LOCUS       NM_007554               2059 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus bone morphogenetic protein 4 (Bmp4), transcript
            variant 1, mRNA.
ACCESSION   NM_007554
VERSION     NM_007554.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Li,B., Pu,Z., Liao,K., Du,Y., Tan,G., Nawy,S., Gao,S. and Shen,Y.
  TITLE     Overexpression of Bmp4 induces microphthalmia by disrupting
            embryonic neural retina
  JOURNAL   Neurobiol Dis 201, 106654 (2024)
   PUBMED   39216769
  REMARK    GeneRIF: Overexpression of Bmp4 induces microphthalmia by
            disrupting embryonic neural retina.
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Hadas,R., Rubinstein,H., Mittnenzweig,M., Mayshar,Y., Ben-Yair,R.,
            Cheng,S., Aguilera-Castrejon,A., Reines,N., Orenbuch,A.H.,
            Lifshitz,A., Chen,D.Y., Elowitz,M.B., Zernicka-Goetz,M.,
            Hanna,J.H., Tanay,A. and Stelzer,Y.
  TITLE     Temporal BMP4 effects on mouse embryonic and extraembryonic
            development
  JOURNAL   Nature 634 (8034), 652-661 (2024)
   PUBMED   39294373
  REMARK    GeneRIF: Temporal BMP4 effects on mouse embryonic and
            extraembryonic development.
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Perez-Shibayama,C., Gil-Cruz,C., Cadosch,N., Lutge,M., Cheng,H.W.,
            De Martin,A., Frischmann,K., Joachimbauer,A., Onder,L.,
            Papadopoulou,I., Papadopoulou,C., Ring,S., Krebs,P., Vu,V.P.,
            Nagele,M.P., Rossi,V.A., Parianos,D., Zsilavecz,V.W., Cooper,L.T.,
            Flammer,A., Ruschitzka,F., Rainer,P.P., Schmidt,D. and Ludewig,B.
  TITLE     Bone morphogenic protein-4 availability in the cardiac
            microenvironment controls inflammation and fibrosis in autoimmune
            myocarditis
  JOURNAL   Nat Cardiovasc Res 3 (3), 301-316 (2024)
   PUBMED   39196111
  REMARK    GeneRIF: Bone morphogenic protein-4 availability in the cardiac
            microenvironment controls inflammation and fibrosis in autoimmune
            myocarditis.
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Phelan,J.P.
  TITLE     Genetic variability and rodent models of human aging
  JOURNAL   Exp Gerontol 27 (2), 147-159 (1992)
   PUBMED   1521591
  REMARK    Review article
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Jones,C.M., Lyons,K.M. and Hogan,B.L.
  TITLE     Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in
            morphogenesis and neurogenesis in the mouse
  JOURNAL   Development 111 (2), 531-542 (1991)
   PUBMED   1893873
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Dickinson,M.E., Kobrin,M.S., Silan,C.M., Kingsley,D.M.,
            Justice,M.J., Miller,D.A., Ceci,J.D., Lock,L.F., Lee,A.,
            Buchberg,A.M. et al.
  TITLE     Chromosomal localization of seven members of the murine TGF-beta
            superfamily suggests close linkage to several morphogenetic mutant
            loci
  JOURNAL   Genomics 6 (3), 505-520 (1990)
   PUBMED   1970330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK145359.1, AK136527.1 and
            CT009556.7.
            
            On Oct 17, 2015 this sequence version replaced NM_007554.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein regulates heart
            development and adipogenesis. Homozygous knockout mice die in
            utero, while a conditional knockout mouse exhibits defects in heart
            development. Transgenic mice overexpressing this gene in a
            neuron-specific manner exhibit a phenotype resembling the rare
            hereditary connective tissue disease, fibrodysplasia ossificans
            progressiva. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145359.1, AK136527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AK145359.1         1-70
            71-1862             AK136527.1         2-1793
            1863-2059           CT009556.7         41721-41917         c
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 23.95 cM"
     gene            1..2059
                     /gene="Bmp4"
                     /gene_synonym="Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1"
                     /note="bone morphogenetic protein 4"
                     /db_xref="GeneID:12159"
                     /db_xref="MGI:MGI:88180"
     exon            1..366
                     /gene="Bmp4"
                     /gene_synonym="Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..491
                     /gene="Bmp4"
                     /gene_synonym="Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..871
                     /gene="Bmp4"
                     /gene_synonym="Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..1725
                     /gene="Bmp4"
                     /gene_synonym="Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1"
                     /note="bone morphogenetic protein 2B"
                     /codon_start=1
                     /product="bone morphogenetic protein 4 preproprotein"
                     /protein_id="NP_031580.2"
                     /db_xref="CCDS:CCDS36897.1"
                     /db_xref="GeneID:12159"
                     /db_xref="MGI:MGI:88180"
                     /translation="MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGG
                     RRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQG
                     TGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFLFNLSSIPENEVISSAELR
                     LFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVHHNVTRWETFDV
                     SPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTF
                     GHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA
                     FYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKV
                     VLKNYQEMVVEGCGCR"
     exon            872..2059
                     /gene="Bmp4"
                     /gene_synonym="Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaggga agaagggagg ggccgctggg gggaaagact ggggaggaag ggaagaaaga
       61 gagggaggga aaagagaagg aaggagtaga tgtgagaggg tggtgctgga gggtgggaag
      121 gcaagagcgc gaggcctggc ccggaagcta ggtgagttcg gcatccgagc tgagagaccc
      181 cagcctaaga cgccgctgcg ctgcaaccca gcctgagtat ctggtctccg tccctgatgg
      241 gattctcgtc taaaccgtct tggagcctgc agcgatccag tctctggccc tcgaccaggt
      301 tcattgcagc tttctagagg tccccagaag cagctgctgg cgagcccgct tctgcaggaa
      361 ccaatggagc cattccgtag tgccattcgg agcgacgcac tgccgcagct tctctgagcc
      421 tttccagcaa gtttgttcaa gattggctcc caagaatcat ggactgttat tatatgcctt
      481 gttttctgtc aagacaccat gattcctggt aaccgaatgc tgatggtcgt tttattatgc
      541 caagtcctgc taggaggcgc gagccatgct agtttgatac ctgagaccgg gaagaaaaaa
      601 gtcgccgaga ttcagggcca cgcgggagga cgccgctcag ggcagagcca tgagctcctg
      661 cgggacttcg aggcgacact tctacagatg tttgggctgc gccgccgtcc gcagcctagc
      721 aagagcgccg tcattccgga ttacatgagg gatctttacc ggctccagtc tggggaggag
      781 gaggaggaag agcagagcca gggaaccggg cttgagtacc cggagcgtcc cgccagccga
      841 gccaacactg tgaggagttt ccatcacgaa gaacatctgg agaacatccc agggaccagt
      901 gagagctctg cttttcgttt cctcttcaac ctcagcagca tcccagagaa tgaggtgatc
      961 tcctcggcag agctccggct ctttcgggag caggtggacc agggccctga ctgggaacag
     1021 ggcttccacc gtataaacat ttatgaggtt atgaagcccc cagcagaaat ggttcctgga
     1081 cacctcatca cacgactact ggacaccaga ctagtccatc acaatgtgac acggtgggaa
     1141 actttcgatg tgagccctgc agtccttcgc tggacccggg aaaagcaacc caattatggg
     1201 ctggccattg aggtgactca cctccaccag acacggaccc accagggcca gcacgtcaga
     1261 atcagccgat cgttacctca agggagtgga gattgggccc aactccggcc cctcctggtc
     1321 acttttggcc atgatggccg gggccatacc ttgacccgca gaagggccaa acgtagtccc
     1381 aagcatcacc cacagcggtc caggaagaag aataagaact gccgtcgcca ttcactatac
     1441 gtggacttca gtgacgtggg ctggaatgat tggattgtgg ccccacccgg ctaccaggcc
     1501 ttctactgcc acggggactg tccctttcca ctggctgatc acctcaactc aaccaaccat
     1561 gccattgtgc agaccctagt caactctgtt aattctagta tccctaaggc ctgttgtgtc
     1621 cccactgaac tgagtgccat ttccatgttg tacctggatg agtatgacaa ggtggtgttg
     1681 aaaaattatc aggagatggt ggtagagggg tgtggatgcc gctgagatca ggcagtccag
     1741 agggcggaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacacg
     1801 ttcccattca accacctaca cataccacac aaactgcttc cctatagctg gacttttatc
     1861 ttaaaaaaaa aaaaaaaaaa agaaagaaag aaagaaaaaa aatgaaagac agaaaagaaa
     1921 aaaaaaaacc ctaaacaact caccttgacc ttatttatga ctttacgtgc aaatgttttg
     1981 accatattga tcatatattt tgacaaatat atttataact acatattaaa agaaaataaa
     2041 atgagtcatt attttaaag
//
