcagacta caacggcagt gagttaaaaa cagcttgcaa
     2041 gaagcatgag ctctatgtga gcttccagga cctgggatgg caggactgga tcattgcacc
     2101 caaaggctac gctgccaact actgtgatgg agagtgttcc ttcccactca acgcacacat
     2161 gaatgccacc aaccacgcca ttgtacagac cttggtccac cttatgaatc ccgagtacgt
     2221 ccccaaacca tgctgcgcac caaccaaact gaatgccatc tcggttcttt acttcgatga
     2281 taactccaat gtcatcttga aaaagtacag gaatatggtc gtgagagctt gtggttgcca
     2341 ttaagttgaa gctggtgtgt gtgtgtgggt gggggcatgg ttctgccttg gattcctaac
     2401 aacaacatct gccttaaacc acgaacaaca gcacagcgaa gcgggatggt gacacacaga
     2461 gggatcgtga cacgcagaca catctcccgc tggtgcctta cccacggagg cttttatgag
     2521 gaccttgtca agggctttcc cagttcctaa ctgagcagtt gctggtctgc aggaagctgg
     2581 aaggcttgta gtacaggcct ggaaactgca gttacctaat gttcgcctcc cccaaccccg
     2641 cccggagtag ttttagcttt tagatctagc tgcttgtggt gtaagtagag agtaaacttg
     2701 aaggaatatt aaatatccct gggttgaaag acccggtggt ggctctacag cacccatccc
     2761 agggagattt ttgcagacat ccgaatggag gggagaaggg cactctttca ggttccattc
     2821 ccagcaaggg cagctcacac aggacctgca gcctggccat cagcaggctc tgtggaggtg
     2881 ccttctgtct actgttgtag ttacgtgttt tgtgttgact ctcggtggtg tgagaatgta
     2941 ctaatctctg tcaagacaaa ctgtagcatt tccaccccat cctcctccct ccctcacaga
     3001 attctttact agaacccaaa gtagacagac cgtactttgt ggcagagcca tgaagcatct
     3061 gccgtagccg tcatttaagc cacagaacag cagaatttga ttctacatct cgtgggcagc
     3121 ctggctggac atgcgtgtta acatcaggaa cactggctcc aacatcggct ctgtaacccc
     3181 taactctgct ctttgccttt tccctaccta agcattccat ggctcagggc tagagtctaa
     3241 agccgaaacc cagagaggga agggccctgc ctgtaagaat gggtttgtca aggtgagcat
     3301 gctgtgtgta aaccaaaacc accatttcct cctgtagaaa gtaagactca gactgaatct
     3361 tagaatattt tttaaatgtc cttttcacaa tcatgtaccg ggaagccaat ttcatactaa
     3421 actgattaaa taatacattt acaatctgta actgtactta cagccttctt tgtaaataga
     3481 aactataatt tattgtctat tttatatcca ttttgctgta acatttaagc aaagaccaga
     3541 ctttttttct ttaaaaaaaa aaagtttatt tagaaagtat aaa
//
