LOCUS       NM_173404               6229 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus bone morphogenetic protein 3 (Bmp3), transcript
            variant 2, mRNA.
ACCESSION   NM_173404
VERSION     NM_173404.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6229)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6229)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 6229)
  AUTHORS   Bottasso-Arias,N., Leesman,L., Burra,K., Snowball,J., Shah,R.,
            Mohanakrishnan,M., Xu,Y. and Sinner,D.
  TITLE     BMP4 and Wnt signaling interact to promote mouse tracheal
            mesenchyme morphogenesis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (2), L224-L242 (2022)
   PUBMED   34851738
REFERENCE   4  (bases 1 to 6229)
  AUTHORS   Banovac,I., Grgurevic,L., Rumenovic,V., Vukicevic,S. and Erjavec,I.
  TITLE     BMP3 Affects Cortical and Trabecular Long Bone Development in Mice
  JOURNAL   Int J Mol Sci 23 (2), 785 (2022)
   PUBMED   35054971
  REMARK    GeneRIF: BMP3 Affects Cortical and Trabecular Long Bone Development
            in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6229)
  AUTHORS   Schneider,A.J., Gawdzik,J., Vezina,C.M., Baker,T.R. and
            Peterson,R.E.
  TITLE     Sox9 in mouse urogenital sinus epithelium mediates elongation of
            prostatic buds and expression of genes involved in epithelial cell
            migration
  JOURNAL   Gene Expr Patterns 34, 119075 (2019)
   PUBMED   31669249
REFERENCE   6  (bases 1 to 6229)
  AUTHORS   Ohta,S., Hiraki,Y., Shigeno,C., Suzuki,F., Kasai,R., Ikeda,T.,
            Kohno,H., Lee,K., Kikuchi,H., Konishi,J. et al.
  TITLE     Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase
            expression of the proto-oncogene c-fos in murine osteoblastic
            MC3T3-E1 cells
  JOURNAL   FEBS Lett 314 (3), 356-360 (1992)
   PUBMED   1468569
REFERENCE   7  (bases 1 to 6229)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
REFERENCE   8  (bases 1 to 6229)
  AUTHORS   Benovic,J.L., Onorato,J.J., Arriza,J.L., Stone,W.C., Lohse,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Caron,M.G. and
            Lefkowitz,R.J.
  TITLE     Cloning, expression, and chromosomal localization of
            beta-adrenergic receptor kinase 2. A new member of the receptor
            kinase family
  JOURNAL   J Biol Chem 266 (23), 14939-14946 (1991)
   PUBMED   1869533
REFERENCE   9  (bases 1 to 6229)
  AUTHORS   van Lohuizen,M., Verbeek,S., Scheijen,B., Wientjens,E., van der
            Gulden,H. and Berns,A.
  TITLE     Identification of cooperating oncogenes in E mu-myc transgenic mice
            by provirus tagging
  JOURNAL   Cell 65 (5), 737-752 (1991)
   PUBMED   1904008
REFERENCE   10 (bases 1 to 6229)
  AUTHORS   Dickinson,M.E., Kobrin,M.S., Silan,C.M., Kingsley,D.M.,
            Justice,M.J., Miller,D.A., Ceci,J.D., Lock,L.F., Lee,A.,
            Buchberg,A.M. et al.
  TITLE     Chromosomal localization of seven members of the murine TGF-beta
            superfamily suggests close linkage to several morphogenetic mutant
            loci
  JOURNAL   Genomics 6 (3), 505-520 (1990)
   PUBMED   1970330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK035299.1, AK040389.1 and
            AC141896.5.
            
            On Oct 17, 2015 this sequence version replaced NM_173404.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein suppresses osteoblast
            differentiation, and negatively regulates bone density, by
            modulating TGF-beta receptor availability to other ligands.
            Homozygous knockout mice for this gene exhibit increased bone
            density and volume, while overexpression of this gene in a
            transgenic mouse causes bone defects resulting in spontaneous rib
            fractures. This gene encodes distinct protein isoforms that may be
            similarly proteolytically processed. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (2) has a distinct, shorter
            C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037225.1, AK040389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK035299.1         3-26
            25-2178             AK040389.1         2-2155
            2179-6229           AC141896.5         173246-177296       c
FEATURES             Location/Qualifiers
     source          1..6229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.24 cM"
     gene            1..6229
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /note="bone morphogenetic protein 3"
                     /db_xref="GeneID:110075"
                     /db_xref="MGI:MGI:88179"
     exon            1..1008
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1913
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..6229
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2306
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /note="major polyA site"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2907
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
     regulatory      6204..6209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6224
                     /gene="Bmp3"
                     /gene_synonym="9530029I04Rik"
ORIGIN      
        1 gtctctccct acccttctgg ttctggctcc ctggttactt cgctccaggc ttctctcttc
       61 tggaggtagt cttgctccag ctgccttagg aaggcgagcc agaggctaga gggagaactc
      121 gctgcaggcg gaccggacag atcagatcag gacaagaagg aacagaacca gtctctctat
      181 ctctgtctct ctgttcgtca ctgtctctgt gtctctgtct ccctgtctcc ctctttctct
      241 gtctgtctgt ctgtcttcac acacacacac acacacacac acacacacac acacacacac
      301 acaccacacg tcctctgaga actcagctgg ctgcgacagc gcacaccccg ccccggcacg
      361 cgtcccaggc tggtggagcg cagatccaga tccccatagc ggcagcccgg ccgggtgttc
      421 ccagtctcag gtggcacgga agggagagcc cgcgcttgac aactcggctg cgctcgccca
      481 gaccttccgc cctccggctg gccggcgaga ggagctgagc gggcgcggct gccacccaga
      541 gcccacctgc cgaccctcgc ggcctcgctc cagctgtgcc cggctctcag tgtcccgctc
      601 cgcagctgga gcaccacccc ggctctgccg ccgtcccttt cgcctccgag gtgtcgcggg
      661 cgacccgaag tagagcggtg cgacagcagg acttcgctat ggccggggcg cgcgggctgc
      721 tctgtctatg gctaggttac ttctgcctga acctggcaca gggacagaga ccaaacttgc
      781 acctcccggg actccgtgag actgagccaa gcgaccgcgc gacaggtggt agcccgagtc
      841 cggacctgag gccgcacgac aaggtgtcgg agcatatgct gtggctctat gacaggtaca
      901 gcggcagcag tagagtccag gctacccgga caccgggctc gcagctcccg ggtcctcagc
      961 ccctgcgcgg tggtaacacg gtccgcagct tcagagccgc agccgcagga actcctcaaa
     1021 cgaaggggtt acacaccttc aatctgactt ctctaaccaa gtcggagaac attttgtcag
     1081 ccacactgta tttctacgtt ggagaattag tgaacatcag cttgagctgt ccagaacccc
     1141 aaggatgctc ccatcacact cagagacaac acatccagat agacctctct gcatggatcc
     1201 tcaaatccaa ccaaagccag ctcttgggtc atctgtctgt agatgtggtc agaccttata
     1261 gagacagcgt gtcttggctg tcaaaagaca tcactcagct cttaagaaag gccaagcaaa
     1321 atgaagagtt tctcataggg tttaacatta cctccagagc acacgagcta cccaagagga
     1381 tgctgttttt cccggaacct tatatcttgg tatacgccaa cgatgctgcc atttctgagc
     1441 cagaaagcgt ggtatccagc ttacagagac accgagattt cacagcggga actgggccca
     1501 gactggatag ccacgtcaga gaagccctct cggttgagag gaggaagaag cgctctactg
     1561 ggatcttgct gcccttgcag aacaatgagc tacctggggc agagtatcag tacaaggagg
     1621 agggagcgtg ggaggagaga aagccttata agagccttca gactcagccc cctgagaaga
     1681 gtaggaacaa aaagaaacag aggaaagggt cccatcagaa gggacagacg ctgcaatttg
     1741 atgagcagac cctgaagaag gcaaggcgaa agcagtgggt cgaacctcgg aactgtgcca
     1801 ggaggtacct taaagtggac tttgctgata tcggctggag cgaatggatt atctctccca
     1861 agtcatttga tgctttctac tgctctggag cctgccagtt ccccatgcca aagtctttga
     1921 aaccatcaaa tcacgccacc atccagagca tagtgcgagc ggtgggggtc gtctccggga
     1981 ttcccgagcc ttgctgtgtg ccggaaaaga tgtcctcact cagcatcttg ttctttgatg
     2041 aaaacaagaa tgtagtgctc aaagtctacc ctaacatgac agtcgactcc tgtgcttgta
     2101 gataacctct tcaagaactc acagatgctc catccaatca cgagttgggt tttatgggct
     2161 tttttttttt ttttttttgt cccaaaagat gtttgatagc aggaagaaaa tgaacaaata
     2221 gattgaaggt ttccaccaaa caaaaccgga ctgtattttc cttcgaatgt aactaaaagt
     2281 gagattttag taaatgtgga tctctatttc tgttgtttct taatcacata agaaaaattg
     2341 ttactcaacc tgtttttttt agaagtgtta gagaacacag tgacttattt ttgtattggg
     2401 ctttaagatt gggtgggaaa tgacagcaat aacttatcat ttgttgctac tcatataaag
     2461 aggaaaggga agtagagagg agctttacaa ttttttctca ctaggtgtct tgccttaggc
     2521 tcctgagcag acagcaactg ctaaacaccc gtctttcttt gatgttcact gggaacgttt
     2581 ctgagacttg tctatcctgg gtttttctct acaatcatgg tgtgagtcga gctagtgtgt
     2641 gcagagtact agtgtgagtg tgcgtgtgtc agctcgctgt acctcctata gaaaaagaaa
     2701 aggcttcctt aatacggttc tatagctgca tcgtcatggc attcctttgt tgtcgtcaat
     2761 aatatcatat tctggccagc accaatccac tgatgattgc atgatccaag agcctatgcc
     2821 aagagcgacg tgtcactgat tggaaataca gatgttttca cggccttgac tcccagtaaa
     2881 agagagccaa aggcttcatt tttaaaaccc cgggtgtcgt tcttctgtag ttttcttttt
     2941 tccctacaca tcttgtcatt tgctctaagg taatttagga agtgcttcct gaagttatta
     3001 actttaaagt ttccttacca ctatactctc tcttcctgtg acgttgttca tagatgttga
     3061 ggcttacaag ccgttgttag aaatgaccaa gtgaattgct atcttgtggt gactaccatg
     3121 ctccacacct gtttctaggc tcttctcccc agagatcaag acactgtcct cagtcatgga
     3181 ccctatactc catcaaagcc tacaaaaaat tattcaccag gaaagagagt caacagagac
     3241 acagtttcca cttccacttg tcataagtat gtcatctttg atttctgctg ttgaaagttg
     3301 ttttatcttt cattaacaga cttgtaaggt atctcagtgg gtaacggtgc ttgctaccaa
     3361 ggcattcctg gaacccacat ggcagaagga gaaaaccagc tgtcacaagt tatcctctga
     3421 cctctacaca cacacacaca cacacacaca cacacacaca ctgaaaaaac ttaaagatct
     3481 ggaaactgta cttacctgga agatggaagt gatttcactt catagatggt tggtcacttt
     3541 gtcgtctctg aggacactcc tgatcttaaa tcactcttat atgatgatta gatagaaatg
     3601 ctccattaca gaacatgtat gagatcagaa tatatgtttt tcccatcttc gcctgtagct
     3661 atcagctgtt tggtcattat gaaatagtga tgaagtgtgt catgttttaa gggcacggca
     3721 actcccatgg gtaaagcaag aggctgatct gtttagctgg acacgctgag agtttggttt
     3781 ctaaaaagct gttccataca tcacctctca ggggtcatga tcagcagata cagaaatggt
     3841 gcaagtatct ctgttcataa atcagacgaa gcaacaggtt cactgtgcag tattctattt
     3901 gaaggctatt acataagaca tccaggcaaa gctctttcca ctttgaaagg ccctaacata
     3961 ttgtggaatt gtcctaactc tcaaggagac acagggggtt tgaaagacta agtgcaagga
     4021 ccaaggttgc ccggattccc tttagcatga agaagttaca gacattcaaa ctccagtggg
     4081 gaataaaatt actttttaac aaaattcctg acaaatttga aagcaaaata cacaacagaa
     4141 acaccaagct acatattcat gggtctttcg tcaaatagaa tttattttcc tgagtagatt
     4201 tgttgagact cttaatttca cttctcctga agatacacca accccaaacc ctggtaataa
     4261 ccctgtgtat cccttctcag ctttttatat tcaattttct gttgcctttc aaaactcaaa
     4321 tccattccta aattttgtgt attaaatcct acaagtgtgg tcaagtcttc ttggaatgat
     4381 aaaaattctc aagtactgac caactaaaac ttcactttga ttaatggtta acatgcaaaa
     4441 ggaagcccac attgaacttt gacattttct cagcaccacg tcagagaaag gccacttgac
     4501 tgttgctcta aacagctgct ggccatactc tcagcgtgtt ctaagttgga ggtacaataa
     4561 catgcacatg gggaaaaaat gactcctagt agggggaatt aaagtaaatt ggctggtgtt
     4621 ttaatcaata gactttactt aagtgcaata ttaaataagc gcctcatctg caatgtgtta
     4681 ggtacacatt tccatacaag attttgacaa ctctcctatg attttggggt tgatgggaaa
     4741 aagcactacg ttttgaaatg ctattttcta aataaaacct gtatgcccta tctctattcc
     4801 catcactttc tcccttctca acatattctt tttctattct caaactgtgt cctagccatt
     4861 cttacaacac acacacacac acacacacac acacacacac acacacagac agagactcag
     4921 agagagacag acagacagac aaagtgagag acagaaagac agatagaata agacagaagc
     4981 agcaactgag acagagacag acagacagac agacagacag acattttaag aaaataattc
     5041 ttttttaaaa aagcctacaa gaatatcact gagttggttt attttgacca tttattcctg
     5101 ggcatagggc ttaccattaa gtgtgattaa tatacccagt gacactccat tccattggag
     5161 aaaactaatt ttttttcctt tgcaagtggg tatcaattgc agacaggctc ttcattggga
     5221 gtggaccctt gtctacttcc tgtttgcagc gctgggaccc cccatctggc tcaaatctat
     5281 acattctatt tctgataact gtttcctaga attccagcta agggattccc catatccatg
     5341 cagtatttta agaattcttc gttgtaaccc gtgtgaataa tatataattt aaggaattta
     5401 atgctgtaga gtggaactgg aatatcgagt gcctttacct cgggattgca gtattccagg
     5461 ttaaatccta tcctaactag ctgcgtattc accgctggtc atctattcgc tgacacaatg
     5521 ctttactatc tctgtagaaa acttgtatta cccatttaat atttcataaa aaatgtgagg
     5581 aacagtatca ccagtctgac ttatacaatg cttatgtaac gacactagtc agttaatctt
     5641 gaagctttac attttctcca tgctaccgag tagcaaatgt ctgaacatgt tgaatcaagg
     5701 ttgggttaga gaatagctat gcattcctga cacgtaagga tgaataagca actgagtaag
     5761 gaagcttggg taaatctgat ttctcagtat ttctatgtgg cttttgaatg ataaaacgat
     5821 ctccactttt ctaaagacaa agctttctct tctacttttc acattagctt ctgtaaatgt
     5881 tttagttgaa aatttaatgc ttgtacagtc catggcaatt ggaatatata ttatatgtat
     5941 atggaaaaag tttaaagatg cttgtaattt atttaatgac tgttgccttt ctatattggt
     6001 aatgactttt ttccttacta ggtgagaaaa acatctttct tactatagtt cctagatagg
     6061 acaggacatt tagttcctta gtcgggtcca ttccaaggct gtggcagtaa ctgtgaaggg
     6121 ttcttcacta ccgatgtgtt aagctttcct gaacttatat cattctcctc cagtaacaaa
     6181 gacctttcgt cctatattac aaaaataaaa acagctcaat taaacattt
//
