LOCUS       NM_007553               3566 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus bone morphogenetic protein 2 (Bmp2), mRNA.
ACCESSION   NM_007553
VERSION     NM_007553.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3566)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3566)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Padilla,C.,
            Iben,J., Faucz,F.R., Cotney,J.L. and D'Souza,R.N.
  TITLE     Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in
            Palatogenesis'
  JOURNAL   J Dent Res 103 (13), 1412-1420 (2024)
   PUBMED   38910391
REFERENCE   3  (bases 1 to 3566)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   4  (bases 1 to 3566)
  AUTHORS   Park,J.Y., Jo,C.S., Ku,C. and Hwang,J.S.
  TITLE     BMP-2 regulates the expression of myosin Va via smad in melan-a
            melanocyte
  JOURNAL   Arch Dermatol Res 316 (6), 225 (2024)
   PUBMED   38787453
  REMARK    GeneRIF: BMP-2 regulates the expression of myosin Va via smad in
            melan-a melanocyte.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3566)
  AUTHORS   Rosen,V.
  TITLE     BMP2 signaling in bone development and repair
  JOURNAL   Cytokine Growth Factor Rev 20 (5-6), 475-480 (2009)
   PUBMED   19892583
  REMARK    Review article
REFERENCE   6  (bases 1 to 3566)
  AUTHORS   Feng,J.Q., Harris,M.A., Ghosh-Choudhury,N., Feng,M., Mundy,G.R. and
            Harris,S.E.
  TITLE     Structure and sequence of mouse bone morphogenetic protein-2 gene
            (BMP-2): comparison of the structures and promoter regions of BMP-2
            and BMP-4 genes
  JOURNAL   Biochim Biophys Acta 1218 (2), 221-224 (1994)
   PUBMED   8018727
REFERENCE   7  (bases 1 to 3566)
  AUTHORS   Ohta,S., Hiraki,Y., Shigeno,C., Suzuki,F., Kasai,R., Ikeda,T.,
            Kohno,H., Lee,K., Kikuchi,H., Konishi,J. et al.
  TITLE     Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase
            expression of the proto-oncogene c-fos in murine osteoblastic
            MC3T3-E1 cells
  JOURNAL   FEBS Lett 314 (3), 356-360 (1992)
   PUBMED   1468569
REFERENCE   8  (bases 1 to 3566)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
REFERENCE   9  (bases 1 to 3566)
  AUTHORS   Lyons,K.M., Pelton,R.W. and Hogan,B.L.
  TITLE     Organogenesis and pattern formation in the mouse: RNA distribution
            patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)
  JOURNAL   Development 109 (4), 833-844 (1990)
   PUBMED   2226202
REFERENCE   10 (bases 1 to 3566)
  AUTHORS   Dickinson,M.E., Kobrin,M.S., Silan,C.M., Kingsley,D.M.,
            Justice,M.J., Miller,D.A., Ceci,J.D., Lock,L.F., Lee,A.,
            Buchberg,A.M. et al.
  TITLE     Chromosomal localization of seven members of the murine TGF-beta
            superfamily suggests close linkage to several morphogenetic mutant
            loci
  JOURNAL   Genomics 6 (3), 505-520 (1990)
   PUBMED   1970330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK133923.1, AK161862.1,
            BC100344.1 and AV333272.1.
            
            On Mar 20, 2013 this sequence version replaced NM_007553.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer, which plays a role in bone and
            cartilage development. While a homozygous knockout mouse for this
            gene exhibits embryonic lethality, conditional knockout mice have
            defects in bone, cartilage and heart development. [provided by
            RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133923.1, AK132433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AK133923.1         2-199
            199-2420            AK161862.1         3-2224
            2421-3555           BC100344.1         1381-2515
            3556-3566           AV333272.1         272-282
FEATURES             Location/Qualifiers
     source          1..3566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 65.21 cM"
     gene            1..3566
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /note="bone morphogenetic protein 2"
                     /db_xref="GeneID:12156"
                     /db_xref="MGI:MGI:88177"
     exon            1..1193
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1543
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             1201..2385
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /note="bone morphogenetic protein 2A"
                     /codon_start=1
                     /product="bone morphogenetic protein 2 preproprotein"
                     /protein_id="NP_031579.2"
                     /db_xref="CCDS:CCDS16782.1"
                     /db_xref="GeneID:12156"
                     /db_xref="MGI:MGI:88177"
                     /translation="MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAAASSRPLSRP
                     SEDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGAPAPDHRLERAA
                     SRANTVRSFHHEEAVEELPEMSGKTARRFFFNLSSVPSDEFLTSAELQIFREQIQEAL
                     GNSSFQHRINIYEIIKPAAANLKFPVTRLLDTRLVNQNTSQWESFDVTPAVMRWTTQG
                     HTNHGFVVEVAHLEENPGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHK
                     REKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADH
                     LNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCG
                     CR"
     exon            1544..3566
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3514..3519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /note="hexamer: AATAAA"
     polyA_site      3555
                     /gene="Bmp2"
                     /gene_synonym="Bmp2a"
                     /note="major polyA site"
ORIGIN      
        1 cggccacggc cgggagggag ccggcaggcg gcgtctcctt taaaagccgc gagcgccgcg
       61 ccacggcgcc tccgtcgtcg ccgccggagt cctcgccctg ccgcgcagag ccctgctcgc
      121 actgcgcccg ccgccgctgc gcttcccaca gcccgcccgg gattggcagc cccggacgta
      181 gcctccccag gcgacaccag gcaccggacg ccctcccggc gaaagacgcg agggtcaccc
      241 gcggcttcga gggactggca cgacacgggt tggaactcca gactgtgcgc gcctggcgct
      301 gtggcctcgg ctgtccggga gaagctagag tcgcggaccg acgctaagaa ccgggagtcc
      361 ggagcacagt cttaccctca atgcggggcc actctgaccc aggagtgagc gcccaaggcg
      421 agcgggcgga agagtgagtg gaccccaggc tgccacaaaa gacacttggc ccgagggctc
      481 ggagcgcgag gtcacccggt ttggcaaccc gagacgcgcg gctggactgt ctcgagaatg
      541 agccccagga cgccggggcg ccgcagccgt gcgggctctg ctggcgagcg ctgatggggg
      601 tgcgccagag tcaggctgag ggatgcagag tggcggcccg cccgccaccc agatcttcgc
      661 tgcgcccttg cccggacacg gcatcgccca cgatggctgc cccgagccat gggtcgcggc
      721 ccagctaacg cagaacgtcc gtccctcgcc cggcgagtcc cggagccagc cccgcgcccc
      781 gccagcgctg gtccctgagg ccgacgacag cagcagcctt gcctcagcct tcccttcccg
      841 tcccggcccc gcactcctcc ccctgctcga ggctgtgtgt cagcacttgg ctggagactt
      901 cttgaacttg ccgggagagt gacttgggct ccccacttcg cgccggtgtc ctcgcccggc
      961 ggatccagtc ttgccgcctc cagcccgatc acctctcttc ctcagcccgc tgggcccacc
     1021 ccaagacaca gttccctaca gggagaacac ccggagaagg aggaggaggc gaagaaaagc
     1081 aacagaagcc cagttgctgc tccaggtccc tcggacagag ctttttccat gtggagactc
     1141 tctcaatgga cgtgccccct agtgcttctt agacggactg cggtctccta aaggtcgacc
     1201 atggtggccg ggacccgctg tcttctagtg ttgctgcttc cccaggtcct cctgggcggc
     1261 gcggccggcc tcattccaga gctgggccgc aagaagttcg ccgcggcatc cagccgaccc
     1321 ttgtcccggc cttcggaaga cgtcctcagc gaatttgagt tgaggctgct cagcatgttt
     1381 ggcctgaagc agagacccac ccccagcaag gacgtcgtgg tgccccccta tatgctagat
     1441 ctgtaccgca ggcactcagg ccagccagga gcgcccgccc cagaccaccg gctggagagg
     1501 gcagccagcc gcgccaacac cgtgcgcagc ttccatcacg aagaagccgt ggaggaactt
     1561 ccagagatga gtgggaaaac ggcccggcgc ttcttcttca atttaagttc tgtccccagt
     1621 gacgagtttc tcacatctgc agaactccag atcttccggg aacagataca ggaagctttg
     1681 ggaaacagta gtttccagca ccgaattaat atttatgaaa ttataaagcc tgcagcagcc
     1741 aacttgaaat ttcctgtgac cagactattg gacaccaggt tagtgaatca gaacacaagt
     1801 cagtgggaga gcttcgacgt caccccagct gtgatgcggt ggaccacaca gggacacacc
     1861 aaccatgggt ttgtggtgga agtggcccat ttagaggaga acccaggtgt ctccaagaga
     1921 catgtgagga ttagcaggtc tttgcaccaa gatgaacaca gctggtcaca gataaggcca
     1981 ttgctagtga cttttggaca tgatggaaaa ggacatccgc tccacaaacg agaaaagcgt
     2041 caagccaaac acaaacagcg gaagcgcctc aagtccagct gcaagagaca ccctttgtat
     2101 gtggacttca gtgatgtggg gtggaatgac tggatcgtgg cacctccggg ctatcatgcc
     2161 ttttactgcc atggggagtg tccttttccc cttgctgacc acctgaactc cactaaccat
     2221 gccatagtgc agactctggt gaactctgtg aattccaaaa tccctaaggc atgctgtgtc
     2281 cccacagagc tcagcgcaat ctccatgttg tacctagatg aaaatgaaaa ggttgtgcta
     2341 aaaaattatc aggacatggt tgtggagggc tgcgggtgtc gttagcacag caagaataaa
     2401 taaataaata tatatatttt agaaacagaa aaaaccctac tccccctgcc tcccccccaa
     2461 aaaaaccagc tgacacttta atatttccca atgaagactt tatttatgga atggaatgga
     2521 aaaaaacaca gctattttga aaatatattt atatctacga aaagaagttg ggaaaacaaa
     2581 tattttaatc agagaattat tccttaaaga tttaaaatgt atttagttgt acattttata
     2641 tgggttcaac tccagcacat gaagtataat ggtcagagtt attttgtatt tatttactat
     2701 tataaccact ttttagggaa aaaagatagt taatttgtat ttatatgtaa tcagaagaaa
     2761 tatcgggttt gtatataatt ttcaaaaaga attgtagttg tttttcagtt gtgtgtattt
     2821 aagatgcaaa gtctacatgg aaggttgctg agcaaagtgc ttgcacactt gctgtctgtt
     2881 tcttgcagca ctactgttaa agttcacaag ttcaagtcca aaaaaaaaaa aaaaggataa
     2941 tctactttgc tgactttcaa gattatattc ttcaattctc aggaatgttg cagagtggtt
     3001 gtccaatccg tgagaacttt cattcttatt agggggaata tttggataag aaccagacat
     3061 tactgatctg atagaaaagc tctcgccacc ctccctgcag caagaacaaa gcaggaccag
     3121 tgggaataat taggaaaact gtgactatgt caggaagtga tgatggcatc ttgttctttc
     3181 ttaagcctat aatcccttcc agggggctga tctggccaaa gtactaaata aaatataata
     3241 tttcttcttt attaacattg tagtcatata tgtgtacaat tgattatctt gtgggccctc
     3301 ataaagaagc agaaattggc ttgtattttg tgtttaccct atcagcaatc tctctattct
     3361 ccaaagcacc caattttcta catttgcctg acacgcagca aaattgagca tatgtttcct
     3421 gcctgcaccc tgttctctga cctgtcagct tgcttttctt tccagggata tgtgtttgaa
     3481 catatttctc caaatgttaa acccatttca gataataaat atcaaaattc tggcatttca
     3541 tcctataaaa cctaacccgt gagagc
//
