LOCUS       NM_080708               6585 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus BMP2 inducible kinase (Bmp2k), mRNA.
ACCESSION   NM_080708 XM_358830
VERSION     NM_080708.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6585)
  AUTHORS   Sah RK, Ma J, Bah FB, Xing Z, Adlat S, Oo ZM, Wang Y, Bahadar N,
            Bohio AA, Nagi FH, Feng X, Zhang L and Zheng Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6585)
  AUTHORS   Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski
            K, Brewinska-Olchowik M, Kominek A, Piwocka K and Miaczynska M.
  TITLE     Splicing variation of BMP2K balances abundance of COPII assemblies
            and autophagic degradation in erythroid cells
  JOURNAL   Elife 9, e58504 (2020)
   PUBMED   32795391
  REMARK    GeneRIF: Splicing variation of BMP2K balances abundance of COPII
            assemblies and autophagic degradation in erythroid cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6585)
  AUTHORS   Gerber SD, Amann R, Wyder S and Trueb B.
  TITLE     Comparison of the gene expression profiles from normal and Fgfrl1
            deficient mouse kidneys reveals downstream targets of Fgfrl1
            signaling
  JOURNAL   PLoS One 7 (3), e33457 (2012)
   PUBMED   22432025
REFERENCE   4  (bases 1 to 6585)
  AUTHORS   Pawlowski TL, Heringer-Walther S, Cheng CH, Archie JG, Chen CF,
            Walther T and Srivastava AK.
  TITLE     Candidate Agtr2 influenced genes and pathways identified by
            expression profiling in the developing brain of Agtr2(-/y) mice
  JOURNAL   Genomics 94 (3), 188-195 (2009)
   PUBMED   19501643
REFERENCE   5  (bases 1 to 6585)
  AUTHORS   Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E,
            Klingensmith J, Camenisch T, Buckingham M and Moon AM.
  TITLE     An FGF autocrine loop initiated in second heart field mesoderm
            regulates morphogenesis at the arterial pole of the heart
  JOURNAL   Development 135 (21), 3599-3610 (2008)
   PUBMED   18832392
REFERENCE   6  (bases 1 to 6585)
  AUTHORS   Mager J, Schultz RM, Brunk BP and Bartolomei MS.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   7  (bases 1 to 6585)
  AUTHORS   Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK,
            Carpenter DA, Johnson DK, Rinchik EM and Culiat CT.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   8  (bases 1 to 6585)
  AUTHORS   Kearns AE, Donohue MM, Sanyal B and Demay MB.
  TITLE     Cloning and characterization of a novel protein kinase that impairs
            osteoblast differentiation in vitro
  JOURNAL   J Biol Chem 276 (45), 42213-42218 (2001)
   PUBMED   11500515
REFERENCE   9  (bases 1 to 6585)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY050249.1.
            
            [WARNING] On Apr 19, 2023 this sequence was replaced by
            NM_080708.2.
            
            On Dec 17, 2003 this sequence version replaced XM_358830.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY050249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6585
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..6585
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /note="BMP2 inducible kinase"
                     /db_xref="GeneID:140780"
                     /db_xref="MGI:MGI:2155456"
     exon            1..408
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..3656
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="BMP-2-inducible protein kinase"
                     /protein_id="NP_542439.1"
                     /db_xref="CCDS:CCDS39175.1"
                     /db_xref="GeneID:140780"
                     /db_xref="MGI:MGI:2155456"
                     /translation="MKKFSRMPKSEGSGGGAAAGGAAGGGLGGGFASSSMGVRVFAVG
                     RYQVTLEESLAEGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKELSGH
                     KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTESEVLQIFCDTC
                     EAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEI
                     KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGSFT
                     IPDNSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFAFKFAKKDCPVSNINNSFLPSTL
                     PEPMTATEAAARKSQMKARITDTIGPTETSIAPRQRPKANSTAATSSVLTIQSSATPV
                     KVPAPGEFSNHKPKGALRPGNGSEVLMVQGPPQQPPQQHRVLQQLQQGDWRLQQLHLH
                     RHPHHHHQQQQQQQQQQQQQQLQQQQQQQQQLLQNAYLQQYQHAMHQQHILQQQFLMH
                     SVYQPQPPASQYPAMMQQYQQAFLQQQMLARHQQPAQQVSPEYLTSPQEFSPALVSYA
                     SSLPAQVGTIVDSSYGANRSVAEKEAVANFTNQKTISHPPDMSGWNPFGEDNFSKLTE
                     EELLDREFDLLRSNRLGASTPSDKTVDLPPAPHSRPPEEPFASVPFISHSGSPEKKTT
                     EHSPNQKSITANLTKNGGSSPLCKDQRAGKKTSENPVIRGQVQKGHDDSESDFESDPP
                     SPKSSEEEQEDEDAQGEHGDFNDDDTEPENLGHRPLLMDSEDEEEDDKHSSDSECEQA
                     KTKRGDTSSLRRDKPGVAPDTALLTPARSPADALTPSQEFDVFGAVPFFAAPAPQSLQ
                     HRGDGKNLSQHAFPEQEDFDVFTKAPFNKKVSVQDWPAVGPDARPLPARPRSVDIFGS
                     TPFQPFSVSASKSESKEDVFGLVPFEEITGSQQQQKVKQRSLQKLSSRQRRTKQDVSK
                     SNGKRHHGTPTSAKKTLKPPYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVAL
                     TDGKDRASVLPSDESLLDPFGAKPFHPPDLWHQPHQGLSDICVDHTTILPGRPRQNSV
                     HGSFHSAETLRMDDFGAVPFTELVVQSVTPQQSQPVELDPFGAAPFPSKQ"
     exon            409..527
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            528..633
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            634..776
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            777..898
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            899..980
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1113
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1217
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1297
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1458
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1709
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1808
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1993
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2151
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2262
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..6568
                     /gene="Bmp2k"
                     /gene_synonym="4933417M22Rik; BIKE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgctggct ctgcgggcgc cgggcagctg cagcgggcgg ccagggctgc gcgctcggga
       61 cgcgcggaat gtgaggcgcg gcgagccgct gcgcaccgac gctcgcgcgc gcgaagggcg
      121 gcgacccctc gaagacggtc ggccgcgccc ggcgctccgc tgtgcgacgc gcgggtctgg
      181 gctctcgccc tcgcgcgccc tagtgccctc ctggtgccct ccagcgcgcc ggcgggacca
      241 tgaagaagtt ctctcggatg cccaagtcgg agggcagcgg cggcggggcg gcggctggcg
      301 gggccgcggg cggcgggctc ggcggcggct tcgcaagctc gtccatgggg gtccgggtgt
      361 tcgccgtcgg ccgctaccag gtcaccctgg aggagtcgct ggccgaaggt ggattctcca
      421 ctgttttcct ggtgcggact cacagtggga tccgatgtgc actgaagcga atgtatgtca
      481 ataacacacc cgacctcaac atttgtaaaa gggaaatcac gattatgaaa gagttatctg
      541 gccacaaaaa tattgtcggt tatttggact gtgctgtcaa ttcaattagt gacaatgtgt
      601 gggaagtgct tatcttaatg gaatattgtc gagctgggca ggttgtgaac cagatgaata
      661 agaagctgca gacaggcttt accgagtcag aagtcctaca aatcttctgt gatacctgcg
      721 aagctgtcgc acgattgcat caatgtaaga ctcccataat ccaccgggat ctgaaggtag
      781 aaaatatttt gctaaatgat gctggaaatt atgtgctttg tgactttggc agtgccacta
      841 ataaatttct caatcctcaa aaagatggag ttaatgtagt agaagaagaa attaaaaaat
      901 acacgactct gtcgtataga gcaccagaaa tgatcaacct ttatggaggg aaaccgatca
      961 ccaccaaggc tgatatctgg gccttgggat gtttactgta taaactttgt ttcttcactc
     1021 ttccttttgg tgagagtcag gttgctatct gtgatggcag cttcaccatc ccagacaatt
     1081 ctcgctactc ccacaacgtg cattgcttga ttaggttcat gcttgaacca gaccccgagt
     1141 gcagacctga catatttcaa gtatcctact ttgcgtttaa attcgccaaa aaggattgtc
     1201 cggtctccaa catcaataat tcttttcttc catcaactct tcccgagccg atgactgcta
     1261 ctgaagctgc tgctaggaaa agccagatga aagccagaat aacagatacc attggaccaa
     1321 cagaaacctc aattgcacca agacaaagac caaaggccaa ttccactgct gccacttcca
     1381 gtgtgctgac cattcagagt tcagcaacgc ctgtcaaagt ccctgctcct ggggagttca
     1441 gcaaccacaa acccaaagga gcattgagac ctggaaatgg gtctgaagtc ttaatggttc
     1501 agggaccccc tcagcaaccc ccacagcagc atagagtcct ccagcagttg cagcagggag
     1561 actggagatt acagcaactt catttgcatc gtcatcccca ccaccaccat cagcaacagc
     1621 aacaacagca acaacaacag cagcaacaac agctgcagca acaacagcaa cagcaacagc
     1681 aactacttca aaatgcttac ttgcagcagt atcagcatgc aatgcaccag cagcatatac
     1741 ttcagcaaca gtttctaatg cactcagtgt atcagccaca accgcctgca tcccagtatc
     1801 ctgccatgat gcagcagtat cagcaggctt tcttgcagca gcagatgcta gctcgccatc
     1861 agcagccagc acagcaggta tcacccgagt atcttacctc cccgcaagag ttctcaccag
     1921 ccttagtttc ctacgcctcg tcacttccag ctcaggttgg aaccatagtg gactcttctt
     1981 acggtgccaa caggtcagtt gctgagaaag aggcagttgc aaattttaca aatcagaaga
     2041 ccattagtca ccctcctgac atgtcaggct ggaatccttt tggagaagac aatttttcca
     2101 agttaacaga agaggaactg ttggacagag aatttgacct tctaagatca aacaggctcg
     2161 gggcgagcac accctcagat aagactgtag acctgccccc cgctccacat agccgtcctc
     2221 cggaggagcc ttttgcttcc gtccctttca tttctcactc aggttctcct gaaaagaaaa
     2281 cgacggaaca ttctccaaat caaaaatcta tcactgcaaa ccttaccaaa aatggaggct
     2341 caagtccact atgtaaagat cagcgagccg gaaagaaaac ctccgagaat cccgtaatta
     2401 ggggtcaagt acaaaaggga catgatgatt ctgaaagtga tttcgaatca gacccccctt
     2461 ctcctaagag cagtgaagaa gaacaagagg atgaagacgc acagggagaa cacggggact
     2521 ttaatgatga cgacactgag ccggagaacc tgggtcacag gcctctgctg atggactctg
     2581 aagatgagga agaggacgac aaacacagct ctgattcaga gtgtgaacag gcaaagacca
     2641 agagaggaga cacgagctcc ctgcgcaggg acaaacctgg cgtggcccca gacacagccc
     2701 tcctgacccc ggcccgctcg cctgctgatg cgctgactcc cagtcaggag ttcgatgtgt
     2761 ttggcgctgt tcccttcttt gcagcgcctg ctccgcagag cctgcagcac agaggggatg
     2821 ggaagaacct gtcccagcat gcttttccag agcaggagga cttcgacgtg ttcacaaagg
     2881 cacccttcaa caagaaggtc agcgtacagg actggcccgc ggtggggcca gatgcccggc
     2941 ctctgcctgc acggcccaga agtgtagata tatttggctc cactcccttc cagcccttct
     3001 ccgtgtcagc cagtaaaagt gaaagcaagg aggatgtttt tgggctcgtg ccctttgagg
     3061 aaataactgg gagtcagcag cagcagaaag tcaagcagcg cagcttgcag aaactctcct
     3121 ctcgccagag acgcacaaag caggatgtgt ccaaaagcaa tgggaagcgc catcacggca
     3181 cccctaccag cgcaaagaag acgctgaagc ccccctaccg cacgcccgag agggcccgca
     3241 gacacaagaa ggtgggccgc agagactccc agagcagcaa tgagttttta accatttccg
     3301 attccaagga gaacatcagc gtcgcgctga ctgatggcaa agacagggcc agtgtcctgc
     3361 catctgacga gagtctgctg gacccattcg gtgccaagcc ctttcatcct ccagacttgt
     3421 ggcaccagcc ccatcagggc ctaagcgaca tctgcgttga tcacaccacc attttgcctg
     3481 ggaggccgcg acagaattca gtacacgggt ccttccacag cgcagagaca ttgagaatgg
     3541 atgactttgg tgccgtgccc tttacagaac tcgtggtgca aagtgtcact ccacaacagt
     3601 cccaaccggt cgaactagac ccctttggtg ctgctccatt tccttctaaa cagtagatac
     3661 ttcaggtgga ctcagcaata actcctgttt caaaaaagta tgaatagttt tatgaatctg
     3721 gaagaaaaag tatttgtata gttgtttata tcatacactc ttcacaggtt aatcaggata
     3781 ggtgattttt aaataaacca aatggaattg tttgtacagg gtagtaagtg gatgccttct
     3841 tcaagcagga ggaggcctaa atcgaaagtt ccaagggctt ttgctactga cagctagctc
     3901 agaggttccc gtgggctccc tgggaaagct gctgtgtagc cgctgaggga caagaaagct
     3961 tatcacttca gatatcacat gtcacctagg tgcacacccc agatgcagcg tttggggctg
     4021 aatgaatgct tccaccatga ggaaacagcc tcgagtgctc ttcatacact gcttcgtaag
     4081 gtggagccag aggaaactga ctgttgtgcc taaaaatact gtttcattaa aaaacaaaac
     4141 aaaacaagtg ccattaataa tggactctgc aatgataagt atatgaaata atgtatatat
     4201 taactcactt tagcccttct atggtgtatg gctcaaaaca tgtatatgat aatatatatg
     4261 cagtttctaa tctgtcaaaa ataaattttt acaatgtgga atgcctagaa caaaaataca
     4321 aagagaaata tctggcattt gaaaaaaatg taaaagaatg atacgtaaaa agaaaagcaa
     4381 catttggtac ttcagaaaga ctttgtcttt gaatgggtat ttgccaaaac ctttatcatc
     4441 atgcccctac tgaagtacat tgatagaagg gggggggcag gttatataga aatttaattt
     4501 cagaaacaat gtagctgaaa ctttaatttt taaagaagtt tacaatgtaa aatcatgttg
     4561 catttactga cctactttct gccagcccca ccctcatcca gcactgggga gtcctgggct
     4621 gcagttcctt cagggtgctc cgacagtgac agactctgca tggacagcca gaccctcagt
     4681 ggatggaaga actgggtggt gggactagga gcttaattct gctacccgac tgcatcagta
     4741 gtgaaaagaa ctaagctacc aaattgcctt ttaaaaaaat atcaccagtc ataataagaa
     4801 acttgaaatt ttgtagttgt ggttagtgat agcagttata catcagttaa tgtgaatgta
     4861 ctatccgtgc gtcctgtgtc tgtcgtaagt tatgattagc ttctttacag atgagcattt
     4921 gaagtttcta ggtcaacagc tattgctatt gattgctata ttttaagttg cccccagtta
     4981 gtgtacctta atgagtaatc ttattaaaac ctcttaactt tagtgcccca gaaggtaaat
     5041 catttgccta ctttcagagt tcagaacttg gaaagaagca aaatacataa ccaaggcatg
     5101 gtccttttat atttcttgtc tcctcctctg caaactcagt gggggtagtg tggacaggag
     5161 caggccacac catgccacgc agaaccgggc tgcaccactt actgtcctgt gccaaaggca
     5221 gagactatgt ttgcaccttt tttttttctg gttctcaggt taattaatct aactaacgca
     5281 aatggtagta gaccctttaa gctacaaaac agattcagta atgcttgctt tttaaagtaa
     5341 tgatgaactg atgtggtctt ctgagttgtg aatatgaaat cagagttcca cttgcctttc
     5401 aatgcactga atattttaag gtgattcact gacaacaacc cctccagctt actctggaca
     5461 aattcttagg aaacaactct gccacagctt aaaatgttta cattgcctct gacagcccag
     5521 caggtgacac tcctcttgga acccgctcat tggacagatg atttaattgg aggtccaatg
     5581 ggtagctcct ttgcattgct gttagaggca ttttctcaag ctgaggagac tccatttaaa
     5641 tttcagtgtc agctgccact gtcactctgt acagctgagc cttaggtagc gaattccctc
     5701 acaagaactt ggctccccca cttaccagca cccaacactc actcaacagc tggcccagtt
     5761 ctggcttaaa gaatgtcatt tgggtgtgcc ctgtgcttct aagtatgcaa agcagttcta
     5821 actaaacccg ttagacttga acatcaaagg gaagtcacgt gaggaaccca gagttgtcag
     5881 ctagaagctt taccagtgct cattaactct gaatcttctt aaaaagtgga ccctttgctc
     5941 cactttgaac acgtcaataa aaggttagtg tcgccagaga atcttttagg gcattgaaga
     6001 aatggatcta gtacagcaca gcacagaggt tgctcagtat gtagctggag aaaaggtctg
     6061 ctccaagcag ggtgagaatg gaactggcta gaatattaag cactgcagtg ctcctcccct
     6121 gggctgtgtg tcctgggcag ttaggaaatc acttggctct cagatgtgtg cactttgcag
     6181 tcagtgctac cctgtttaac aggaactgac tcctctcatc ttcctgatgg aagatactaa
     6241 ggtggtgccc actctggctc ctctccattc ggccatccag gcctgggtac ttcactaaag
     6301 cattgttaga aggtgcacgt gtattaatat cactacttac gggaagtttg ggtatatttg
     6361 cttaatacct gtagagtgca cagtgaactc tgttattttt ttcttttctt tttaagcaaa
     6421 actagtcatc aaattacatc cagtttctga actgatggtc tactgtgaga tgatgtatct
     6481 actgagagaa tagcaaatga ctgttgggaa aaaaaaaatc tatactcggt gttgttttct
     6541 actaagataa aaagatactt gcacaccaaa aaaaaaaaaa aaaaa
//
