LOCUS       NM_009757               3116 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus bone morphogenetic protein 15 (Bmp15), mRNA.
ACCESSION   NM_009757
VERSION     NM_009757.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Liu,Y., Fan,H., Kang,X., Hao,Y., Wang,N., Zheng,H., Li,Y. and
            Kang,S.
  TITLE     A rare germline BMP15 missense mutation causes hereditary ovarian
            immature teratoma in human
  JOURNAL   Proc Natl Acad Sci U S A 121 (10), e2310409121 (2024)
   PUBMED   38427603
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Ito,H., Emori,C., Kobayashi,M., Maruyama,N., Fujii,W., Naito,K. and
            Sugiura,K.
  TITLE     Cooperative effects of oocytes and estrogen on the forkhead box L2
            expression in mural granulosa cells in mice
  JOURNAL   Sci Rep 12 (1), 20158 (2022)
   PUBMED   36424497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Gindi,N., Grossman,H., Bar-Joseph,H., Miller,I., Nemerovsky,L.,
            Hadas,R., Nevo,N., Galiani,D., Dekel,N. and Shalgi,R.
  TITLE     Fyn and argonaute 2 participate in maternal-mRNA degradation during
            mouse oocyte maturation
  JOURNAL   Cell Cycle 21 (8), 792-804 (2022)
   PUBMED   35104175
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Tanaka,K., Hayashi,Y., Takehara,A., Ito-Matsuoka,Y., Tachibana,M.,
            Yaegashi,N. and Matsui,Y.
  TITLE     Abnormal early folliculogenesis due to impeded pyruvate metabolism
            in mouse oocytesdagger
  JOURNAL   Biol Reprod 105 (1), 64-75 (2021)
   PUBMED   33824958
  REMARK    GeneRIF: Abnormal early folliculogenesis due to impeded pyruvate
            metabolism in mouse oocytesdagger.
            Erratum:[Biol Reprod. 2021 Oct 11;105(4):1069. doi:
            10.1093/biolre/ioab154.. PMID: 34390336]
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   Ge,W., Tan,S.J., Wang,S.H., Li,L., Sun,X.F., Shen,W. and Wang,X.
  TITLE     Single-cell Transcriptome Profiling reveals Dermal and Epithelial
            cell fate decisions during Embryonic Hair Follicle Development
  JOURNAL   Theranostics 10 (17), 7581-7598 (2020)
   PUBMED   32685006
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Yan,C., Wang,P., DeMayo,J., DeMayo,F.J., Elvin,J.A., Carino,C.,
            Prasad,S.V., Skinner,S.S., Dunbar,B.S., Dube,J.L., Celeste,A.J. and
            Matzuk,M.M.
  TITLE     Synergistic roles of bone morphogenetic protein 15 and growth
            differentiation factor 9 in ovarian function
  JOURNAL   Mol Endocrinol 15 (6), 854-866 (2001)
   PUBMED   11376106
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   Galloway,S.M., McNatty,K.P., Cambridge,L.M., Laitinen,M.P.,
            Juengel,J.L., Jokiranta,T.S., McLaren,R.J., Luiro,K., Dodds,K.G.,
            Montgomery,G.W., Beattie,A.E., Davis,G.H. and Ritvos,O.
  TITLE     Mutations in an oocyte-derived growth factor gene (BMP15) cause
            increased ovulation rate and infertility in a dosage-sensitive
            manner
  JOURNAL   Nat Genet 25 (3), 279-283 (2000)
   PUBMED   10888873
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Jaatinen,R., Laitinen,M.P., Vuojolainen,K., Aaltonen,J., Louhio,H.,
            Heikinheimo,K., Lehtonen,E. and Ritvos,O.
  TITLE     Localization of growth differentiation factor-9 (GDF-9) mRNA and
            protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel
            homolog GDF-9B
  JOURNAL   Mol Cell Endocrinol 156 (1-2), 189-193 (1999)
   PUBMED   10612437
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Dube,J.L., Wang,P., Elvin,J., Lyons,K.M., Celeste,A.J. and
            Matzuk,M.M.
  TITLE     The bone morphogenetic protein 15 gene is X-linked and expressed in
            oocytes
  JOURNAL   Mol Endocrinol 12 (12), 1809-1817 (1998)
   PUBMED   9849956
REFERENCE   10 (bases 1 to 3116)
  AUTHORS   Laitinen,M., Vuojolainen,K., Jaatinen,R., Ketola,I., Aaltonen,J.,
            Lehtonen,E., Heikinheimo,M. and Ritvos,O.
  TITLE     A novel growth differentiation factor-9 (GDF-9) related factor is
            co-expressed with GDF-9 in mouse oocytes during folliculogenesis
  JOURNAL   Mech Dev 78 (1-2), 135-140 (1998)
   PUBMED   9858711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK135882.1, AK139773.1 and
            AU019682.1.
            
            On Aug 30, 2016 this sequence version replaced NM_009757.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate subunits of a
            disulfide-linked homodimer, or alternatively, a heterodimer, with
            the related protein, growth differentiation factor 9 (GDF9). This
            protein plays a role in oocyte maturation and follicular
            development, through activation of granulosa cells. Female mice
            lacking a functional copy of this gene exhibit impaired fertility.
            [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139847.1, BC055363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK135882.1         2-2
            2-3035              AK139773.1         2-3035
            3036-3116           AU019682.1         1-81                c
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 2.81 cM"
     gene            1..3116
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="bone morphogenetic protein 15"
                     /db_xref="GeneID:12155"
                     /db_xref="MGI:MGI:1316745"
     exon            1..683
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1540
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="growth/differentiation factor 9B"
                     /codon_start=1
                     /product="bone morphogenetic protein 15 preproprotein"
                     /protein_id="NP_033887.1"
                     /db_xref="CCDS:CCDS29958.1"
                     /db_xref="GeneID:12155"
                     /db_xref="MGI:MGI:1316745"
                     /translation="MALLTILRILLWGVVLFMEQRVQMAKPGWPSTALLADDPTLPSI
                     LDLAKEAPGKEMKQWPQGYPLRYMLKLYHRSADPHGHPRENRTIGAKMVRLVKPSANT
                     VRPPRGSWHVQTLDFPLASNQVAYELIRATVVYRHQLHLVNYHLSCHVETWVPKCRTK
                     HLPSSKSGSSKPSPMSKAWTEIDITHCIQQKLWNRKGRSVLRLRFMCQQQKGNETREF
                     RWHGMTSLDVAFLLLYFNDTDDRVQGKLLARGQEELTDRESSFLMRSVRQACSIESDA
                     SCPSQEHDGSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTRVLPYGLNS
                     PNHAIIQSLVNELVNHSVPQPSCVPYNFLPMSILLIETNGSILYKEYEGMIAQSCTCR
                     "
     exon            684..3116
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="hexamer: AATAAA"
     polyA_site      3064
                     /gene="Bmp15"
                     /gene_synonym="Bmp-15; GDF-9B"
                     /note="major polyA site"
ORIGIN      
        1 tgcttccttt taacctatta gattgggtgc aggccaggtt cctggaatgg gcctcttctc
       61 ctcggttact ttagcctgtc tgagaactgc tgtgtacttc ccaccagtgg ggagtgggaa
      121 gggcatgctg ccttgtccca cttgcttttt ctgtttgttt tcatgccaag aagcctagtc
      181 aggagactcg ctttggccca gaagattctc ccacaggaag taagataggg tctgccagtc
      241 ggcgtttctt tttatttctt gccccgtctt tggtatttgt taaaccagga tgtggaagag
      301 gtcagactga tgttctttgg acttggttag gaatctgctg aaaagcacca agctttgcaa
      361 gatggccctt ctcacaattc ttagaattct tttgtgggga gtggtgcttt ttatggaaca
      421 gagggtccaa atggcaaagc cagggtggcc ctccaccgcc ctccttgctg acgaccctac
      481 attgccctca attttggatc tggccaaaga agcccctggc aaggagatga agcaatggcc
      541 ccaaggctat cccctgaggt acatgctcaa gttataccat cgttcggctg acccgcatgg
      601 ccatccaagg gagaaccgca cgattggagc gaaaatggtg aggctggtaa agccgtcggc
      661 caacacagta aggcctccca gaggttcctg gcatgtacag accctggact ttcctctagc
      721 atcaaaccag gtagcatacg aactaatcag agccactgtg gtttaccgcc atcaacttca
      781 tctagttaat taccatctct cctgccatgt ggaaacttgg gttcctaaat gccggaccaa
      841 gcacttacct tcttctaaat cgggttcctc aaagccttct cccatgtcta aagcctggac
      901 agagatagat attacacatt gtattcagca gaagctctgg aatcgcaagg gacggagtgt
      961 tcttcgcctc cgcttcatgt gtcagcagca aaaaggcaat gagactcgtg agttccggtg
     1021 gcatggcatg acatccttgg atgttgcctt cttgctactc tatttcaatg acaccgatga
     1081 cagagttcag ggtaaacttc ttgcaagagg ccaagaggag ttaactgata gggaatcttc
     1141 ttttctcatg cggagtgtcc ggcaagcatg cagcattgaa tctgatgcct cttgtccttc
     1201 tcaggaacat gatgggtctg taaataacca gtgttccctc catccttaca aggtcagctt
     1261 ccaccaacta ggctgggatc actggatcat tgctcctcgt ctctataccc caaattactg
     1321 taaaggaatc tgtactcggg tattacccta tggtctcaat tcacccaacc atgccatcat
     1381 tcagagcctt gtcaatgaac tagtgaatca cagtgtacct cagccttcct gtgtccctta
     1441 taattttctt cctatgagca tcctcctgat tgagaccaac gggagtatct tgtacaagga
     1501 gtatgagggt atgattgccc agtcctgtac atgtagataa tagtgaagtt gttgctatct
     1561 caggtttccc aagaagctat agatgtttaa agaaaactgt gttaaagctg gcagtgatct
     1621 acccaaccta cagattctgt tccttatctt taaaaaatat attgtgctta tgcttaaaat
     1681 ataagagccc tttgtactct ataaacaaaa tgctaggatc ccatcttaat attttttaaa
     1741 agtaatttaa aataccatga aatggttatc ttaagcattg tttaaatctc tcaccccatt
     1801 tttgagctcc tcagcttgta aaaatgtttc tggtgctggt atcctagcat ggatcagtag
     1861 aacttaacta gcccccaata ctgagataag atgctttctg gagatacatt attacatcat
     1921 ttttattgtg actttgggaa aaaaaatcaa gaaaatactg gtccatggta gaagaacata
     1981 tggagtcctg gaggtgactt cattctgggc tcacttgatt gatgtgtcca gttgggctct
     2041 tctgggctta ggtctctggg agacaacctt gctgtttggg aggaagtata gagctctttc
     2101 ttgaactaaa ttatgttcac aggatgattt cttgtttttt tccctgtttt ttttgttttg
     2161 gattattatt attattatta ttttgtgctg agaataagca agtgttctac cactgtgctg
     2221 tatccccagc ccagtttatc ttctctataa ttctatacta tatttaagtg ttgggacaat
     2281 attgcaaatg aatgatgctt ttttttttgt taaagatctt gaatgctttg gagattagga
     2341 gagagtgaaa agaaagaatt tatatctttt attctctatg gctataatct agagctctac
     2401 tttaatccct gagggatggg gccagaggct cctctgagtt ctgtctcaga cagcactact
     2461 aataaacagc tcttactaag gtactagtta aagaagccca gcatgtctca gtacctgcct
     2521 agctattgac tagttttatc acattctctc tgggatggaa cctgatttag ggcatgggca
     2581 tgtgctcatc attgttcatt cctatctgtt ccttacattt cccatacatt aactcagtta
     2641 tttctttctc aacagttgat gctcacagga ctgaatatat gtggatctat tccttagcat
     2701 cattttgctc acatatctac ttagaaatca attcaggctt tactgttctt ctcttcagta
     2761 ttctcatgac aaccagtttc aagtcgctgt ctctcctccc atctcaaagc acagcatggt
     2821 ttcccttaaa atgctctagt attactgtct tcactgagaa aagatggagc tccctttgaa
     2881 cgctttactt ggctcattgt cttctgaata gccagaactg aaaacctagg aagtcctttg
     2941 atgaatacaa aaagttgact tttttgtgtg tgtgagacat ggaatacccc cctatttata
     3001 tatttgtatg tttatgtatt ttcttaatct taaagaataa attttcattt atgtgtgctt
     3061 tgcatataaa gttagtaatt tcaaaactgt acaaattata agagatgatg aaagct
//
