LOCUS       NM_007555               3827 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus bone morphogenetic protein 5 (Bmp5), mRNA.
ACCESSION   NM_007555
VERSION     NM_007555.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Allen,R.S., Biswas,S.K. and Seifert,A.W.
  TITLE     Ear pinna growth and differentiation is conserved in murids and
            requires BMP signaling for chondrocyte proliferation
  JOURNAL   Development 152 (3) (2025)
   PUBMED   39846506
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Wu,Y., Liu,W., Li,J., Shi,H., Ma,S., Wang,D., Pan,B., Xiao,R.,
            Jiang,H. and Liu,X.
  TITLE     Decreased Tiam1-mediated Rac1 activation is responsible for
            impaired directional persistence of chondrocyte migration in
            microtia
  JOURNAL   J Cell Mol Med 28 (11), e18443 (2024)
   PUBMED   38837873
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Koutsioumpa,C., Santiago,C., Jacobs,K., Lehnert,B.P., Barrera,V.,
            Hutchinson,J.N., Schmelyun,D., Lehoczky,J.A., Paul,D.L. and
            Ginty,D.D.
  TITLE     Skin-type-dependent development of murine mechanosensory neurons
  JOURNAL   Dev Cell 58 (20), 2032-2047 (2023)
   PUBMED   37607547
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Chang,J.W., Lin,Y.Y., Tsai,C.H., Liu,S.C., He,X.Y., Wu,Y.S.,
            Huang,C.C. and Tang,C.H.
  TITLE     Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in
            rheumatoid arthritis
  JOURNAL   Biochem Pharmacol 215, 115687 (2023)
   PUBMED   37481139
  REMARK    GeneRIF: Nesfatin-1 stimulates BMP5 expression and
            osteoclastogenesis in rheumatoid arthritis.
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Heinlein,U.A. and Wille,W.
  TITLE     Evidence for a thymus-affecting, recessive mouse gene (sty) located
            between the staggerer (sg) and short-ear (se) loci on chromosome 9
  JOURNAL   Cell Biol Int Rep 16 (12), 1247-1250 (1992)
   PUBMED   1288897
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Merchant,M., Morrison,V., Santostefano,M. and Safe,S.
  TITLE     Mechanism of action of aryl hydrocarbon receptor antagonists:
            inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1
            gene expression
  JOURNAL   Arch Biochem Biophys 298 (2), 389-394 (1992)
   PUBMED   1329656
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Kingsley,D.M., Bland,A.E., Grubber,J.M., Marker,P.C., Russell,L.B.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     The mouse short ear skeletal morphogenesis locus is associated with
            defects in a bone morphogenetic member of the TGF beta superfamily
  JOURNAL   Cell 71 (3), 399-410 (1992)
   PUBMED   1339316
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Wallace,M.E.
  TITLE     Hydronephrosis in the mouse: the effects of the short-ear gene, sex
            and ureteral vascular system
  JOURNAL   Am J Anat 147 (1), 1932 (1976)
   PUBMED   970345
REFERENCE   10 (bases 1 to 3827)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK033362.1, AK135704.1 and
            AC079245.35.
            
            On Oct 17, 2015 this sequence version replaced NM_007555.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer, which plays a role in bone and
            cartilage development. Mice with null mutations in this gene
            exhibit a short ear phenotype, which is characterized by reduced
            size of the external ear, altered size and shape of the sternum,
            and other skeletal and soft-tissue abnormalities. [provided by
            RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033362.1, AK160412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2528              AK033362.1         4-2531
            2529-3821           AK135704.1         697-1989
            3822-3822           AC079245.35        103256-103256
            3823-3827           AK135704.1         1991-1995
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.34 cM"
     gene            1..3827
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /note="bone morphogenetic protein 5"
                     /db_xref="GeneID:12160"
                     /db_xref="MGI:MGI:88181"
     exon            1..1218
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     CDS             729..2093
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /codon_start=1
                     /product="bone morphogenetic protein 5 preproprotein"
                     /protein_id="NP_031581.2"
                     /db_xref="CCDS:CCDS23348.1"
                     /db_xref="GeneID:12160"
                     /db_xref="MGI:MGI:88181"
                     /translation="MHWTVFLLRGIVGFLWSGWVQVGYAKGGLGDNHVHSSFIYRRLR
                     NHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEDNPEESEYLVR
                     VSLAGEAKETRKGYPASPNGYAHRLHLPPRTPLTTQSPPLASLHDTNFLNDADMVMSF
                     VNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDKGNHRFENETIKISI
                     YQIIKEYTNRDADLFLLDTRKTQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETG
                     DGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNKSNSHQD
                     PSRMPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNA
                     HMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS
                     CGCH"
     exon            1219..1411
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1560
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1755
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1832
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1943
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..3827
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3805..3810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /note="hexamer: ATTAAA"
     polyA_site      3823
                     /gene="Bmp5"
                     /gene_synonym="se"
                     /note="major polyA site"
ORIGIN      
        1 tttctcctta gatctctctt gaagagggct ggtatatttg tgcctgctgg aggtggaatt
       61 aactgtaaga aggggggaag agattgaatg gatttacagg gaggattgca agtaaattca
      121 gggaaacaca tttacttgaa cactataacc ttgggtcttg ttttacacta agaccataca
      181 aaagatgttc aagttatcac taggctgccg gacaaatcta attccaacac caaggtgcag
      241 atcagcgtag atctgtgatt cagacctcag gatttgcttt ggaaagagtt caagtgttga
      301 gaagaagtca gagcaagtga agagaacttg ggagctacag tctatcagaa gaccagcttt
      361 cgtcagttca aataccaaag gcctgattag cataaattca cataggaatg cataggttat
      421 ttgatcaaat aattttaacc agcttttgct acatcaacct ctcaaaagtt cttaacaact
      481 gtggataatt agaaatctga atttcaactt tctaaggaat aactactctt gacgtgttct
      541 aaaatattta aagcaggaga agaagatgga ctgagggcgc ggtgttcaga aatatcactg
      601 tcatgaagaa caggtaaatt tgtttttaca tctcctggtg aagtatactt ccaaggaacc
      661 tggattatta ttttttttcc aagtggacaa gaaggattaa aaatatcgac ttttgctttt
      721 gcacaaaaat gcattggact gtatttttac ttaggggtat tgtgggcttc ctctggagcg
      781 gctgggttca agtgggttat gcaaaaggag gcttgggaga caatcacgtt cactccagtt
      841 ttatttatag aaggctacgg aaccatgaga gacgggaaat acagagggaa attctgtcta
      901 ttttgggttt gcctcacaga cccaggccct tttcaccagg gaaacaagca tcttctgccc
      961 ccctctttat gctggatctc tacaatgcca tggctagcga agacaaccct gaggagtcgg
     1021 agtatttggt gagggtgtcc ctggctggag aggccaaaga gacaagaaag ggatacccag
     1081 cctctcccaa tgggtatgcg catcgtctgc acttaccacc aaggactcct ctgactaccc
     1141 agagcccacc tcttgccagc ctacatgata ccaactttct gaatgatgct gacatggtca
     1201 tgagctttgt caacttagtt gaaagagaca aggacttttc tcatcagagg aggcattaca
     1261 aagagtttcg gtttgatctg acccagattc cacatggaga agcagtgaca gcagcagaat
     1321 tccggattta taaggacaag ggaaaccatc gatttgaaaa tgaaacaatt aagatcagca
     1381 tatatcagat catcaaggaa tacacaaaca gggatgcaga tctttttctg ctagatacga
     1441 ggaagacaca agctttagat gtgggctggc ttgtctttga tatcactgtg accagcaacc
     1501 actgggtgat taatccacag aacaatttgg gcttacagct ctgtgcagag acgggggatg
     1561 gccgcagcat caatgtaaaa tctgctggtc ttgtgggaag acatgggcct cagtcaaaac
     1621 agccattcat ggtggccttc ttcaaggcaa gcgaggtact tcttcgatcc gtgagagcag
     1681 ccagcaaacg gaaaaatcaa aaccgcaata aatccaactc tcatcaggac ccctccagga
     1741 tgcccagtgc tggagattat aataccagtg aacaaaaaca agcctgcaag aagcacgaac
     1801 tctatgtgag tttccgagat ctgggatggc aggactggat catagcacca gaagggtatg
     1861 ctgcatttta ttgtgacggg gaatgttctt ttccacttaa tgcccatatg aatgccacca
     1921 accatgccat agtccagacc ctggtacacc tgatgtttcc agaccatgtt cccaagcctt
     1981 gctgcgctcc aaccaaacta aatgccatct cggtcctgta ttttgatgac agctccaatg
     2041 tcattttgaa aaagtacaga aatatggtag tacgttcgtg tggctgccac tagctggaag
     2101 tgcctgtgat aataacaaaa cagatctgtg ctatgtttat gaccacaata aaaagcaggg
     2161 gaatggggaa tttcctaaaa tcaacctggg tcatttcatc tctctatgta tgatatcatg
     2221 tatatacact tcttatttat ttaaaattat gtattctctt ttggatacct taccagtaaa
     2281 acctgttaaa gatcccccta ttatataata gattcctatt ctaacttttg ttggggtgtg
     2341 gtgggtccag tttaacacta tgctaacatt tttcccaagg ctaatataaa taactttctg
     2401 atattaagta gaattccttt gacagcttaa tgttggaggg aaatgaatat atctgacata
     2461 ttgcactaac taaaactaag ataggatatc tagaaataaa gtaactaaca accaaaattt
     2521 taaaaaccac attgtttacc atttgtgctt ctttggctaa agtaaaatgt ggaactggat
     2581 ttgagttagt gatcagtagg caagacacag aagctggaag actttgtaat tcttttaact
     2641 gttcccttta atggaattgg tggacctcta gaaacatgct gcctcttgct tctgaccggc
     2701 agattttttc tcttttgttt tgttttgttt gtttttcttt tgttctgttt ttgcaagaag
     2761 atgaaagctt caggcttgag tctacttcca cctgtttcca aactgacaca aaaaagtacc
     2821 tcaaataaat cagcccagcc attatctaga acactactgc tacagtgggt tttttctttc
     2881 tttcttgttt aaaacttaac ccaaagtaag gaaataatca catgtactcc attccattcc
     2941 ctacagacaa gagtcatttc atgcataaaa tgtgctggaa cccatcacgt cgacacagtg
     3001 tcttgctgtc acttgccttt ataatagaca tttccagctg atgtgatata agggatttta
     3061 ttcagtgtga gaatattgtc attaaactga aaaaaaaaat tcccagagtt gctttgacag
     3121 aaccaccatt ttaaaacagc taaatcctgt ttttcacatt ttttgggaaa aaactcagtg
     3181 aaaaccccca attttacaaa gggattttgg aaaacttcct ctgagcatga gtaagtaggg
     3241 tagggaaggt tctggggtgg tgtgaagtgt ggtgcgtgcg tgcgtgcgtg cgtgcgtgcg
     3301 tgcgtgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg cgcgcatgct tttctctctg
     3361 atgtttattt atttcatctc tgttggaagg gtgactggtt actaaggtct ttctccagcc
     3421 cacgctgact ttctgaggag tggggctcta gtcttccaac tttttgtgag ctccgtggtg
     3481 aggcttgtag caatcaactg aaaatattca tggagcgcca ttcccaactc cccgcttgta
     3541 gctttcaagc aagaatccat ccttactaac tttcagacat tgtggcttgt ttgtaattca
     3601 gatattttac aatgttgttt taaaacacag tttacaatat agaaactatg atattgatga
     3661 tattggggga tgcactaagt aatatatttt tagttaataa cttaatagtg tatcaatgag
     3721 gataaggcta gagattaaga aatagaattc tattatatta ttcttaaaat gtactacttg
     3781 gatgtatgtt tacatttaaa atttattaaa ctcataatgt caatctc
//
